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73 results on '"Stanisavljević, A."'

1. Brain inflammation in experimental autoimmune encephalomyelitis induced in Dark Agouti rats with spinal cord homogenate

Author

Stegnjaić, Goran, primary, Jevtić, Bojan, additional, Lazarević, Milica, additional, Ignjatović, Đurđica, additional, Tomić, Mirko, additional, Nikolovski, Neda, additional, Bjelobaba, Ivana, additional, Momčilović, Miljana, additional, Dimitrijević, Mirjana, additional, Miljković, Đorđe, additional, and Stanisavljević, Suzana, additional

Published
2024
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2. Ethyl pyruvate ameliorates acute respiratory distress syndrome in mice

Author

Mićanović, Dragica, primary, Lazarević, Milica, additional, Kulaš, Jelena, additional, Despotović, Sanja, additional, Stegnjaić, Goran, additional, Jevtić, Bojan, additional, Koprivica, Ivan, additional, Mirkov, Ivana, additional, Stanisavljević, Suzana, additional, Nikolovski, Neda, additional, Miljković, Đorđe, additional, and Saksida, Tamara, additional

Published
2024
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6. Fluoxetine exerts subregion/layer specific effects on parvalbumin/GAD67 protein expression in the dorsal hippocampus of male rats showing social isolation-induced depressive-like behaviour

Author

Andrijana Stanisavljević, Dragana Filipović, Ivana Perić, and Peter Gass

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, animal structures, Glutamate decarboxylase, Hippocampus, Hippocampal formation, Inhibitory postsynaptic potential, gamma-Aminobutyric acid, Marble burying, 03 medical and health sciences, 0302 clinical medicine, Fluoxetine, Internal medicine, medicine, Animals, Rats, Wistar, Social Behavior, Parvalbumin, Neurons, Behavior, Animal, biology, Depression, Glutamate Decarboxylase, Chemistry, General Neuroscience, Dentate gyrus, Rats, Chronic social isolation, Parvalbumins, 030104 developmental biology, Endocrinology, Social Isolation, GAD67, biology.protein, Selective Serotonin Reuptake Inhibitors, 030217 neurology & neurosurgery, medicine.drug
Abstract

The molecular background of depression is intensively studied in terms of alterations of inhibitory circuits, mediated by gamma aminobutyric acid (GABA) signalization. We investigated the effects of chronic social isolation (CSIS) and chronic fluoxetine (Flx) treatment (15 mg/kg/day) (3 weeks), on Parvalbumin (PV) and GAD67 expression in a layer-specific manner in rat dorsal hippocampal subregions. CSIS-induced depressive- and anxiety-like behaviours were confirmed with decrease in sucrose preference and increase in marble burying during behavioural testing, while Flx antagonized these effects. CSIS altered PV expression in stratum pyramidale (SP) of dorsal cornu ammonis 1 (dCA1) and stratum radiatum (SR) of dCA3. Flx antagonized this effect, and boosted PV expression in SP of the entire dCA and the dorsal dentate gyrus (dDG), as well as in the SR of dCA1/CA3. CSIS showed no significant effects on GAD67 expression, while Flx boosted its expression within the SR of the entire CA and SO of the dCA3. A correlation between SP of dCA1 and SR of dCA3 with regard to PV changes, implicates their possible role in the inhibitory circuit alterations. Flx-induced increase in GAD67 expression, specifically in SR of the entire dHIPP, may impose its involvement in the cell metabolic processes. Strong negative correlation between GAD67 and sucrose preference following Flx-treatment of CSIS rats was revealed. PV + cells of the SP layer of dCA1 and CA2 could be a potential target for the antidepressant action of Flx, while strong effect of Flx on GAD67 expression in the SR should be more extensively studied.

Published
2021

7. Anatomic and MRI bases for medullary infarctions with patients’ presentation

Author

Vlašković, Tatjana, primary, Brkić, Biljana Georgievski, additional, Stević, Zorica, additional, Kostić, Dejan, additional, Stanisavljević, Nataša, additional, Marinković, Ivan, additional, Vojvodić, Aleksandra, additional, Nikolić, Valentina, additional, Puškaš, Laslo, additional, Blagojević, Miloš, additional, and Marinković, Slobodan, additional

Published
2022
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8. Anatomic and MRI Bases for Pontine Infarctions with Patients Presentation

Author

Vlašković, Tatjana, primary, Brkić, Biljana Georgievski, additional, Stević, Zorica, additional, Vukićević, Marjana, additional, Đurović, Olivera, additional, Kostić, Dejan, additional, Stanisavljević, Nataša, additional, Marinković, Ivan, additional, Kapor, Slobodan, additional, and Marinković, Slobodan, additional

Published
2022
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10. The correlation between genetic factors and freezing of gait in patients with Parkinson's disease

Author

Radojević, Branislava, primary, Dragašević-Mišković, Nataša T., additional, Marjanović, Ana, additional, Branković, Marija, additional, Milovanović, Andona, additional, Petrović, Igor, additional, Svetel, Marina, additional, Jančić, Ivan, additional, Stanisavljević, Dejana, additional, Milićević, Ognjen, additional, Savić, Miroslav M., additional, and Kostić, Vladimir S., additional

Published
2022
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12. Vertebrobasilar and internal carotid arteries dissection in 188 patients

Author

Brkić, Biljana Georgievski, primary, Jaramaz, Tatjana Dučić, additional, Vukičević, Marjana, additional, Stanisavljević, Nataša, additional, Kostić, Dejan, additional, Lučić, Miloš, additional, Marinković, Ivan, additional, Apostolović, Tija, additional, Vlašković, Tatjana, additional, Ćirković, Ana, additional, and Marinković, Slobodan, additional

Published
2021
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14. Pike-perch larvae growth in response to administration of lactobacilli-enriched inert feed during first feeding

Author

Ljubobratović, Uroš, primary, Fazekas, Georgina, additional, Koljukaj, Alan, additional, Ristović, Tijana, additional, Vass, Vivien, additional, Ardó, László, additional, Stanisavljević, Nemanja, additional, Vukotić, Goran, additional, Pešić, Mirjana, additional, Milinčić, Danijel, additional, Kostić, Aleksandar, additional, and Lukić, Jovanka, additional

Published
2021
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16. Novel Nanoporous Carbon/Iron Oxide Catalyst for SO2 Degradation

Author

Marko Čađo, Radovan Kukobat, Zoran Kukrić, Maja Stanisavljević, Denis Međed, Suzana Gotovac Atlagić, Savka Janković, Dragana Milisavić, Dragana Stevic, Magdalena Parlinska Wojtan, and Predrag Ilić

Subjects
inorganic chemicals, 010302 applied physics, Green chemistry, Chemistry, technology, industry, and agriculture, Oxide, chemistry.chemical_element, Sulfuric acid, 02 engineering and technology, Manganese, 021001 nanoscience & nanotechnology, 01 natural sciences, Catalysis, Filter (aquarium), chemistry.chemical_compound, Adsorption, Chemical engineering, 0103 physical sciences, 0210 nano-technology, Sulfur dioxide
Abstract

A green chemistry approach for fabrication of active carbon, enriched with remediated iron is shown. Detailed characterization (HRSTEM, STM, and N2 adsorption) was performed, followed by active carbon soaking in iron and manganese ionic solutions obtained from remediated mining sludge. Novel forms of active carbons with round or needle-like oxide particles on the surface were obtained by combining these materials. The materials were tested as filters for sulfur dioxide, on sulfur-rich coals fume. After adsorption, the iron structures seem to play a stronger catalytic role in the filter regeneration, transforming the adsorbed sulfur dioxide into sulfuric acid.

Published
2019

17. Honeybees as sentinels of lead pollution: Spatio-temporal variations and source appointment using stable isotopes and Kohonen self-organizing maps

Author

Isidora Deljanin, Ivan Gržetić, Konstantin Ilijević, Nenad M. Zarić, Ljubiša Stanisavljević, and Mirjana Ristić

Subjects
Environmental Engineering, 010504 meteorology & atmospheric sciences, Lead pollution, Environmental pollution, 010501 environmental sciences, 01 natural sciences, Honeybees, Isotopes, Environmental monitoring, Biomonitoring, Animals, Environmental Chemistry, Waste Management and Disposal, 0105 earth and related environmental sciences, Stable isotope ratio, Lead isotope, Sampling (statistics), Kohonen self organizing map, Bees, SOM, Pollution, Lead, 13. Climate action, Environmental science, Physical geography, Environmental Pollution, Serbia, Bioindicator, Environmental Monitoring
Abstract

In this study, honeybees were used to determine spatio-temporal variations and origin sources of Pb. Lead concentrations and isotopic composition were used in combination with selected statistical methods. The sampling was carried out at five different locations in Serbia: urban region (BG), petrochemical industry (PA), suburban region (PV), rural region (MS) and thermal power plant region (TPP) during 2014. At PA and PV locations, samples were taken during multiple years. This is the first use of Kohonen self-organizing map (SOM) in combination with honeybees as bioindicators to determine spatio-temporal variations and origin of Pb pollution. It was observed that during the years Pb concentrations were in decline. Anthropogenic sources are most dominant in BG and TPP, in PA there are mixed sources of natural and anthropogenic origin and in PV Pb is of natural origin. It can be concluded that honeybees in combination with SOM can be used to differentiate between slight changes in spatio-temporal variations of Pb, as well as for source appointment. (C) 2018 Elsevier B.V. All rights reserved.

Published
2018

18. Polyphenol bioaccessibility and antioxidant properties of in vitro digested spray-dried thermally-treated skimmed goat milk enriched with pollen

Author

Kostić, Aleksandar Ž., primary, Milinčić, Danijel D., additional, Stanisavljević, Nemanja S., additional, Gašić, Uroš M., additional, Lević, Steva, additional, Kojić, Milan O., additional, Lj. Tešić, Živoslav, additional, Nedović, Viktor, additional, Barać, Miroljub B., additional, and Pešić, Mirjana B., additional

Published
2021
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19. Complete Freund's adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies

Author

Lazarević, Milica, primary, Djedovic, Neda, additional, Stanisavljević, Suzana, additional, Dimitrijević, Mirjana, additional, Stegnjaić, Goran, additional, Krishnamoorthy, Gurumoorthy, additional, Mostarica Stojković, Marija, additional, Miljković, Đorđe, additional, and Jevtić, Bojan, additional

Published
2021
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20. Phenolic compounds and biopotential of grape pomace extracts from Prokupac red grape variety

Author

Milinčić, Danijel D., primary, Stanisavljević, Nemanja S., additional, Kostić, Aleksandar Ž., additional, Soković Bajić, Svetlana, additional, Kojić, Milan O., additional, Gašić, Uroš M., additional, Barać, Miroljub B., additional, Stanojević, Sladjana P., additional, Lj Tešić, Živoslav, additional, and Pešić, Mirjana B., additional

Published
2021
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21. Supplementation of lactobacilli improves growth, regulates microbiota composition and suppresses skeletal anomalies in juvenile pike-perch ( Sander lucioperca ) reared in recirculating aquaculture system (RAS): A pilot study

Author

Géza Péter, Tijana Ristović, Uroš Ljubobratović, Goran Vukotic, Dejana Kosanovic, Zsuzsanna Molnar, Galina Jeney, Nemanja Stanisavljević, and Jovanka Lukić

Subjects
0301 basic medicine, Digestive capacity, Lactobacillus paracasei, Recirculating aquaculture system (RAS), Pilot Projects, Aquaculture, Microbiology, Fish Diseases, 03 medical and health sciences, Lactobacillus rhamnosus, Lactobacillus, Animals, 14. Life underwater, Food science, General Veterinary, biology, Hatching, Microbiota, Probiotics, Lactobacillus salivarius, Pike-perch, Water, Recirculating aquaculture system, 04 agricultural and veterinary sciences, biology.organism_classification, Animal Feed, Diet, Perciformes, Lactobacillus reuteri, Skeletal deformities, 030104 developmental biology, Dietary Supplements, Digestive enzyme, 040102 fisheries, biology.protein, 0401 agriculture, forestry, and fisheries, Animal Nutritional Physiological Phenomena, Artemia, Bone Diseases
Abstract

This research aimed to test the effects of lactobacilli, applied to cultured pike-perch, either through hydrolyzed OTOHIME fish diet, or through Artemia nauplii, on fish growth, microbiota balance and skeletal development. On the 12th Day Post Hatching (DPH) fish were divided into following treatment groups: two groups received the combination of OTOHIME and nauplii enriched either with Lactobacillus paracasei BGHN14 + Lactobacillus rhamnosus BGTH or with Lactobacillus reuteri BGGO6-55 + Lactobacillus salivarius BGHO1, and one group received OTOHIME hydrolyzed by BGHN14 + BGT10 and non-enriched nauplii. Control group received non-enriched nauplii and non-hydrolyzed OTOHIME. The treatment lasted 14 days and fish were sacrificed on the 26th DPH for the assessment of digestive enzyme activity and microbiota composition. Individual total lengths and individual body weights were recorded at the end of the treatments, on the 26th DPH, and also on the 45th DPH, in parallel with the evaluation of skeletal deformities and fish survival. Our results indicated positive effect of Anemia enriched with BGGO6-55 + BGHO1 on fish growth, skeletal development and trypsin to chymotrypsin activity ratio (T/C), as an indicator of protein digestibility. Hydrolysis of OTOHIME was also associated with better skeletal development, higher T/C values and lower levels of Aeromonas and Mycobacterium spp., which are important fish pathogens. Though additional testing in larger cohort studies is needed, these observations are promising in terms of usage of probiotics for improved environmentally friendly production of pike-perch in Recirculating Aquaculture System (RAS).

Published
2017

22. Ontogenetic stage, plant vigor and sex mediate herbivory loads in a dioecious understory herb

Author

Vukica Vujić, Dragana Cvetković, Sara Selaković, Nemanja Stanisavljević, Svetlana Radović, and Živko Jovanović

Subjects
2. Zero hunger, 0106 biological sciences, Herbivore, Specific leaf area, Ecology, media_common.quotation_subject, Dioecy, fungi, food and beverages, Mercurialis perennis, Understory, 15. Life on land, Biology, 010603 evolutionary biology, 01 natural sciences, Sexual dimorphism, medicine.drug_formulation_ingredient, Botany, medicine, Chemical defense, Reproduction, Ecology, Evolution, Behavior and Systematics, 010606 plant biology & botany, Nature and Landscape Conservation, media_common
Abstract

Plant-herbivore interactions can be mediated by plant apparency, defensive and nutritional quality traits that change through plant ontogeny, resulting in age-specific herbivory. In dioecious species, opposing allocation patterns in defense may lead to sex-biased herbivory. Here, we examine how onto stage and plant sex determine levels of herbivore damage in understory herb Mercurialis perennis under field conditions. We analyzed variation in plant size (height, total leaf area), physical (specific leaf area) and chemical (total phenolic and condensed tannins contents) defense, and nutritional quality (total water, soluble protein and nonstructural carbohydrate contents) during the shift from reproductive to post-reproductive stage. Furthermore, we explored correlations between the analyzed traits and levels of foliar damage. Post-reproductive plants had lower levels of chemical defense, and larger leaf area removed, in spite of having lower nutritive quality. Opposing patterns of intersexual differences were detected in protein and phenolic contents during reproductive stage, while in post-reproductive stage total leaf area was sexually dimorphic. Female-biased herbivory was apparent only after reproduction. Plant size parameters combined with condensed tannins content determined levels of foliar damage during post-reproductive stage, while the only trait covarying with herbivory in reproductive stage was total nonstructural carbohydrate content. Our results support claims of optimal defense theory – sensitive stage of reproduction was better defended. We conclude that different combinations of plant traits mediated interactions with herbivores in mature stages. Differences in reproductive allocation between the sexes may not immediately translate into different levels of damage, stressing the need for considering different ontogenetic stages when exploring sex bias in herbivory.

Published
2017

24. Pike-perch larvae growth in response to administration of lactobacilli-enriched inert feed during first feeding

Author

Alan Koljukaj, Danijel D. Milinčić, Mirjana B. Pešić, Uroš Ljubobratović, Vivien Vass, Goran Vukotic, Georgina Fazekas, Nemanja Stanisavljević, Aleksandar Ž. Kostić, Jovanka Lukić, László Ardó, and Tijana Ristović

Subjects
chemistry.chemical_classification, 0303 health sciences, Perch, Larva, Live food, 04 agricultural and veterinary sciences, Aquatic Science, Biology, biology.organism_classification, Skeleton (computer programming), Enzyme assay, Amino acid, 03 medical and health sciences, Animal science, chemistry, 040102 fisheries, biology.protein, 0401 agriculture, forestry, and fisheries, Weaning, Incubation, 030304 developmental biology
Abstract

This study evaluated whether inert feed enriched with Lb. paracasei subsp. paracasei BGHN14 may be used as a weaning diet for first feeding pike-perch larvae. Three experimental groups were weaned from the start of exogenous feeding: two groups were given inert feed enriched with BGHN14 either via 12 h incubation with live BGHN14 cells or via coating with homogenized BGHN14 cells and one group was supplemented non-enriched inert feed. In all three groups Artemia was co-fed with inert feed during weaning. Control group larvae were fed Artemia exclusively during the treatment period. Treatment lasted fourteen days, starting from the 6th day post-hatch (DPH). Larval sampling was performed on the 20th DPH for gene expression and enzyme activity analysis. Larvae were also sampled on the 32nd DPH for morphometric and body composition analysis. Our results showed that weaning of first feeding pike-perch larvae was associated with an increase of fish condition (0.72 ± 0.12–0.77 ± 0.11 versus 0.67 ± 0.11 in controls), but it suppressed skeleton development, according to Col1 mRNA expression (1 ± 0.51–1.06 ± 0.36 versus 2.07 ± 0.53 in controls) and reduced fat deposition (1.25 ± 0.23–1.49 ± 0.33 versus 1.84 ± 0.31% in controls). This presumably reflected lower availability of soluble proteins in microdiet as opposed to live food, along with high leaching rate of amino acids from solid feed particles, as reported in our previous studies. However, skeleton differentiation was not impaired in group weaned on BGHN14 homogenate coated feed (Col1 mRNA expression: 2.68 ± 0.72), which was enriched in skeleton building and taste stimulating amino acids. These larvae were also presented with substantially higher length (15.28 ± 2.55 versus 13.93 ± 2.31 mm in controls) and weight (26.56 ± 13.83 versus 21.03 ± 11.25 mg in controls), which correlated with lower trypsin activity (1.06 ± 0.13 versus 1.43 ± 0.26 mU/mg of proteins in controls) and an increase of PLA2 to trypsin activity ratio (453.12 ± 109.36 versus 264.84 ± 69.03 in controls). Present study suggests that weaning of first feeding pike-perch larvae using BGHN14 homogenate coated microdiet supports skeleton development and improves fish growth.

Published
2021

26. In vitro assessment of pesticide residues bioaccessibility in conventionally grown blueberries as affected by complex food matrix

Author

Milinčić, Danijel D., primary, Vojinović, Uroš D., additional, Kostić, Aleksandar Ž., additional, Pešić, Mirjana B., additional, Špirović Trifunović, Bojana D., additional, Brkić, Dragica V., additional, Stević, Milan Ž., additional, Kojić, Milan O., additional, and Stanisavljević, Nemanja S., additional

Published
2020
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28. Polyphenol bioaccessibility and antioxidant properties of in vitro digested spray-dried thermally-treated skimmed goat milk enriched with pollen

Author

Uroš Gašić, Danijel D. Milinčić, Mirjana B. Pešić, Aleksandar Ž. Kostić, Milan Kojic, Viktor Nedović, Nemanja Stanisavljević, Steva Lević, Miroljub B. Barać, and Živoslav Lj. Tešić

Subjects
Antioxidant, Flavonols, Antioxidant properties, medicine.medical_treatment, Monofloral sunflower bee-collected pollen, medicine.disease_cause, 01 natural sciences, Antioxidants, Analytical Chemistry, Ingredient, 0404 agricultural biotechnology, Glucosides, Pollen, medicine, Animals, Chelation, Food science, Goat milk/pollen powder, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Chemistry, Goats, 010401 analytical chemistry, Polyphenols, food and beverages, 04 agricultural and veterinary sciences, General Medicine, Bees, 040401 food science, Sunflower, 0104 chemical sciences, Milk, Polyphenol, Quercetin, Digestion, In vitro polyphenol bioaccessibility, Food Science
Abstract

The aim of research was to determine polyphenols bioaccessibility and antioxidant properties of thermally-treated skimmed goat milk enriched with sunflower bee-collected pollen through in vitro digestion. HPLC analysis confirmed that pollen-enriched milk contained flavonols as the main phenolic fraction (80.7–76.2%) followed by phenolic acids (14.2–17.4%). Among individual compounds quercetin-3-O-glucoside (155.1–197.2 μg/L) and p-coumaric acid (29.5–30.7 μg/L) were the main quantified flavonols and phenolic acids, respectively. After digestion of milk/pollen sample, total polyphenols recovery was 30.71% with higher phenolic acids recovery (40.1%) compared to flavonols (28.3%) indicating strong interactions between caprine milk casein micelles and pollen polyphenols. Applied antioxidant assays (phosphomolybdenum, ABTS•+scavenging activity and ferrous-ion-chelating capacity) have confirmed complexity of prepared product- it had high ability to quench ABTS•+ radicals and to form chelating complexes with Fe2+ ions. Digestion provoked 20% reduction in total antioxidant capacity compared to the initial sample. TTSG milk/pollen powder could be good functional ingredient. © 2021 Elsevier Ltd Supplementary material: [https://cherry.chem.bg.ac.rs/handle/123456789/4408]

Published
2021

29. Strain-specific helper T cell profile in the gut-associated lymphoid tissue

Author

Boško Milovanović, Bojan Jevtić, Tamara Saksida, Ivana Stojanovic, Neda Đedović, Miljana Momčilović, Milica Vujicic, Đorđe Miljković, and Suzana Stanisavljević

Subjects
0301 basic medicine, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, T cell, Gut-associated lymphoid tissue, Immunology, Autoimmunity, Nod, Biology, medicine.disease_cause, T-Lymphocytes, Regulatory, Multiple sclerosis, Mice, Peyer's Patches, 03 medical and health sciences, Th2 Cells, 0302 clinical medicine, Immune system, Species Specificity, Mice, Inbred NOD, medicine, Animals, Humans, Immunology and Allergy, Mesenteric lymph nodes, Intestinal Mucosa, Cells, Cultured, NOD mice, Mice, Inbred BALB C, Experimental autoimmune encephalomyelitis, Th1 Cells, medicine.disease, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, Type 1 diabetes, 030104 developmental biology, medicine.anatomical_structure, Organ Specificity, Immunization, Genetic Background, 030215 immunology
Abstract

C57BL/6, BALB/c and NOD mice are among the most frequently used strains in autoimmunity research. NOD mice spontaneously develop type 1 diabetes (T1D) and they are prone to induction of experimental autoimmune encephalomyelitis (EAE). Both diseases can be routinely induced in C57BL/6 mice, but not in BALB/c mice. Also, C57BL/6 mice are generally considered T helper (Th)1-biased and BALB/c Th2-biased mice. Having in mind increasingly appreciated role of gut associated lymphoid tissue (GALT) cells in autoimmunity, especially in relation to gut Th17 and regulatory T (Treg) cells, our aim was to determine if there are differences in proportion of CD4 + T cell populations in mesenteric lymph nodes and Peyer's p atches of these mouse strains. Lower proportion of Treg was observed in NOD PP, Th2 cells dominated in BALB/c mice in mesenteric lymph nodes (MLN) and Peyer's patches (PP), while Th1 cells prevailed in C57BL/6 MLN. Intradermal immunization of mice with complete Freund's adjuvant resulted in significant difference in Th cell distribution in GALT of NOD mice. Differences were less pronounced in C57BL/6 mice, while GALT of BALB/c mice was almost unresponsive to the immunization. The observed strain- and tissue-dependent changes in Treg proportion after the immunization was probably a consequence of different CCR2 or CCR6-related migration patterns and/or in situ Treg proliferation. In conclusion, NOD, a highly autoimmunity-prone mouse strain, exhibits more profound GALT-related immune response upon immunization compared to the strains that are less prone to autoimmunity. Immunology Letters (2017), 190: 282-288

Published
2017

30. Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes

Author

Nebojša Menković, Jelena Živković, Milica Vujicic, Neda Đedović, Katarina Šavikin, Đorđe Miljković, Ivan Koprivica, Tamara Saksida, Miljana Momčilović, Ivana Stojanovic, and Suzana Stanisavljević

Subjects
0301 basic medicine, Medicine (miscellaneous), Autoimmunity, Inflammation, medicine.disease_cause, Pomegranate, Multiple sclerosis, 03 medical and health sciences, chemistry.chemical_compound, Immune system, medicine, TX341-641, Punicalagin, Nutrition and Dietetics, Nutrition. Foods and food supply, business.industry, Pancreatic islets, Interleukin-17, Experimental autoimmune encephalomyelitis, medicine.disease, 3. Good health, Type 1 diabetes, 030104 developmental biology, medicine.anatomical_structure, chemistry, Immunology, Tumor necrosis factor alpha, Interleukin 17, medicine.symptom, business, Food Science
Abstract

Pomegranate peel extract (PPE) was obtained by aqueous-ethanol extraction and was abundant in punicalin, punicalagin and ellagic acid. As these compounds are known to act against inflammation and oxidative stress in synergistic fashion, effects of PPE were tested in vitro on immune cells and in animal models of multiple sclerosis and type 1 diabetes (T1D). In vitro, PPE inhibited interleukin-17 (IL-17) production from gut-associated lymphoid tissue (GALT) cells. PPE also reduced production of IL-17 in activated T cells isolated from animals with experimental autoimmune encephalomyelitis (EAE). It efficiently down-regulated clinical symptoms of EAE in DA rats and of streptozotocin-induced T1D in C57BL/6 mice. The effect of PPE in T1D was mediated by inhibition of immune cell infiltration into pancreatic islets and through interference with IL-17 and IFN-γ production in GALT. Our results suggest that PPE has the potential to be used as phytopharmaceutical for certain autoimmune and chronic inflammatory disorders. Journal of Functional Foods (2017), 35: 522-530

Published
2017

31. Chronic fluoxetine treatment directs energy metabolism towards the citric acid cycle and oxidative phosphorylation in rat hippocampal nonsynaptic mitochondria

Author

Peter Findeisen, Dragana Filipović, Ivana Perić, Victor Costina, and Andrijana Stanisavljević

Subjects
Male, 0301 basic medicine, Proteome, Blotting, Western, Citric Acid Cycle, Fluorescent Antibody Technique, Oxidative phosphorylation, Mitochondrion, Hippocampus, Mass Spectrometry, Oxidative Phosphorylation, Mass spectrometry-based proteomics, 03 medical and health sciences, Cytosol, 0302 clinical medicine, Signaling networks, Fluoxetine, Animals, Nonsynaptic mitochondria, Rats, Wistar, Molecular Biology, Glyceraldehyde 3-phosphate dehydrogenase, Calcium signaling, biology, ATP synthase, General Neuroscience, Mitochondria, 3. Good health, Cell biology, Citric acid cycle, Parvalbumins, 030104 developmental biology, Biochemistry, Calbindin 2, Chaperone (protein), Rat hippocampus, biology.protein, Antidepressive Agents, Second-Generation, Electrophoresis, Polyacrylamide Gel, Neurology (clinical), 030217 neurology & neurosurgery, Developmental Biology
Abstract

Fluoxetine (Flx) is the principal treatment for depression; however, the precise mechanisms of its actions remain elusive. Our aim was to identify protein expression changes within rat hippocampus regulated by chronic Flx treatment versus vehicle-controls using proteomics. Fluoxetine-hydrohloride (15 mg/kg) was administered daily to adult male Wistar rats for 3 weeks, and cytosolic and nonsynaptic mitochondrial hippocampal proteomes were analyzed. All differentially expressed proteins were functionally annotated according to biological process and molecular function using Uniprot and Blast2GO. Our comparative study revealed that in cytosolic and nonsynaptic mitochondrial fractions, 60 and 3 proteins respectively, were down-regulated, and 23 and 60 proteins, respectively, were up-regulated. Proteins differentially regulated in cytosolic and nonsynaptic mitochondrial fractions were primarily related to cellular and metabolic processes. Of the identified proteins, the expressions of calretinin and parvalbumine were confirmed. The predominant molecular functions of differentially expressed proteins in both cell hippocampal fractions were binding and catalytic activity. Most differentially expressed proteins in nonsynaptic mitochondria were catalytic enzymes involved in the pyruvate metabolism, citric acid cycle, oxidative phosphorylation, ATP synthesis, ATP transduction and glutamate metabolism. Results indicate that chronic Flx treatment may influence proteins involved in calcium signaling, cytoskeletal structure, chaperone system and stimulates energy metabolism via the upregulation of GAPDH expression in cytoplasm, as well as directing energy metabolism toward the citric acid cycle and oxidative phosphorylation in nonsynaptic mitochondria. This approach provides new insight into the chronic effects of Flx treatment on protein expression in a key brain region associated with stress response and memory. (C) 2017 Elsevier B.V. All rights reserved.

Published
2017

32. The effect of live and inert feed treatment with lactobacilli on weaning success in intensively reared pike-perch larvae

Author

Ferenc Demény, Jovanka Lukić, Uroš Ljubobratović, Adrienn Krajcsovics, Goran Vukotic, Galina Jeney, Dejana Kosanovic, Nemanja Stanisavljević, and Nataša Golić

Subjects
media_common.quotation_subject, Weaning, Aquatic Science, 03 medical and health sciences, Animal science, Phospholipase A2, 14. Life underwater, Metamorphosis, Skeleton, 030304 developmental biology, media_common, chemistry.chemical_classification, 0303 health sciences, Larva, Perch, biology, Lactobacillus salivarius, Pike-perch, Fatty acid, 04 agricultural and veterinary sciences, Ichthyoplankton, biology.organism_classification, chemistry, Lactobacilli, Digestive enzyme, 040102 fisheries, biology.protein, 0401 agriculture, forestry, and fisheries
Abstract

Weaning to inert diet in intensively reared pike-perch larvae is confronted with significant fish loss, which prevents successful commercialization of pike-perch production. Achievement of satisfactory feed quality and effective assimilation of nutrients by larval fish is the major challenge in larval production process. Aim of this study was to evaluate whether treatment of live and inert feed with lactobacilli could alleviate growth retardation associated with early weaning of pike-perch reared in recirculating system. Weaning started on 18th day post-hatching (DPH) either as sudden weaning (SW) or by co-administration of Artemia for six days (gradual weaning, GW). Prior to administration to fish, Artemia was treated with Lactobacillus salivarius BGHO1/Lb. reuteri BGGO6-55, while inert feed was treated with Lb. paracasei subsp. paracasei BGHN14/Lb. rhamnosus BGT10. Treatment with lactobacilli slightly raised neutral lipid level in Artemia nauplii, but significantly reduced their content in dry feed. Fish were sampled on the 24th DPH. Survival, morphometric indices, skeleton differentiation, digestive enzyme activity and opportunistic pathogenic bacteria level were assessed in whole fish specimens. GW fish were presented with better survival, body growth and phospholipase A2 (PLA2) activity. Alongside, Vibrio spp. growth was suppressed in these fish and skeleton development was improved, according to Alizarin Red staining and Col1A1/Sparc mRNA expression data. Lactobacilli application in GW fish correlated with an increase of survival, condition factor and growth rate, according to trypsin and chymotrypsin activities, indicating better utilization of dietary proteins for muscle building. In SW fish, lactobacilli elevated chymotrypsin activity, PLA2 to lipase activity ratio and improved survival and ossification, as evident from Alizarin Red staining and Col1A1/Sparc mRNA expression. This indicated improved fatty acid absorption and control of metamorphosis process. Furthermore, lactobacilli suppressed Vibrio spp. growth in SW fish. Aside from demonstrating the ability of lactobacilli to aid weaning in pike-perch larvae, this study indicated that different types of food treatment may direct fish growth in a predictable manner, allowing further cost-effective improvements of larval pike-perch rearing in intensive system.

Published
2020

33. A contribution to the estimation of berry fruits quality

Author

Darko Micić, Nemanja Stanisavljević, Boris Pejin, Lato Pezo, Sanja Ostojić, Mladen Simonovic, and Branislav R. Simonović

Subjects
0106 biological sciences, 0301 basic medicine, biology, Chemistry, DPPH, Berry, Horticulture, Fragaria, biology.organism_classification, 01 natural sciences, Blowing a raspberry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Soft fruit, Rubus, 010606 plant biology & botany, EC50
Abstract

This study aimed to estimate the quality (in terms of standard chemical parameters, total antioxidative activity /AO/ and thermal properties) of the fresh strawberry (Fragaria xananassa L. Duch.), raspberry (Rubus idaeus L.) and blackberry (Rubus fruticosusL.) samples grown in the Western Serbia. The examined blackberry variety was found to exhibit the most potent AO (DPPH /2,2-diphenyl-1-picrylhydrazyl/ assay, EC50 4.05 ± 0.22 μg and ARP 0.25 ± 0.03 μg−1; Hydroxo-Perhydroxyl Mercury(II) Complex /HPMC/ assay, 0.072 ± 0.007%/μL), due to the enriched contents of both total phenolics and anthocyanins. It was actually followed by the raspberry and strawberry samples. Unlike the aforementioned trend for AO, thermal behaviour of all samples was similar. This is first time ever that a DC polarographic HPMC assay has been applied for the characterisation of the fresh berry fruits. Further studies aiming to screen total AO of the soft fruit during growth, storage and processing might be well facilitated by the application of this low cost, rapid, easy-to-handle and reliable electrochemical assay.

Published
2019

37. In vitro digestion of meat- and cereal-based food matrix enriched with grape extracts: How are polyphenol composition, bioaccessibility and antioxidant activity affected?

Author

Pešić, Mirjana B., primary, Milinčić, Danijel D., additional, Kostić, Aleksandar Ž., additional, Stanisavljević, Nemanja S., additional, Vukotić, Goran N., additional, Kojić, Milan O., additional, Gašić, Uroš M., additional, Barać, Miroljub B., additional, Stanojević, Slađana P., additional, Popović, Dušanka A., additional, Banjac, Nebojša R., additional, and Tešić, Živoslav Lj., additional

Published
2019
Full Text
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38. Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study

Author

Kirmeier, Eva, primary, Eriksson, Lars I, additional, Lewald, Heidrun, additional, Jonsson Fagerlund, Malin, additional, Hoeft, Andreas, additional, Hollmann, Markus, additional, Meistelman, Claude, additional, Hunter, Jennifer M, additional, Ulm, Kurt, additional, Blobner, Manfred, additional, Abad Gurumeta, Alfredo, additional, Abernethy, Caroline, additional, Abigail, Patrick, additional, Achaibar, Kira, additional, Adam, Emily, additional, Afshari, Arash, additional, Agudelo Montoya, M. Elizabeth, additional, Akgün, Fatma Nur, additional, Aletti, Gabriele, additional, Alkış, Neslihan, additional, Allan, Katie, additional, Allan, Ashley, additional, Allaouchiche, Bernard, additional, Allcock, Clare, additional, Almasy, Emoke, additional, Amey, Isobel, additional, Amigoni, Maria, additional, Andersen, Elin, additional, Andersson, Peder, additional, Anipchenko, Natalya, additional, Antunes, Pedro, additional, Armstrong, Earlene, additional, Aslam, Tayyba Naz, additional, Aslin, Bjorn, additional, Assunção, José Pedro, additional, Ausserer, Julia, additional, Avvai, Mary, additional, Awad, Nahla, additional, Ayas Montero, Begoña, additional, Ayuso, Mercedes, additional, Azevedo, Patricia, additional, Badarau, Victoria, additional, Badescu, Roxana, additional, Baiardo Redaelli, Martina, additional, Baird, Colin, additional, Baird, Yolanda, additional, Baker, Tim, additional, Balaji, Packianathaswamy, additional, Bălan, Cristina, additional, Balandin, Alina, additional, Balescu-Arion, Carmen, additional, Baliuliene, Vilda, additional, Baltasar Isabel, Jorge, additional, Baluch, Saif Nasr, additional, Bandrabur, Daniela, additional, Bankewitz, Carla, additional, Barber, Katrina, additional, Barbera, Francesco, additional, Barcraft-Barnes, Helena, additional, Barletti, Valentina, additional, Barnett, Gill, additional, Baron, Kirsty, additional, Barros, Ana, additional, Barsan, Victoria, additional, Bartlett, Pauline, additional, Batistaki, Chrysanthi, additional, Baumgarten, Georg, additional, Baytas, Volkan, additional, Beauchamp, Nigel, additional, Becerra Cayetano, Isabel A., additional, Bell, Stephanie, additional, Bellandi, Mattia, additional, Belletti, Alessandro, additional, Belmonte Cuenca, Julio, additional, Benitez-Cano, Adela, additional, Beretta, Luigi, additional, Berger, Marc, additional, Bergmann, Nicole, additional, Bergmark, Kristina, additional, Bermudez Lopez, Maria, additional, Bernotaite, Monika, additional, Beurskens, Charlotte, additional, Bidd, Heena, additional, Bifulco, Francesca, additional, Bignami, Elena, additional, Bilic, Aleksandar, additional, Bilskiene, Diana, additional, Bischoff, Petra, additional, Bishop, Luke, additional, Bjonness, Therese, additional, Blaylock, Hether, additional, Blethyn, Kate, additional, Blincoe, Thomas, additional, Blokhin, Ivan, additional, Blunt, Nadia, additional, Boer, Christa, additional, Bois, Grégory, additional, Bonicolini, Eleonora, additional, Booth, Joanna, additional, Borecka-Kedzierska, Miroslawa, additional, Borstnar, Katarina, additional, Borys, Michał, additional, Boselli, Emmanuel, additional, Bouvet, Lionel, additional, Bouwman, Arthur, additional, Bowen, Leonora, additional, Bowrey, Sarah, additional, Boxall, Leigh, additional, Božić, Teodora, additional, Bradley, Tom, additional, Branco, Teresa, additional, Brazzi, Luca, additional, Brazzoni, Marcella, additional, Brear, Tracy, additional, Brogly, Nicolas, additional, Brohi, Farooq, additional, Broms, Jacob, additional, Bubliauskas, Andrius, additional, Bucolo, Gea Erika, additional, Buerkle, Hartmut, additional, Buggy, Donal, additional, Buhre, Wolfgang, additional, Bukauskas, Tomas, additional, Butturini, Francesco, additional, Byttner, Anders, additional, Cabrera Díaz, Itahísa, additional, Calderon, Adriana, additional, Calhau, Ricardo, additional, Callejo, Angel, additional, Cammu, Guy, additional, Campesato, Manuela, additional, Can, Özlem S, additional, Candeias, Margarida, additional, Cantor, Andreea, additional, Carise, Elsa, additional, Carmona, Cristina, additional, Carreteiro, Joana, additional, Carrieri, Cosima, additional, Carter, Anna, additional, Casal, Manuela, additional, Casanova, Irene, additional, Cascella, Marco, additional, Casero, Luis M., additional, Casiraghi, Guiseppina Maria, additional, Castelo-Branco, Laila, additional, Castro Arranz, Carlos, additional, Cernea, Daniela Denisa, additional, Cervantes, Jesoporiol, additional, Chandler, Ben, additional, Charnock, Robert, additional, Chatzimicali, Aikaterini, additional, Chinery, Elane, additional, Chishti, Ahmed, additional, Chondhury, Priyakam, additional, Christie, Emily, additional, Christodoudiles, George, additional, Ciardo, Stefano, additional, Cimpeanu, Luminata, additional, Cindea, Iulia, additional, Cinnella, Gilda, additional, Clark, Sebastian, additional, Clayton, Matthew, additional, Cocu, Simona, additional, Collyer, Thomas, additional, Colvin, Carie, additional, Cope, Sean, additional, Copeta, Filomena, additional, Copotoiu, Sanda-Maria, additional, Correia de Barros, Filinto, additional, Corso, Ruggero Massimo, additional, Cortegiani, Andrea, additional, Costa, Gabriela, additional, Cowton, Amanda, additional, Cox, Nicolas, additional, Craig, James, additional, Cricca, Valentina, additional, Cronin, John, additional, Cunha, Mariana, additional, Cuomo, Arturo, additional, Curley, Katherine, additional, Czuczwar, Mirosław, additional, Dabrowska, Domenika, additional, Damster, Sabrine, additional, Danguy des Déserts, Marc, additional, Daniliuc, Aura, additional, Danninger, Thomas, additional, Darwish, Imad, additional, Dascalu, Corina, additional, Davies, Kirsty, additional, Davies, Simon, additional, De Boer, Hans, additional, De Flaviis, Adelisa, additional, De Selincourt, Gabrielle, additional, Deana, Cristian, additional, Debaene, Bertrand, additional, Debreceni, Gabor, additional, Dedhia, Jatin, additional, Delgado Garcia, Isabel, additional, Della Rocca, Giorgio, additional, Delroy-Buelles, Llana, additional, Desai, Tejal, additional, Dhillon, Parveen, additional, Di Giacinto, Ida, additional, Di Mauro, Piero, additional, Diaz Gomez, Tamara V., additional, Dimitrovski, Aleksandar, additional, Dinic, Vesna, additional, Dîrzu, Dan-Sebastian, additional, Divander, Mona Britt, additional, Dolinar, Janez, additional, Domingues, Susana, additional, Doolan, James, additional, Downes, Charlotte, additional, Dragoescu, Nicoleta Alice, additional, Droc, Gabriela, additional, Dum, Elisabeth, additional, Dumitrescu, Alexandra, additional, Duncan, Louise, additional, Dzurňáková, Paul, additional, Eberl, Susanne, additional, Edwards, Jayne, additional, Edwards, Mark, additional, Ekelund, Kim, additional, Ekengren, Patrik, additional, Elghouty, Eyad, additional, Ellerkmann, Richard, additional, Ellis, Helen, additional, Elme, Andreas, additional, Ernst, Thomas, additional, Errando, Carlos Luis, additional, Estenes, Simao, additional, Ewaldsson, Callis, additional, Farid, Nahla, additional, Featherstone, James, additional, Febres, Daniela, additional, Fedorov, Sergey, additional, Feggeler, Johanna, additional, Feijten, Prisca, additional, Fellmann, Tobias, additional, Fernandez Candil, Juan, additional, Fernandez Castineira, Ana, additional, Fernández Castineira, Juan, additional, Fernando, Aruna, additional, Ferrando, Carlos, additional, Ferreira, Leonia, additional, Ferreira, Patrick, additional, Feyling, Anders, additional, Filipescu, Daniela, additional, Fleischer, Andreas, additional, Floris, Leda, additional, Foerster, Urs, additional, Fox, Benjamin, additional, Franke, Uwe, additional, Frasca, Denis, additional, Frey, Christian, additional, Frost, Victoria, additional, Fullin, Giorgio, additional, Fumagalli, Jacopo, additional, Furneval, Julie, additional, Fusari, Maurizio, additional, Gallacher, Stuart, additional, Galushka, Svetlana, additional, Gambale, Giorgio, additional, Gambino, Irene, additional, Garcia-Perez, Maria Luisa, additional, Garg, Sanjeev, additional, Garlak, Justyna, additional, Gavranovic, Zeljka, additional, Gavrilov, Roman, additional, Gaynor, Lames, additional, Gecaj Gashi, Agreta, additional, Georghiou, Maria, additional, Gerjevic, Bozena, additional, Gferer, Gudrun, additional, Giarratano, Antonino, additional, Gibson, Andy, additional, Gievski, Vanja, additional, Giles, Julian, additional, Gillberg, Lars, additional, Gilowska, Katarzyna, additional, Gilsanz Rodriguez, Fernando, additional, Gioia, Antonio, additional, Giovannoni, Cecilia, additional, Girotra, Vandana, additional, Gkinas, Dimitrios, additional, Gkiokas, George, additional, Godoroja, Daniela, additional, Goebel, Ulrich, additional, Goel, Vandana, additional, Gonzalez, Matilde, additional, Goranovic, Tatjana, additional, Gornik-Wlaszczuk, Ewa, additional, Gosavi, Smita, additional, Gottfridsson, peter, additional, Gottschalk, André, additional, Granell, Manuel, additional, Granstrom, Anna, additional, Grassetto, Alberto, additional, Greenwood, Anna, additional, Grigoras, Ioana, additional, Grintescu, Ioana, additional, Gritsan, Alexey, additional, Gritsan, Galina, additional, Grynyuk, Andriy, additional, Guadagnin, Giovanni Maria, additional, Guarnieri, Marcello, additional, Güçlü, Çiğdem, additional, Guerrero Diez, Maria, additional, Gunenc, Ferim, additional, Günther, Ulf, additional, Gupta, Pawan, additional, Guttenthaler, Vera, additional, Hack, Yvonne, additional, Hafisayena, Ade, additional, Hagau, Natalia, additional, Haldar, Jagannath, additional, Hales, Dawn, additional, Hancı, Volkan, additional, Hanna-Jumma, Sameer, additional, Harazim, Hana, additional, Harlet, Pierre, additional, Harper, Daniel, additional, Harris, Benjamin, additional, Harvey, Orla, additional, Hashimi, Medita, additional, Hawkins, Lesley, additional, Hayes, Conrad, additional, Heaton, James, additional, Heier, Tom, additional, Helliwell, Laurence, additional, Hemmes, Sabrine, additional, Henderson, Kate, additional, Hermanides, Jeroen, additional, Hermanns, Henning, additional, Herrera Hueso, Berta, additional, Hestenes, Siv, additional, Hettiarachchi, Roshane, additional, Highgate, Judith, additional, Hodgson, Keith, additional, Hoelbling, Daniel, additional, Holland, Jonathan, additional, Horhota, Lucian, additional, Hormis, Anil, additional, Hribar, Renata, additional, Hua, Alina, additional, Humphreys, Sally, additional, Humphries, Ryan, additional, Humpliková, Simona, additional, Hunt, Janez, additional, Husnain, Ali, additional, Hussein, Ahmed, additional, Hyams, Benjamin, additional, Iannuccelli, Fabrizio, additional, Ilette, Katie, additional, Ilyas, Carl, additional, Inan, Turgay, additional, India, Immaculada, additional, Ionițăv, Victor, additional, Irwin, Foo, additional, Jain, Vipul, additional, Janez, Benedikt, additional, Jankovic, Radmilo, additional, Jenkins, Sarah, additional, Jenko, Matej, additional, Jimenez, Raquel, additional, Jiménez Gomez, Bárbara, additional, Joachim, Sugganthi, additional, Joelsson-Alm, Eva, additional, John, John, additional, Jonikaite, Lina, additional, Jovic, Miomir, additional, Jungwirth, Bettina, additional, Junke, Etienne, additional, Kabakov, Borys, additional, Kadaoui, Salah-Din, additional, Kanski, Andrzej, additional, Karadag, Süheyla, additional, Karbonskiene, Aurika, additional, Karjagin, Juri, additional, Kasnik, Darja, additional, Katanolli, Fatos, additional, Katsika, Eleni, additional, Kaufmann, Kai, additional, Keane, Helen, additional, Kelly, Martin, additional, Kent, Melanie, additional, Keraitiene, Grazina, additional, Khudhur, Ahmed, additional, Khuenl-Brady, Karin, additional, Kidd, Laurie, additional, King, Siobhan, additional, Kirchgäßner, Katharina, additional, Klancir, Tino, additional, Klucniks, Andris, additional, Knotzer, Johann, additional, Knowlden, Peter, additional, Koers, Lena, additional, Kompan, Janez, additional, Koneti, Kiran K, additional, Kooij, Fabian, additional, Koolen, Eric, additional, Koopman - van Gemert, Anna Wilhelmina Margaretha Maria, additional, Kopp, Kristen, additional, Korfiotis, Dimitrios, additional, Korolkov, Oleg, additional, Kosinová, Martina, additional, Köstenberger, Markus, additional, Kotzinger, Oskar, additional, Kovačević, Marko, additional, Kranke, Peter, additional, Kranke, Eva, additional, Kraus, Christiane, additional, Kraus, Stephanie, additional, Kubitzek, Christiane, additional, Kucharski, Rafal, additional, Kucukguclu, Semih, additional, Kudrashou, Allaksandr, additional, Kumar, Vinayak, additional, Kummen, Live, additional, Kunit, Cornelia, additional, Kushakovsky, Vlad, additional, Kuvaki, Bahar, additional, Kuzmanovska, Biljana, additional, Kyttari, Aikaterina, additional, Landoni, Giovanni, additional, Lau, Gary, additional, Lazarev, Konstantin, additional, Legett, Samantha, additional, Legrottaglie, Anna Maria, additional, Leonardi, Silvia, additional, Leong, Maria, additional, Lercher, Helene, additional, Leuvrey, Matthieu, additional, Leva, Brigitte, additional, Levstek, Meta, additional, Limb, James, additional, Lindholm, Espen, additional, Linton, Fiona, additional, Liperi, Corradero, additional, Lipski, Fabian, additional, Lirk, Philipp, additional, Lisi, Alberto, additional, Lišková, Katarina, additional, Lluch Oltra, Aitana, additional, Loganathan, Vinothan, additional, Lombardi, Stefania, additional, Lopez, Eloisa, additional, Lopez Rodríguez, Maria, additional, Lorenzini, Laura, additional, Lowicka, Malgorzata, additional, Lugovoy, Alexander, additional, Luippold, Madeleine, additional, Lumb, Andrew, additional, Macas, Andrius, additional, Macgregor, Mark, additional, Machado, Humberto, additional, Maciariello, Maria, additional, Madeira, Isabel, additional, Maitan, Stefan, additional, Majewski, Jacek, additional, Maldini, Branka, additional, Malewski, Georgia, additional, Manfredini, Livia, additional, Männer, Olja, additional, Marchand, Bahareh, additional, Marcu, Alexandra, additional, Margalef, Jordi, additional, Margarson, Michael, additional, Marinheiro, Lucia, additional, Markic, Ana, additional, Markovic Bozic, Jasmina, additional, Marrazzo, Francesco, additional, Martin, Jane, additional, Martin Ayuso, Maria, additional, Martinez, Esteher, additional, Martino, Enrico Antonio, additional, Martinson, Victoria, additional, Marusic-Gaser, Katarina, additional, Mascarenhas, Catia, additional, Mathis, Cindy, additional, Matsota, Paraskevi, additional, Mavrommati, Eleni, additional, Mazul Sunko, Branka, additional, McCourt, Killian, additional, McGill, Neil, additional, McKee, Raymond, additional, Meço, Başak Ceyda, additional, Meier, Sonja, additional, Melbourne, Susan, additional, Melbybråthen, Grethe, additional, Meli, Andrea, additional, Melia, Aiden, additional, Melotti, Rita Maria, additional, Menga, Maria Rosaria, additional, Mercer, Pauline, additional, Merotra, Susan, additional, Mescolini, Silvia, additional, Metterlein, Thomas, additional, Michalov, Martin, additional, Michlig, Sam, additional, Midgley, Susan, additional, Milić, Morena, additional, Milojevic, Milan, additional, Miñana, Amanda, additional, Minto, Gary, additional, Mirabella, Lucia, additional, Mirea, Liliana, additional, Mittelstädt, Ludger, additional, Moeglen, Aude, additional, Moise, Alida, additional, Mokini, Zhirajr, additional, Molin, Anna, additional, Moltó, Luis, additional, Monea, Maria Concetta, additional, Montalto, Francesca, additional, Montgomery, Jane, additional, Montgomery, Claire, additional, Montillo, Gerardo, additional, Moore, Sally, additional, Moore, Faye, additional, Moreira, Zelia, additional, Moreno, Tania, additional, Moreno, Ricardo, additional, Moret, Enrique, additional, Moreton, Sarah, additional, Morgan, Marianne, additional, Moro Velasco, Concepción, additional, Morri, Davide, additional, Moull, Alice, additional, Moura, Fernando, additional, Mráz, Peter, additional, Mrozek, Katarzyna, additional, Mukhtar, Karim, additional, Muniyappa, Sudeshkumar, additional, Murray, Heather, additional, Murthy, Burra VS, additional, Mushambi, Mary, additional, Nadolski, Maria, additional, Nardelli, Pasquale, additional, Nardin, Giordano, additional, Navarro Pérez, Rosalía, additional, Naveiro, Andrea, additional, Negri, Manuela, additional, Nesek Adam, Visnja, additional, Neskovic, Vojislava, additional, Neuwersch, Stefan, additional, Neves, Miriam, additional, Nguyen, Bavinh, additional, Ní Eochagáin, Aisling, additional, Nicholas, Caroline, additional, Nightingale, Jeremy, additional, Norrie, Kylie, additional, Novak-Jankovic, Vesna, additional, Novakova, Andrea, additional, Novillo, Marta, additional, Numan, Sandra, additional, Oduro-Dominah, Louise, additional, Oldner, Anders, additional, Oliveira, Isabel, additional, Ologoiu, Daniela, additional, Oloktsidou, Irini, additional, O'Reilly, Rosalind, additional, Orlando, Alessandro, additional, Ovezov, Alexey, additional, Ozbilgin, Sule, additional, Paal, Peter, additional, Padin Barreiro, Lidia, additional, Palugniok, Ryszard, additional, Papaioannou, Alexandra, additional, Papapostolou, Konstantinos, additional, Paranthaman, Prabhakar, additional, Pardey Bracho, Gilda, additional, Parente, Suzana, additional, Parfeni, Alexandru, additional, Pasin, Laura, additional, Passey, Samuel, additional, Pastor, Ernesto, additional, Patch, Sarah, additional, Patil, Andan, additional, Paunescu, Marilena-Alina, additional, Pehboeck, Daniel, additional, Pereira, Manuela, additional, Pereira, Carla, additional, Perez Caballero, Paula, additional, Pérez García, Aníbal, additional, Pérez Soto, Antonia, additional, Perez Tejero, Gisela, additional, Perez-Cerda, Francisco, additional, Pesenti, Antonio, additional, Petta, Rocco, additional, Philippe, Simon, additional, Pickering, David, additional, Pico Veloso, Jandro, additional, Pina, Pedro, additional, Pinho-Oliveira, Vítor, additional, Pinol, Santiago, additional, Pinto, Rita, additional, Pistidda, Laura, additional, Pitterle, Manuela, additional, Piwowarczyk, Paweł, additional, Plotnikova, Olga, additional, Pohl, Holger, additional, Poldermann, Jorinde, additional, Polkovicová, Lucia, additional, Pompei, Livia, additional, Popescu, Mihai, additional, Popović, Radmila, additional, Pota, Vincenzo, additional, Potocnik, Miriam, additional, Potręć, Beata, additional, Potter, Alison, additional, Pramod, Nalwaya, additional, Prchalova, Martina, additional, Preckel, Benedikt, additional, Pugh, Richard, additional, Pulletz, Mark, additional, Radoeshki, Aleksandar, additional, Rafi, Amir, additional, Ragazzi, Riccardo, additional, Raineri Santi, Maurizio, additional, Rajamanickam, Tamiselvan, additional, Rajput, Zahra, additional, Ramachandran, Rajeskar, additional, Ramasamy, Radhika, additional, Ramessur, Suneil, additional, Rao, Roshan, additional, Rasmussen, Anders, additional, Rato, André, additional, Razaque, Usman, additional, Real Navacerrada, M. Isabel, additional, Reavley, Caroline, additional, Reid, James, additional, Reschreiter, Henrik, additional, Rial, Erick, additional, Ribas Carrasco, Patricia, additional, Ribeiro, Sandy, additional, Rich, Nathalie, additional, Richardson, Lydia, additional, Rimaitis, Kestutis, additional, Rimaitis, Marius, additional, Ringvold, Else-Marie, additional, Ripke, Fabian, additional, Ristescu, Irina, additional, Ritchie, Keith, additional, Ródenas, Frederic, additional, Rodrigues, Patrícia, additional, Rogers, Emma, additional, Rogerson, David, additional, Romagnoli, Stefano, additional, Romero, Esther, additional, Rondovic, Goran, additional, Rose, Bernd Oliver, additional, Roth, Winfried, additional, Rotter, Marie-Therese, additional, Rousseau, Guy, additional, Rudjord, Anders, additional, Rueffert, Henrik, additional, Rundgren, Malin, additional, Rupprecht, Korbinian, additional, Rushton, Andrew, additional, Russotto, Vincenzo, additional, Rypulak, Elżbieta, additional, Ryszka, Maciej, additional, Sà, Jacinta, additional, Sà Couto, Paula, additional, Saby, Sandrine, additional, Sagic, Jelena, additional, Saleh, Omar, additional, Sales, Gabriele, additional, Sánchez Sánchez, Yván, additional, Sanghera, Sumayer, additional, Şanli Karip, Ceren, additional, Santiveri Papiol, Francisco Javier, additional, Santos, Sofia, additional, Sarno, Stephen, additional, Saul, Daniel, additional, Saunders, David, additional, Savic, Nenad, additional, Scalco, Loïc, additional, Scanlon, Deborah, additional, Schaller, Stefan, additional, Schax, Christoph, additional, Scheffer, Gert Jan, additional, Schening, Anna, additional, Schiavone, Vincenzo, additional, Schmidt-Ehrenberg, Florian, additional, Schmidt-Mutter, Catherine, additional, Schönberg, Christina, additional, Schopflin, Christian, additional, Schreiber, Jan-Uwe, additional, Schultz, Marcus, additional, Schurig, Marlen, additional, Scott, Carmen, additional, Sebestian, Siby, additional, Sehgal, Selena, additional, Sem, Victoria, additional, Semenas, Egidijus, additional, Serafini, Elena, additional, Serchan, Pashalitsa, additional, Shields, Martin, additional, Shobha, Ramakrishnan, additional, Shosholcheva, Mirjana, additional, Siamansour, Tanja, additional, Siddaiah, Narendra, additional, Siddiqi, Khalid, additional, Sinclair, Rhona, additional, Singh, Permendra, additional, Singh, Rajendra, additional, Sinha, Aneeta, additional, Sinha, Ashok, additional, Skinner, Amanda, additional, Smee, Elizabeth, additional, Smekalova, Olga, additional, Smith, Neil, additional, Smith, Thomas, additional, Smitz, Carine, additional, Smole, Daniel, additional, Sojčić, Nataša, additional, Soler Pedrola, Maria, additional, Somanath, Sameer, additional, Sonksen, Julian, additional, Sorella, Maria Christina, additional, Sörmus, Alar, additional, Soro, Marina, additional, Soto, Carmen, additional, Spada, Anna, additional, Spadaro, Savino, additional, Spaeth, Johannes, additional, Sparr, Harald, additional, Spielmann, Annika, additional, Spindler-Vesel, Alenka, additional, Stamelos, Matthaios, additional, Stancombe L, Liucia, additional, Stanculescu, Andreea, additional, Standl, Thomas, additional, Standley, Tom, additional, Stanek, Ondrej, additional, Stanisavljević, Snežana, additional, Starczewska, Malgorzata, additional, Stäuble, Christiane, additional, Steen, Julie, additional, Stefan, Oana Maria, additional, Stell, Elizabeth, additional, Stera, Caterina, additional, Stevens, Markus, additional, Stoerckel, Marlène, additional, Stošić, Biljana, additional, Stourac, Petr, additional, Stroumpoulis, Konstantinos, additional, Struck, Rafael, additional, Suarez de la Rica, Alejandro, additional, Sultanpori, Altaf, additional, Sundara Rajan, Rajinikanth, additional, Suying, Ong, additional, Svensen, Christer, additional, Swan, Louise, additional, Syrogianni, Paulina, additional, Sysiak, Justyna, additional, Szederjesi, Janos, additional, Taddei, Stefania, additional, Tan Hao, Ern, additional, Tanou, Virginia, additional, Tarabová, Katarina, additional, Tardaguila Sancho, Paula, additional, Tarroso, Maria, additional, Tartaglione, Marco, additional, Taylor, Emma, additional, Tbaily, Lee, additional, Telford, Richard, additional, Terenzoni, Massimo, additional, Theodoraki, Kassiani, additional, Thornley, Helen, additional, Tiganiuc, Liviu, additional, Toim, Hardo, additional, Tomescu, Dana, additional, Tommasino, Concezione, additional, Toni, Jessica, additional, Toninelli, Arturo, additional, Toretti, Ilaria, additional, Townley, Stephen, additional, Trepenaitis, Darius, additional, Trethowan, Brian, additional, Tsaousi, Georgia, additional, Tsiftsi, Aikaterini, additional, Tudor, Adrada, additional, Turan, Güldem, additional, Turhan, Sanem Çakar, additional, Unic-Stojanovic, Dragana, additional, Unterbuchner, Christoph, additional, Unzueta, Carmen, additional, Uranjek, Jasna, additional, Ursic, Tomaz, additional, Vaida, Simona, additional, Valldeperas Ferrer, Silvia, additional, Valldeperas Hernandez, Maria Inmaculada, additional, Valsamidis, Dimitri, additional, Van Beek, Rienk, additional, Van dasselaer, Nick, additional, Van Der Beek, Tim, additional, Van Duivenvoorde, Yoni, additional, van Klei, Wilton A., additional, Van Poorter, Frans, additional, Van Zaane, Bas, additional, Van Zundert, Tom, additional, Van Zyl, Rebekka, additional, Vargas Munoz, Ana Milena, additional, Varsani, Nimu, additional, Vasconcelos, Pedro, additional, Vassilakis, Georgios, additional, Vecchiatini, Tommaso, additional, Vecera, Lubomir, additional, Vercauteren, Marcel, additional, Verdouw, Bas, additional, Verheyen, Veerle, additional, Verri, Marco, additional, Vicari Sottosanti, Luigi Giancarlo, additional, Vico, Manuel, additional, Vidal Mitjans, Patricia, additional, Vilardi, Anna, additional, Vissicchio, Daniela, additional, Vitale, Giovanni, additional, Vitković, Bibiana, additional, Vizcaychipi, Marcela Paola, additional, Voicu, Alexandra, additional, Voje, Minca, additional, Volfová, Ivana, additional, Volta, Carlo Alberto, additional, Von Lutterotti, Theresa, additional, von Tiesenhausen, Anna, additional, Vrecic-Slabe, Simona, additional, Vukcevic, Dejan, additional, Vukovic, Rade, additional, Vullo, P. Agostina, additional, Wade, Andrew, additional, Wallberg, Hanna, additional, Wallden, Jakob, additional, Wallner, Johann, additional, Walther Sturesson, Louise, additional, Watson, Davina, additional, Weber, Stefan, additional, Wegiel Leskiewiq, Anna, additional, Weller, Debbie, additional, Wensing, Carine, additional, Werkmann, Markus, additional, Westberg, Henrik, additional, Wikström, Erik, additional, Williams, Benedict, additional, Wilson, Robin, additional, Wirth, Steffen, additional, Wittmann, Maria, additional, Wood, Laura, additional, Wright, Stella, additional, Zachoval, Christian, additional, Zambon, Massimo, additional, Zampieri, Silvia, additional, Zampone, Salvatore, additional, Zangrillo, Alberto, additional, Zani, Gianluca, additional, Zavackiene, Asta, additional, Zieglerder, Raphael, additional, Zonneveldt, Harry, additional, Zsisku, Lajos, additional, Zucker, Tom-Philipp, additional, Żukowski, Maciej, additional, Zuleika, Mehrun, additional, and Zupanĕiĕ, Darja, additional

Published
2019
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41. Novel Nanoporous Carbon/Iron Oxide Catalyst for SO2 Degradation

Author

Stanisavljević, Maja, primary, Janković, Savka, additional, Milisavić, Dragana, additional, Čađo, Marko, additional, Kukrić, Zoran, additional, Stević, Dragana, additional, Kukobat, Radovan, additional, Ilić, Predrag, additional, Međed, Denis, additional, Wojtan, Magdalena Parlinska, additional, and Atlagić, Suzana Gotovac, additional

Published
2019
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44. Micro RNA-155 participates in re-activation of encephalitogenic T cells

Author

Suzana Stanisavljević, Bojan Jevtić, Gordana Timotijević, Miljana Momčilović, Djordje Miljković, and Marija Mostarica Stojković

Subjects
CD4-Positive T-Lymphocytes, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, T cell, Autoimmunity, Biology, TCIRG1, 03 medical and health sciences, Interleukin 21, 0302 clinical medicine, Immune system, medicine, Animals, Cytotoxic T cell, IL-2 receptor, 030304 developmental biology, Pharmacology, 0303 health sciences, ZAP70, Experimental autoimmune encephalomyelitis, Myelin Basic Protein, General Medicine, medicine.disease, Molecular biology, micro RNA, Rats, 3. Good health, Disease Models, Animal, MicroRNAs, medicine.anatomical_structure, Gene Expression Regulation, Spinal Cord, Central nervous system, Immunology, Cytokines, Female, 030215 immunology
Abstract

MicroRNAs (miR) are small non-coding RNAs involved in the immune response regulation. miR-155 has been attributed a major pro-inflammatory role in the pathogenesis of multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). Here, a role of miR-155 in re-activation of encephalitogenic CD4(+) T cells was investigated. Dark Agouti rats were immunized with myelin basic protein (MBP) emulsified in complete Freund's adjuvant. CD4(+) T cells were purified from draining lymph node cells (DLNC) obtained in the inductive phase and from spinal cord immune cells (SCIC) isolated at the peak of EAE. CD4(+) T cells obtained from SCIC (i.e., in vivo re-activated cells) had markedly higher expression of miR-155 in comparison to those purified from DLNC (not re-activated). Likewise, in vitro re-activation of DLNC with MBP led to increase in miR-155 expression. Further, DLNC and DLNC CD4(+) T cells were transfected with an inhibitor of miR-155 during in vitro re-activation. As a result, expression of important CD4(+) T cell effector cytokines IFN-gamma and IL-17, but not of regulatory cytokines IL-10 and TGF-beta, was reduced. These results imply that miR-155 supports re-activation of encephalitogenic CD4+ T cells. Our results contribute to a view that miR-155 might be a valuable target in multiple sclerosis therapy. (C) 2015 Elsevier Masson SAS. All rights reserved. Ministry of Education, Science and Technological Development of the Republic of Serbia {[}173035, 175038, 173013]

Published
2015

45. Water deficit down-regulates miR398 and miR408 in pea (Pisum sativum L.)

Author

Živko Jovanović, Aleksandar Mikić, Nemanja Stanisavljević, Svetlana Radović, and Vesna Maksimović

Subjects
0106 biological sciences, Physiology, Down-Regulation, Plant Science, 01 natural sciences, Pisum, Superoxide dismutase, 03 medical and health sciences, Sativum, Gene expression, Botany, Genetics, Cytochrome c oxidase, Gene, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, biology, Gene Expression Profiling, Peas, food and beverages, Biotic stress, biology.organism_classification, 6. Clean water, Droughts, Cell biology, MicroRNAs, Shoot, biology.protein, 010606 plant biology & botany
Abstract

MicroRNAs (miRNAs), recently recognized as important regulator of gene expression at posttranscriptional level, have been found to be involved in plant stress responses. The observation that some miRNAs are up- or down regulated by stress implies that they could play vital roles in plant resistance to abiotic and biotic stress. We investigated the effect of water stress treatment during 10 days on expression of conserved miRNAs-miR398a/b and miR408 in pea plants. This time frame reflects the changes as close as possible to the changes where water stress causes visible effects under field condition. It was observed that dehydration strongly down regulates the expression of both miR398a/b and miR408 in pea roots and shoots. The down-regulation of miR398a/b and the up-regulation of potential target genes - copper superoxide dismutase, CSD1, highlight the involvement of this miRNA in pea stress response. To the contrary, the mRNA level of cytochrome c oxidase subunit 5 (COX5b) did not change in roots and shoots of water-stressed plants, compared to control (well) hydrated plants. This suggests that COX5b is not the target of miR398, or that its expression is regulated by some other mechanism. P1B-ATPase expression increased during water deficit only in the shoots of pea; in the roots there were no changes in expression. Our results help to understand the possible role of investigated miRNAs and their contribution to pea capacity to cope with water deficit.

Published
2014

46. Victims or Bullies – Students or Teachers

Author

Ass Zoran Stankovic, Bisera Jevtić, and Zorica Stanisavljević Petrović

Subjects
prevention, media_common.quotation_subject, aggression, Current period, Violence, Representation (politics), State (polity), bully, Phenomenon, Personal competence, victim, General Materials Science, Psychology, Social psychology, media_common
Abstract

The problem of violence in schools has been considered globally through teachers’ assessments of violence in schools- sometimes of the actual state of violence in the schools where they work; of the representation of the form of violent behavior and the reactions of students in the situations where they find themselves in the spectator role of a violent scene. This work is the result of research which serves to empirically confirm the representation of violent behavior of both students and teachers in verified, controlled (part of the School without violence network) and unverified elementary schools of the Rasina District in Serbia, as well as the attitudes of teachers on violence and on personal competence to suppress the aforementioned phenomenon. The beginning results of the research on the problem of violence- in the past and at present have shown a tendency for the increase in violence in educational institutions. Through a longitudinal consideration of subjective assessments of teachers on violence in the previous and current period, we come to a conclusion that the greatest percentage of teachers points out that the problem of violence today is the same or greater in relation to earlier periods. Further analysis of the results has contributed to the conclusion that the teachers’ awareness of the presence of violence is greater in schools which are a part of the School without violence network, which caused the display of a greater degree of violence in these schools.

Published
2014
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50. Antioxidant and Antimicrobial Activities of Echinacea (Echinacea purpurea L.) Extracts Obtained by Classical and Ultrasound Extraction

Author

Miodrag L. Lazić, Vlada B. Veljković, Dragan T. Veličković, Saša S. Stojičević, and Ivana T. Stanisavljević

Subjects
Environmental Engineering, Antioxidant, Chromatography, biology, DPPH, General Chemical Engineering, medicine.medical_treatment, Aspergillus niger, Extraction (chemistry), General Chemistry, biology.organism_classification, Antimicrobial, Biochemistry, chemistry.chemical_compound, chemistry, medicine, Growth inhibition, Candida albicans, EC50
Abstract

Antioxidant and antimicrobial activities of Echinacea purpurea L. ( Asteraceae ) extracts obtained by classical and ultrasound solvent extraction were compared. The dry aerial part of plant was extracted by 70% ethanol at a solid-to-liquid ratio of 1:10 (m/v) and 25°C. The extract obtained by classical solvent extraction contained 29% larger amounts of phenolic compounds and 20% higher content of flavonoids. 2,2-diphenyl-1-picril hydrazyl radical (DPPH) scavenging reached 93.6% and the values of EC50 were (34.16±0.65) μg·ml −1 and (65.48±1.12) μg·ml −1 for the extracts obtained by the classical and ultrasound extractions, respectively. The extracts, independent of the extraction technique applied, showed a considerable growth inhibition on Candida albicans and Saccharomyces cerevisiae , while no growth inhibition zones were observed for Aspergillus niger . The diameters of inhibition zone observed for all the microorganisms were larger for extracts obtained by classical extraction than those by ultrasound extraction.

Published
2009

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