61 results on '"Sohei Satoi"'
Search Results
2. Long-term outcomes of patients with multifocal intraductal papillary mucinous neoplasm following pancreatectomy
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Daisuke Hashimoto, Sohei Satoi, Tomohisa Yamamoto, So Yamaki, Mitsuaki Ishida, Satoshi Hirooka, Nobuhiro Shibata, Shogen Boku, Tsukasa Ikeura, and Mitsugu Sekimoto
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Pancreatic Neoplasms ,Pancreatectomy ,Hepatology ,Lymphatic Metastasis ,Endocrinology, Diabetes and Metabolism ,Pancreatic Intraductal Neoplasms ,Gastroenterology ,Humans ,Carcinoma, Pancreatic Ductal ,Retrospective Studies - Abstract
The decision to perform surgery is complicated by the presence of multifocal (MF) intraductal papillary mucinous neoplasms (IPMNs), which are characterized by two or more cysts located in different areas of the pancreas.We aimed to establish a suitable treatment strategy and surgical indications in patients with MF-IPMNs.This single-center retrospective study included patients with IPMNs who underwent pancreatic resection from 2006 to 2020. Patients with distant metastasis and patients with IPMNs of the main pancreatic duct were excluded from the analysis.After excluding 22 patients, 194 patients were included. One hundred thirteen patients (58.2%) had unifocal IPMNs, while 81 patients (41.8%) had MF-IPMNs. There were no significant differences in the 5-year disease-specific survival (DSS) rate (92.3% vs. 92.4%, p = 0.976) and the 5-year disease-free survival rate (88.6% vs. 86.5%, p = 0.461). The multivariate analysis identified high-risk stigmata, invasive carcinoma, and lymph node metastasis as independent predictors of DSS. The presence of cystic lesions in the pancreatic remnant was not a predictor of survival. Even in the MF-IPMN group, there were no significant differences in DSS when stratified by procedure (total pancreatectomy vs. segmental pancreatectomy, p = 0.268) or presence of cystic lesions in the pancreatic remnant (p = 0.476). The multivariate analysis identified lymph node metastasis as an independent predictor of DSS in the MF-IPMN group.In patients with MF-IPMNs, each cyst should be evaluated individually for the presence of features associated with malignancy.
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- 2022
3. Risk factors associated with hypoglycemic events after total pancreatectomy: A nationwide multicenter prospective study in Japan
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Hironobu Suto, Keiko Kamei, Hiroyuki Kato, Takeyuki Misawa, Michiaki Unno, Hiroyuki Nitta, Sohei Satoi, Yasunari Kawabata, Masayuki Ohtsuka, Toshiki Rikiyama, Takeshi Sudo, Ippei Matsumoto, Tomohiro Hirao, Keiichi Okano, Yasuyuki Suzuki, Naohiro Sata, Shuji Isaji, Masanori Sugiyama, and Yoshifumi Takeyama
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Blood Glucose ,Glycated Hemoglobin ,Cholesterol ,Pancreatectomy ,Japan ,Risk Factors ,Insulin, Short-Acting ,Weight Loss ,Humans ,Hypoglycemic Agents ,Insulin ,Surgery ,Prospective Studies - Abstract
The number of total pancreatectomy cases have increased worldwide, expanding the need for new insulin products and high-titer pancrelipases. However, the current data that is focused on hypoglycemic events after a total pancreatectomy from large nationwide series are still lacking. This study is aimed to assess the risk factors associated with hypoglycemic events after a total pancreatectomy.Data were prospectively collected from 216 consecutive patients who underwent total pancreatectomies between August 2015 and December 2017 from 68 Japanese centers. Of the 216 patients, 166 with a follow-up period of 1 year were analyzed. The risk factors for hypoglycemic events at 6 and 12 months (postoperative months 6 and 12) were investigated based on the results of a nationwide multicenter prospective study.Of the 166 patients, 57 (34%) and 70 (42%) experienced moderate or severe hypoglycemic events or hypoglycemia unawareness on a monthly basis at postoperative months 6 and 12, respectively. Multivariate analysis revealed that body weight loss after surgery ≥0.3 kg and total cholesterol level ≤136 mg/dL at postoperative month 6, and glycated hemoglobin level ≤8.9% and rapid-acting insulin use at postoperative month 12 were independent risk factors for hypoglycemic events after a total pancreatectomy. There were different independent risk factors depending on the postoperative period.Patients with body weight loss after surgery, low total cholesterol level, strict glycemic control, and using rapid-acting insulin should be aware of the occurrence of hypoglycemic events after their total pancreatectomy. In order to prevent hypoglycemic events after a total pancreatectomy, we need to consider optimal nutritional and glycemic control according to the postoperative period.
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- 2022
4. Academic value and impact of continuous global academic learning: the International HPB surgery journal club concept
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Aiste Gulla, Povilas Ignatavicius, Camilo Correa, Yosuke Inohue, Daisuke Hashimoto, Daisuke Ban, Ulrike Heger, Doris Wagner, Qinfen Xie, Perry Shen, Arthur L. Michel, Jan Lerut, Marco Del Chiaro, Thilo Hackert, Christopher L. Wolfgang, Jin He, Peter Kingham, Timothy M. Pawlik, Sohei Satoi, Peter Schemmer, Kestutis Strupas, and Ajith K. Siriwardena
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Hepatology ,Gastroenterology - Published
- 2023
5. External validation of postoperative pancreatic fistula prediction scores in pancreatoduodenectomy: a systematic review and meta-analysis
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Euan J. Dickson, Ewen M Harrison, Thomas Thorne, Robert P. Sutcliffe, Stefan Stättner, Liam Phelan, Darius F. Mirza, Stephen R Knight, Kevin Cp Conlon, Nicola de Liguori Carino, Benjamin Loveday, Laura Magill, Rita J Perry, R. Pande, Ajith K. Siriwardena, Bobby Tingstedt, Keith J. Roberts, Thomas Pinkney, James R A Skipworth, M. Panikkar, James M. Halle-Smith, Saxon Connor, Sanjay Pandanaboyana, Sohei Satoi, Ali Arshad, Todd Hore, Francesco Giovinazzo, and James Hodson
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medicine.medical_specialty ,Future studies ,Framingham Risk Score ,Hepatology ,business.industry ,Gastroenterology ,External validation ,MEDLINE ,medicine.disease ,Risk Assessment ,Pancreaticoduodenectomy ,Clinical Practice ,Pancreatic Fistula ,Postoperative Complications ,Risk Factors ,Pancreatic fistula ,Meta-analysis ,Internal medicine ,Clinical validity ,Humans ,Medicine ,business ,Pancreas ,Retrospective Studies - Abstract
Background Multiple risk scores claim to predict the probability of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy. However, it is unclear which scores have undergone external validation, and which score is the most accurate. Objective To identify risk scores for POPF, and assess the clinical validity of these scores. Methods Areas under receiving operator characteristic curve (AUROCs) were extracted from studies that performed external validation of POPF risk scores. These were pooled for each risk score, using intercept-only random-effects meta-regression models. Results Systematic review identified 34 risk scores, of which six had been subjected to external validation, and so were included in the meta-analysis, namely the Tokyo (N=2 validation studies), Birmingham (N=5), FRS (N=19), a-FRS (N=12), m-FRS (N=3) and ua-FRS (N=3) scores. The overall predictive accuracies were found to be similar for all six scores, with pooled AUROCs of 0.61, 0.70, 0.71, 0.70, 0.70 and 0.72, respectively. Considerably heterogeneity was observed, with I2 statistics ranging from 52.1-88.6%. Conclusion Most risk scores lack external validation; where this was performed, risk scores were found to have limited predictive accuracy. . Consensus is needed for which score to use in clinical practice. Due to the limited predictive accuracy, future studies to derive a more accurate risk score are warranted.
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- 2022
6. Role of phosphorylated Smad3 signal components in intraductal papillary mucinous neoplasm of pancreas
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Koichi Matsuzaki, Takashi Yamaguchi, Tsukasa Ikeura, Katsunori Yoshida, Yuichi Hori, Mitsuaki Ishida, Kazuichi Okazaki, and Sohei Satoi
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Male ,Poor prognosis ,Pathology ,medicine.medical_specialty ,endocrine system diseases ,Pancreatic Intraductal Neoplasms ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Biomarkers, Tumor ,Humans ,Medicine ,Smad3 Protein ,Phosphorylation ,Aged ,Retrospective Studies ,Invasive carcinoma ,Hepatology ,Intraductal papillary mucinous neoplasm ,business.industry ,Carcinoma ,Gastroenterology ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Up-Regulation ,Pancreatic Neoplasms ,medicine.anatomical_structure ,Dysplasia ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Neoplasm Grading ,business ,Pancreas ,Carcinogenesis ,Immunostaining - Abstract
Malignant intraductal papillary mucinous neoplasm (IPMN) has poor prognosis. The carcinogenesis of IPMN is not clear. The aim of this study was to clarify transitions in phosphorylated Smad3 signaling during IPMN carcinogenesis.By using immunohistochemistry, we examined the expression of pSmad3C and pSmad3L from 51 IPMN surgical specimens resected at our institution between 2010 and 2013. We also examined the expression of Ki-67, c-Myc and p-JNK.The median immunostaining index of pSmad3C was 79.2% in low-grade dysplasia, 74.9% in high-grade dysplasia, and 42.0% in invasive carcinoma (P0.01), whereas that of pSmad3L was 3.4%, 4.3%, and 42.4%, respectively (P0.01). There was a negative relationship between the expression of pSmad3C and c-Myc (P0.001, r = -0.615) and a positive relationship between the expression of pSmad3L and c-Myc (P0.001, r = 0.696). Negative relationship between the expression of pSmad3C and Ki-67 (P0.01, r = -0.610) and positive relationship between the expression of pSmad3L and Ki-67 (P0.01, r = 0.731) were confirmed. p-JNK-positive cells were frequently observed among pSmad3L-positive cancer cells. The median of pSmad3L/pSmad3C ratio in the non-recurrence group and the recurrence group were 0.58 (range, 0.05-0.93), 3.83 (range, 0.85-5.96), respectively (P = 0.02). The median immunostaining index of c-Myc in the non-recurrence group and the recurrence group were 2.91 (range, 0-36.9) and 82.1 (range, 46.2-97.1), respectively (P = 0.02). The median immunostaining index of Ki-67 in the non-recurrence group and the recurrence group were 12.9 (range 5.7-30.8) and 90.9 (range 52.9-98.5), respectively (P = 0.02).pSmad3L was upregulated in malignant IPMN. pSmad3L/pSmad3C ratio may be a useful prognostic factor in IPMN.
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- 2020
7. Assessment of clinical outcome of cholecystectomy according to age in preparation for the 'Silver Tsunami'
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Masaya Kotsuka, Tomohisa Yamamoto, Hisashi Kosaka, Yoichi Matsui, So Yamaki, Sohei Satoi, and Satoshi Hirooka
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Disease ,Biliary disease ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Cholelithiasis ,medicine ,Humans ,Cholecystectomy ,Gallbladder cancer ,Child ,Aged ,Retrospective Studies ,Aged, 80 and over ,Bile duct ,business.industry ,General surgery ,Age Factors ,General Medicine ,Perioperative ,Middle Aged ,medicine.disease ,Treatment Outcome ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Concomitant ,Female ,030211 gastroenterology & hepatology ,Surgery ,business ,Developed country - Abstract
Background Recent rapid increases in the aging population have created an impending “Silver Tsunami” in advanced countries. The overall prevalence of gallstone disease and its related complications will soon increase, and there will be a larger demand for gallbladder surgery. Methods We examined the outcomes of cholecystectomy according to age among patients with cholelithiasis to determine how a patient's age influences the outcome of cholecystectomy. All patients with gallstone disease who presented for cholecystectomy at our institute from January 2006 to December 2018 were analyzed. Results All perioperative outcomes (operation length, length of hospital stay, rate of open surgery, urgent surgery, postoperative complications, incidental gallbladder cancer, postoperative hospital death, concomitant bile duct stones, and total medical costs per patient) increased as patients aged. Conclusions To prevent the progression of biliary disease, elective laparoscopic cholecystectomy is recommended before patients with cholelithiasis advance in age.
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- 2019
8. Surgical treatment of metastatic pancreatic ductal adenocarcinoma: A review of current literature
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Kimitaka Tanaka, Sohei Satoi, Tatsuma Sakaguchi, Marco Del Chiaro, and Roberto Valente
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medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Peritoneum ,medicine ,Carcinoma ,Humans ,Neoplasm Metastasis ,Survival analysis ,Chemotherapy ,Lung ,Hepatology ,business.industry ,Gastroenterology ,medicine.disease ,Survival Analysis ,Peritoneal washing ,Pancreatic Neoplasms ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Radiology ,Metastasectomy ,business ,Carcinoma, Pancreatic Ductal - Abstract
Background There is no international consensus concerning the role of surgical treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC), but favorable prognoses can be expected for highly selected patients. Methods A comprehensive literature search of the PubMed and Cochrane databases was conducted using combinations of keywords to 4 July 2018. Eligible studies were those reporting on patients with histologically confirmed mPDAC undergoing surgery with curative intent. We excluded case reports with fewer than five patients, insufficient descriptions of survival data, and palliative or cytoreductive surgery as well as studies that assessed para-aortic lymph node metastasis or peritoneal washing cytology. Results Thirteen studies were deemed eligible, and six studies were identified from their references. The studies involved 428 patients who underwent surgical resection for liver metastases (n = 343), lung metastases (n = 57), and peritoneal dissemination (n = 28). Median overall survival (OS) in patients with synchronous liver metastases who underwent conversion surgery following favorable response to initial chemotherapy was 27 or 34 months, and peritoneum metastases was 28 months. Median OS after the initial treatment was varied from 51 to 121 months in metachronous lung metastasis and from 24 to 40 months in metachronous liver metastasis, respectively. Conclusion Encouraging OS was indicated in patients with synchronous mPDAC of liver and peritoneum who underwent conversion surgery. Metastasectomy for metachronous lung and liver oligometastases could be considered a practical treatment option.
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- 2019
9. Adipophilin expression is an indicator of poor prognosis in patients with pancreatic ductal adenocarcinoma: An immunohistochemical analysis
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Tomohisa Yamamoto, Hiroaki Yanagimoto, Hironori Ryota, Hisashi Kosaka, Masaya Kotsuka, Koji Tsuta, So Yamaki, Mitsuaki Ishida, Satoshi Hirooka, Sohei Satoi, Yuki Hashimoto, and Yoichi Matsui
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Male ,medicine.medical_specialty ,Poor prognosis ,Pancreatic ductal adenocarcinoma ,Early Recurrence ,Endocrinology, Diabetes and Metabolism ,Protein Array Analysis ,Adenocarcinoma ,Gastroenterology ,Perilipin-2 ,Resection ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,In patient ,Aged ,Aged, 80 and over ,Tissue microarray ,Hepatology ,business.industry ,Incidence (epidemiology) ,Middle Aged ,Gene Expression Regulation, Neoplastic ,Pancreatic Neoplasms ,030220 oncology & carcinogenesis ,Immunohistochemistry ,Female ,030211 gastroenterology & hepatology ,business ,Carcinoma, Pancreatic Ductal - Abstract
Objective Adipophilin is a lipid droplet-associated protein, and its expression has been correlated with aggressive clinical behavior in some types of carcinomas, though its role in pancreatic ductal adenocarcinoma (PDAC) has not been clarified. This study aimed to evaluate the role of adipophilin in PDAC. Methods By immunohistochemical staining using tissue microarrays, we analyzed the expression profiles of adipophilin in 181 consecutive PDAC patients who underwent macroscopic margin-negative resection from January 2008 to December 2015. Overall survival (OS) and recurrence-free survival (RFS) were compared based on adipophilin expression, and the risk factors for OS, RFS, and early recurrence (within 6 months) were analyzed. Results Of the 181 evaluated patients, 51 (28.2%) were positive for adipophilin expression. A histopathological grade of 3 (p = 0.0012), higher CA19-9 level (p = 0.0016), and R1 status (p = 0.028) were significantly associated with adipophilin-positive patients who had significantly poor OS and RFS compared to those associated with adipophilin-negative patients (p = 0.0007 and p = 0.0022, respectively). They also showed a significantly higher incidence of early recurrence (p = 0.030), based on multivariate analyses. Conclusions Adipophilin is a potential independent prognostic marker for PDAC.
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- 2019
10. Does modified Blumgart anastomosis without intra-pancreatic ductal stenting reduce post-operative pancreatic fistula after pancreaticojejunostomy?
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Taku Michiura, Hiroaki Yanagimoto, Masaya Kotsuka, Yoichi Matsui, Satoshi Hirooka, Kentaro Inoue, Sohei Satoi, Tomohisa Yamamoto, Hironori Ryota, Hisashi Kosaka, and So Yamaki
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Adult ,Male ,medicine.medical_specialty ,Fistula ,medicine.medical_treatment ,lcsh:Surgery ,Anastomosis ,Pancreatic Fistula ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Pancreaticojejunostomy ,medicine ,Humans ,Pancreatic carcinoma ,Post operative ,Pancreas ,Aged ,Retrospective Studies ,Aged, 80 and over ,Pancreatic duct ,business.industry ,Anastomosis, Surgical ,Pancreatic Ducts ,lcsh:RD1-811 ,Middle Aged ,medicine.disease ,Pancreaticoduodenectomy ,Surgery ,Jejunum ,medicine.anatomical_structure ,Pancreatic fistula ,030220 oncology & carcinogenesis ,Female ,Stents ,030211 gastroenterology & hepatology ,business ,Pancreatic stump - Abstract
Summary: Background: Post-operative pancreatic fistula (POPF) is one of the most common and serious complications after pancreaticoduodenectomy (PD). The aim of this study is to retrospectively compare clinically relevant (CR) POPF and other complications after pacreaticojejunostomy (PJ) after modified Kakita (m-Kakita) or modified Blumgart (m-Blumgart) anastomoses without stenting in a single institution. Methods: One hundred twenty-eight patients underwent PJ using m-Kakita anastomoses (two interrupted penetrating sutures) between January 2009 and December 2011. One hundred eighteen patients underwent m-Blumgart anastomoses (two transpancreatic/jejunal seromuscular sutures to cover the pancreatic stump with jejunal serosa) between January 2014 and December 2015. Demographics, clinical characteristics, and post-operative mortality and morbidity were retrospectively compared between the two groups. Results: There were no significant differences in demographics or clinical characteristics between the two groups except operative time. A significantly lower rate of CR-POPF was found in the m-Blumgart group relative to the m-Kakita group (10% vs. 19%, p = 0.038). Univariate and multivariate analyses revealed that the m-Blumgart anastomosis and fistula risk category (Negligible, Low) were independently protective against CR-POPF (p
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- 2019
11. Splenic Vein Resection with the Pancreatic Parenchyma Versus Separate Resection After Isolating the Parenchyma During Distal Pancreatectomy (COSMOS-DP Trial): A Multicentre, Randomised, Phase 3 Trial
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Hiroki Yamaue, Tsutomu Fujii, Michiaki Unno, Ippei Matsumoto, Kenichiro Uemura, Etsuro Hatano, Suguru Yamada, Kengo Fukuzawa, Akihiko Horiguchi, Yasuhiro Kodera, Takeshi Aoki, Manabu Kawai, Masayuki Sho, Yutaka Takeda, Kazuto Shibuya, Yoji Kishi, Fuminori Sonohara, Sohei Satoi, Toshio Shimokawa, and Hideo Baba
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medicine.medical_specialty ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,Population ,Odds ratio ,Institutional review board ,medicine.disease ,Surgery ,Splenic vein ,Pancreatic fistula ,Parenchyma ,Clinical endpoint ,Medicine ,business ,education - Abstract
Background: In distal pancreatectomy (DP), the splenic vein is isolated from the pancreatic parenchyma prior to being ligated and divided, to prevent intra-abdominal haemorrhage from the splenic vein stump with pancreatic fistula (PF). Conversely, dissecting the splenic vein with the pancreatic parenchyma is easy and timesaving. We aimed to establish the safety of combined resection of the splenic vein compared with separate resection of the splenic vein. Methods: This study was designed as a multicentre prospective randomised phase 3 trial. Patients undergoing DP for pancreatic body and tail tumours were eligible for inclusion. Patients were centrally randomised (1:1) to either separate resection of the splenic vein or combined resection of the splenic vein. The primary endpoint was the incidence of grade B/C PF, and the incidence of intra-abdominal haemorrhage was included as one of the secondary endpoints. All results were analysed using the full analysis set. Findings: Between August 10, 2016 and July 30, 2019, 318 patients were randomly assigned, and two patients were excluded as ineligible. The full analysis population constituted 159 patients in the separate resection group and 157 patients in the combined resection group. In the full analysis set, the proportion of grade B/C PF in the separate resection group was 27·1% vs 28·6% in the combined resection group (adjusted odds ratio: 1·108, 95% confidence interval: 0·847–1·225; P=0·047), demonstrating non-inferiority of the combined resection of the splenic vein against separate resection. The incidence of postoperative intra-abdominal haemorrhage in the two groups was identical at 1·3%. Interpretation: This study demonstrated non-inferiority of the combined resection of the splenic vein compared with separate resection of the splenic vein regarding safety. Thus, isolating the splenic vein from the pancreatic parenchyma is deemed unnecessary. Trial Registration: This trial is registered at UMIN000023237 and clinical trials.gov, NCT02871804. Funding Statement: Wakayama Medical University. Declaration of Interests: We declare that we have no conflicts of interest. Ethics Approval Statement: This study was conducted according to the Declaration of Helsinki (Fortaleza, Brazil, October 2013) and the ethical guidelines for medical and health research involving human subjects in Japan. Written informed consent was obtained from all of the enrolled patients. Ethical approval for this study was obtained from the Institutional Review Board of each institution.
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- 2020
12. Does Direct Invasion of Peripancreatic Lymph Nodes Impact Survival in Patients with Pancreatic Ductal Adenocarcinoma? a Retrospective Dual-Center Study
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Kenji Nakagawa, Masaya Kotsuka, Tatsuma Sakaguchi, Takahiro Akahori, Minako Nagai, Mitsugu Sekimoto, Taichi Terai, Hironori Ryota, Mitsuaki Ishida, Masayuki Sho, So Yamaki, Tadataka Takagi, Tomohisa Yamamoto, Daisuke Hashimoto, and Sohei Satoi
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medicine.medical_specialty ,Pancreatic ductal adenocarcinoma ,Endocrinology, Diabetes and Metabolism ,Lymph node metastasis ,Adenocarcinoma ,Gastroenterology ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Borderline resectable ,Internal medicine ,Humans ,Medicine ,In patient ,Lymph node ,Retrospective Studies ,Hepatology ,business.industry ,Significant difference ,Prognosis ,medicine.disease ,Pancreatic Neoplasms ,Survival Rate ,medicine.anatomical_structure ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Lymph Nodes ,Lymph ,business ,Carcinoma, Pancreatic Ductal - Abstract
Pancreatic ductal adenocarcinoma can directly invade the peripancreatic lymph nodes; however, the significance of direct lymph node invasion is controversial, and it is currently classified as lymph node metastasis. This study aimed to identify the impact of direct invasion of peripancreatic lymph nodes on survival in patients with pancreatic ductal adenocarcinoma.A total of 411 patients with resectable/borderline resectable pancreatic ductal adenocarcinoma who underwent pancreatic resection at two high-volume centers from 2006 to 2016 were evaluated retrospectively.Sixty (14.6%) patients had direct invasion of the peripancreatic lymph nodes without isolated lymph node metastasis (N-direct group), 189 (46.0%) had isolated lymph node metastasis (N-met group), and 162 (39.4%) had neither direct invasion nor isolated metastasis (N0 group). There was no significant difference in median overall survival between the N-direct group (35.0 months) and the N0 group (45.6 month) (p = 0.409), but survival was significantly longer in the N-direct compared with the N-met group (25.0 months) (p = 0.003). Similarly, median disease-free survival was similar in the N-direct (21.0 months) and N0 groups (22.7 months) (p = 0.151), but was significantly longer in the N-direct compared with the N-met group (14.0 months) (p 0.001). Multivariate analysis identified resectability, adjuvant chemotherapy, and isolated lymph node metastasis as independent predictors of overall survival. However, direct lymph node invasion was not a predictor of survival.Direct invasion of the peripancreatic lymph nodes had no effect on survival in patients undergoing pancreatic resection for pancreatic ductal adenocarcinoma, and should therefore not be classified as lymph node metastasis.
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- 2022
13. Use of a piece of free omentum to prevent bile leakage after subtotal cholecystectomy
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Masaya Kotsuka, Hisashi Kosaka, Tomohisa Yamamoto, So Yamaki, Satoshi Hirooka, Sohei Satoi, and Yoichi Matsui
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Adult ,Male ,medicine.medical_specialty ,Operative Time ,Anastomotic Leak ,Gallbladder Diseases ,030230 surgery ,Bile leakage ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Bile ,Humans ,Cholecystectomy ,Aged ,Retrospective Studies ,Aged, 80 and over ,Interventional treatment ,business.industry ,Gallbladder ,Retrospective cohort study ,Perioperative ,Length of Stay ,Middle Aged ,Subtotal cholecystectomy ,digestive system diseases ,Surgery ,body regions ,Treatment Outcome ,surgical procedures, operative ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Operative time ,Cystic duct ,Female ,business ,Omentum - Abstract
Background Bile leakage after subtotal cholecystectomy (SC) is clinically serious. To prevent such leakage, we developed a new surgical technique in which a free piece of omentum is plugged into the gallbladder stump (omentum plugging technique). We evaluated whether the omentum plugging technique prevents bile leakage after subtotal cholecystectomy. Methods Prospectively collected data of patients who had undergone subtotal cholecystectomy without cystic duct closure in the Department of Surgery of Kansai Medical University during the 12 years from January 2006 to March 2018 were reviewed retrospectively. The outcomes of patients who had undergone subtotal cholecystectomy with the omentum plugging technique (omentum plugging technique group) were compared with those of patients who had undergone subtotal cholecystectomy without the omentum plugging technique (Control group). The outcomes of interest were perioperative data and postoperative complications including bile leakage, necessity for interventions for complications, and duration of hospitalization. Results Fifty of 2,447 consecutive patients (2.0%) had undergone subtotal cholecystectomy. Of these 50 patients, 18 were treated with the omentum plugging technique (omentum plugging technique group) and 32 were treated without the omentum plugging technique (Control group). One of 18 patients in the omentum plugging technique group and 14 of 32 in the Control group developed postoperative bile leakage. One postoperative interventional treatment for complications was performed in the omentum plugging technique group and 12 in the Control group. The duration of postoperative hospitalization was less in the omentum plugging technique group. Conclusion The omentum plugging technique appears to be an effective operative technique for preventing postoperative bile leakage in selected situations when a “difficult gallbladder” is encountered.
- Published
- 2018
14. Is distal pancreatectomy with en-bloc celiac axis resection effective for patients with locally advanced pancreatic ductal adenocarcinoma? -Multicenter surgical group study
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Tomohisa Yamamoto, Masanori Kon, Sohei Satoi, Hirochika Toyama, Manabu Kawai, Yoshiaki Murakami, Goro Honda, Ken Ichi Okada, Hiroaki Yanagimoto, Ippei Matsumoto, Masayuki Sho, Ken ichiro Uemura, Hiroki Yamaue, Masanao Kurata, Michiaki Unno, Takahiro Akahori, and Fuyuhiko Motoi
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Adult ,Male ,medicine.medical_specialty ,Pancreatic ductal adenocarcinoma ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Splenectomy ,Celiac axis ,Gastroenterology ,Resection ,03 medical and health sciences ,Pancreatectomy ,Postoperative Complications ,0302 clinical medicine ,Japan ,Internal medicine ,Overall survival ,Adjuvant therapy ,Humans ,Medicine ,Aged ,Retrospective Studies ,Aged, 80 and over ,Hepatology ,business.industry ,Middle Aged ,Survival Analysis ,Pancreatic Neoplasms ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Positive Surgical Margin ,business ,Distal pancreatectomy ,Carcinoma, Pancreatic Ductal - Abstract
Objectives We retrospectively investigated the operative outcomes of patients who underwent distal pancreatectomy (DP) for invasive pancreatic ductal adenocarcinoma (PDAC) located at the body and tail. Methods Data from 395 patients with PDAC who underwent DP with margin-negative resection (R0 or R1) were collected from seven high-volume centers in Japan from 2001 to 2012. Among them, 72 patients underwent DP with en-bloc celiac axis resection (DP-CAR). The remaining 323 patients underwent conventional DP with splenectomy (DP-S). To determine the efficacy of DP-CAR, clinicopathological data were compared between the DP-CAR and the DP-S groups. Results The DP-S group consisted mainly of patients with resectable disease (93%), and conversely, all patients in the DP-CAR group had borderline resectable or unresectable disease. The overall morbidity was significantly higher in the DP-CAR group than in the DP-S group (63% vs 47%, respectively; P = 0.017). The median survival time (MST) of the DP-CAR group was significantly shorter than that of the DP-S group (17.5 vs 28.6 months, respectively; P = 0.004). However, the MST of patients in the DP-CAR group (n = 61, 85%) who received adjuvant therapy was significantly longer than that of patients in the DP-S group (n = 65, 20%) who underwent R1 resection (21.9 vs 16.7 months, respectively; P = 0.024). Conclusion DP-CAR followed by adjuvant chemotherapy provided an acceptable overall survival rate in patients with highly advanced PDAC, but should be performed with great caution because of high morbidity. Patients with a high risk of positive surgical margins with DP-S may be candidates for DP-CAR.
- Published
- 2018
15. Hepatic actinomycosis after total pancreatectomy: A case report
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Sohei Satoi, Daisuke Hashimoto, Tatsuma Sakaguchi, Tomohisa Yamamoto, So Yamaki, and Mitsugu Sekimoto
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Exploratory laparotomy ,Hepatic actinomycosis ,medicine.medical_treatment ,Transverse colon ,Case Report ,medicine.disease ,Malignancy ,Pancreatectomy ,Liver ,Biliary tract ,Laparotomy ,Biopsy ,medicine ,Actinomyces ,Surgery ,Actinomycosis ,Radiology ,business - Abstract
Introduction and importance Hepatic actinomycosis (HA) is a rare infection mimicking a malignancy. HA after total pancreatectomy for a pancreatic tumor has not been reported. Case presentation A 70-year-old woman with a history of gastrectomy and sigmoidectomy for benign lesions, underwent a total pancreatectomy for a non-invasive, intraductal papillary mucinous carcinoma (IPMC). She required partial resection of the transverse colon due to insufficient blood flow and had an anastomotic failure. Four months later, she developed a fever and effusion from the upper abdominal midline incision. No bacteria were cultured from the effusion. Contrast-enhanced computed tomography demonstrated an 80-mm iso-vascular liver mass. A slightly high-signal intensity on T2-weighted magnetic resonance imaging was demonstrated. Positron emission tomography (PET) showed a standardized uptake value of 11.9 at the liver mass. The percutaneous liver biopsy did not establish a diagnosis. Because a malignancy could not be ruled out, an exploratory laparotomy was performed. A tissue sample revealed aggregates of branched filamentous microorganisms; actinomycosis was diagnosed. Oral amoxicillin for 4 months resolved the mass. Clinical discussion This patient had several causative factors for HA, including multiple surgical procedures involving the gastrointestinal tract, reconstruction of the biliary tract, anastomotic failure of the transverse colon, and diabetes mellitus following total pancreatectomy. Based on the past treatment history for IPMC and PET findings mimicking a malignancy, a laparotomy was performed to biopsy the lesion. Typically, penicillin is recommended for >6 months. Conclusion A rare case of HA mimicking a malignancy after a total pancreatectomy for IPMC is presented., Highlights • Hepatic actinomycosis (HA) is a rare infection mimicking a malignancy. • A total pancreatectomy and gastrointestinal surgeries were the causable factors. • Typically, penicillin therapy is recommended for over 6 months. • Surgical exploration was important avoiding unnecessary hepatectomy.
- Published
- 2021
16. Risk Factors for Pancreatic Fistula Grade C after Pancreaticoduodenectomy: A Large Prospective, Multicenter Japan-Taiwan Collaboration Study
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Manabu Kawai, Yoshiaki Murakami, Yuichi Nagakawa, Ryosuke Amano, Shoji Nakamori, Yan Shen Shan, Hiroyuki Nitta, Kazuhisa Uchiyama, Seiko Hirono, Yi-Ming Shyr, Takehiro Okabayashi, Masakazu Yamamoto, Kazuyuki Kawamoto, Chih-Po Hsu, Hideyuki Yoshitomi, Ippei Matsumoto, Chie Kitami, Sohei Satoi, Toshio Shimokawa, Tsann-Long Hwang, Satoshi Hirano, Fuyuhiko Motoi, Hiroki Yamaue, Hiroyoshi Matsukawa, and Shinjiro Kobayashi
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,General surgery ,Organ dysfunction ,Pancreaticoduodenectomy ,medicine.disease ,Discontinuation ,Clinical trial ,Pancreatic fistula ,medicine ,Risk factor ,medicine.symptom ,Complication ,business ,Body mass index - Abstract
Background: Postoperative pancreatic fistula (POPF) is a harmful complication after pancreaticoduodenectomy (PD). Grade C POPF, as defined by International Study Group of Pancreatic Fistula (ISGPF), is the most life-threatening complication. This study aims to evaluate risk factors for Grade C POPF after PD. Methods: This is a prospective, multicenter collaboration study based in Japan and Taiwan. Between 2014 and 2017, 3,022 patients were enrolled in this study and 2,762 patients were analysed after 260 patients were excluded (discontinuation of protocol treatment: n=241, incomplete information: n=19). We analysed risk factors of Grade C POPF based on the 2005 ISGPF scheme (sepsis, organ dysfunction, haemorrhage, reoperation, and/or death) and then separately by the updated 2016 ISGPF scheme (organ failure, reoperation, and/or death). Findings: Among 2,762 patients that underwent PD, 93 patients (3∙4%) developed Grade C POPF as defined by 2005 ISGPF and 46 patients (1∙7%) developed Grade C POPF as defined by 2016 ISGPF. We found eight independent risk factors associated with Grade C POPF as defined by 2005 ISGPF on multivariate analyses; male sex, body mass index (BMI) ≥25∙0 kg/m2, chronic steroid use, preoperative serum C-reactive protein ≥1∙0 mg/dL, soft pancreas, main duct size
- Published
- 2019
17. Grade B pancreatic fistulas do not affect survival after pancreatectomy for pancreatic cancer: A multicenter observational study
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Seiko Hirono, Ippei Matsumoto, Ken-ichi Okada, Masanao Kurata, Hiroki Yamaue, Manabu Kawai, Yoshiaki Murakami, Takumi Fukumoto, Yoshiyuki Nakajima, Kenichiro Uemura, Sohei Satoi, Fuyuhiko Motoi, Goro Honda, Michiaki Unno, A-Hon Kwon, and Masayuki Sho
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Fistula ,030230 surgery ,Severity of Illness Index ,Gastroenterology ,Pancreatic Fistula ,03 medical and health sciences ,Pancreatectomy ,Postoperative Complications ,0302 clinical medicine ,Japan ,Internal medicine ,Pancreatic cancer ,Severity of illness ,Humans ,Medicine ,Survival rate ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Proportional hazards model ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Pancreatic Neoplasms ,Survival Rate ,Pancreatic fistula ,030220 oncology & carcinogenesis ,Female ,Surgery ,business ,Hospitals, High-Volume ,Carcinoma, Pancreatic Ductal - Abstract
Several studies have demonstrated that postoperative complications after pancreatectomy for pancreatic cancer adversely affect survival. The impact on survival of a pancreatic fistula according to the classification of the International Study Group for Pancreatic Surgery has not been fully evaluated. The aim of this multicenter, observational study was to evaluate the impact of pancreatic fistula on pancreatic cancer patients who had undergone pancreatectomy.Between 2001 and 2012, 1,397 patients who underwent pancreatectomy for pancreatic cancer at 7 high-volume centers in Japan were reviewed retrospectively. The impact of pancreatic fistula on survival was evaluated by univariate and multivariate analysis.Pancreatic fistula occurred in 327 of 1,397 patients (23.4%) and was classified based on the International Study Group for Pancreatic Surgery as follows: grade A in 9.9%, grade B in 10.6%, and grade C in 2.9% of the patients. Median survival time in no fistula/grade A, grade B, and grade C were 23.6, 26.0, and 9.0 months, respectively. There was no significant difference in overall survival between patients with no fistula/grade A and those with grade B (P = .403); in contrast, overall survival in patients with grade C was worse than in patients without grade C (P .001). The multivariate Cox proportional hazard analysis demonstrated that grade C pancreatic fistula was an independent prognostic factor (hazard ratio 1.59; 95% confidence interval, 1.03-2.45; P = .035).Grade B pancreatic fistula after pancreatectomy does not adversely affect long-term survival, but a grade C pancreatic fistula has a negative impact on long-term survival of patients with pancreatic cancer.
- Published
- 2016
18. Proposed preoperative risk factors for early recurrence in patients with resectable pancreatic ductal adenocarcinoma after surgical resection: A multi-center retrospective study
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Sohei Satoi, Makoto Shinzeki, Tadahiro Goto, Masanao Kurata, Goro Honda, Masaji Tani, Yonson Ku, Sadaki Asari, A-Hon Kwon, Yoshiaki Murakami, Fuyuhiko Motoi, Tetsuo Ajiki, Michiaki Unno, Hiroki Yamaue, Takahiro Akahori, Ippei Matsumoto, Kenichiro Uemura, Masayuki Sho, and Takumi Fukumoto
- Subjects
medicine.medical_specialty ,Pancreatic ductal adenocarcinoma ,Early Recurrence ,Endocrinology, Diabetes and Metabolism ,Adenocarcinoma ,Pancreatectomy ,Risk Factors ,Pancreatic cancer ,Odds Ratio ,medicine ,Humans ,In patient ,Retrospective Studies ,Hepatology ,business.industry ,Gastroenterology ,Cancer ,Retrospective cohort study ,Odds ratio ,medicine.disease ,Confidence interval ,Surgery ,Pancreatic Neoplasms ,Neoplasm Recurrence, Local ,business ,Carcinoma, Pancreatic Ductal - Abstract
Although surgical resection remains the only chance for cure in patients with pancreatic ductal adenocarcinoma (PDAC), postoperative early recurrence (ER) is frequently encountered. The purpose of this study is to determine the preoperative predictive factors for ER after upfront surgical resection.Between 2001 and 2012, 968 patients who underwent upfront surgery with R0 or R1 resection for PDAC at seven high-volume centers in Japan were retrospectively reviewed. ER was defined as relapse within 6 months after surgery. Study analysis stratified by resectable (R) and borderline resectable (BR) PDACs was conducted according to the National Comprehensive Cancer Network guidelines.ER occurred in 239 patients (25%) with a median survival time (MST) of 8.8 months. Modified Glasgow prognostic score = 2 (odds ratio (OR) 2.06, 95% confidence interval (CI) 1.05-3.95; P = 0.044), preoperative CA19-9 ≥300 U/ml (OR 1.94, 1.29-2.90; P = 0.003), and tumor size ≥30 mm (OR 1.72, 1.16-2.56; P = 0.006), were identified as preoperative independent predictive risk factors for ER in patients with R-PDAC. In the R-PDAC patients, MST was 35.5, 26.3, and 15.9 months in patients with 0, 1 and ≥2 risk factors, respectively. There were significant differences in overall survival between the three groups (P0.001). No preoperative risk factors were identified in BR-PDAC patients with a high rate of ER (39%).There is a high-risk subset for ER even in patients with R-PDAC and a simple risk scoring system is useful for prediction of ER.
- Published
- 2015
19. Development of a nomogram based on radiologic findings for predicting malignancy and invasiveness in intraductal papillary mucinous neoplasms of the pancreas: an international multicenter study
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Hyeong Seok Kim, Taesung Park, Yongkang Kim, Heonjun Park, Youngmin Han, Jin He, Christopher L. Wolfgang, Alex Blair, M. Farzan Rashid, Michael D. Kluger, Gloria H. Su, Song-Cheol Kim, Ki-Byung Song, Masakazu Yamamoto, Takashi Hatori, Ching-Yao Yang, Hiroki Yamaue, Seiko Hirono, Sohei Satoi, Tsutomu Fujii, Satoshi Hirano, Wenhui Lou, Yasushi Hashimoto, Yasuhiro Shimizu, Roberto Valente, Marco Del Chiaro, Dong Wook Choi, Seong Ho Choi, Jin Seok Heo, Fuyuhiko Motoi, Ippei Matsumoto, Woo Jung Lee, Chang Moo Kang, Yi-Ming Shyr, Shin-E. Wang, Ho-Seong Han, Yoo-Seok Yoon, Nadine C.M. van Huijgevoort, Marc G. Besselink, Masayuki Sho, Hiroaki Nagano, Sang Geol Kim, Goro Honda, Yinmo Yang, Hee Chul Yu, Jun Chul Chung, Yuichi Nagakawa, Hyung Il Seo, Hongbeom Kim, Wooil Kwon, Sun-Whe Kim, and Jin-Young Jang
- Subjects
Hepatology ,Endocrinology, Diabetes and Metabolism ,Gastroenterology - Published
- 2019
20. Evaluation of relative criteria for single-incision laparoscopic cholecystectomy
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Tomohisa Yamamoto, Sohei Satoi, Masanori Kon, Yoichi Matsui, Satoshi Hirooka, So Yamaki, and Hiroaki Yanagimoto
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,lcsh:Surgery ,030230 surgery ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Outcome Assessment, Health Care ,medicine ,Humans ,Elective surgery ,Laparoscopic cholecystectomy ,business.industry ,Patient Selection ,General surgery ,Cosmesis ,lcsh:RD1-811 ,Middle Aged ,Surgery ,Single incision laparoscopic ,Cholecystectomy, Laparoscopic ,Elective Surgical Procedures ,030220 oncology & carcinogenesis ,Concomitant ,Female ,Cholecystectomy ,Patient Safety ,SILC ,business ,Abdominal surgery - Abstract
Summary: Background/Objective: Although single-incision laparoscopic cholecystectomy (SILC) has no advantage over conventional laparoscopic cholecystectomy (LC), except for better cosmesis, few reports have discussed the criteria for SILC. The aim of this study was to evaluate the suitability of our criteria for SILC. Methods: During the study period, SILC was performed at our institution under the following criteria. The inclusion criteria were elective surgery, age of < 60 years, and body mass index of < 30 kg/m2. The exclusion criteria were a thick gallbladder wall, history of choledocholithiasis, previous abdominal surgery, and serious concomitant disease. We reviewed data regarding consecutive patients who underwent LC at our institution from November 2009 to March 2016. The data were assessed with respect to patient characteristics, operative data, and postoperative outcomes. Results: A total of 1093 patients underwent elective LC, and 232 (21.2%) of these patients underwent SILC using our criteria. Fourteen patients (6.0%) who underwent SILC required extra ports. Among the patients aged < 60 years, 50.2% (232/462) underwent SILC. There were few adverse events, including intra- and postoperative complications, among the patients who underwent SILC. Conclusion: The above-mentioned criteria are safe, necessary, and sufficient for SILC over conventional LC. Keywords: criteria, indication, single-incision laparoscopic cholecystectomy
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- 2016
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21. Randomized clinical trial exploring the optimal duration of antimicrobial prophylaxis in patients undergoing pancreaticoduodenectomy following biliary drainage
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Hiroaki Yanagimoto, Hisashi Kosaka, Sohei Satoi, Suguru Yamada, Masaya Kotsuka, Tsutomu Fujii, Yasuhiro Kodera, Hideki Takami, Yomohisa Yamamoto, So Yamaki, and Satoshi Hirooka
- Subjects
medicine.medical_specialty ,Biliary drainage ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Gastroenterology ,Pancreaticoduodenectomy ,Antimicrobial ,Surgery ,law.invention ,Randomized controlled trial ,law ,medicine ,In patient ,Duration (project management) ,business - Published
- 2018
22. Clinicopathological features and immune profiles of follicular pancreatitis
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Hiroaki Yanagimoto, Mitsuaki Ishida, Yamamoto Tomohisa, Koji Tsuta, Hironori Ryota, Yoichi Matsui, Kazuichi Okazaki, So Yamaki, Hisashi Kosaka, Satoshi Hirooka, Masaya Kotsuka, and Sohei Satoi
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Pathology ,medicine.medical_specialty ,Immune system ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Follicular phase ,Gastroenterology ,Medicine ,Pancreatitis ,Clinicopathological features ,business ,medicine.disease - Published
- 2018
23. Surgical management of main duct IPMN and mixed type IPMN: an international survey and case-vignette study among experts
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N. C. M. van Huijgevoort, M Del Chiaro, Lianne Scholten, Miguel Bruno, Suresh T. Chari, C. Fernandez del Castillo, Alain Sauvanet, Paul Fockens, J. E. van Hooft, Sohei Satoi, C.L. Wolfgang, and M.G. Besselink
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medicine.medical_specialty ,Hepatology ,business.industry ,General surgery ,International survey ,medicine ,Case vignette ,Gastroenterology ,Mixed Type IPMN ,business ,Main duct - Published
- 2019
24. Decreased serum CA19-9 levels after neoadjuvant therapy predict a low incidence of hepatic recurrence after surgery and a better prognosis for patients with pancreatic adenocarcinoma: A multicenter case-control study of 240 patients
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Michiaki Unno, Fuyuhiko Motoi, Ippei Matsumoto, Shuichi Aoki, Hiroki Yamaue, Masayuki Sho, Sohei Satoi, Goro Honda, and Yoshiaki Murakami
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medicine.medical_specialty ,Hepatology ,business.industry ,medicine.medical_treatment ,Incidence (epidemiology) ,Gastroenterology ,Case-control study ,medicine.disease ,Internal medicine ,medicine ,Adenocarcinoma ,CA19-9 ,business ,Neoadjuvant therapy - Published
- 2019
25. International multicenter study to characterize the individual risk of malignancy in branch duct IPMN and proposal of nomogram to predict malignancy
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Tsutomu Fujii, Woo Jung Lee, Sun Whe Kim, Satoshi Hirano, Taesung Park, S.C. Kim, Hiroki Yamaue, Sohei Satoi, Dong Wook Choi, T. Hatori, and Jin-Young Jang
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,General surgery ,Gastroenterology ,Nomogram ,Malignancy ,medicine.disease ,Individual risk ,Surgery ,Branch Duct ,Multicenter study ,medicine ,business - Published
- 2016
- Full Text
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26. Circulating Myeloid Dendritic Cells as Prognostic Factors in Patients with Pancreatic Cancer Who Have Undergone Surgical Resection
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A-Hon Kwon, Sohei Satoi, Hiroaki Yanagimoto, Tomohisa Yamamoto, Jun Yamao, Hideyoshi Toyokawa, Songtae Kim, Kanji Takahashi, and Naoyoshi Terakawa
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Myeloid ,medicine.medical_treatment ,chemical and pharmacologic phenomena ,Adenocarcinoma ,Peripheral blood mononuclear cell ,Pancreatic cancer ,medicine ,Humans ,Aged ,Aged, 80 and over ,business.industry ,Cancer ,hemic and immune systems ,Dendritic Cells ,Middle Aged ,Prognosis ,medicine.disease ,Immunohistochemistry ,Survival Analysis ,Pancreatic Neoplasms ,medicine.anatomical_structure ,Case-Control Studies ,Pancreatectomy ,Female ,Surgery ,CA19-9 ,Pancreas ,business - Abstract
Objective Pancreatic cancer is a malignant neoplasm with poor prognosis that might be associated with defective immune function. We aimed to determine the influence on survival of circulating myeloid dendritic cells (c-m-DCs), circulating lymphoid DCs (c-l-DCs), and DCs within the tumor tissue in patients with pancreatic cancer. Patients and Methods Between December 2001 and June 2006, of a total of 110 patients with ductal adenocarcinoma of the pancreas, 42 underwent pancreatectomy, and 68 had unresectable disease. Numbers of c-m-DCs and c-l-DCs were assessed by flow cytometry, and DCs in the tumor tissue by immunohistochemical staining with anti-fascin mAb. Results The percentage of the c-m-DCs subset in pancreatic cancer patients was significantly lower than in healthy volunteers, and the similar finding was observed between patients who underwent surgical resection and non-resection. Patients with a high percentage of c-m-DCs or with many DCs accumulated in the cancer tissue survived longer than patients with a low percentage or low number in peripheral blood or the tumor, respectively. Moreover, there was a positive correlation between c-m-DCs within peripheral blood mononuclear cells and the number of DCs per field in the cancer tissue. Conclusions Preoperative c-m-DCs levels in the PBMC of patients with pancreatic cancer and DCs counts in the cancer tissue can be a prognostic factor after surgical resection. Modulating the distribution of DCs may be an effective therapy in pancreatic cancer patients with a dismal prognosis.
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- 2012
27. Commentary on: Prevention of postoperative bile leakage using an omental plugging technique for subtotal cholecystectomy in the 'difficult gallbladder'
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Masanori Kon, Tomohisa Yamamoto, Yoichi Matsui, Sohei Satoi, Hiroaki Yanagimoto, So Yamaki, and Satoshi Hirooka
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Treatment outcome ,Anastomotic Leak ,030230 surgery ,Anastomosis ,Bile leakage ,Risk Assessment ,Surgical methods ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,medicine ,Bile ,Humans ,Retrospective Studies ,business.industry ,General surgery ,Gallbladder ,Anastomosis, Surgical ,Middle Aged ,Prognosis ,Subtotal cholecystectomy ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Cholecystectomy, Laparoscopic ,Case-Control Studies ,030220 oncology & carcinogenesis ,Female ,Cholecystectomy ,Patient Safety ,business ,Omentum - Published
- 2017
28. Risk factors of hepatico-jejunostomy stenosis in 444 patients who underwent pancreaticoduodenectomy
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Hironori Ryota, Hiroaki Yanagimoto, Sohei Satoi, Tomohisa Yamamoto, Hisashi Kosaka, Masaya Kotsuka, So Yamaki, Yoichi Matsui, and Satoshi Hirooka
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Stenosis ,medicine.medical_specialty ,Hepatology ,Hepatico jejunostomy ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Gastroenterology ,medicine ,medicine.disease ,Pancreaticoduodenectomy ,business ,Surgery - Published
- 2018
29. Safety of hepatectomy for living donors as evaluated using asialoscintigraphy
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Yasuo Kamiyama, A.-H. Kwon, Y. Matsui, Sohei Satoi, and Masaki Kaibori
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Serum albumin ,Urology ,Liver transplantation ,Scintigraphy ,chemistry.chemical_compound ,Living Donors ,medicine ,Hepatectomy ,Humans ,Radionuclide Imaging ,Technetium Tc 99m Aggregated Albumin ,Technetium Tc 99m Pentetate ,Aged ,Transplantation ,medicine.diagnostic_test ,biology ,business.industry ,Liver Diseases ,Liver Neoplasms ,Middle Aged ,Liver Transplantation ,Surgery ,Liver ,chemistry ,Tissue and Organ Harvesting ,biology.protein ,Female ,Asialoglycoprotein receptor ,Radiopharmaceuticals ,Safety ,Tomography, X-Ray Computed ,business ,Indocyanine green - Abstract
In the living donor operation, accurate estimation of hepatic functional reserve is essential. Technetium-99m-galactosyl-human serum albumin (GSA) is a liver scintigraphy agent that binds to asialoglycoprotein receptors. We evaluated the preoperative assessment of the safety of an elective hepatectomy using GSA liver scintigraphy in 152 patients. GSA scintigraphy was performed after intravenous injection of GSA. The maximal removal rate of GSA (GSA-Rmax) was calculated using a radiopharmacokinetic model. We determined the areas for resection preoperatively depending on the operative procedures and calculated the local GSA-Rmax in the predicted residual liver (GSA-RL). A significant correlation was obtained between the GSA-Rmax and the 15-minute retention rate of indocyanine green. With sub- and monosegmentectomy, 2 patients had postoperative hepatic failure; in those 2 patients, the GSA-RL was 0.127 and 0.133, respectively, but these patients recovered well. Among those having di- and tri-segmentectomy, 5 patients experienced postoperative hepatic failure, in all subjects the GSA-RL was0.15. Two patients died of postoperative liver failure 1 to 2 months after the operation. We concluded that GSA-RL is useful to select the procedure for hepatectomy in living donors and that GSA-RL should be0.15 (mg/min/50 kg body weight) to avoid postoperative hepatic failure.
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- 2004
30. Reappraisal of total pancreatectomy in 45 patients with pancreatic ductal adenocarcinoma in the modern era using matched-pairs analysis
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Makoto Shinzeki, Kenichiro Uemura, Goro Honda, Hiroki Yamaue, Shoichi Kinoshita, Takahiro Akahori, Tomohisa Yamamoto, Masanao Kurata, Ippei Matsumoto, Masamichi Mizuma, Manabu Kawai, Masayuki Sho, Hiroaki Yanagimoto, Seiko Hirono, Yoshiaki Murakami, Yasushi Hashimoto, Michiaki Unno, Masanori Kon, Fuyuhiko Motoi, and Sohei Satoi
- Subjects
medicine.medical_specialty ,Pancreatic ductal adenocarcinoma ,Hepatology ,business.industry ,Total pancreatectomy ,Endocrinology, Diabetes and Metabolism ,Internal medicine ,Gastroenterology ,medicine ,business - Published
- 2016
31. Clinical benefits of neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreatic head: A dual-institution observational study using IPTW
- Author
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Hiroaki Yanagimoto, Masanori Kon, Kenta Murotani, Hideki Takami, Yasuhiro Kodera, Sohei Satoi, Suguru Yamada, Tsutomu Fujii, and Tomohisa Yamamoto
- Subjects
Oncology ,medicine.medical_specialty ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Gastroenterology ,medicine.disease ,Pancreatic head ,Internal medicine ,medicine ,Adenocarcinoma ,Observational study ,business ,Neoadjuvant chemoradiotherapy - Published
- 2016
32. Increased Nitric Oxide Production in Hepatocytes Is Involved in Liver Dysfunction Following Obstructive Jaundice
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Sohei Satoi, Masaki Kaibori, Yasuo Kamiyama, Zhong Tao Zhang, Tadayoshi Okumura, A-Hon Kwon, Hiroaki Kitade, and Wei Tu
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Male ,medicine.medical_specialty ,Arginine ,Ketone Bodies ,Biology ,Mitochondrion ,Nitric Oxide ,Nitric oxide ,chemistry.chemical_compound ,Adenosine Triphosphate ,Internal medicine ,medicine ,Animals ,Aspartate Aminotransferases ,Rats, Wistar ,Cells, Cultured ,Liver injury ,Cholestasis ,Alanine Transaminase ,Bilirubin ,medicine.disease ,Rats ,Nitric oxide synthase ,Disease Models, Animal ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Hepatocyte ,Hepatocytes ,Ketone bodies ,biology.protein ,Surgery ,Liver function ,Interleukin-1 - Abstract
Background. Obstructive jaundice damages critical functions in the liver. However, the mechanisms involved in hepatic dysfunction are obscure. Nitric oxide is implicated in liver injury under various pathological conditions. We previously reported that proinflammatory cytokine interleukin-1β (IL-1β) stimulated the production of nitric oxide in hepatocytes, which was associated with mitochondrial dysfunction. Studies were performed to examine whether obstructive jaundice influences the production of nitric oxide in hepatocytes and alters hepatic energy metabolism. Material and methods. Hepatocytes were isolated and cultured from a rat model of obstructive jaundice or sham control. Nitric oxide production, ATP content, and ketone body ratio (acetoacetate/β-hydroxybutyrate; KBR) were compared between the two groups in the presence of IL-1β. Results. Hepatocytes obtained from obstructive jaundice rats markedly increased the levels of nitric oxide production stimulated by IL-1β compared with those from sham control. Western blot analysis revealed that the enhancement of nitric oxide production was a posttranslational event, since protein levels of inducible nitric oxide synthase (NOS) were unchanged between the two groups. IL-1β decreased cellular ATP content in obstructive jaundice but not in sham control. Further, the KBR, which is a marker of mitochondrial redox state, was lower in obstructive jaundice than in sham control. Addition of N G -monomethyl- l -arginine, an inhibitor of NOS, abolished the decreases in ATP content and KBR as well as the nitric oxide production. Conclusions. These results indicate that a priming of nitric oxide production following obstructive jaundice is associated with the alteration of hepatic energy metabolism in part through mitochondrial dysfunction. Regulation of nitric oxide production may be a useful therapy for preventing liver dysfunction in obstructive jaundice.
- Published
- 2002
33. Corrigendum to ‘Surgical management of main duct IPMN and mixed type IPMN: An international survey and case-vignette study among experts’[Pancraetology Volume 17, Issue 3, Supplement, July (2017) S87]
- Author
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Lianne Scholten, Nadine C. van Huijgevoort, Marco Bruno, Carlos Fernandez–del Castillo, Sohei Satoi, Alain Sauvanet, Christopher Wolfgang, Paul Fockens, Suresh T. Chari, Marco Del Chiaro, Jeanin E. van Hooft, and Marc G. Besselink
- Subjects
Hepatology ,Endocrinology, Diabetes and Metabolism ,Gastroenterology - Published
- 2017
34. Clinical benefits of neoadjuvant chemoradiotherapy for borderline resectable pancreatic head adenocarcinoma: An observational study using inverse probability of treatment weighting
- Author
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Suguru Yamada, Masanori Kon, Kenta Murotani, Isaku Yoshioka, Yasuhiro Kodera, Sohei Satoi, Hiroaki Yanagimoto, and Tsutomu Fujii
- Subjects
Oncology ,medicine.medical_specialty ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Gastroenterology ,medicine.disease ,Pancreatic head ,Inverse probability of treatment weighting ,Borderline resectable ,Internal medicine ,medicine ,Adenocarcinoma ,Observational study ,Radiology ,business ,Neoadjuvant chemoradiotherapy - Published
- 2017
35. The original criteria of drain removal could decrease re-drainage rate of pancreatic fistula related intra-abdominal abscess after pancreatectomy
- Author
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Hisashi Kosaka, Masanori Kon, Sohei Satoi, Satoshi Hirooka, Masaya Kotsuka, Tomohisa Yamamoto, So Yamaki, and Hiroaki Yanagimoto
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Gastroenterology ,Intra-abdominal Abscess ,medicine.disease ,Surgery ,Drainage rate ,Pancreatic fistula ,Pancreatectomy ,medicine ,Drain removal ,business - Published
- 2017
36. Surgical management of main duct IPMN and mixed type IPMN: an international survey and case-vignette study among experts
- Author
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Lianne Scholten, Carlos Fernandez-del Castillo, Alain Sauvanet, Paul Fockens, Nadine C.M. van Huijgevoort, Marco Del Chiaro, Christopher L. Wolfgang, Sohei Satoi, Marco J. Bruno, and Suresh T. Chari
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,General surgery ,Gastroenterology ,International survey ,Case vignette ,Main duct ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,Mixed Type IPMN ,Medicine ,030211 gastroenterology & hepatology ,business - Published
- 2017
37. Multicenter single-arm, prospective study of reinforced stapler with bioabsorbable materials to prevent pancreatic fistula after distal pancreatectomy
- Author
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Takahiro Akahori, Hisashi Ikoma, Jiro Fujimoto, Masanori Kon, Masayuki Sho, Naru Kondo, Yutaka Takeda, Hiroki Yamaue, Ippei Matsumoto, Hiroaki Yanagimoto, Seiko Hirono, Sohei Satoi, Hirochika Toyama, Hidetoshi Eguchi, Manabu Kawai, Takumi Fukumoto, Tsutomu Fujii, Yoshiaki Murakami, and Ken-ichi Okada
- Subjects
medicine.medical_specialty ,Hepatology ,Pancreatic fistula ,business.industry ,Endocrinology, Diabetes and Metabolism ,General surgery ,Gastroenterology ,medicine ,medicine.disease ,Distal pancreatectomy ,Prospective cohort study ,business ,Surgery - Published
- 2017
38. The role of basophil via TLR signaling in patients with type 1 autoimmune pancreatitis
- Author
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Masato Yanagawa, Makoto Takaoka, Manami Ikemune, Sohei Satoi, Masaaki Shimatani, Kazushige Uchida, Akiyoshi Nishio, Tsukasa Ikeura, Toshiro Fukui, and Kazuichi Okazaki
- Subjects
Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Gastroenterology ,Basophil ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Immunology ,medicine ,030211 gastroenterology & hepatology ,In patient ,business ,Autoimmune pancreatitis - Published
- 2016
39. Japan Pancreatic Cancer Registry of Japan Pancreas Society: Comparison between the conventional database and National Clinical Database (NCD)
- Author
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Masamichi Mizuma, Hiraku Kumamaru, Sohei Satoi, Shin Hamada, Hiroyuki Konno, Yasuyuki Seto, Tooru Shimosegawa, Shinichi Egawa, Hisato Igarashi, Yuzo Kodama, Hiroaki Miyata, Michiaki Unno, Kazuhiro Mizumoto, and Takao Itoi
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,General surgery ,Gastroenterology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Internal medicine ,Pancreatic cancer ,medicine ,030211 gastroenterology & hepatology ,Pancreas ,business - Published
- 2016
40. A clinical role of conversion surgery in patients with initially unresectable pancreatic ductal adenocarcinoma
- Author
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Masanori Kon, Hironori Ryota, Masaya Kotsuka, Tomohisa Yamamoto, So Yamaki, Satoshi Hirooka, Sohei Satoi, Hiroaki Yanagimoto, and Yoichi Matsui
- Subjects
medicine.medical_specialty ,Pancreatic ductal adenocarcinoma ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Gastroenterology ,Medicine ,In patient ,business ,Surgery - Published
- 2016
41. Optimal duration of prophylactic antibiotics administration in pancreaticoduodenectomy
- Author
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Masaya Kotsuka, Tomohisa Yamamoto, Hiroaki Yanagimoto, Masanori Kon, Kentaro Inoue, Taku Michiura, So Yamaki, Satoshi Hirooka, Yoichi Matsui, Sohei Satoi, and Yuki Hashimoto
- Subjects
Frozen section procedure ,medicine.medical_specialty ,Hepatology ,medicine.drug_class ,business.industry ,medicine.medical_treatment ,Endocrinology, Diabetes and Metabolism ,Antibiotics ,Gastroenterology ,Octreotide ,Pancreaticoduodenectomy ,Resection ,Recurrent Tumor ,Surgery ,medicine.anatomical_structure ,medicine ,Hepatectomy ,business ,Lymph node ,medicine.drug - Abstract
s / Pancreatology 13 (2013) S1–S80 S75 with everolimusþoctreotide without surgical resection. Tumor recurrences were identified in 3 patients (liver 2, liverþN 1), and hepatectomy was performed in one patient, TACEþoctreotide in 1 and everolimusþoctretotide in one. Two patients died of disease. Conclusions: The non-functioning pNET should be managed by surgical resection, however, in case of the limited resection the intraoperative examination of the lymph node is necessary by frozen section. The tumor control is important for the patients with unresectable or recurrent tumor by TACE, octreotide and molecular target agents.
- Published
- 2016
42. Identification of risk factors for peritoneal metastasis in patients with radiographically defined locally advanced pancreatic ductal adenocarcinoma
- Author
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Youichi Matsui, Satoshi Hirooka, Masanori Kon, Hironori Ryota, Sohei Satoi, So Yamaki, Hiroaki Yanagimoto, Masaya Kotsuka, and Tomohisa Yamamoto
- Subjects
Oncology ,medicine.medical_specialty ,Peritoneal metastasis ,Pancreatic ductal adenocarcinoma ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Gastroenterology ,Locally advanced ,Internal medicine ,medicine ,Identification (biology) ,In patient ,business - Published
- 2016
43. Clinical effect of pancreaticojejunostomy with a long-internal stent during pancreaticoduodectomy in patients with a main pancreatic duct of small diameter
- Author
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Yoichi Matsui, Taku Michiura, Masanori Kon, Sohei Satoi, Tomohisa Yamamoto, So Yamaki, Satoshi Hirooka, Masaya Kotsuka, Hiroaki Yanagimoto, and Kentaro Inoue
- Subjects
Pancreatic duct ,medicine.medical_specialty ,Small diameter ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,General surgery ,Gastroenterology ,Stent ,Surgery ,medicine.anatomical_structure ,Medicine ,In patient ,business - Published
- 2016
44. A protective role of pancrelipase delayed-release capsules against nonalcoholic fatty liver disease after pancreatoduodenectomy in patients with pancreatic cancer: A randomized controlled trial
- Author
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Satoshi Hirooka, Minako Nagai, Yoshiyuki Nakajima, Sohei Satoi, Masanori Kon, Hironori Ryota, Tomohisa Yamamoto, Takahiro Akahori, Naoya Ikeda, So Yamaki, Hiroaki Yanagimoto, Shoichi Kinoshita, Masayuki Sho, and Satoshi Nishiwada
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Gastroenterology ,Delayed release (linguistics) ,medicine.disease ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,Pancreatic cancer ,Pancrelipase ,Nonalcoholic fatty liver disease ,medicine ,In patient ,business - Published
- 2016
45. Clinico-pathological features of the patients who received pancreatectomy for neuroendocrine tumor of pancreas
- Author
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Tomohisa Yamamoto, Hiroaki Yanagimoto, Masanori Kwon, Masaya Kotsuka, Hironori Ryota, So Yamaha, Sohei Satoi, and Satoshi Hirooka
- Subjects
Pathology ,medicine.medical_specialty ,medicine.anatomical_structure ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Pancreatectomy ,Gastroenterology ,medicine ,Clinico pathological ,Pancreas ,business - Published
- 2016
46. Sa1451 Phase II Study of Intravenous and Intraperitoneal Paclitaxel With S-1 for Pancreatic Ductal Adenocarcinoma Patients With Peritoneal Metastasis
- Author
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Goro Honda, Masamichi Mizuma, Tomohisa Yamamoto, Michiaki Unno, Fuyuhiko Motoi, Hironori Ishigami, Hiroaki Yanagimoto, Masanao Kurata, Hiroyuki Isayama, Tsutomu Fujii, A-Hon Kwon, Naminatsu Takahara, Sohei Satoi, and Suguru Yamada
- Subjects
Oncology ,medicine.medical_specialty ,Peritoneal metastasis ,Pancreatic ductal adenocarcinoma ,Hepatology ,business.industry ,Gastroenterology ,Phases of clinical research ,chemistry.chemical_compound ,Paclitaxel ,chemistry ,Internal medicine ,Medicine ,business - Published
- 2016
47. Mo1653 Serum Carbohydrate Antigen 19-9 Values After Neoadjuvant Therapy Predict Survival of Patients With Pancreatic Adenocarcinoma: A Multicenter Case-Control Study of 269 Patients
- Author
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Goro Honda, Sohei Satoi, Masayuki Sho, Hiroki Yamaue, Ippei Matsumoto, Shuichi Aoki, Yoshiaki Murakami, Michiaki Unno, and Fuyuhiko Motoi
- Subjects
Oncology ,medicine.medical_specialty ,Hepatology ,business.industry ,medicine.medical_treatment ,Gastroenterology ,Case-control study ,medicine.disease ,Internal medicine ,Medicine ,Adenocarcinoma ,business ,Carbohydrate antigen ,Neoadjuvant therapy - Published
- 2015
48. Tu1787 Randomized Clinical Trial of Duct-to-Mucosa Pancreaticogastrostomy of Pancreatic Stump Versus Hand-Sewn Closure After Distal Pancreatectomy
- Author
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Koji Fukase, Yu Katayose, Fuyuhiko Motoi, Hiroaki Yanagimoto, Yoshiaki Murakami, Michiaki Unno, Naru Kondo, A-Hon Kwon, Yasushi Hashimoto, Sohei Satoi, Kenichiro Uemura, and Tomohisa Yamamoto
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,General surgery ,Gastroenterology ,Surgery ,law.invention ,medicine.anatomical_structure ,Randomized controlled trial ,law ,medicine ,business ,Distal pancreatectomy ,Duct (anatomy) ,Pancreatic stump ,Hand sewn - Published
- 2015
49. The detrimental effect of the epidural anesthesia and analgesia after pancreaticoduodenectomy
- Author
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Satoshi Hirooka, Hiroaki Yanagimoto, A.-Hon Kwon, Kentoro Inoue, Taku Michiura, Rintaro Yui, Sohei Satoi, So Yamaki, Hideyoshi Toyokawa, Yoichi Matsui, and Tomohisa Yamamoto
- Subjects
Blood transfusion ,Hepatology ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Gastroenterology ,medicine.disease ,Pancreaticoduodenectomy ,Group A ,Group B ,Pneumonia ,medicine.anatomical_structure ,Anesthesia ,medicine ,Overall survival ,Pancreas ,business ,Hemodynamic instability - Abstract
Background/aim: There is a report suggesting that epidural anaesthesia and analgesia (EAA) after pancreatic resection is associated with hemodynamic instability and complications. The objective of this study is to retrospectively analyze the effect of EAA for the postoperative course and complications after pancreaticoduodenectomy (PD). Methods: 160 consecutive patients who underwent PD from January, 2006 to May, 2010 were analyzed. The patients whowere given an EAAwere divided into 2 groups according to existence of hypotension (< 90 mmHg) or not during postoperative 3 days. Demographics, surgical details, and postoperative complications were compared between two groups. Results: 93 patients did not show postoperative hypotension (Group A). 54 patients showed postoperative hypotension (Group B). The patients in group B (48%) whose pre-operative hemoglobin level were less than 11 mg/dl were significantly higher than in group A (26 %, p1⁄40.0065). Allogenic blood transfusion rate (44%) in group B was significantly higher than in group A (22%) (p1⁄40.004). Rate of surgical sight infection (SSI), wound infection, pneumonia in group B were significantly higher than those in group A (SSI: 12% in group A v.s. 28% in group B, p1⁄40.016. wound infection: 9% v.s. 28%, p1⁄40.002. pneumonia: 0% v.s. 7%, p1⁄40.008). Conclusions: Postoperative hemodynamic instability due to EAA may lead to increase postoperative complications. The Transverse Abdominal Table 2 The results of the univariate and multivariate analyses of prognostic factors associated with overall survival in the 56 patients with invasive ductal carcinoma of the pancreas.
- Published
- 2013
50. Can surgical resection be acceptable in pancreatic cancer patients with positive peritoneal washing cytology?
- Author
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Sohei Satoi, Goro Honda, Masamichi Mizuma, Ippei Matsumoto, Masayuki Sho, Hiroki Yamaue, Manabu Kawai, Yoshiyuki Nakajima, Sadaki Asari, Yoshiaki Murakami, Fuyuhiko Motoi, Hiroaki Yanagimoto, Kenichiro Uemura, A-Hon Kwon, Tomohisa Yamamoto, and Masanao Kurata
- Subjects
Surgical resection ,medicine.medical_specialty ,Hepatology ,business.industry ,Pancreatic tissue ,Endocrinology, Diabetes and Metabolism ,Computer processing ,Gastroenterology ,Venous phase ,medicine.disease ,Peritoneal washing ,Surgery ,Pancreatic cancer ,Cytology ,medicine ,Pancreatitis ,Radiology ,business - Abstract
s / Pancreatology 14 (2014) S1eS129 S90 We got such digits in case of chronic pancreatitis (in venous phase of the study) e F11⁄43,21 [2,91-3,33] (P
- Published
- 2014
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