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2. A Meta-Analysis of Sensitive Periods for the Effects of Childhood Adversity on DNA Methylation

Author

Lussier, Alexandre, primary, Wood, Natasha, additional, Fischer, Jonah, additional, Luo, Mannan, additional, Melton, Phillip, additional, Neumann, Alexander, additional, Tuhkanen, Johanna, additional, Ware, Erin, additional, Cecil, Charlotte, additional, Cohen-Woods, Sarah, additional, Felix, Janine, additional, Huang, Rae-Chi, additional, Hivert, Marie-France, additional, Koss, Kalsea, additional, Lahti, Jari, additional, Meaney, Michael, additional, Meier, Helen, additional, Mitchell, Colter, additional, Notterman, Daniel, additional, O'Donnell, Kieran, additional, Räikkönen, Katri, additional, Relton, Caroline, additional, Sammallahti, Sara, additional, Schneper, Lisa, additional, Ressler, Kerry, additional, Simpkin, Andrew, additional, Suderman, Matthew, additional, Walton, Esther, additional, Smith, Andrew, additional, and Dunn, Erin, additional

Published
2024
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3. Novel Machine Learning Algorithms for Predicting Early Right Heart Failure Post Left Ventricular Assist Device Implantation: An Analysis from Theeuromacs Registry

Author

Abdelshafy, M., primary, Soliman, O., additional, Simpkin, A., additional, Veen, K., additional, Elkoumy, A., additional, Elzomor, H., additional, De By, T., additional, Logstrup, B., additional, Loforte, A., additional, Schoenrath, F., additional, Potapov, E., additional, Paluszkiewicz, L., additional, Gummert, J., additional, Mohacsi, P., additional, Meyns, B., additional, and Caliskan, K., additional

Published
2024
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4. Impact of the COVID-19 Pandemic on Global TAVR Activity

Author

Armario, Xavier, primary, Carron, Jennifer, additional, Simpkin, Andrew J., additional, Elhadi, Mohamed, additional, Kennedy, Ciara, additional, Abdel-Wahab, Mohamed, additional, Bleiziffer, Sabine, additional, Lefèvre, Thierry, additional, Wolf, Alexander, additional, Pilgrim, Thomas, additional, Villablanca, Pedro A., additional, Blackman, Daniel J., additional, Van Mieghem, Nicolas M., additional, Hengstenberg, Christian, additional, Swaans, Martin J., additional, Prendergast, Bernard D., additional, Patterson, Tiffany, additional, Barbanti, Marco, additional, Webb, John G., additional, Behan, Miles, additional, Resar, Jon, additional, Chen, Mao, additional, Hildick-Smith, David, additional, Spence, Mark S., additional, Zweiker, David, additional, Bagur, Rodrigo, additional, Teles, Rui, additional, Ribichini, Flavio L., additional, Jagielak, Dariusz, additional, Park, Duk-Woo, additional, Kornowski, Ran, additional, Wykrzykowska, Joanna J., additional, Bunc, Matjaz, additional, Estévez-Loureiro, Rodrigo, additional, Poon, Karl, additional, Götberg, Matthias, additional, Jeger, Raban V., additional, Ince, Hüseyin, additional, Packer, Erik J.S., additional, Angelillis, Marco, additional, Nombela-Franco, Luis, additional, Guo, Yingqiang, additional, Savontaus, Mikko, additional, Al-Moghairi, Abdulrahman M., additional, Parasca, Catalina Andreea, additional, Kliger, Chad, additional, Roy, David, additional, Molnár, Levente, additional, Silva, Mariana, additional, White, Jonathon, additional, Yamamoto, Masanori, additional, Carrilho-Ferreira, Pedro, additional, Toggweiler, Stefan, additional, Voudris, Vassileios, additional, Ohno, Yohei, additional, Rodrigues, Inês, additional, Parma, Radosław, additional, Ojeda, Soledad, additional, Toutouzas, Kostas, additional, Regueiro, Ander, additional, Grygier, Marek, additional, AlMerri, Khaled, additional, Cruz-González, Ignacio, additional, Fridrich, Viliam, additional, de la Torre Hernández, José M., additional, Noble, Stephane, additional, Kala, Petr, additional, Asmarats, Lluis, additional, Kurt, Ibrahim Halil, additional, Bosmans, Johan, additional, Erglis, Martins, additional, Casserly, Ivan, additional, Iskandarani, Dounia, additional, Bhindi, Ravinay, additional, Kefer, Joelle, additional, Yin, Wei-Hsian, additional, Rosseel, Liesbeth, additional, Kim, Hyo-Soo, additional, O'Connor, Stephen, additional, Hellig, Farrel, additional, Sztejfman, Matias, additional, Mendiz, Oscar, additional, Pineda, Andres M., additional, Seth, Ashok, additional, Pllaha, Elton, additional, de Brito, Fabio S., additional, Bajoras, Vilhelmas, additional, Balghith, Mohammed A., additional, Lee, Michael, additional, Eid-Lidt, Guering, additional, Vandeloo, Bert, additional, Vaz, Vinicius Daher, additional, Alasnag, Mirvat, additional, Ussia, Gian Paolo, additional, Tay, Edgar, additional, Mayol, Jorge, additional, Gunasekaran, Sengottuvelu, additional, Sardella, Gennaro, additional, Buddhari, Wacin, additional, Kao, Hsien-Li, additional, Dager, Antonio, additional, Tzikas, Apostolos, additional, Gudmundsdottir, Ingibjörg J., additional, Edris, Ahmad, additional, Gutiérrez Jaikel, Luis Abel, additional, Arias, Eduardo A., additional, Al-Hijji, Mohammed, additional, Ertürk, Mehmet, additional, Conde-Vela, César, additional, Boljević, Darko, additional, Ferrero Guadagnoli, Adolfo, additional, Hermlin, Toomas, additional, ElGuindy, Ahmed M., additional, Lima-Filho, Moysés de Oliveira, additional, de Moura Santos, Luciano, additional, Perez, Luis, additional, Maluenda, Gabriel, additional, Akyüz, Ali Rıza, additional, Alhaddad, Imad A., additional, Amin, Haitham, additional, So, Chak-Yu, additional, Al Nooryani, Arif A., additional, Vaca, Carlos, additional, Albistur, Juan, additional, Nguyen, Quang Ngoc, additional, Arzamendi, Dabit, additional, Grube, Eberhard, additional, Modine, Thomas, additional, Tchétché, Didier, additional, Hayashida, Kentaro, additional, Latib, Azeem, additional, Makkar, Raj R., additional, Piazza, Nicolo, additional, Søndergaard, Lars, additional, McEvoy, John William, additional, and Mylotte, Darren, additional

Published
2024
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10. Efficient orchestration of Node-RED IoT workflows using a Vector Symbolic Architecture

Author

Graham Bent, Raghu K. Ganti, Chris Simpkin, Daniel Harborne, Alun Preece, and Ian Taylor

Subjects
Scheme (programming language), Service (systems architecture), Computer Networks and Communications, business.industry, Computer science, Distributed computing, Node (networking), 020206 networking & telecommunications, Context (language use), 02 engineering and technology, QA76, Workflow, Hardware and Architecture, 0202 electrical engineering, electronic engineering, information engineering, Web application, 020201 artificial intelligence & image processing, Orchestration (computing), User interface, business, computer, Software, computer.programming_language
Abstract

Numerous workflow systems span multiple scientific domains and environments, and for the Internet of Things (IoT), Node-RED offers an attractive Web based user interface to execute IoT service-based workflows. However, like most workflow systems, it coordinates the workflow centrally, and cannot run within more transient environments where nodes are mobile. To address this gap, we show how Node-RED workflows can be migrated into a decentralized execution environment for operation on mobile ad-hoc networks, and we demonstrate this by converting a Node-RED based traffic congestion detection workflow to operate in a decentralized environment. The approach uses a Vector Symbolic Architecture (VSA) to dynamically convert Node-Red applications into a compact semantic vector representation that encodes the service interfaces and the workflow in which they are embedded. By extending existing services interfaces, with a simple cognitive layer that can interpret and exchange the vectors, we show how the required services can be dynamically discovered and interconnected into the required workflow in a completely decentralized manner. The resulting system provides a convenient environment where the Node-RED front-end graphical composition tool can be used to orchestrate decentralized workflows. In this paper, we further extend this work by introducing a new dynamic VSA vector compression scheme that compresses vectors for on-the-wire communication, thereby reducing communication bandwidth while maintaining the semantic information content. This algorithm utilizes the holographic properties of the symbolic vectors to perform compression taking into consideration the number of combined vectors along with similarity bounds that determine conflict with other encoded vectors used in the same context. The resulting savings make this approach extremely efficient for discovery in service-based decentralized workflows.

Published
2020

11. Finding Diagnostically Useful Patterns in Quantitative Phenotypic Data

Author

Stuart Aitken, Helen V. Firth, Jeremy McRae, Mihail Halachev, Usha Kini, Michael J. Parker, Melissa M. Lees, Katherine Lachlan, Ajoy Sarkar, Shelagh Joss, Miranda Splitt, Shane McKee, Andrea H. Németh, Richard H. Scott, Caroline F. Wright, Joseph A. Marsh, Matthew E. Hurles, David R. FitzPatrick, T.W. Fitzgerald, S.S. Gerety, W.D. Jones, M. van Kogelenberg, D.A. King, J. McRae, K.I. Morley, V. Parthiban, S. Al-Turki, K. Ambridge, D.M. Barrett, T. Bayzetinova, S. Clayton, E.L. Coomber, S. Gribble, P. Jones, N. Krishnappa, L.E. Mason, A. Middleton, R. Miller, E. Prigmore, D. Rajan, A. Sifrim, A.R. Tivey, M. Ahmed, N. Akawi, R. Andrews, U. Anjum, H. Archer, R. Armstrong, M. Balasubramanian, R. Banerjee, D. Barelle, P. Batstone, D. Baty, C. Bennett, J. Berg, B. Bernhard, A.P. Bevan, E. Blair, M. Blyth, D. Bohanna, L. Bourdon, D. Bourn, A. Brady, E. Bragin, C. Brewer, L. Brueton, K. Brunstrom, S.J. Bumpstead, D.J. Bunyan, J. Burn, J. Burton, N. Canham, B. Castle, K. Chandler, S. Clasper, J. Clayton-Smith, T. Cole, A. Collins, M.N. Collinson, F. Connell, N. Cooper, H. Cox, L. Cresswell, G. Cross, Y. Crow, P.M. D’Alessandro, T. Dabir, R. Davidson, S. Davies, J. Dean, C. Deshpande, G. Devlin, A. Dixit, A. Dominiczak, C. Donnelly, D. Donnelly, A. Douglas, A. Duncan, J. Eason, S. Edkins, S. Ellard, P. Ellis, F. Elmslie, K. Evans, S. Everest, T. Fendick, R. Fisher, F. Flinter, N. Foulds, A. Fryer, B. Fu, C. Gardiner, L. Gaunt, N. Ghali, R. Gibbons, S.L. Gomes Pereira, J. Goodship, D. Goudie, E. Gray, P. Greene, L. Greenhalgh, L. Harrison, R. Hawkins, S. Hellens, A. Henderson, E. Hobson, S. Holden, S. Holder, G. Hollingsworth, T. Homfray, M. Humphreys, J. Hurst, S. Ingram, M. Irving, J. Jarvis, L. Jenkins, D. Johnson, D. Jones, E. Jones, D. Josifova, S. Joss, B. Kaemba, S. Kazembe, B. Kerr, U. Kini, E. Kinning, G. Kirby, C. Kirk, E. Kivuva, A. Kraus, D. Kumar, K. Lachlan, W. Lam, A. Lampe, C. Langman, M. Lees, D. Lim, G. Lowther, S.A. Lynch, A. Magee, E. Maher, S. Mansour, K. Marks, K. Martin, U. Maye, E. McCann, V. McConnell, M. McEntagart, R. McGowan, K. McKay, S. McKee, D.J. McMullan, S. McNerlan, S. Mehta, K. Metcalfe, E. Miles, S. Mohammed, T. Montgomery, D. Moore, S. Morgan, A. Morris, J. Morton, H. Mugalaasi, V. Murday, L. Nevitt, R. Newbury-Ecob, A. Norman, R. O’Shea, C. Ogilvie, S. Park, M.J. Parker, C. Patel, J. Paterson, S. Payne, J. Phipps, D.T. Pilz, D. Porteous, N. Pratt, K. Prescott, S. Price, A. Pridham, A. Proctor, H. Purnell, N. Ragge, J. Rankin, L. Raymond, D. Rice, L. Robert, E. Roberts, G. Roberts, J. Roberts, P. Roberts, A. Ross, E. Rosser, A. Saggar, S. Samant, R. Sandford, A. Sarkar, S. Schweiger, C. Scott, R. Scott, A. Selby, A. Seller, C. Sequeira, N. Shannon, S. Sharif, C. Shaw-Smith, E. Shearing, D. Shears, I. Simonic, D. Simpkin, R. Singzon, Z. Skitt, A. Smith, B. Smith, K. Smith, S. Smithson, L. Sneddon, M. Splitt, M. Squires, F. Stewart, H. Stewart, M. Suri, V. Sutton, G.J. Swaminathan, E. Sweeney, K. Tatton-Brown, C. Taylor, R. Taylor, M. Tein, I.K. Temple, J. Thomson, J. Tolmie, A. Torokwa, B. Treacy, C. Turner, P. Turnpenny, C. Tysoe, A. Vandersteen, P. Vasudevan, J. Vogt, E. Wakeling, D. Walker, J. Waters, A. Weber, D. Wellesley, M. Whiteford, S. Widaa, S. Wilcox, D. Williams, N. Williams, G. Woods, C. Wragg, M. Wright, F. Yang, M. Yau, N.P. Carter, M. Parker, H.V. Firth, D.R. FitzPatrick, C.F. Wright, J.C. Barrett, and M.E. Hurles

Subjects
Male, 0301 basic medicine, Proband, Nonsynonymous substitution, Heterozygote, phenotype, Developmental Disabilities, genotype, Dwarfism, Biology, Article, naive Bayes, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Similarity (network science), developmental disease, Exome Sequencing, Genotype, Genetics, medicine, Humans, tSNE, Exome, Genetic Predisposition to Disease, Child, Gene, Allele frequency, Genetics (clinical), Spectrin, Bayes Theorem, medicine.disease, Repressor Proteins, Developmental disorder, 030104 developmental biology, Mutation, Mutation (genetic algorithm), Female, 030217 neurology & neurosurgery
Abstract

Trio-based whole-exome sequence (WES) data have established confident genetic diagnoses in ∼40% of previously undiagnosed individuals recruited to the Deciphering Developmental Disorders (DDD) study. Here we aim to use the breadth of phenotypic information recorded in DDD to augment diagnosis and disease variant discovery in probands. Median Euclidean distances (mEuD) were employed as a simple measure of similarity of quantitative phenotypic data within sets of ≥10 individuals with plausibly causative de novo mutations (DNM) in 28 different developmental disorder genes. 13/28 (46.4%) showed significant similarity for growth or developmental milestone metrics, 10/28 (35.7%) showed similarity in HPO term usage, and 12/28 (43%) showed no phenotypic similarity. Pairwise comparisons of individuals with high-impact inherited variants to the 32 individuals with causative DNM in ANKRD11 using only growth z-scores highlighted 5 likely causative inherited variants and two unrecognized DNM resulting in an 18% diagnostic uplift for this gene. Using an independent approach, naive Bayes classification of growth and developmental data produced reasonably discriminative models for the 24 DNM genes with sufficiently complete data. An unsupervised naive Bayes classification of 6,993 probands with WES data and sufficient phenotypic information defined 23 in silico syndromes (ISSs) and was used to test a “phenotype first” approach to the discovery of causative genotypes using WES variants strictly filtered on allele frequency, mutation consequence, and evidence of constraint in humans. This highlighted heterozygous de novo nonsynonymous variants in SPTBN2 as causative in three DDD probands.

Published
2019

12. Constructing distributed time-critical applications using cognitive enabled services

Author

Liang Ma, Christopher Simpkin, Ian Taylor, Mudhakar Srivatsa, Geeth de Mel, Swati Rallapalli, and Graham Bent

Subjects
Service (systems architecture), Computer Networks and Communications, Computer science, Wireless network, business.industry, Distributed computing, 020206 networking & telecommunications, 02 engineering and technology, Mobile ad hoc network, Construct (python library), QA76, Workflow, Hardware and Architecture, Analytics, Scalability, 0202 electrical engineering, electronic engineering, information engineering, Wireless, 020201 artificial intelligence & image processing, business, Software
Abstract

Time-critical analytics applications are increasingly making use of distributed service interfaces (e.g., micro-services) that support the rapid construction of new applications by dynamically linking the services into different workflow configurations. Traditional service-based applications, in fixed networks, are typically constructed and managed centrally and assume stable service endpoints and adequate network connectivity. Constructing and maintaining such applications in dynamic heterogeneous wireless networked environments, where limited bandwidth and transient connectivity are commonplace, presents significant challenges and makes centralized application construction and management impossible. In this paper we present an architecture which is capable of providing an adaptable and resilient method for on-demand decentralized construction and management of complex time-critical applications in such environments. The approach uses a Vector Symbolic Architecture (VSA) to compactly represent an application as a single semantic vector that encodes the service interfaces, workflow, and the time-critical constraints required. By extending existing services interfaces, with a simple cognitive layer that can interpret and exchange the vectors, we show how the required services can be dynamically discovered and interconnected in a completely decentralized manner. We demonstrate the viability of this approach by using a VSA to encode various time-critical data analytics workflows. We show that these vectors can be used to dynamically construct and run applications using services that are distributed across an emulated Mobile Ad-Hoc Wireless Network (MANET). Scalability is demonstrated via an empirical evaluation.

Published
2019

14. DNA METHYLATION PARTIALLY MEDIATES THE RELATIONSHIP BETWEEN TIME-DEPENDENT CHILDHOOD ADVERSITY AND DEPRESSIVE SYMPTOMS IN ADOLESCENCE

Author

Alexandre A. Lussier, Erin C. Dunn, Esther Walton, Janine Cerutti, Andrew J Simpkin, Matthew Suderman, Smith Bj, and Andrew Smith

Subjects
Pharmacology, Psychiatry and Mental health, Neurology, business.industry, Immunology, DNA methylation, Medicine, Pharmacology (medical), Neurology (clinical), business, Biological Psychiatry, Depressive symptoms
Published
2021

16. Stress From Uncertainty and Resilience Among Depressed and Burned Out Residents: A Cross-Sectional Study

Author

Briana M. Garcia, Alisa Khan, Arabella L Simpkin, Daniel C. West, Theodore C. Sectish, Nancy D. Spector, and Christopher P. Landrigan

Subjects
Adult, Male, 020205 medical informatics, Cross-sectional study, media_common.quotation_subject, education, 02 engineering and technology, Burnout, Pediatrics, 03 medical and health sciences, 0302 clinical medicine, Physicians, Depersonalization, 0202 electrical engineering, electronic engineering, information engineering, medicine, Humans, Personality, 030212 general & internal medicine, Emotional exhaustion, Burnout, Professional, Depression (differential diagnoses), media_common, Psychiatric Status Rating Scales, Depression, business.industry, Uncertainty, Internship and Residency, Resilience, Psychological, Hospitals, Pediatric, Cross-Sectional Studies, Scale (social sciences), North America, Pediatrics, Perinatology and Child Health, Female, Psychological resilience, medicine.symptom, business, Demography
Abstract

Depression and burnout are highly prevalent among residents, but little is known about modifiable personality variables, such as resilience and stress from uncertainty, that may predispose to these conditions. Residents are routinely faced with uncertainty when making medical decisions.To determine how stress from uncertainty is related to resilience among pediatric residents and whether these attributes are associated with depression and burnout.We surveyed 86 residents in pediatric residency programs from 4 urban freestanding children's hospitals in North America in 2015. Stress from uncertainty was measured with the use of the Physicians' Reaction to Uncertainty Scale, resilience with the use of the 14-item Resilience Scale, depression with the use of the Harvard National Depression Screening Scale; and burnout with the use of single-item measures of emotional exhaustion and depersonalization from the Maslach Burnout Inventory.Fifty out of 86 residents responded to the survey (58.1%). Higher levels of stress from uncertainty correlated with lower resilience (r = -0.60; P .001). Five residents (10%) met depression criteria and 15 residents (31%) met burnout criteria. Depressed residents had higher mean levels of stress due to uncertainty (51.6 ± 9.1 vs 38.7 ± 6.7; P .001) and lower mean levels of resilience (56.6 ± 10.7 vs 85.4 ± 8.0; P .001) compared with residents who were not depressed. Burned out residents also had higher mean levels of stress due to uncertainty (44.0 ± 8.5 vs 38.3 ± 7.1; P = .02) and lower mean levels of resilience (76.7 ± 14.8 vs 85.0 ± 9.77; P = .02) compared with residents who were not burned out.We found high levels of stress from uncertainty, and low levels of resilience were strongly correlated with depression and burnout. Efforts to enhance tolerance of uncertainty and resilience among residents may provide opportunities to mitigate resident depression and burnout.

Published
2018

17. Corrigendum to ‘Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children’ [Psychoneuroendocrinology 113 March (2020) 104484]

Author

Marini, Sandro, primary, Davis, Kathryn A., additional, Soare, Thomas W., additional, Zhu, Yiwen, additional, Suderman, Matthew J., additional, Simpkin, Andrew J., additional, Smith, Andrew D.A.C., additional, Wolf, Erika J., additional, Relton, Caroline L., additional, and Dunn, Erin C., additional

Published
2020
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22. Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline

Author

Freyer, David R, primary, Brock, Penelope R, additional, Chang, Kay W, additional, Dupuis, L Lee, additional, Epelman, Sidnei, additional, Knight, Kristin, additional, Mills, Denise, additional, Phillips, Robert, additional, Potter, Emma, additional, Risby, Demie, additional, Simpkin, Philippa, additional, Sullivan, Michael, additional, Cabral, Sandra, additional, Robinson, Paula D, additional, and Sung, Lillian, additional

Published
2020
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25. Finding Diagnostically Useful Patterns in Quantitative Phenotypic Data

Author

Aitken, Stuart, primary, Firth, Helen V., additional, McRae, Jeremy, additional, Halachev, Mihail, additional, Kini, Usha, additional, Parker, Michael J., additional, Lees, Melissa M., additional, Lachlan, Katherine, additional, Sarkar, Ajoy, additional, Joss, Shelagh, additional, Splitt, Miranda, additional, McKee, Shane, additional, Németh, Andrea H., additional, Scott, Richard H., additional, Wright, Caroline F., additional, Marsh, Joseph A., additional, Hurles, Matthew E., additional, FitzPatrick, David R., additional, Fitzgerald, T.W., additional, Gerety, S.S., additional, Jones, W.D., additional, van Kogelenberg, M., additional, King, D.A., additional, McRae, J., additional, Morley, K.I., additional, Parthiban, V., additional, Al-Turki, S., additional, Ambridge, K., additional, Barrett, D.M., additional, Bayzetinova, T., additional, Clayton, S., additional, Coomber, E.L., additional, Gribble, S., additional, Jones, P., additional, Krishnappa, N., additional, Mason, L.E., additional, Middleton, A., additional, Miller, R., additional, Prigmore, E., additional, Rajan, D., additional, Sifrim, A., additional, Tivey, A.R., additional, Ahmed, M., additional, Akawi, N., additional, Andrews, R., additional, Anjum, U., additional, Archer, H., additional, Armstrong, R., additional, Balasubramanian, M., additional, Banerjee, R., additional, Barelle, D., additional, Batstone, P., additional, Baty, D., additional, Bennett, C., additional, Berg, J., additional, Bernhard, B., additional, Bevan, A.P., additional, Blair, E., additional, Blyth, M., additional, Bohanna, D., additional, Bourdon, L., additional, Bourn, D., additional, Brady, A., additional, Bragin, E., additional, Brewer, C., additional, Brueton, L., additional, Brunstrom, K., additional, Bumpstead, S.J., additional, Bunyan, D.J., additional, Burn, J., additional, Burton, J., additional, Canham, N., additional, Castle, B., additional, Chandler, K., additional, Clasper, S., additional, Clayton-Smith, J., additional, Cole, T., additional, Collins, A., additional, Collinson, M.N., additional, Connell, F., additional, Cooper, N., additional, Cox, H., additional, Cresswell, L., additional, Cross, G., additional, Crow, Y., additional, D’Alessandro, P.M., additional, Dabir, T., additional, Davidson, R., additional, Davies, S., additional, Dean, J., additional, Deshpande, C., additional, Devlin, G., additional, Dixit, A., additional, Dominiczak, A., additional, Donnelly, C., additional, Donnelly, D., additional, Douglas, A., additional, Duncan, A., additional, Eason, J., additional, Edkins, S., additional, Ellard, S., additional, Ellis, P., additional, Elmslie, F., additional, Evans, K., additional, Everest, S., additional, Fendick, T., additional, Fisher, R., additional, Flinter, F., additional, Foulds, N., additional, Fryer, A., additional, Fu, B., additional, Gardiner, C., additional, Gaunt, L., additional, Ghali, N., additional, Gibbons, R., additional, Pereira, S.L. Gomes, additional, Goodship, J., additional, Goudie, D., additional, Gray, E., additional, Greene, P., additional, Greenhalgh, L., additional, Harrison, L., additional, Hawkins, R., additional, Hellens, S., additional, Henderson, A., additional, Hobson, E., additional, Holden, S., additional, Holder, S., additional, Hollingsworth, G., additional, Homfray, T., additional, Humphreys, M., additional, Hurst, J., additional, Ingram, S., additional, Irving, M., additional, Jarvis, J., additional, Jenkins, L., additional, Johnson, D., additional, Jones, D., additional, Jones, E., additional, Josifova, D., additional, Joss, S., additional, Kaemba, B., additional, Kazembe, S., additional, Kerr, B., additional, Kini, U., additional, Kinning, E., additional, Kirby, G., additional, Kirk, C., additional, Kivuva, E., additional, Kraus, A., additional, Kumar, D., additional, Lachlan, K., additional, Lam, W., additional, Lampe, A., additional, Langman, C., additional, Lees, M., additional, Lim, D., additional, Lowther, G., additional, Lynch, S.A., additional, Magee, A., additional, Maher, E., additional, Mansour, S., additional, Marks, K., additional, Martin, K., additional, Maye, U., additional, McCann, E., additional, McConnell, V., additional, McEntagart, M., additional, McGowan, R., additional, McKay, K., additional, McKee, S., additional, McMullan, D.J., additional, McNerlan, S., additional, Mehta, S., additional, Metcalfe, K., additional, Miles, E., additional, Mohammed, S., additional, Montgomery, T., additional, Moore, D., additional, Morgan, S., additional, Morris, A., additional, Morton, J., additional, Mugalaasi, H., additional, Murday, V., additional, Nevitt, L., additional, Newbury-Ecob, R., additional, Norman, A., additional, O’Shea, R., additional, Ogilvie, C., additional, Park, S., additional, Parker, M.J., additional, Patel, C., additional, Paterson, J., additional, Payne, S., additional, Phipps, J., additional, Pilz, D.T., additional, Porteous, D., additional, Pratt, N., additional, Prescott, K., additional, Price, S., additional, Pridham, A., additional, Proctor, A., additional, Purnell, H., additional, Ragge, N., additional, Rankin, J., additional, Raymond, L., additional, Rice, D., additional, Robert, L., additional, Roberts, E., additional, Roberts, G., additional, Roberts, J., additional, Roberts, P., additional, Ross, A., additional, Rosser, E., additional, Saggar, A., additional, Samant, S., additional, Sandford, R., additional, Sarkar, A., additional, Schweiger, S., additional, Scott, C., additional, Scott, R., additional, Selby, A., additional, Seller, A., additional, Sequeira, C., additional, Shannon, N., additional, Sharif, S., additional, Shaw-Smith, C., additional, Shearing, E., additional, Shears, D., additional, Simonic, I., additional, Simpkin, D., additional, Singzon, R., additional, Skitt, Z., additional, Smith, A., additional, Smith, B., additional, Smith, K., additional, Smithson, S., additional, Sneddon, L., additional, Splitt, M., additional, Squires, M., additional, Stewart, F., additional, Stewart, H., additional, Suri, M., additional, Sutton, V., additional, Swaminathan, G.J., additional, Sweeney, E., additional, Tatton-Brown, K., additional, Taylor, C., additional, Taylor, R., additional, Tein, M., additional, Temple, I.K., additional, Thomson, J., additional, Tolmie, J., additional, Torokwa, A., additional, Treacy, B., additional, Turner, C., additional, Turnpenny, P., additional, Tysoe, C., additional, Vandersteen, A., additional, Vasudevan, P., additional, Vogt, J., additional, Wakeling, E., additional, Walker, D., additional, Waters, J., additional, Weber, A., additional, Wellesley, D., additional, Whiteford, M., additional, Widaa, S., additional, Wilcox, S., additional, Williams, D., additional, Williams, N., additional, Woods, G., additional, Wragg, C., additional, Wright, M., additional, Yang, F., additional, Yau, M., additional, Carter, N.P., additional, Parker, M., additional, Firth, H.V., additional, FitzPatrick, D.R., additional, Wright, C.F., additional, Barrett, J.C., additional, and Hurles, M.E., additional

Published
2019
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26. Bow hunter's syndrome in a patient with vertebral artery atresia, an arcuate foramen, and unilateral deafness: a case report

Author

Brady S. Davis, Kelly E. Davis, Charles T. Simpkin, Michael E. Jorgensen, and Andrew M. Vosko

Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine, Vertebral artery atresia, lcsh:R895-920, Vertebral artery, Case Report, 03 medical and health sciences, 0302 clinical medicine, medicine.artery, Occlusion, medicine, Cervical spondylosis, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Vertebrobasilar insufficiency, Subclavian artery, Arcuate foramen, business.industry, Sensorineural deafness, Anatomy, medicine.disease, body regions, Atresia, Unilateral hearing loss, business, 030217 neurology & neurosurgery, Bow hunter's syndrome
Abstract

Bow hunter's syndrome (BHS) is a rare cause of vertebrobasilar insufficiency that occurs when the vertebral artery (VA) is occluded on rotation of the head and neck. This dynamic occlusion of the VA can occur anywhere along its course after it arises from the subclavian artery. Although most cases are associated with compression by osteophytes, cervical spondylosis, or lateral disc herniation, BHS has a highly variable clinical course that depends on the patient's specific anatomy. Therefore, it may be important for clinicians to be aware of anatomical variants that predispose individuals to BHS. Here, we report on a patient with BHS who was found to have two uncommon anatomical anomalies: an atretic right VA and a left-sided arcuate foramen.

Published
2017

27. Unilateral right-sided varicocele associated with pancreatic cancer: A cadaveric case report

Author

Kelly E. Davis, Charles T. Simpkin, and Cindy K. Funk

Subjects
medicine.medical_specialty, business.industry, Testicular vein, Varicocele, 030232 urology & nephrology, lcsh:Human anatomy, medicine.disease, Inferior vena cava, Pampiniform plexus, Spermatic cord, lcsh:QM1-695, Surgery, 03 medical and health sciences, Dissection, 0302 clinical medicine, medicine.anatomical_structure, medicine.vein, Pancreatic tumor, 030220 oncology & carcinogenesis, cardiovascular system, medicine, Anatomy, Pancreas, business
Abstract

A testicular varicocele is an abnormal dilation of the pampiniform plexus of veins within the spermatic cord. Due to the asymmetrical drainage pattern of the right and left testicular veins, the vast majority of varicoceles are found on the left side. Isolated right testicular varicoceles occur rarely and should raise clinical suspicion for underlying intra-abdominal pathology. During the dissection of a 67-year-old male cadaver a unilateral varicocele was discovered in the right spermatic cord. Upon dissection of the abdomen, a tumor was found in the head and body of the pancreas. The section of the inferior vena cava where the right testicular vein inserted laid directly posterior to the tumor and was markedly dilated. We hypothesize that this pancreatic tumor impeded venous return into the inferior vena cava from the right testicular vein and not the left renal vein (where the left testicular vein drains) resulting in a unilateral right varicocele (URV). To our knowledge, the relationship between URV and pancreatic cancer has not been previously described in the literature. Our findings suggest URV could be a clinical warning sign of cancer of the head and/or body of the pancreas and may be a source of discomfort to address in patients with pancreatic cancer in order to improve quality of life. Keywords: Testicular varicocele, Unilateral right-sided varicocele, Pancreatic cancer

Published
2017

28. Corrigendum to ‘Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children’ [Psychoneuroendocrinology 113 March (2020) 104484]

Author

Andrew J Simpkin, Andrew D A C Smith, Erika J. Wolf, Kathryn A. Davis, Sandro Marini, Matthew Suderman, Erin C. Dunn, Caroline L Relton, Yiwen Zhu, and Thomas W. Soare

Subjects
Psychiatry and Mental health, Endocrinology, Endocrine and Autonomic Systems, business.industry, Endocrinology, Diabetes and Metabolism, Sensitive periods, Medicine, Epigenetics, Bioinformatics, business, Biological Psychiatry, Psychoneuroendocrinology
Published
2020

29. Ototoxicity-induced hearing loss and quality of life in survivors of paediatric cancer

Author

Kaukab Rajput, Phillippa Simpkin, Penelope Brock, Anne Abiodun, Ghada Al-Malky, and Lindsey Edwards

Subjects
medicine.medical_specialty, Hearing loss, Population, Psychological intervention, Antineoplastic Agents, Audiology, Carboplatin, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Paediatric cancer, Ototoxicity, Neoplasms, 030225 pediatrics, otorhinolaryngologic diseases, medicine, Humans, Survivors, Child, Hearing Loss, 030223 otorhinolaryngology, education, education.field_of_study, business.industry, Cancer, General Medicine, medicine.disease, Otorhinolaryngology, Pediatrics, Perinatology and Child Health, Quality of Life, Sensorineural hearing loss, Cisplatin, medicine.symptom, business
Abstract

Introduction Hearing loss is a permanent and debilitating side-effect of a range of interventions commonly used in the treatment of childhood cancers, primarily ototoxic medications such as cisplatin. The purpose of this study was to examine the impact of hearing loss, in a population already at risk of reduced quality of life due to the cancer and treatment-related factors. Methods This study used a questionnaire specifically designed to tap issues relevant to children with hearing loss, the Paediatric Audiology Quality of Life questionnaire (PAQL). Parents of 78 children treated for a wide range of solid tumours and leukaemias completed the PAQL, 41 of whom had sensorineural hearing loss as a result of the cancer treatment. Results Significant differences between those children with hearing loss and those whose hearing remained normal were found on all four scales of the questionnaire. Children affected by ototoxicity were rated as having poorer quality of life in terms of their ability to communicate with family and peers, their independence, interactions with peers and emotional well-being. Conclusion These results highlight the impact of acquired hearing loss and reinforce the importance of assessing quality of life with a measure capable of tapping the issues of consequence to the population under investigation. They also have implications for the clinical management of children during and following treatment for a wide range of cancers: medically, audiologically, psychologically and educationally.

Published
2020

30. Association of haemodynamic changes measured by serial central venous saturation during ultrafiltration for acutely decompensated heart failure with diuretic resistance and change in renal function

Author

Andrew Ludman, Arshad Ghori, Philip Marino, Peter D. Alexander, Guido Tavazzi, Victoria L. Simpkin, Winston Banya, Ali Vazir, Anthony J. Bastin, Mark J.D. Griffiths, Martin R. Cowie, Rakesh Sharma, Susanna Price, Sarah Trenfield, and Imperial College Trust

Subjects
Male, Cardiac output, Cardiac & Cardiovascular Systems, Acute decompensated heart failure, Drug Resistance, Worsening renal function, Ultrafiltration, Hemodynamics, 030204 cardiovascular system & hematology, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Medicine, Prospective Studies, 030212 general & internal medicine, Diuretics, Middle Aged, Treatment Outcome, Acute Disease, Cardiology, Female, TRIAL, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, Catheterization, Central Venous, medicine.medical_specialty, Central Venous Pressure, Renal function, Heart failure, 1102 Cardiovascular Medicine And Haematology, 03 medical and health sciences, Internal medicine, Heart rate, Humans, Aged, Retrospective Studies, Creatinine, Science & Technology, business.industry, MORTALITY, medicine.disease, OXYGEN-SATURATION, Blood pressure, Endocrinology, Cardiovascular System & Hematology, chemistry, Cardiovascular System & Cardiology, Central venous saturation, business, Follow-Up Studies
Abstract

BACKGROUND: Patients with acute decompensated heart failure with diuretic resistance (ADHF-DR) have a poor prognosis. The aim of this study was to assess in patients with ADHF-DR, whether haemodynamic changes during ultrafiltration (UF) are associated with changes in renal function (Δcreatinine) and whether Δcreatinine post UF is associated with mortality. METHODS: Seventeen patients with ADHF-DR underwent 20 treatments with UF. Serial bloods (4-6 hourly) from the onset of UF treatment were measured for renal function, electrolytes and central venous saturation (CVO2). Univariate and multivariate analysis were performed to assess the relationship between changes in markers of haemodynamics [heart rate (HR), systolic blood pressure (SBP), packed cell volume (PCV) and CVO2] and Δcreatinine. Patients were followed up and mortality recorded. Cox-regression survival analysis was performed to determine covariates associated with mortality. RESULTS: Renal function worsened after UF in 17 of the 20 UF treatments (baseline vs. post UF creatinine: 164±58 vs. 185±69μmol/l, P

Published
2016

31. Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children

Author

Caroline L Relton, Yiwen Zhu, Andrew J Simpkin, Matthew Suderman, Sandro Marini, Erika J. Wolf, Andrew D A C Smith, Thomas W. Soare, Kathryn A. Davis, and Erin C. Dunn

Subjects
Male, Aging, Longitudinal study, Endocrinology, Diabetes and Metabolism, Article, Epigenesis, Genetic, Developmental psychology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Adverse Childhood Experiences, Sensitive periods, Humans, Medicine, Child Abuse, Longitudinal Studies, Prospective Studies, Epigenetics, Child, Cellular Senescence, Biological Psychiatry, Endocrine and Autonomic Systems, business.industry, Repeated measures design, DNA Methylation, Mental health, Life stage, 030227 psychiatry, Psychiatry and Mental health, Cellular Aging, DNA methylation, Female, business, Stress, Psychological, 030217 neurology & neurosurgery
Abstract

Objectives Exposure to adversity has been linked to accelerated biological aging, which in turn has been shown to predict numerous physical and mental health problems. In recent years, measures of DNA methylation-based epigenetic age––known as “epigenetic clocks”––have been used to estimate accelerated epigenetic aging. Although a small number of studies have found an effect of adversity exposure on epigenetic age in children, none have investigated if there are “sensitive periods” when adversity is most impactful. Methods Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC; n = 973), we tested the prospective association between repeated measures of childhood exposure to seven types of adversity on epigenetic age assessed at age 7.5 using the Horvath and Hannum epigenetic clocks. With a Least Angle Regression variable selection procedure, we evaluated potential sensitive period effects. Results We found that exposure to abuse, financial hardship, or neighborhood disadvantage during sensitive periods in early and middle childhood best explained variability in the deviation of Hannum-based epigenetic age from chronological age, even after considering the role of adversity accumulation and recency. Secondary sex-stratified analyses identified particularly strong sensitive period effects. These effects were undetected in analyses comparing children “exposed” versus “unexposed” to adversity. We did not identify any associations between adversity and epigenetic age using the Horvath epigenetic clock. Conclusions Our results suggest that adversity may alter methylation processes in ways that either directly or indirectly perturb normal cellular aging and that these effects may be heightened during specific life stages.

Published
2020

32. Predictive Livestock Early Warning System (PLEWS): Monitoring forage condition and implications for animal production in Kenya

Author

Jay P. Angerer, Emmanuella Olesambu, Folorunso Oludayo Fasina, Piers Simpkin, Selvaraju Ramasamy, and Joseph Matere

Subjects
Atmospheric Science, Decision support system, Food security, 010504 meteorology & atmospheric sciences, business.industry, media_common.quotation_subject, Geography, Planning and Development, 0207 environmental engineering, Weather and climate, 02 engineering and technology, lcsh:QC851-999, Management, Monitoring, Policy and Law, Livelihood, 01 natural sciences, Extreme weather, Early warning system, lcsh:Meteorology. Climatology, Livestock, Psychological resilience, 020701 environmental engineering, business, Environmental planning, 0105 earth and related environmental sciences, media_common
Abstract

Weather and climate extremes have impacted forage conditions and lead to loss of animal production and livelihood of livestock-dependent communities in Kenya. Monitoring of forage conditions and developing a reliable early warning system can reduce the loss of livestock and improve the resilience. In order to enhance resilience of affected populations, through a collaboration of multiple agencies in Kenya and beyond, a dynamic web-based Predictive Livestock Early Warning System (PLEWS) decision support tool was developed. The system combines the water balance, PHYGROW (Phytomass Growth Model) simulation model and spatial analysis tools to generate current and a 6-monthly forecast of forage conditions. Although in its pilot phase, the tool holds potentials to provide decision support with anticipatory actions by communities, regional and national governments. By utilizing the output and engaging such pre-emptive interventions, emergencies can be prevented by promoting proactive decision-making conditioned on advance information of forage conditions. Timely actions based on advanced information can reduce potential impacts of extreme weather and climate events on livestock. The pro-active actions can reduce the losses and response costs associated with the impacts of weather, climate extremes and can improve food security of most vulnerable populations. Keywords: Early warning, Livestock, Community resilience, Drought, Livelihoods

Published
2020

34. DEVELOPMENTAL TIMING OF EXPOSURE TO ADVERSITY PREDICTS DNA METHYLATION IN LATE CHILDHOOD MORE THAN RECENCY OR ACCUMULATION OF EXPOSURE

Author

Matthew Suderman, Andrew J Simpkin, Kerry J. Ressler, Erin C. Dunn, Andrew Smith, Caroline L Relton, Torsten Klengel, and Thomas W. Soare

Subjects
Pharmacology, Longitudinal study, dNaM, Biology, Late childhood, 030227 psychiatry, 03 medical and health sciences, Psychiatry and Mental health, symbols.namesake, Developmental timing, 0302 clinical medicine, Bonferroni correction, Neurology, CpG site, DNA methylation, symbols, Pharmacology (medical), Neurology (clinical), 030217 neurology & neurosurgery, Biological Psychiatry, Demography, Epigenomics
Abstract

Background Exposure to “early life” adversity (e.g., in the first two decades of life) is known to predict DNA methylation (DNAm). However, few studies have investigated whether adversity has time-dependent effects based on the age at exposure. Methods Data for our prospective study came from the Accessible Resource for Integrated Epigenomics Studies (ARIES), a subsample of 1,018 mother-child pairs from the Avon Longitudinal Study of Parents and Children (ALSPAC). Results After covariate and cell-type adjustment and Bonferroni correction for multiple testing, we identified 40 CpG sites that were differentially methylated following exposure to adversity. Nearly all of these loci (n=38) were related to adversity exposure in infancy. Financial stress, maternal psychopathology, and neighborhood disadvantage predicted the greatest number of epigenome-wide DNAm changes. Discussion These results suggest that the developmental timing of adversity explains more variability in DNAm than the accumulation or recency of exposure. Infancy appears to be a sensitive period when exposure to adversity predicts differential DNAm patterns.

Published
2019

40. The significance of hand dominance in hip osteoarthritis

Author

Andrew J Simpkin, James C. Walsh, Shane Guerin, Derek T. Cawley, and Eric L. Masterson

Subjects
Male, musculoskeletal diseases, medicine.medical_specialty, Arthroplasty, Replacement, Hip, medicine.medical_treatment, Osteoarthritis, Logistic regression, Functional Laterality, Osteoarthritis, Hip, Rheumatology, Hip osteoarthritis, Humans, Medicine, Registries, Aged, business.industry, Cerebral laterality, Mean age, Middle Aged, medicine.disease, Arthroplasty, Surgery, Hand dominance, Anesthesiology and Pain Medicine, Female, Level iii, business
Abstract

Objectives Hip arthroplasty registries, encompassing all-cause end-stage hip degeneration, have shown that slightly more right hip replacements are performed than left. Given that greater than 85% of individuals are right-handed, we sought to investigate the association between side of hand dominance and side of hip osteoarthritis. Methods This Level III observational study evaluated exclusively end-stage osteoarthritis of the hip, using 3 independent centres totalling 386 consecutive arthroplasty patients. Logistic regression was used as a statistical model. Results In total, 322 patients with hip osteoarthritis were included in the final analysis, including 146 (45.5%) women and 176 (54.5%) men, with a mean age of 68.1 years (SD = 9.5 years). There were 133 (41.2%) right, 73 (22.6%) left, and 116 (35.9%) bilateral hips where the contralateral side had been previously replaced. The proportion of individuals requiring unilateral hip arthroplasty on their dominant side was 67.4%. Conclusions In the development of hip osteoarthritis, one is significantly more likely to require hip arthroplasty on their dominant side than in the contralateral hip. Assessment of hand dominance identifies cerebral laterality as a contributing factor in predisposing one’s dominant side to hip osteoarthritis.

Published
2015

41. An additive penalty P-Spline approach to derivative estimation

Author

Andrew J Simpkin and John Newell

Subjects
Statistics and Probability, Computational Mathematics, Mathematical optimization, Spline (mathematics), Computational Theory and Mathematics, Applied Mathematics, Derivative estimation, P splines, Smoothing, Second derivative, Mathematics
Abstract

P -Splines are commonly used for derivative estimation where a non-linear relationship exists between the response and explanatory variables. However, questions about the error of these estimates have arisen. Incorporating an extra penalty term in a P -Spline model is proposed as an improvement when derivative estimation is of primary concern. This additive penalty approach to derivative estimation is shown to improve on the P -Spline estimates based on the results of a simulation study to compare the performance when estimating the first and second derivatives of six simulated functions. A method for generating variability bands for P -Spline derivative estimates with and without an additive penalty is given. The proposed additive penalty variability bands are shown to behave better than their single penalty counterpart. Motivating examples in environmental and sports science are used to demonstrate the need for accurate derivative estimates and the benefit of using an additional penalty term to this end.

Published
2013

43. Energy Efficient Vehicles for Road Transport

Author

S. Scridon, J. Simonsson, R. Simpkin, A. Ferré, C. D’Ambrosio, L. Rollenitz, R. Estrada Vazquez, Ion Boldea, and M. Abele

Subjects
energy management algorithm, Engineering, business.industry, Energy management, conventional vehicles, Electrical engineering, electrified auxiliaries, Energy consumption, Automotive engineering, Electric power system, dual voltage power net architecture, Auxiliary power unit, Fuel efficiency, media_common.cataloged_instance, General Materials Science, European union, lithium ion battery, Energy source, business, claw pole generator with permanent magnets, Improved energy efficiency, media_common, Efficient energy use
Abstract

Road transport is the second largest producer of greenhouse gases within the European Union. This project, Energy Efficient VEhicles for Road Transport (EE-VERT) targets a 10-12% reduction in fuel consumption and CO2 generation for conventional vehicles with only minimal changes. Hybrid Electric Vehicles (HEVs) and Full Electric Vehicles (EVs) offer good CO2 savings but their market penetration is slow, therefore conventional vehicles will play a significant role for the foreseeable future. Despite improvements in modern conventional vehicles, a considerable amount of energy is wasted due to the lack of an overall on-board energy management strategy. Electrification of auxiliary systems and operating them only when needed promises energy and efficiency gains, but there is an additional need for a coordinated approach to the generation, distribution and use of energy. EE-VERT offers a solution to bridge the gap in the market between present conventional vehicles and HEVs/EVs. The central EE-VERT concept is the electrification of auxiliary systems and supplying their energy from energy sources such as recuperated braking energy, waste heat recovery or solar cells, as part of an overall energy management strategy. The conventional car uses a 14V network and the EE-VERT concept retains the majority of this to minimise additional costs. However, to achieve improved efficiency and power, the generator operates at 40V. To connect the elements to the standard electrical system a new architecture has been devised that works with 40V and 14V levels. The main components of the 40V network are a new generator based on the claw pole technology with integrated permanent magnets, a Li-Ion battery system and a DC/DC converter with multiple inputs (MIPEC) for interfacing between the two voltage levels and the additional energy sources such as the solar panel. The available generator power during recuperation is up to 11kW. The efficiency of the new generator is above 80% in the low range of speed while in the high range of speed the efficiency is still above 70%. The MIPEC efficiency is around 94%. The simulation work indicates that average fuel savings of 10% for real life driving cycles and up to 17% when the start and stop functionality is applied to real life urban cycles are possible and that real life urban driving cycles benefit the most from the EE-VERT concept. The final phases of the project work on the Test Bench and with the demonstrator car will confirm the potential fuel saving benefits of the EE-VERT concept.

Published
2012
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44. Association of Resident Depression With Harmful Medical Errors (Research Abstract)

Author

Briana M. Garcia, Arabella L Simpkin, Carter R. Petty, Theodore C. Sectish, Nancy D. Spector, Christopher P. Landrigan, Katherine A. Brunsberg, Amy J. Starmer, Sharon Calaman, and Daniel C. West

Subjects
medicine.medical_specialty, business.industry, Pediatrics, Perinatology and Child Health, Medicine, Association (psychology), business, Psychiatry, Depression (differential diagnoses), Clinical psychology
Published
2017

46. Integrating Research, Quality Improvement, and Medical Education for Better Handoffs and Safer Care: Disseminating, Adapting, and Implementing the I-PASS Program

Author

Starmer, Amy J., primary, Spector, Nancy D., additional, West, Daniel C., additional, Srivastava, Rajendu, additional, Sectish, Theodore C., additional, Landrigan, Christopher P., additional, Starmer, Amy J., additional, Menon, Aravind Ajakumar, additional, Ali, Arshia, additional, Allair, Brenda K., additional, Allen, April D., additional, Almaddah, Nureddin, additional, Alminde, Claire, additional, Alvarado-Little, Wilma, additional, Anson, Elizabeth, additional, Ashland, Michele, additional, Atsatt, Marisa, additional, Aylor, Megan, additional, Baird, Jennifer D., additional, Bale, James F., additional, Balmer, Dorene, additional, Barber, Aisha, additional, Barton, Kevin, additional, Bates, Kimberly, additional, Beck, Carolyn, additional, Berchelmann, Kathleen, additional, Bhan, Renuka, additional, Bismilla, Zia, additional, Blankenburg, Rebecca L., additional, Boa-Hocbo, Aileen, additional, Bordin-Wosk, Talya, additional, Brooks, Michelle, additional, Calaman, Sharon, additional, Campe, Julie, additional, Campos, Maria Lucia, additional, Chandler, Debra, additional, Cheung, Yvonne, additional, Choudhary, Amanda, additional, Christensen, Eileen, additional, Clark, Katherine, additional, Coffey, Maitreya, additional, Coghlan-McDonald, Sally, additional, Cohen, Ellen, additional, Cole, F. Sessions, additional, Corless, Elizabeth, additional, Cray, Sharon, additional, Da Silva, Roxi, additional, Dahale, Devesh, additional, Dalal, Anuj K., additional, Destino, Lauren A., additional, Doroshow, Jonathan, additional, Dreyer, Benard, additional, duPont, Katharine, additional, Eagle, Steven, additional, Edgar-Zarate, Courtney, additional, Etzenhouser, Angie, additional, Everhart, Jennifer L., additional, Feraco, Angela M., additional, Ferrer, Alexandra, additional, Galardy, Paul, additional, Garcia, Briana M., additional, Gaspar-Oishi, Maria, additional, Goldstein, Jenna, additional, Good, Brian P., additional, Graham, Dionne A, additional, Growdon, Amanda S., additional, Gubler, LeAnn, additional, Guiot, Amy, additional, Hanlon, Charin, additional, Hanna-Attisha, Mona, additional, Harris, Roben, additional, Haskell, Helen, additional, Hecht, Melvyn, additional, Hehn, Rebecca S, additional, Held, Justin, additional, Hepps, Jennifer H., additional, Hillier, Debra, additional, Hiraoka, Mark, additional, Howell, Eric, additional, Hrach, Christine, additional, Hughes, Helen, additional, Huskins, Charles, additional, Kaatz, Scott, additional, Kanala, Vishnu, additional, Kantrowitz, Michael, additional, Kaplan, Peter, additional, Kashiwagi, Deanne, additional, Kaul, Rajat, additional, Keohane, Carol A., additional, Kern, Jeremy, additional, Khan, Alisa, additional, Khan, Nazia Naz S., additional, Kitch, Barry, additional, Kocolas, Irene, additional, Kothari, Lara, additional, Kruvand, Elizabeth, additional, Kuzma, Nicholas, additional, Lacy, Mary, additional, Lane, Michele, additional, Langrish, Kate, additional, Ledford, Christy J.W., additional, LeRoux, Laura, additional, Lewis, Kheyandra, additional, Lipsitz, Stuart, additional, Litterer, Katherine P., additional, Lopreiato, Joseph O., additional, Lyons, Aimee, additional, Mack, Avram, additional, Mallouk, Meghan, additional, Maloney, Christopher G., additional, Mangan, Amanda, additional, Mann, Keith, additional, Markle, Peggy, additional, Marrese, Christine, additional, Marseille, David, additional, Maynard, Greg, additional, Mehta, Bijal, additional, Mendoza, Fernando, additional, Mercer, Alexandra N., additional, Micalizzi, Dale, additional, Mims, Lisa, additional, Mittal, Vineeta, additional, Mueller, Stephanie, additional, Ngo, Thuy L., additional, Nolan, Ann, additional, Nyenpan, Christopher, additional, Obermeyer, Maria, additional, O'Donnell, Katherine, additional, O'Toole, Jennifer K., additional, Ottolini, Mary, additional, Owolabi, Mobola, additional, Patel, Aarti, additional, Patel, Rajesh, additional, Patel, Shilpa J., additional, Perron, Catherine, additional, Pickler, Rita, additional, Popa, Alina, additional, Reppert, Patrick, additional, Riss, Robert, additional, Roesch, Justin, additional, Rogers, Jayne E., additional, Rosenbluth, Glenn, additional, Rothschild, Jeffrey M., additional, Sanders, Lee, additional, Sauder, Kimberly, additional, Schnipper, Jeff, additional, Schnock, Kumiko O, additional, Scholtz, Amy, additional, Seltz, Barry, additional, Serra, Theresa, additional, Serwint, Janet, additional, Shah, Samir, additional, Sharma, Meesha, additional, Sheppard, Kathleen, additional, Simpkin, Arabella, additional, Sloan, Karin A, additional, Solan, Lauren G., additional, Southgate, Michael W, additional, Spackman, Jaime Blank, additional, Stevens, Scott M., additional, Stevenson, Adam, additional, Stevenson, Windy, additional, Subramony, Anupama, additional, Surkis, William, additional, Thangarasu, Sudhagar, additional, Thompson, E. Douglas, additional, Toole, Cheryl, additional, Trueman, Laura, additional, Trujillo, Tanner, additional, Tse, Lisa, additional, Turmelle, Michael P., additional, Vaniawala, Vishwas, additional, Wagner, Tamara, additional, Warnick, Cindy, additional, Webster, John, additional, Webster, Mary, additional, Weinerman, Adina, additional, Welch, Chelsea, additional, White, Andrew J., additional, Wien, Matthew F., additional, Winn, Ariel S., additional, Wintch, Stephanie, additional, Yin, H. Shonna, additional, Yoon, Catherine S., additional, Yu, Clifton E., additional, Zampino, Dominick, additional, and Zigmont, Katherine R., additional

Published
2017
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