1. Cyclic RGD peptide by ring-closing metathesis
- Author
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René Lazaro, Christian Bijani, Stéphane Varray, Nelly Kieffer, Jean Martinez, and Frédéric Lamaty
- Subjects
Stereochemistry ,Chemistry ,Organic Chemistry ,Sequence (biology) ,Biological activity ,Metathesis ,Biochemistry ,Combinatorial chemistry ,Catalysis ,chemistry.chemical_compound ,Ring-closing metathesis ,Yield (chemistry) ,Drug Discovery ,Tetrahydrofuran ,Integrin binding - Abstract
A cyclic pseudopeptide containing the RGD sequence has been synthesized in high yield by ring-closing metathesis using a Grubbs’ catalyst in tetrahydrofuran. Conformational analysis has been correlated to structure modeling and preliminary biological activity as an integrin binding inhibitor has been evaluated.
- Published
- 2002
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