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Your search keyword '"Shirali, Masoud"' showing total 4 results
Start Over Author "Shirali, Masoud" Publisher elsevier bv
4 results on '"Shirali, Masoud"'

1. Insulin resistance: Genetic associations with depression and cognition in population based cohorts

Author

Frangou, Sophia, primary, Shirali, Masoud, additional, Adams, Mark J., additional, Howard, David M., additional, Gibson, Jude, additional, Hall, Lynsey S., additional, Smith, Blair H., additional, Padmanabhan, Sandosh, additional, Murray, Alison D., additional, Porteous, David J., additional, Haley, Chris S., additional, Deary, Ian J., additional, Clarke, Toni-Kim, additional, and McIntosh, Andrew M., additional

Published
2019
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2. SU76EXPLORING THE RELATIONSHIP OF BIRTH WEIGHT ON CORTICAL BRAIN STRUCTURE IN UK BIOBANK USING GENETIC INSTRUMENTS

Author

Neilson, Emma, primary, Clarke, Toni, additional, Shen, Xueyi, additional, Cox, Simon, additional, Shirali, Masoud, additional, Howard, David, additional, Gibson, Jude, additional, Adams, Mark, additional, Harris, Mathew, additional, Davies, Gail, additional, Deary, Ian J., additional, Boardman, James, additional, Lawrie, Stephen, additional, McIntosh, Andrew, additional, and Whalley, Heather, additional

Published
2019
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3. Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder

Author

Zeng, Yanni, Navarro, Pau, Shirali, Masoud, Howard, David M., Adams, Mark J., Hall, Lynsey S., Clarke, Toni-Kim, Thomson, Pippa A., Smith, Blair, Murray, Alison, Padmanabhan, Sandosh, Hayward, Caroline, Boutin, Thibaud, MacIntyre, Donald J., Lewis, Cathryn M., Wray, Naomi R., Mehta, Divya, Penninx, Brenda W.J.H., Milaneschi, Yuri, Baune, Bernhard T., Air, Tracy, Hottenga, Jouke-Jan, Mbarek, Hamdi, Castelao, Enrique, Pistis, Giorgio, Schulze, Thomas G., Streit, Fabian, Forstner, Andreas J., Byrne, Enda M., Martin, Nicholas G., Breen, Gerome, Müller-Myhsok, Bertram, Lucae, Susanne, Kloiber, Stefan, Domenici, Enrico, Deary, Ian J., Porteous, David J., Haley, Chris S., McIntosh, Andrew M., Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Amsterdam Neuroscience - Complex Trait Genetics, Psychiatry, and APH - Digital Health

Subjects
Male, MDD, Genome-wide analyses, Haplotype block, HRHM, Regional heritability, TOX2, Biological Psychiatry, Polymorphism, Single Nucleotide, Cohort Studies, SDG 3 - Good Health and Well-being, HMGB Proteins, Journal Article, Humans, Genetic Predisposition to Disease, Depressive Disorder, Major, Middle Aged, United Kingdom, Priority Communication, Haplotypes, Genetic Loci, Female, Ireland, Genome-Wide Association Study
Abstract

Background: \ud \ud Major depressive disorder (MDD) is the second largest cause of global disease burden. It has an estimated heritability of 37%, but published genome-wide association studies have so far identified few risk loci. Haplotype-block-based regional heritability mapping (HRHM) estimates the localized genetic variance explained by common variants within haplotype blocks, integrating the effects of multiple variants, and may be more powerful for identifying MDD-associated genomic regions.\ud \ud Methods: \ud \ud We applied HRHM to Generation Scotland: The Scottish Family Health Study, a large family- and population-based Scottish cohort (N = 19,896). Single-single nucleotide polymorphism (SNP) and haplotype-based association tests were used to localize the association signal within the regions identified by HRHM. Functional prediction was used to investigate the effect of MDD-associated SNPs within the regions.\ud \ud Results: \ud \ud A haplotype block across a 24-kb region within the TOX2 gene reached genome-wide significance in HRHM. Single-SNP- and haplotype-based association tests demonstrated that five of nine genotyped SNPs and two haplotypes within this block were significantly associated with MDD. The expression of TOX2 and a brain-specific long noncoding RNA RP1-269M15.3 in frontal cortex and nucleus accumbens basal ganglia, respectively, were significantly regulated by MDD-associated SNPs within this region. Both the regional heritability and single-SNP associations within this block were replicated in the UK–Ireland group of the most recent release of the Psychiatric Genomics Consortium (PGC), the PGC2–MDD (Major Depression Dataset). The SNP association was also replicated in a depressive symptom sample that shares some individuals with the PGC2–MDD.\ud \ud Conclusions: \ud \ud This study highlights the value of HRHM for MDD and provides an important target within TOX2 for further functional studies.

Published
2016
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4. Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder

Author

Zeng, Yanni, primary, Navarro, Pau, additional, Shirali, Masoud, additional, Howard, David M., additional, Adams, Mark J., additional, Hall, Lynsey S., additional, Clarke, Toni-Kim, additional, Thomson, Pippa A., additional, Smith, Blair H., additional, Murray, Alison, additional, Padmanabhan, Sandosh, additional, Hayward, Caroline, additional, Boutin, Thibaud, additional, MacIntyre, Donald J., additional, Lewis, Cathryn M., additional, Wray, Naomi R., additional, Mehta, Divya, additional, Penninx, Brenda W.J.H., additional, Milaneschi, Yuri, additional, Baune, Bernhard T., additional, Air, Tracy, additional, Hottenga, Jouke-Jan, additional, Mbarek, Hamdi, additional, Castelao, Enrique, additional, Pistis, Giorgio, additional, Schulze, Thomas G., additional, Streit, Fabian, additional, Forstner, Andreas J., additional, Byrne, Enda M., additional, Martin, Nicholas G., additional, Breen, Gerome, additional, Müller-Myhsok, Bertram, additional, Lucae, Susanne, additional, Kloiber, Stefan, additional, Domenici, Enrico, additional, Deary, Ian J., additional, Porteous, David J., additional, Haley, Chris S., additional, and McIntosh, Andrew M., additional

Published
2017
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