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Start Over Author "Sowmya, N" Publisher elsevier bv
37 results on '"Sowmya, N"'

7. Depigmenting effect of banana stem and flower on melanocytes

Author

Sowmya N K, Goriparthi Neeharika Sree, Pooja Patil, and D.S. Mehta

Subjects
Otorhinolaryngology, fungi, food and beverages, General Dentistry, Article
Abstract

Gingival repigmentation is an inevitable hindrance among different procedures accepted for gingival depigmentation. To overcome this, there is a need for the procedure that can delay the duration of reappearance of pigmentation. A number of studies using herbal extracts with antioxidant property shown to have anti melanogenic effect. In the present in - vitro study, we investigated the effect of banana stem and flower extracts on melanocytes, as Banana stem and flower are rich in polyphenols and flavonoids, which are potent antioxidants. The melanocytes were exposed to ethanolic extract of banana stem and flower at 2 concentrations (100 μgm, 150 μgm) for 72 h. The cellular melanin contents were measured using Bradford assay which depicted the reduction in the melanin content and Resazurin assay was used for assessment of cell viability showed no significant cytotoxic effect of banana stem and flower on the cells. The cells exposed to higher concentration (150 μgm) of banana stem and flower showed significant reduction in melanin content. Flower extract showed better reduction in the melanin content. Based on these results both banana flower and stem can be tried as potent gingival depigmenting agent.

Published
2022

26. Regional mechanical properties of human brain tissue for computational models of traumatic brain injury

Author

Sowmya N. Sundaresh, John D. Finan, Benjamin S. Elkin, Barclay Morrison, and Guy M. McKhann

Subjects
Materials science, Traumatic brain injury, Models, Neurological, 0206 medical engineering, Biomedical Engineering, 02 engineering and technology, Hippocampus, Biochemistry, Viscoelasticity, Biomaterials, White matter, 03 medical and health sciences, 0302 clinical medicine, Indentation, Cortex (anatomy), Brain Injuries, Traumatic, medicine, Humans, Computer Simulation, Epilepsy surgery, Molecular Biology, General Medicine, Human brain, Anatomy, medicine.disease, White Matter, 020601 biomedical engineering, medicine.anatomical_structure, Deformation (engineering), 030217 neurology & neurosurgery, Biotechnology
Abstract

To determine viscoelastic shear moduli, stress relaxation indentation tests were performed on samples of human brain tissue resected in the course of epilepsy surgery. Through the use of a 500 µm diameter indenter, regional mechanical properties were measured in cortical grey and white matter and subregions of the hippocampus. All regions were highly viscoelastic. Cortical grey matter was significantly more compliant than the white matter or hippocampus which were similar in modulus. Although shear modulus was not correlated with the age of the donor, cortex from male donors was significantly stiffer than from female donors. The presented material properties will help to populate finite element models of the brain as they become more anatomically detailed. Statement of Significance We present the first mechanical characterization of fresh, post-operative human brain tissue using an indentation loading mode. Indentation generates highly localized data, allowing structure-specific mechanical properties to be determined from small tissue samples resected during surgery. It also avoids pitfalls of cadaveric tissue and allows data to be collected before degenerative processes alter mechanical properties. To correctly predict traumatic brain injury, finite element models must calculate intracranial deformation during head impact. The functional consequences of injury depend on the anatomical structures injured. Therefore, morbidity depends on the distribution of deformation across structures. Accurate prediction of structure-specific deformation requires structure-specific mechanical properties. This data will facilitate deeper understanding of the physical mechanisms that lead to traumatic brain injury.

Published
2017

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