48 results on '"Shen, Jingkang"'
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2. Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis
3. Multi-omics characterization of WNT pathway reactivation to ameliorate BET inhibitor resistance in liver cancer cells
4. Facile synthesis of new functionalized 3,4-dihydro-2H-pyrroles using 2-isocyanoacetates
5. Stereoselective N-glycosylation with N4-acyl cytosines and efficient synthesis of gemcitabine
6. Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study
7. Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor
8. Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma
9. Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction
10. Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups
11. Convenient preparation of pinometostat and related 5′-deoxy-5′-amino adenosine derivatives as well as their activity against DOT1L
12. Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site
13. Preparation of 5′-deoxy-5′-amino-5′-C-methyl adenosine derivatives and their activity against DOT1L
14. Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor
15. Design and optimization of purine derivatives as in vivo active PDE10A inhibitors
16. Stereoselective addition of Grignard reagents to (2-methyl-5-tert-butyl)phenyl 1-thio-β-D-ribopentodialdo-1,4-furanoside derivative
17. Design and synthesis of benzylpiperidine inhibitors targeting the menin–MLL1 interface
18. Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity
19. Formation of 1,3-diazocine by palladium catalyzed C–H arylation
20. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents
21. Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors
22. Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer
23. Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic
24. Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design
25. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors
26. 1,2-trans-1-Dihydroxyboryl benzyl S-glycoside as glycosyl donor
27. Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
28. Synthesis and biological evaluation of 6H-pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-ones as antimitotic agents and inhibitors of tubulin polymerization
29. Discovery of pyrazole as C-terminus of selective BACE1 inhibitors
30. Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors
31. Design, synthesis and SAR of piperidyl-oxadiazoles as 11β-hydroxysteroid dehydrogenase 1 inhibitors
32. (N,N-Diisopropylcarbamoyloxy)-methyl p-tolyl sulfone: preparation and application for the syntheses of 1,2-diols
33. WITHDRAWN: Design, synthesis and biological evaluation of 3-substituted-4-anilinequinoline as EGFR tyrosine kinase inhibitors
34. CCLab—a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design
35. Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11β-hydroxysteroid dehydrogenase type 1
36. Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists
37. Potent and novel 11β-HSD1 inhibitors identified from shape and docking based virtual screening
38. Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach
39. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase
40. A facile one-pot synthesis of 3-unsubstituted-2,4-oxazolidinediones via in situ generation of carbamates from α-hydroxyesters using trichloroacetyl isocyanate
41. Illudalic acid as a potential LAR inhibitor: Synthesis, SAR, and preliminary studies on the mechanism of action
42. Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors
43. Microwave-assisted rapid and straightforward synthesis of 2-aryl-4-quinolones from acylated 2′-aminoacetophenones
44. Heterologous expression of lipoprotein-associated phospholipase A2 in different expression systems
45. One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation
46. Design, synthesis, and evaluation of Leu∗Ala hydroxyethylene-based non-peptide β-secretase (BACE) inhibitors
47. Synthesis of pyrrolidine analogues of solamin
48. Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A
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