Search

In this work, living diatoms (LDT) were fed Eu3+ -complex-polysaccharide aggregates (EIPA), and the living diatoms integrated-EIPAs (LDT-E) in a completely new UV downconversion biophotonic material. The EIPAs were embedded inside siliceous cell walls of living diatoms. When dried, these diatoms (LDT-Es) are luminescent at 612 nm, due to the Eu3+ - complex. As UV-downconversion material, LDT-E absorbs UV light in the band of 250-400 nm and converts into useful visible light, thus contributing to UV-protection and potentially to photocurrent generation in photovoltaic devices. This downconversion material from living diatom retains the porous characteristics of the diatom siliceous cells, as well as the diatom organic components. Most important is the absence of a chemical process to generate this biomaterial from natural living diatoms, in order to obtain UV protection and downconversion. (C) 2022 The Author(s). Published by Elsevier B.V. Funding Agencies|National Natural Science Foundation of China [51473082]; State Key Project of INTERNATIONALCOOPERATION Research [2017YFE0108300, 2016YFE0110800]; National High-End Foreign Expert of China; Program for Introducing Talents of Discipline to Universities (111); high level of discipline program of Materials Science of Shandong Province; Knut and Alice Wallenberg foundation

Based on core description, thin section identification, X-ray diffraction analysis, scanning electron microscopy, low-temperature gas adsorption and high-pressure mercury intrusion porosimetry, the shale lithofacies of Shan23 sub-member of Permian Shanxi Formation in the east margin of Ordos Basin was systematically analyzed in this study. The Shan23 sub-member has six lithofacies, namely, low TOC clay shale (C-L), low TOC siliceous shale (S-L), medium TOC siliceous shale (S-M), medium TOC hybrid shale (M-M), high TOC siliceous shale (S-H), and high TOC clay shale (C-H). Among them, S-H is the best lithofacies, S-M and M-M are the second best. The C-L and C-H lithofacies, mainly found in the upper part of Shan23 sub-member, generally developed in tide-dominated delta facies; the S-L, S-M, S-H and M-M shales occurring in the lower part of Shan23 sub-member developed in tide-dominated estuarine bay facies. The S-H, S-M and M-M shales have good pore structure and largely organic matter pores and mineral interparticle pores, including interlayer pore in clay minerals, pyrite intercrystalline pore, and mineral dissolution pore. C-L and S-L shales have mainly mineral interparticle pores and clay mineral interlayer pores, and a small amount of organic matter pores, showing poorer pore structure. The C-H shale has organic micro-pores and a small number of interlayer fissures of clay minerals, showing good micro-pore structure, and poor meso-pore and macro-pore structure. The formation of favorable lithofacies is jointly controlled by depositional environment and diagenesis. Shallow bay-lagoon depositional environment is conducive to the formation of type II2 kerogen which can produce a large number of organic cellular pores. Besides, the rich biogenic silica is conducive to the preservation of primary pores and enhances the fracability of the shale reservoir.

Cisplatin plays a key role in treating small cell lung cancer (SCLC); however, the rapid development of cisplatin resistance limits its treatment effect. The detailed mechanisms of cisplatin-resistance, particularly in SCLC, remain unclear. We analyzed the differentially expressed genes (DEGs) between cisplatin-resistant small cell lung cancer cell line H446/CDDP and its parental cell line H446, using the transcriptome sequencing technique. Gene ontology (GO) analysis and the subsequent tests demonstrated that the functions of protein ubiquitination and autophagy are more active in the H446/CDDP cells. Autophagy plays a protective role in the H446/CDDP cells by using the autophagy inhibitors, 3-methyladenine and bafilomycin A1. Moreover, antimalarial drugs that inhibit autophagy by increasing the pH of lysosomes can also enhance cisplatin-induced cell death.

Arbuscular mycorrhizal fungi as an important soil microbe have been demonstrated to mitigate the harmful effects of stress on plants. However, little is known about the molecular mechanisms underlying the AM symbiotic response to low temperature. Here, differentially expressed genes (DEGs) in the maize seedlings were identified after inoculating AMF under low temperature conditions. A total of 10,400 DEGs were obtained among four treatments, including non-inoculated AMF under ambient temperature (NMA), inoculated AMF under ambient temperature (MA), non-inoculated with low temperature stress (NML), and inoculated with low temperature stress (ML). The relative expression of 858 genes increased and that of 497 genes decreased in AM plants under low temperature stress. 24 DEGs were identified related to photosynthesis and respiratory metabolism. Among these DEGs, 10 genes were upregulated, and 14 genes were downregulated. The results show that inoculating AMF might decrease the production and transmission of electrons under low temperature, and the cyclic electron flow process in chloroplasts was stimulated to protect plants against low temperature. The fungi also influenced transmission of electrons and production of phosphoric acid in mitochondria in response to low temperature. CO2 assimilation capacity was affected and the tricarboxylic acid cycle was promoted by the adjustments in the glycolysis, pentose phosphate pathway, gamma-aminobutyric acid shunt pathway, and glyoxylic acid cycle to produce more adenosine triphosphate and raw materials for other metabolic pathways under low temperature. These findings provide new insight into low temperature tolerance induced by AMF, and help identify genes for further investigation and functional analyses.

Severed CNS axons fail to regenerate in adult mammals and there are no effective regenerative strategies to treat patients with CNS injuries. Several genes, including phosphatase and tensin homolog (PTEN) and Krüppel-like factors, regulate intrinsic growth capacity of mature neurons. The Lin28 gene is essential for cell development and pluripotency in worms and mammals. In this study, we evaluated the role of Lin28a in regulating regenerative capacity of diverse populations of CNS neurons in adult mammals. Using a neuron-specific Thy1 promoter, we generated transgenic mice that overexpress Lin28a protein in multiple populations of projection neurons, including corticospinal tracts and retinal ganglion cells. We demonstrate that upregulation of Lin28a in transgenic mice induces significant long distance regeneration of both corticospinal axons and the optic nerve in adult mice. Importantly, overexpression of Lin28a by post-injury treatment with adeno-associated virus type 2 (AAV2) vector stimulates dramatic regeneration of descending spinal tracts and optic nerve axons after lesions. Upregulation of Lin28a also enhances activity of the Akt signaling pathway in mature CNS neurons. Therefore, Lin28a is critical for regulating growth capacity of multiple CNS neurons and may become an important molecular target for treating CNS injuries.

The shales in the 2nd Member of Shanxi Formation in the east margin of the Ordos Basin were deposited in a marine-nonmarine transitional environment during the Permian. Based on the recent breakthroughs in the shale gas exploration and theoretical understandings on the shale gas of the study area, with a comparison to marine shale gas in the Sichuan Basin and marine-nonmarine transitional shale gas in the U.S., this study presents the geological characteristics and development potential of marine-nonmarine transitional gas in the study area. Four geological features are identified in the 2nd Member of the Shanxi Formation in the study area has: (1) stable sedimentary environment is conductive to deposition of widely distributed organic shale; (2) well-developed micro- and nano- scale pore and fracture systems, providing good storage capacity; (3) high content of brittle minerals such as quartz, leading to effectively reservoir fracturing; and (4) moderate reservoir pressure and relatively high gas content, allowing efficient development of shale gas. The 2nd Member of Shanxi Formation in the east margin of Ordos Basin is rich in shale gas resource. Three favorable zones, Yulin-Linxian, Shiloubei-Daning-Jixian, and Hancheng-Huangling are developed, with a total area of 1.28×104 km2 and resources between 1.8×1012 and 2.9×1012 m3, indicating a huge exploration potential. Tests of the 2nd Member of Shanxi Formation in vertical wells show that the favorable intervals have stable gas production and high reserves controlled by single well, good recoverability and fracability. This shale interval has sufficient energy, stable production capacity, and good development prospects, as evidenced by systematic well testing. The east margin of the Ordos Basin has several shale intervals in the Shanxi and Taiyuan formations, and several coal seams interbedded, so collaborative production of different types of natural gas in different intervals can be considered. The study results can provide reference for shale gas exploration and development and promote the rapid exploitation of shale gas in China.

Graphical abstract, The global outbreak of coronavirus infectious disease-2019 (COVID-19) draws attentions in the transport and spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in aerosols, wastewater, surface water and solid wastes. As pathogens eventually enter the subsurface system, e.g., soils in the vadose zone and groundwater in the aquifers, they might survive for a prolonged period of time owing to the uniqueness of subsurface environment. In addition, pathogens can transport in groundwater and contaminate surrounding drinking water sources, possessing long-term and concealed risks to human society. This work critically reviews the influential factors of pathogen migration, unravelling the impacts of pathogenic characteristics, vadose zone physiochemical properties and hydrological variables on the migration of typical pathogens in subsurface system. An assessment algorithm and two rating/weighting schemes are proposed to evaluate the migration abilities and risks of pathogens in subsurface environment. As there is still no evidence about the presence and distribution of SARS-CoV-2 in the vadose zones and aquifers, this study also discusses the migration potential and behavior of SARS-CoV-2 viruses in subsurface environment, offering prospective clues and suggestions for its potential risks in drinking water and effective prevention and control from hydrogeological points of view.

Low temperature is one of the main abiotic stresses that inhibit wheat growth and development. To understand the physiological mechanism of salt priming induced low temperature tolerance and its transgenerational effects, the chlorophyl b-deficient mutant (ANK) and its wild type (WT) wheat were subjected to low temperature stress after parental salt priming. Salt priming significantly decreased the levels of superoxide anions, hydrogen peroxide and malondialdehyde in both parental and offspring plants under low temperature. The catalase activity in parental wheat and activities of dehydroascorbate reductase and glutathione reductase in the offspring were significantly increased by salt priming under low temperature. Meanwhile, salt priming contributed to mantaining the integrity of chloroplast structure and relatively higher net photosynthetic rate (Pn) in both generations under low temperature. Salt priming also improved the carbohydrate metabolism enzyme activities of parental and offspring plants, such as phosphoglucomutase, fructokinase and sucrose synthase. In addition, ANK plants had significantly higher carbohydrate metabolism enzyme activities than WT plants. The differential expressed proteins (DEP) in seeds of two genotypes under salt priming were mainly related to homeostasis, electron transfer activity, photosynthesis and carbohydrate metabolism. Correlation network analysis showed that the expression of DEP under salt priming was significantly correlated to sucrose concentration and cytoplasmic peroxidase (POX) activity in WT, while that was correlated to various carbohydrate metabolism enzyme activities in ANK plants. These results indicated that the parental salt priming induced modulations of seed proteome regulated the ROS metabolism, photosynthetic carbon assimilation and carbohydrate metabolism, hence enhancing the low temperature tolerance in offspring wheat.

The behaviour of moisture absorption and evolution of various mechanical properties for the sandwich composites immersed into two humid conditions: seawater with 30 °C (SWL) and purewater with 80 °C (PWH) have been examined by Ding et al. (2018). In this paper, three relatively harsh environmental conditions: salt-fog spray ageing (SFS), hygrothermal atmosphere alternating high low temperature (HHL) and solar radiation in combination with water vapour (SRW) are determined. Further studies on the ageing behaviour of previously selected sandwich composites constituted of thick ECR glass fibre reinforced vinylester composite faces bonded to closed-cell PVC were carried out under aggression of newly added three artificial environmental conditions. To this end, the specimens were prepared by VIMP and then exposed to the new three conditions for 1008 h. The moisture uptake before desiccation and after desiccation as well as various mechanical properties, including flatwise tension strength, flatwise compressive strength , in-plane shear strength, shear strength using short beam bending and edgewise compressive strength, were measured and compared with previous data from SWL and PWH. The weight change indicates that the specimens exposed to newly added environmental conditions absorb much less moisture and chemically bound water, meanwhile the mechanical characterization reveals that specimens exposed to the SRW deteriorate significantly in the faces-core interfacial properties .

A new analytical solution for the prediction of cure-induced spring-in of L-shaped composite parts has been proposed based on modification of the model presented by authors (2017). In the newly proposed analytical solution, the flange length is incorporated into the formulation to theoretically derive the spring-in of corner of L-shaped composite part using shear-lag theory. Consequently, in addition to the cure process generated non-mechanical strain in the rubbery state in the through-thickness and length directions, the new solution can quantitatively give the correlation of spring-in of corner of L-shaped composite part with the flange length. Then, the newly proposed analytical solution is verified by the good agreement between the analytically calculated and experimentally measured spring-in angles for both the unidirectional and cross-ply L-shaped composite parts. Further numerical simulation on the elaborately selected L-shaped composite parts with various configurations also provides a favourable comparison with analytical results, showing the validity of newly proposed analytical solution.

Liver kinase B1 (LKB1), a downstream effector of cyclic AMP (cAMP)/PKA and phosphatidylinositol 3-kinase (PI3K) pathways, is a determinant for migration and differentiation of many cells, but its role in CNS axon regeneration is unknown. Therefore, LKB1 was overexpressed in sensorimotor cortex of adult mice five days after mid-thoracic spinal cord injury, using an AAV2 vector. Regeneration of corticospinal axons was dramatically enhanced. Next, systemic injection of a mutant-AAV9 vector was used to upregulate LKB1 specifically in neurons. This promoted long-distance regeneration of injured corticospinal fibers into caudal spinal cord in adult mice and regrowth of descending serotonergic and tyrosine hydroxylase immunoreactive axons. Either intracortical or systemic viral delivery of LKB1 significantly improved recovery of locomotor functions in adult mice with spinal cord injury. Moreover, we demonstrated that LKB1 used AMPKα, NUAK1, and ERK as the downstream effectors in the cortex of adult mice. Thus, LKB1 may be a critical factor for enhancing the growth capacity of mature neurons and may be an important molecular target in the treatment of CNS injuries.

The influence of nano-organic montmorillonites (nano-OMMTs) on mode I and mode II interlaminar fracture toughness of continuous glass fibre reinforced ammonium polyphosphate polypropylene (CGF/PP/APP) composites was experimentally studied in this paper. Nano-OMMTs modified CGF/PP/APP unidirectional prepreg composites were fabricated by hot-melt impregnation process. To investigate the effect of nano-OMMTs on the interlaminar fracture toughness of composites, double cantilever beam (DCB) test and end-notched flexure (ENF) test were conducted to obtain the mode I initiation interlaminar fracture toughness (G IC init.), mode I propagation interlaminar fracture toughness (GIC prop.), and mode II initiation interlaminar fracture toughness (GII C init.) of samples, respectively. Through comparison against to the neat CGF/PP/APP composites, with the addition of 6.5 wt% nano-OMMTs into PP matrix, the GIC init., GIC prop., and GII C init. of composites can be enhanced from 0.502 kJ/m2, 0.746 kJ/m2 and 0.623 kJ/m2 to 0.712 kJ/m2, 1.119 kJ/m2, and 1.195 kJ/m2 , respectively. Finally, it was found that nano-OMMTs in matrix can act as “pins”, which could absorb energy in the forms of nano-particles pullout and enhance the interlaminar fracture toughness values in DCB and ENF tests.

The purposes of this study were to probe spectral behaviors of the toxic targets in trans-crotonaldehyde (TCA) in mitochondria altered by diallyl disulfides (DADS) derived from garlic. Ultraviolet absorption spectra showed that when ethanol as a solvent, the DADS blue shifted the peak of TCA from 318 nm to 312 nm. In mitochondria, the DADS further blue displaced the peak of TCA from 312 nm to 308 nm. Raman spectra displayed that the S S of DADS directly interacted with the C C toxic target of TCA, then the C C C of DADS interacted with the CH O toxic target of TCA. When DADS to TCA was 1:2, the DADS was the most powerful for the removal of the C C and CH O toxic targets of TCA. Study suggested that the S S of DADS altered the C C toxic target of TCA, while the C C C of DADS eliminated the CH O toxic target of TCA via local electron delocalization. The above two together clearly depicted the spectral behaviors of the toxic targets of TCA in mitochondria altered by DADS. These results are of great significance and value to elucidate the effects of garlic organic polysulfide on myocardial ischemia for the extensive development and use of garlic extracts.

This paper aims to assess the hygroscopic behaviour of nonstandard size sandwich composites constituted of thick Electronical-Chemical Resistance (ECR) glass fibre reinforced vinylester composite faces bonded to closed-cell Polyvinyl Chloride (PVC) foam core in the service environment as a reference and basis for materials selection. In order to exhibit the change of sandwich composites properties in realistic environment, the specimens fabricated by Vacuum Infusion Moulding Processing (VIMP) were immersed in two humid conditions: seawater with 30 °C (SWL) and purewater with 80 °C (PWH) for 1680 h. The moisture uptake and various mechanical properties of specimens, including the flatwise tension strength, flatwise compressive strength, in-plane shear strength, shear strength using short beam bending and edgewise compressive strength were tracked periodically. The results from water absorption measurement indicate that the specimens immersed in two humid conditions reach saturation levels after immersion of 1008 h, and non-Fickian and Fickian diffusion occur simultaneously. The characterization on mechanical properties was mainly placed on the variation of PVC foam core and faces-core interface properties, and corresponding results reveal that the moisture absorption has insignificant effects on the PVC foam core properties but appreciably affects the composite faces and face-core interface properties, especially for the specimens immersed in PWH.

The accumulation of heavy metals in soil, especially cadmium (Cd), may influence the tolerance of crops to other abiotic stress, such as low temperature. In this study, the low temperature tolerance of abscisic acid (ABA)-deficient mutant (Az34) barley and its wild-type (WT) irrigated with Cd solution (1 g L

With increasing plastic consumption, the large amount of polystyrene nanoplastics (PS-NPs) in agricultural soil may not only directly affect the plant growth, but also indirectly affect the abiotic stress tolerance in crops. In this study, the barley (Hordeum vulgare L.) was irrigated with 2 g L−1 PS-NPs (65.776 ± 0.528 nm) solution for 7 days, then subjected to low temperature (2 ℃) for 24 h. The imaging of protoplasts indicated that polymethylmethacrylate nanoplastics could across the cell wall and accumulate in plant cells. The PS-NPs significantly decreased Rubisco activities and ATP production, hence limiting the photosynthetic carbon assimilation in barley under low temperature. The PS-NPs accumulated in cells also caused the significantly decreased activities of key enzymes involved in sucrolytic, glycolysis and starch metabolism pathways, including UDP-glucose pyrophorylase, ADP-Glucose pyrophosphorylase, phosphoglucomutase, glucose-6-phosphate dehydrogenase, phosphoglucoisomerase, fructokinase and phosphofructokinase. In addition, under low temperature, the PS-NPs presence significantly reduced the activities of superoxide dismutase, ascorbate peroxidase and catalase in chloroplasts, and significantly reduced the activities of ascorbate peroxidase and catalase in mitochondria. Thus, it is suggested that the PS-NPs accumulated in plant cells impaired the low temperature tolerance in barley mainly by the negative effects on photosynthetic carbon assimilation, carbohydrate metabolism and ROS homeostasis in sub-cellular level.

In many domains we have witnessed the need to search a large entity-relation graph for direct and indirect relationships between a set of entities specified in a query. A search result, called a semantic association (SA), is typically a compact (e.g., diameter-constrained) connected subgraph containing all the query entities. For this problem of SA search, efficient algorithms exist but will return empty results if some query entities are distant in the graph. To reduce the occurrence of failing query and provide alternative results, we study the problem of query relaxation in the context of SA search. Simply relaxing the compactness constraint will sacrifice the compactness of an SA, and more importantly, may lead to performance issues and be impracticable. Instead, we focus on removing the smallest number of entities from the original failing query, to form a maximum successful sub-query which minimizes the loss of result quality caused by relaxation. We prove that verifying the success of a sub-query turns into finding an entity (called a certificate) that satisfies a distance-based condition about the query entities. To efficiently find a certificate of the success of a maximum sub-query, we propose a best-first search algorithm that leverages distance-based estimation to effectively prune the search space. We further improve its performance by adding two fine-grained heuristics: one based on degree and the other based on distance. Extensive experiments over popular RDF datasets demonstrate the efficiency of our algorithm, which is more scalable than baselines., 16 pages, accepted to JoWS

One of the most important issues for designing variable-stiffness composite structures reflects on determination of the steered fiber paths. In this paper a linear variation of steered fiber curves and the change rule of the fiber angles were presented to create the mathematical model of variable-stiffness composite laminates. Compared to the straight-fiber laminate, the reference path with linearly changed angles leads to higher mechanical strength and more design freedoms. A novel methodology was developed to predict the distributions of process-induced residual stresses during cure. A three-dimensional (3D) thermochemical model of the curing process was established and the mechanical responses during cure were evaluated coupled with the results of thermochemical analyses. The distributions of the temperature and the degree of cure were obtained. The process-induced residual stresses were calculated using ABAQUS. The resin modulus was determined using the cure hardening instantaneous linear elastic (CHILE) model. The cure kinetic process was simulated using Kamal model for AS4/3501-6 prepregs. The results show that the process-induced residual stresses of variable-stiffness composite panels are reduced with increasing the end angle of the present fiber path during cure.

Due to the appearance of temperature gradient and non-uniform gelation , fully understanding of residual stresses is even more complex in thick laminates. In this paper, basic mechanisms of cure process were presented firstly. Then, experimental investigation of the non-uniform gelation was carried out together with characterization of necessary material properties. Tailed FBG sets were applied to monitor the cure of thick laminates with temperature gradient. The non-uniform gelation and chemical shrinkage gradient were captured successfully. Lastly, FEM analysis integrating thermal-chemical sub-model and stress-displacement sub-model was carried out to reveal the development of residual stresses. It is demonstrated that the high temperature layer gelled earlier and showed more chemical shrinkage. The chemical strain gradient would introduce compression internal stresses in prior gelled layer and introduces tensile internal stresses in later gelled layer. For the case studied here, transverse residual stress generated by non-uniform chemical shrinkage is small. The strategy used here is promising to estimate the residual stresses for more complex cases further.

The current work is concerned with ageing behaviour of sandwich composites constituted of E-glass fibre-reinforced vinylester bonded to PVC foam core being in service near the sea as a reference and basis for materials selection. In order to simulate the properties evolution of sandwich composites as real as possible, the sandwich composites were exposed to the two accelerated synergistic environmental conditions: solar radiation in conjunction with water vapour (condition A) and hygrothermal atmosphere alternating thermal cycling (condition B) for 1680 h, and the weight change and mechanical properties degradation were carried out. The results show that the sandwich composites lost weight in the condition A while gained weight in the condition B, and shear strength of sandwich composites fell finitely, revealing that PVC foam core was insensitive to the two ageing conditions. Meanwhile, the core fracture, interface-core fracture, interface debonding, and piles peel were observed as the increase of exposure time in the flatwise tension test , indicating debonding properties between skin and foam as well as between piles of composites skin were influenced by the two synergistic ageing conditions.

The thermal residual stresses (TRSes) can noticeably increase the yield strength and flow stresses of particle-reinforced metal-matrix composites (PR-MMCs) and show size-dependence due to thermal geometrically necessary dislocations (GNDs) when the size of particles is on the order of micron. This TRSes strengthening is attributed to the conventional thermal-elasto-plastic constituent mismatch (regardless of particles’ size) and the presence of GNDs (size-dependent). A modified Taylor-based nonlocal theory (TNT) of plasticity is proposed to quantify the individual contributions of size-dependent GND strengthening. An axisymmetric unit-cell model of uniform and aligned particle distribution with various particle sizes is built to study thermal-induced non-uniformly distributed GNDs, their evolution and contributions to the stress strengthening under combined thermal and mechanical loading. The results show that the proposed methodology can effectively capture the size dependence of thermal-induced GNDs which keeps a sharp gradient variation in the zone near the matrix-inclusion interface and gradually flattens out in the zone far away from the interface. It is demonstrated that TRSes significantly improve the yield strength and flow stresses. It also revealed that the contribution of thermal-induced GNDs increased as the particle size in the PR-MMCs decreased. The simulation results were validated by experimental results reported in the literature.

Surface functionalization of Al2O3 nano-particles by mussel-inspired poly(dopamine) (PDA) was developed to improve the dielectric properties, mechanical properties, and thermal conductivity properties of nitrile rubber (NBR) matrix. As strong adhesion of PDA to Al2O3 nano-particles and hydrogen bonds formed by the catechol groups of PDA and the polar acrylonitrile groups of NBR, the dispersion of Al2O3-PDA/NBR composites was improved and the interfacial force between Al2O3-PDA and NBR matrix was enhanced. Thus, the Al2O3-PDA/NBR composites exhibited higher dielectric constant, better mechanical properties, and larger thermal conductivity comparing with Al2O3/NBR composites at the same filler content. The largest thermal conductivity of Al2O3-PDA/NBR composite filled with 30 phr Al2O3-PDA was 0.21 W/m K, which was 122% times of pure NBR. In addition, the Al2O3-PDA/NBR composite filled with 30 phr Al2O3-PDA displayed a high tensile strength about 2.61 MPa, which was about 255% of pure NBR. This procedure is eco-friendly and easy handling, which provides a promising route to polymer composites in application of thermal conductivity field.

Tyrosine phosphorylation is a common means of regulating protein functions and signal transduction in multiple cells. Protein tyrosine phosphatases (PTPs) are a large family of signaling enzymes that remove phosphate groups from tyrosine residues of target proteins and change their functions. Among them, receptor-type PTPs (RPTPs) exhibit a distinct spatial pattern of expression and play essential roles in regulating neurite outgrowth, axon guidance, and synaptic organization in developmental nervous system. Some RPTPs function as essential receptors for chondroitin sulfate proteoglycans that inhibit axon regeneration following CNS injury. Interestingly, certain RPTPs are also important to regulate functions of immune cells and development of autoimmune diseases. PTPσ, a RPTP in the LAR subfamily, is expressed in various immune cells and regulates their differentiation, production of various cytokines and immune responses. In this review, we highlight the physiological and pathological significance of PTPσ and related molecules in both nervous and immune systems.

Silicone rubber (SR) composites exhibited significantly improved electromechanical properties via tuning the molecular flexibility by adding plasticizer. To decrease the enhanced elastic modulus of SR composites filled with high-dielectric-constant BaTiO3 (BT) particles, silicone oil (SO) plasticizer was incorporated into the BT/SR composite to weaken the intermolecular interactions and break the structure of the filler network as result of swelling effect. The obviously decreased elastic modulus resulted in a high electromechanical sensitivity β and a relatively large actuated strain of 10.6% for 20 phr BT/SR composite filled with 50 phr SO at a low electric field of 25 kV/mm, approximately 380% increase compared to that of pure SR at the same electric field. The result indicates that tuning flexibility of composites is a good strategy to obtain high-performance dielectric elastomers.

Carbon fiber reinforced composite materials have been widely used in aerospace and other high-tech fields because of their excellent performance. However barely visible impact damage can be introduced by low velocity impact, which might bring out tremendous risk. In this paper, a new method is proposed to predict the position of low velocity impact. The dynamic strain signal that is caused by low velocity impact is obtained by the fiber Bragg grating (FBG) sensor. The amplitude of the first K order natural frequency is extracted by Fast Fourier Transform (FFT). The amplitude data is normalized, and then establish k order vector matrix model is established. It is proposed that K order sum of squares of deviations can be used as the basis to predict positioning. Two different validation tests were performed. The experimental model was made of different layers. FBG were used to embed and paste type method, experiments were conducted with impact of different energy levels. The results show that proposed method is feasible.

Analytical solutions for predicting spring-in angles of U-shaped composite parts generating in rubbery and glassy states are proposed. In the newly developed analytical solutions, the process-induced distortions of web and flange are mathematically converted to spring-in angles within the scope of small deformation theory, and then corresponding analytical expressions of web, corner, flange and total spring-in are separately derived. These new solutions can quantitatively give the correlation of web, corner, flange and total spring-in with material properties-related and geometrical configuration-dependent parameters, and evaluate the spring-in angles of multi-angle ply composite parts just using lamina properties. The reliability of newly proposed analytical solutions is checked by the comparison between the analytically calculated and experimentally measured spring-in angles for unidirectional and quasi-isotropic U-shaped composite parts. Meanwhile, numerical simulations on the U-shaped composite parts with various geometries and layups also provide a favourable agreement with analytical results.

Process-induced distortions in composite structures lead to problems with dimensional control, which can be a major concern in the manufacturing. This paper focuses on the prediction of the warpages and curvatures in unsymmetrical laminate plates using closed-form solution and finite element method. A new characterization method that the shape of the deformed composite specimen is conducted in virtue of the coordinate measuring machine through contact method is adopted to experimentally measure the process-induced distortions in unsymmetrical laminate plates. The comparison of numerical and analytical prediction with experimental results for warpages in [06/906] and [09/903] unsymmetrical laminates indicates that shear layer between tool and part has a significant effect on the process-induced distortions, and PTFE release film and release agent between tool and part cannot eliminate effect of the tool-part interaction on the process-induced distortions in unsymmetrical laminate plates. Moreover, the comparison of analytically and numerically predicted development of curvature with experimental results presented by previous literature for unsymmetrical laminates further reveals the effect of tool-part interaction on the process-induced distortions and the accuracy of closed-form solution.