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Start Over Author "Senjobe, Fernando" Publisher elsevier bv
4 results on '"Senjobe, Fernando"'

1. T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals

Author

Naranbhai, Vivek, primary, Nathan, Anusha, additional, Kaseke, Clarety, additional, Berrios, Cristhian, additional, Khatri, Ashok, additional, Choi, Shawn, additional, Getz, Matthew A., additional, Tano-Menka, Rhoda, additional, Ofoman, Onosereme, additional, Gayton, Alton, additional, Senjobe, Fernando, additional, Zhao, Zezhou, additional, St Denis, Kerri J., additional, Lam, Evan C., additional, Carrington, Mary, additional, Garcia-Beltran, Wilfredo F., additional, Balazs, Alejandro B., additional, Walker, Bruce D., additional, Iafrate, A. John, additional, and Gaiha, Gaurav D., additional

Published
2022
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2. Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses

Author

Nathan, Anusha, primary, Rossin, Elizabeth J., additional, Kaseke, Clarety, additional, Park, Ryan J., additional, Khatri, Ashok, additional, Koundakjian, Dylan, additional, Urbach, Jonathan M., additional, Singh, Nishant K., additional, Bashirova, Arman, additional, Tano-Menka, Rhoda, additional, Senjobe, Fernando, additional, Waring, Michael T., additional, Piechocka-Trocha, Alicja, additional, Garcia-Beltran, Wilfredo F., additional, Iafrate, A. John, additional, Naranbhai, Vivek, additional, Carrington, Mary, additional, Walker, Bruce D., additional, and Gaiha, Gaurav D., additional

Published
2021
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3. HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV

Author

Kaseke, Clarety, primary, Park, Ryan J., additional, Singh, Nishant K., additional, Koundakjian, Dylan, additional, Bashirova, Arman, additional, Garcia Beltran, Wilfredo F., additional, Takou Mbah, Overbeck C., additional, Ma, Jiaqi, additional, Senjobe, Fernando, additional, Urbach, Jonathan M., additional, Nathan, Anusha, additional, Rossin, Elizabeth J., additional, Tano-Menka, Rhoda, additional, Khatri, Ashok, additional, Piechocka-Trocha, Alicja, additional, Waring, Michael T., additional, Birnbaum, Michael E., additional, Baker, Brian M., additional, Carrington, Mary, additional, Walker, Bruce D., additional, and Gaiha, Gaurav D., additional

Published
2021
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4. HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV

Author

Koch Institute for Integrative Cancer Research at MIT, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Massachusetts Institute of Technology. Department of Biology, Kaseke, Clarety, Park, Ryan J, Singh, Nishant K, Koundakjian, Dylan, Bashirova, Arman, Garcia Beltran, Wilfredo F, Takou Mbah, Overbeck C, Ma, Jiaqi, Senjobe, Fernando, Urbach, Jonathan M, Nathan, Anusha, Rossin, Elizabeth J, Tano-Menka, Rhoda, Khatri, Ashok, Piechocka-Trocha, Alicja, Waring, Michael T, Birnbaum, Michael E, Baker, Brian M, Carrington, Mary, Walker, Bruce D, Gaiha, Gaurav D, Koch Institute for Integrative Cancer Research at MIT, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Massachusetts Institute of Technology. Department of Biology, Kaseke, Clarety, Park, Ryan J, Singh, Nishant K, Koundakjian, Dylan, Bashirova, Arman, Garcia Beltran, Wilfredo F, Takou Mbah, Overbeck C, Ma, Jiaqi, Senjobe, Fernando, Urbach, Jonathan M, Nathan, Anusha, Rossin, Elizabeth J, Tano-Menka, Rhoda, Khatri, Ashok, Piechocka-Trocha, Alicja, Waring, Michael T, Birnbaum, Michael E, Baker, Brian M, Carrington, Mary, Walker, Bruce D, and Gaiha, Gaurav D

Abstract

Defining factors that govern CD8+ T cell immunodominance is critical for the rational design of vaccines for viral pathogens. Here, we assess the contribution of human leukocyte antigen (HLA) class-I-peptide stability for 186 optimal HIV epitopes across 18 HLA alleles using transporter associated with antigen processing (TAP)-deficient mono-allelic HLA-expressing cell lines. We find that immunodominant HIV epitopes increase surface stabilization of HLA class-I molecules in comparison to subdominant epitopes. HLA class-I-peptide stability is also strongly correlated with overall immunodominance hierarchies, particularly for epitopes from high-abundance proteins (e.g., Gag). Moreover, HLA alleles associated with HIV protection are preferentially stabilized by epitopes derived from topologically important viral regions at a greater frequency than neutral and risk alleles. These findings indicate that relative stabilization of HLA class-I is a key factor for CD8+ T cell epitope immunodominance hierarchies, with implications for HIV control and the design of T-cell-based vaccines.

Published
2021

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