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1. First World Consensus Conference on pancreas transplantation: Part II – recommendations

Author

Boggi, U, Vistoli, F, Andres, A, Arbogast, H, Badet, L, Baronti, W, Bartlett, S, Benedetti, E, Branchereau, J, Burke, G, Buron, F, Caldara, R, Cardillo, M, Casanova, D, Cipriani, F, Cooper, M, Cupisti, A, Davide, J, Drachenberg, C, de Koning, E, Ettorre, G, Fernandez Cruz, L, Fridell, J, Friend, P, Furian, L, Gaber, O, Gruessner, A, Gruessner, R, Gunton, J, Han, D, Iacopi, S, Kauffmann, E, Kaufman, D, Kenmochi, T, Khambalia, H, Lai, Q, Langer, R, Maffi, P, Marselli, L, Menichetti, F, Miccoli, M, Mittal, S, Morelon, E, Napoli, N, Neri, F, Oberholzer, J, Odorico, J, Ollinger, R, Oniscu, G, Orlando, G, Ortenzi, M, Perosa, M, Perrone, V, Pleass, H, Redfield, R, Ricci, C, Rigotti, P, Paul Robertson, R, Ross, L, Rossi, M, Saudek, F, Scalea, J, Schenker, P, Secchi, A, Socci, C, Sousa Silva, D, Squifflet, J, Stock, P, Stratta, R, Terrenzio, C, Uva, P, Watson, C, White, S, Marchetti, P, Kandaswamy, R, Berney, T, Boggi U., Vistoli F., Andres A., Arbogast H. P., Badet L., Baronti W., Bartlett S. T., Benedetti E., Branchereau J., Burke G. W., Buron F., Caldara R., Cardillo M., Casanova D., Cipriani F., Cooper M., Cupisti A., Davide J., Drachenberg C., de Koning E. J. P., Ettorre G. M., Fernandez Cruz L., Fridell J. A., Friend P. J., Furian L., Gaber O. A., Gruessner A. C., Gruessner R. W. G., Gunton J. E., Han D. -J., Iacopi S., Kauffmann E. F., Kaufman D., Kenmochi T., Khambalia H. A., Lai Q., Langer R. M., Maffi P., Marselli L., Menichetti F., Miccoli M., Mittal S., Morelon E., Napoli N., Neri F., Oberholzer J., Odorico J. S., Ollinger R., Oniscu G., Orlando G., Ortenzi M., Perosa M., Perrone V. G., Pleass H., Redfield R. R., Ricci C., Rigotti P., Paul Robertson R., Ross L. F., Rossi M., Saudek F., Scalea J. R., Schenker P., Secchi A., Socci C., Sousa Silva D., Squifflet J. P., Stock P. G., Stratta R. J., Terrenzio C., Uva P., Watson C. C. E., White S. A., Marchetti P., Kandaswamy R., Berney T., Boggi, U, Vistoli, F, Andres, A, Arbogast, H, Badet, L, Baronti, W, Bartlett, S, Benedetti, E, Branchereau, J, Burke, G, Buron, F, Caldara, R, Cardillo, M, Casanova, D, Cipriani, F, Cooper, M, Cupisti, A, Davide, J, Drachenberg, C, de Koning, E, Ettorre, G, Fernandez Cruz, L, Fridell, J, Friend, P, Furian, L, Gaber, O, Gruessner, A, Gruessner, R, Gunton, J, Han, D, Iacopi, S, Kauffmann, E, Kaufman, D, Kenmochi, T, Khambalia, H, Lai, Q, Langer, R, Maffi, P, Marselli, L, Menichetti, F, Miccoli, M, Mittal, S, Morelon, E, Napoli, N, Neri, F, Oberholzer, J, Odorico, J, Ollinger, R, Oniscu, G, Orlando, G, Ortenzi, M, Perosa, M, Perrone, V, Pleass, H, Redfield, R, Ricci, C, Rigotti, P, Paul Robertson, R, Ross, L, Rossi, M, Saudek, F, Scalea, J, Schenker, P, Secchi, A, Socci, C, Sousa Silva, D, Squifflet, J, Stock, P, Stratta, R, Terrenzio, C, Uva, P, Watson, C, White, S, Marchetti, P, Kandaswamy, R, Berney, T, Boggi U., Vistoli F., Andres A., Arbogast H. P., Badet L., Baronti W., Bartlett S. T., Benedetti E., Branchereau J., Burke G. W., Buron F., Caldara R., Cardillo M., Casanova D., Cipriani F., Cooper M., Cupisti A., Davide J., Drachenberg C., de Koning E. J. P., Ettorre G. M., Fernandez Cruz L., Fridell J. A., Friend P. J., Furian L., Gaber O. A., Gruessner A. C., Gruessner R. W. G., Gunton J. E., Han D. -J., Iacopi S., Kauffmann E. F., Kaufman D., Kenmochi T., Khambalia H. A., Lai Q., Langer R. M., Maffi P., Marselli L., Menichetti F., Miccoli M., Mittal S., Morelon E., Napoli N., Neri F., Oberholzer J., Odorico J. S., Ollinger R., Oniscu G., Orlando G., Ortenzi M., Perosa M., Perrone V. G., Pleass H., Redfield R. R., Ricci C., Rigotti P., Paul Robertson R., Ross L. F., Rossi M., Saudek F., Scalea J. R., Schenker P., Secchi A., Socci C., Sousa Silva D., Squifflet J. P., Stock P. G., Stratta R. J., Terrenzio C., Uva P., Watson C. C. E., White S. A., Marchetti P., Kandaswamy R., and Berney T.

Abstract

The First World Consensus Conference on Pancreas Transplantation provided 49 jury deliberations regarding the impact of pancreas transplantation on the treatment of diabetic patients, and 110 experts’ recommendations for the practice of pancreas transplantation. The main message from this consensus conference is that both simultaneous pancreas-kidney transplantation (SPK) and pancreas transplantation alone can improve long-term patient survival, and all types of pancreas transplantation dramatically improve the quality of life of recipients. Pancreas transplantation may also improve the course of chronic complications of diabetes, depending on their severity. Therefore, the advantages of pancreas transplantation appear to clearly surpass potential disadvantages. Pancreas after kidney transplantation increases the risk of mortality only in the early period after transplantation, but is associated with improved life expectancy thereafter. Additionally, preemptive SPK, when compared to SPK performed in patients undergoing dialysis, appears to be associated with improved outcomes. Time on dialysis has negative prognostic implications in SPK recipients. Increased long-term survival, improvement in the course of diabetic complications, and amelioration of quality of life justify preferential allocation of kidney grafts to SPK recipients. Audience discussions and live voting are available online at the following URL address: http://mediaeventi.unipi.it/category/1st-world-consensus-conference-of-pancreas-transplantation/246.

Published
2021

10. P.10.7 GASTRIC ELECTRICAL STIMULATION IN GASTROPARESIS: PRELIMINARY RESULTS OF THE ITALIAN EXPERIENCE

Author

Costantini, M., primary, Santi, S., additional, Parise, P., additional, Pianadei, S., additional, Abate, S., additional, Abete, R., additional, Altomare, D., additional, Bosi, E., additional, Crepaldi, C., additional, Dughera, L., additional, Falletto, E., additional, Galeazzi, F., additional, Ganio, E., additional, Galimberti, G., additional, Giannini, I., additional, Grasso, M., additional, La Manna, S., additional, Martina, S., additional, Orsenigo, E., additional, Rinaldi, M., additional, Socci, C., additional, Solito, B., additional, Staudacher, C., additional, Uccellatore, A., additional, Urbano, M.T., additional, Zanatta, L., additional, Battaglia, E., additional, and Bellini, M., additional

Published
2012
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14. Pancreata From Pediatric Donors Restore Insulin Independence in Adult Insulin-Dependent Diabetes Mellitus Recipients

Author

Socci, C., primary, Orsenigo, E., additional, Santagostino, I., additional, Caumo, A., additional, Caldara, R., additional, Parolini, D., additional, Aldrighetti, L., additional, Castoldi, R., additional, Frasson, M., additional, Carvello, M., additional, Ghirardelli, L., additional, Secchi, A., additional, Di Carlo, V., additional, and Staudacher, C., additional

Published
2010
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15. High Levels of Donor CCL2/MCP-1 Predict Graft-Related Complications and Poor Graft Survival After Kidney-Pancreas Transplantation

Author

Ogliari, A.C., primary, Caldara, R., additional, Socci, C., additional, Sordi, V., additional, Cagni, N., additional, Moretti, M.P., additional, Dell’Acqua, A., additional, Mercalli, A., additional, Scavini, M., additional, Secchi, A., additional, Bonifacio, E., additional, Bosi, E., additional, and Piemonti, L., additional

Published
2008
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29. Comorbidity in social phobia

Author

Nassini, S., primary, Ruffolo, G., additional, Moretti, L., additional, Simonini, E., additional, Socci, C., additional, De Soricellis, E., additional, and Perugi, G., additional

Published
1997
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33. High Levels of Donor CCL2/MCP-1 Predict Graft-Related Complications and Poor Graft Survival After Kidney-Pancreas Transplantation

Author

N. Cagni, Alessia Mercalli, Carlo Socci, M. P. Moretti, Marina Scavini, A. C. Ogliari, Rossana Caldara, Ezio Bonifacio, Emanuele Bosi, Antonio Secchi, Valeria Sordi, A. Dell'Acqua, Lorenzo Piemonti, Ogliari, Ac, Caldara, R, Socci, C, Sordi, V, Cagni, N, Moretti, Mp, Dell'Acqua, A, Mercalli, A, Scavini, M, Secchi, Antonio, Bonifacio, E, Bosi, Emanuele, and Piemonti, Lorenzo

Subjects
Adult, Male, Brain Death, medicine.medical_specialty, medicine.medical_treatment, Ischemia, Delayed Graft Function, Renal function, Pancreas transplantation, Gastroenterology, Predictive Value of Tests, Internal medicine, Diabetes mellitus, medicine, Humans, Immunology and Allergy, Diabetic Nephropathies, Pharmacology (medical), Chemokine CCL2, Kidney transplantation, Retrospective Studies, Transplantation, Kidney, business.industry, Graft Survival, medicine.disease, Kidney Transplantation, Tissue Donors, Surgery, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Kidney Failure, Chronic, Female, Transplantation Tolerance, Pancreas Transplantation, business, Complication
Abstract

In this study we analyzed the role of CCL2, a member of the chemokine family, in early graft damage. Using simultaneous kidney-pancreas transplantation (SPK) as a model, we showed that brain death significantly increases circulating CCL2 levels in humans. We found that in such situations, high donor CCL2 levels (measured before organ recovery and at the onset of cold preservation) correlate with increased postreperfusion release of CCL2 by both the graft and recipient throughout the week following transplantation (n = 28). In a retrospective study of 77 SPK recipients, we found a significant negative association between high donor levels of CCL2 and graft survival. Decreased survival in these patients is related to early posttransplant complications, including a higher incidence of pancreas thrombosis and delayed kidney function. Taken together our data indicate that high CCL2 levels in the donor serum predict both an increase in graft/recipient CCL2 production and poor graft survival. This suggests that the severity of the inflammatory response induced by brain death influences the posttransplant inflammatory response, independent of subsequent ischemia and reperfusion.

Published
2008

34. Long-Term survival after kidney and Kidney–Pancreas transplantation in diabetic patients

Author

Carlo Socci, Paolo Fiorina, L. Invernizzi, E. La Rocca, V. Zuber, M. Cristallo, Antonio Secchi, Paola Maffi, Elena Orsenigo, V. Di Carlo, Orsenigo, E, Fiorina, P, Cristallo, M, Socci, C, La Rocca, E, Maffi, P, Invernizzi, L, Zuber, V, Secchi, Antonio, and Di Carlo, V.

Subjects
Graft Rejection, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Urology, Peritoneal dialysis, Diabetic nephropathy, Diabetes mellitus, medicine, Humans, Diabetic Nephropathies, Survivors, Treatment Failure, Renal replacement therapy, Dialysis, Kidney transplantation, Retrospective Studies, Transplantation, business.industry, Middle Aged, medicine.disease, Kidney Transplantation, Survival Analysis, Surgery, Diabetes Mellitus, Type 1, Kidney Failure, Chronic, Pancreas Transplantation, Hemodialysis, business, Follow-Up Studies
Abstract

Purpose To investigate the influence of diabetes mellitus on patient and graft survival among renal versus renal–pancreatic recipients. Methods Among 270 renal transplants performed from 1985 to 2002, a total of 204 (75%) were in diabetic patients and 66 (25%) in nondiabetic patients. Among the 204 diabetic patients 161 (60%) kidneys were transplanted simultaneously with a pancreatic graft (SKPT group). The overall group of patient included 164 (61%) men and 106 (39%) women with mean time on dialysis of 31 ± 21 months (range 0 to 126 months). The mean duration of diabetes was 24 ± 7 years (range 5 to 51 years). Ninety-nine percent of the patients were on renal replacement therapy (79% hemodialysis and 20% peritoneal dialysis). Results The overall rejection rate was similar (NS). Both patient and kidney graft survival rates were worse in diabetics. Patient survival was 82% at 5 years among patients undergoing SKPT, 60% in diabetics receiving only a kidney, and 88% in nondiabetic transplanted patients. Kidney graft survival at 5 years was 77% in diabetics receiving SKPT, 68% in diabetics receiving a kidney alone, and 82% in nondiabetic patients. Overall patient survival was significantly greater among nondiabetics (P = .002) or in diabetics who received SKPT compared with diabetics who only had a kidney transplant (P = .001). Conclusions This retrospective clinical evaluation confirms that combined pancreas and kidney transplantation should be the first choice to insulin-dependent diabetes mellitus (IDDM) patients with end-stage diabetic nephropathy.

Published
2004

35. Impact of Recipient and Donor Ages on Patient and Graft Survival After Kidney Transplantation

Author

Elena Orsenigo, Carlo Socci, V. Zuber, Antonio Secchi, Rossana Caldara, T. Casiraghi, C. Staudacher, Orsenigo, E, Casiraghi, T, Socci, C, Zuber, V, Caldara, R, Secchi, Antonio, and Staudacher, C.

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Gastroenterology, Group A, Donor age, Group B, Internal medicine, medicine, Humans, Kidney transplantation, Retrospective Studies, Transplantation, Kidney, business.industry, Graft Survival, Mean age, Middle Aged, medicine.disease, Kidney Transplantation, Survival Analysis, Tissue Donors, Surgery, medicine.anatomical_structure, Kidney Failure, Chronic, Female, Graft survival, business, Follow-Up Studies
Abstract

Background The purpose of the study was to evaluate the impact of donor and recipient ages on patient and graft survival after kidney transplant. Methods Patients in a hospital database undergoing kidney transplant for end-stage renal disease (ESRD) during the period 1985 to May 2006 ( n = 410; mean age 42 ± 10 years; 61% men and 39% women) were divided into two groups: group A, patients of 60 years or older (6%, n = 24), and group B, those younger than 60 years (94, n = 386). In 204 patients (49.8%) the pancreas was transplanted simultaneously with the kidney. Results Overall 1-, 3-, 5-year patient survivals were 92%, 90%, 88% in group A and 95%, 90%, 87% in group B ( P = .6, NS). Overall 1-, 3-, 5-year kidney graft was 92%, 75%, 65% in group A and 92%, 84%, 79% in group B ( P = .7, NS). Donors were divided into two groups: group 1, 55 years or older (15%, n = 62), versus group 2, those younger than 55 years (85%, n = 348). Overall 1-, 3-, 5-year patient survivals were 91%, 86%, 76% in group 1 and 97%, 94%, 90% in group 2 ( P = .0009). Overall 1-, 3-, 5-year kidney graft survivals were 87%, 82%, 76% in group 1 and 94%, 86%, 82% in group 2 ( P = .02). Conclusions Renal transplantation is an effective option for the treatment of ESRD in elderly patients. The overall rates of patient and kidney graft survival are comparable to those of younger patients. Donor age ≥55 years had a negative effect on patient and kidney graft survival.

Published
2007

36. Techniques of Pancreas Transplantation Through the World: An IPITA Center Survey

Author

Guido Pozza, Giuliana Ferrari, A. Baldi, B. Molteni, Renato Castoldi, Carlo Socci, M. Cristallo, V. Di Carlo, Antonio Secchi, Di Carlo, V, Castoldi, R, Cristallo, M, Ferrari, G, Socci, C, Baldi, A, Molteni, B, Secchi, Antonio, and Pozza, G.

Subjects
Transplantation, medicine.medical_specialty, business.industry, Data Collection, medicine.medical_treatment, General surgery, Professional practice, Pancreas transplantation, Exocrine secretion, Surveys and Questionnaires, medicine, Humans, Surgery, Center (algebra and category theory), Pancreas Transplantation, business
Published
1998

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