1. Systematic Review and Meta-analysis: The Science of Early-Life Precursors and Interventions for Attention-Deficit/Hyperactivity Disorder
- Author
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Shephard, E, Zuccolo, P, Idrees, I, Godoy, P, Salomone, E, Ferrante, C, Sorgato, P, Catao, L, Goodwin, A, Bolton, P, Tye, C, Groom, M, Polanczyk, G, Shephard E., Zuccolo P. F., Idrees I., Godoy P. B. G., Salomone E., Ferrante C., Sorgato P., Catao L. F. C. C., Goodwin A., Bolton P. F., Tye C., Groom M. J., Polanczyk G. V., Shephard, E, Zuccolo, P, Idrees, I, Godoy, P, Salomone, E, Ferrante, C, Sorgato, P, Catao, L, Goodwin, A, Bolton, P, Tye, C, Groom, M, Polanczyk, G, Shephard E., Zuccolo P. F., Idrees I., Godoy P. B. G., Salomone E., Ferrante C., Sorgato P., Catao L. F. C. C., Goodwin A., Bolton P. F., Tye C., Groom M. J., and Polanczyk G. V.
- Abstract
Objective: To evaluate which early neurocognitive and behavioral precursors are associated with the development of attention-deficit/hyperactivity disorder (ADHD) and whether these are currently targeted in early interventions. Method: We conducted 2 systematic reviews and meta-analyses of empirical studies to examine the following: (1) early-life (0-5 years) neurocognitive and behavioral precursors associated with familial likelihood for ADHD, an early ADHD diagnosis/elevated ADHD symptoms, and/or the presence of later-childhood ADHD; and (2) interventions delivered to children aged 0 to 5 years targeting the identified precursors or measuring these as outcomes. Standardized mean differences (Hedges’ g) and pre-post-treatment change scores (SMD) were computed. Results: A total of 149 studies (165,095 participants) investigating 8 neurocognitive and behavioral domains met inclusion criteria for part 1. Multi-level random-effects meta-analyses on 136 studies revealed significant associations between ADHD and poorer cognitive (g = −0.46 [95% CIs: −0.59, −0.33]), motor (g = −0.35 [CIs: −0.48, −0.21]) and language (g = −0.43 [CIs: −0.66, −0.19]) development, social (g = 0.23 [CIs: 0.03, 0.43]) and emotional (g = 0.46 [CIs: 0.33, 0.58]) difficulties, early regulatory (g = 0.30 [CIs: 0.18, 0.43]) and sleep (g = 0.29 [CIs: 0.14, 0.44]) problems, sensory atypicalities (g = 0.52 [CIs: 0.16, 0.88]), elevated activity levels (g = 0.54 [CIs: 0.37, 0.72]), and executive function difficulties (g = 0.34 [CIs: 0.05, 0.64] to −0.87 [CIs: −1.35, −0.40]). A total of 32 trials (28 randomized, 4 nonrandomized, 3,848 participants) testing early interventions that targeted the identified precursors met inclusion criteria for part 2. Multi-level random-effects meta-analyses on 22 studies revealed significant intervention-related improvements in ADHD symptoms (SMD = 0.43 [CIs: 0.22, 0.64]) and working memory (SMD = 0.37 [CIs: 0.06, 0.69]). Conclusion: Children aged 0 to 5 years with current
- Published
- 2022