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36 results on '"Sierra D."'

3. Prevalence and patterns of executive function, adaptive function, and behavioral outcomes in preschool and school age children with congenital diaphragmatic hernia

Author

Danzer, Enrico, primary, Schreiber, Jane E., additional, Hoffman, Casey, additional, Mathew, Leny, additional, Flohr, Sabrina J., additional, Eppley, Elizabeth, additional, Land, Sierra D., additional, Herkert, Lisa, additional, Rintoul, Natalie E., additional, Adzick, N. Scott, additional, and Hedrick, Holly L., additional

Published
2023
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5. Age-related no-go P300 amplitudes are moderated by exposure to early-life stress

Author

Elizabeth R. Paitel, Sierra D. Peters, Michelle Lobermeier, and Raquel A. Lopez

Subjects
Aging, Young Adult, Neuropsychology and Physiological Psychology, Adverse Childhood Experiences, Parietal Lobe, Physiology (medical), General Neuroscience, Humans, Electroencephalography, Event-Related Potentials, P300, Article, Aged
Abstract

Deficits in inhibitory control are common with advancing age and may underlie declines in other complex cognitive functions. The inhibitory P300 event-related potential (ERP) generally decreases in amplitude with age, reflecting deficits in inhibitory performance evaluation and adaptation, with possible generators including precentral and inferior frontal gyri and midcingulate and parietal cortex. Exposure to early-life stress (ELS) is also associated with deficits in inhibitory control, smaller P300 amplitudes, and dysfunction in regions associated with P300 generation. Although biopsychosocial effects of ELS are evident in older adulthood, the influence of ELS on neural processes in later life is unknown. In the current study, 13 young adults and 21 healthy older adults completed a high-accuracy go/no-go task and the Juvenile Victimization Questionnaire (JVQ), an indicator of ELS. Regression analyses revealed significant central-parietal models, with smaller P300 amplitudes predicted by both older age and greater exposure to ELS. Age group*ELS interactions moderated P300 prediction at central and centro-parietal electrodes, such that older age predicted smaller P300 amplitudes only in those with lower to moderate ELS. Amplitudes did not significantly differ by age in those with higher ELS. Post-hoc within-age group correlations showed that greater ELS was associated with smaller P300 amplitudes in young adults. However, greater ELS was modestly associated with larger central amplitudes in older adults, potentially suggestive of anterior age-related compensatory recruitment to maintain high task performance. These findings suggest long-lasting neural implications of ELS that interact with normative neuro-cognitive aging processes, such that ELS may be an important risk factor for age-related cognitive decline.

Published
2022
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8. VAB-8 stops dynein in its tracks to regulate synaptic delivery

Author

Sierra D, Palumbos and Erika L F, Holzbaur

Subjects
Dyneins, Cell Communication, Cell Biology, Molecular Biology, General Biochemistry, Genetics and Molecular Biology, Developmental Biology
Abstract

How synaptogenic signals trigger the targeted delivery of synaptic material is a fundamental question in neuroscience. In this issue of Developmental Cell, Balseiro-Gomez et al. identify a mechanism through which local synatogenic pathways control synaptic cargo delivery.

Published
2022
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18. Synthesis of β-carbolines via a silver-mediated oxidation of tetrahydro-β-carbolines

Author

Scott Eagon, Maximillian J. Gomez, Brianna Sierra, Nick A. Whittington-Davis, Marc O. Anderson, Jennifer K. Tran, and Sierra D. Durham

Subjects
chemistry.chemical_compound, Moisture, 010405 organic chemistry, Chemistry, Organic Chemistry, Drug Discovery, Aromatization, Organic chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Silver carbonate, 0104 chemical sciences
Abstract

The oxidation of tetrahydro-β-carbolines to β-carbolines using silver carbonate was developed as an alternative to current methods. The oxidation is extremely mild and provides the products in modest to good yields after purification. A number of functional groups are tolerated by this methodology, including reduction-sensitive groups which are often cleaved with other methods. Though the mechanism is not fully understood, the reaction proceeds in an open flask, is not sensitive to light or moisture, and provides a viable synthetic route to compounds that are not easily prepared via other methodologies.

Published
2017
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19. Light vector mediators facing XENON1T data

Author

Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Aristizábal Sierra, D., De Romeri, V., Flores, L.J., Papoulias, D.K., Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Aristizábal Sierra, D., De Romeri, V., Flores, L.J., and Papoulias, D.K.

Abstract

Recently the XENON1T collaboration has released new results on searches for new physics in low-energy electronic recoils. The data shows an excess over background in the low-energy tail, particularly pronounced at about 2−3keV. With an exposure of 0.65 tonne-year, large detection efficiency and energy resolution, the detector is sensitive as well to solar neutrino backgrounds, with the most prominent contribution given by pp neutrinos. We investigate whether such signal can be explained in terms of new neutrino interactions with leptons mediated by a light vector particle. We find that the excess is consistent with this interpretation for vector masses below ≲0.1MeV. The region of parameter space probed by the XENON1T data is competitive with constraints from laboratory experiments, in particular GEMMA, Borexino and TEXONO. However we point out a severe tension with astrophysical bounds and cosmological observations.

Published
2020

29. Síndrome de Peutz-Jeghers

Author

Pérez Rodríguez, M.aJ., primary, Anaya Barea, F.M., additional, Galiano Fernández, E., additional, de Diego Sierra, D., additional, and Condado Sánchez-Rojas, I., additional

Published
2008
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31. Mastitis in small ruminants.

Author

Contreras, A., primary, Sierra, D., additional, Sánchez, A., additional, Corrales, J.C., additional, Marco, J.C., additional, Paape, M.J., additional, and Gonzalo, C., additional

Published
2007
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35. Standardized Mitotic Counts in Breast Cancer Evaluation of the Method

Author

Collan, Y.U.I., primary, Kuopio, T., additional, Baak, J.P.A., additional, Becker, R., additional, Bogomoletz, W.V., additional, Deverell, M., additional, Van Diest, P., additional, Van Galen, C., additional, Gilchrist, K., additional, Javed, A., additional, Kosma, V.-M., additional, Kujari, H., additional, Luzi, P., additional, Mariuzzi, G.M., additional, Matze, E., additional, Montironi, R., additional, Scarpelli, M., additional, Sierra, D., additional, Sisti, S., additional, Toikkanen, S., additional, Tosi, P., additional, Whimster, W.F., additional, and Wisse, E., additional

Published
1996
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