156 results on '"Selkoe, Dennis J"'
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2. The Parkinson-Associated Toxin Paraquat Shifts Physiological α-Synuclein Tetramers toward Monomers That Can Be Calpain-Truncated and Form Oligomers
3. Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer’s disease
4. Aβ oligomers from human brain impair mossy fiber LTP in CA3 of hippocampus, but activating cAMP-PKA and cGMP-PKG prevents this
5. Generation and application of semi-synthetic p-Tau181 calibrator for immunoassay calibration
6. Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
7. Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease
8. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides
9. Potential human transmission of amyloid β pathology: surveillance and risks
10. Amyloid β-protein and beyond: the path forward in Alzheimer’s disease
11. Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways
12. A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family
13. Altered Conformation of α-Synuclein Drives Malfunction of Synaptic Vesicles in a Model of Parkinson's Disease
14. Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease
15. Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region
16. Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability
17. Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory
18. Prediction of cognition in Parkinson's disease with a clinical–genetic score: a longitudinal analysis of nine cohorts
19. Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols
20. Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones
21. Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs
22. Editorial overview: Neurobiology of disease
23. Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance
24. Systematic analysis of time-dependent neural effects of soluble amyloid β oligomers in culture and in vivo: Prevention by scyllo-inositol
25. Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate
26. Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction
27. γ-Secretase: A Horseshoe Structure Brings Good Luck
28. Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes
29. SnapShot: Pathobiology of Alzheimer's Disease
30. Environmental Novelty Activates β2-Adrenergic Signaling to Prevent the Impairment of Hippocampal LTP by Aβ Oligomers
31. Recommendations for the incorporation of biomarkers into Alzheimer clinical trials: an overview
32. Aβ oligomers inhibit synapse remodelling necessary for memory consolidation
33. Giving Alzheimer's the Old One-Two
34. Aph-1 Associates Directly with Full-length and C-terminal Fragments of γ-Secretase Substrates
35. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life
36. Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia
37. Toward Structural Elucidation of the γ-Secretase Complex
38. γ-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons
39. Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution
40. Aggregation and catabolism of disease-associated intra-Aβ mutations: reduced proteolysis of AβA21G by neprilysin
41. Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
42. Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment
43. Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes
44. LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-β peptide in a blood–brain barrier in vitro model
45. Polyunsaturated Fatty Acids Induce α-Synuclein-Related Pathogenic Changes in Neuronal Cells
46. Soluble Aβ Inhibits Specific Signal Transduction Cascades Common to the Insulin Receptor Pathway
47. Presenilin: Running with Scissors in the Membrane
48. Loss of Neprilysin Function Promotes Amyloid Plaque Formation and Causes Cerebral Amyloid Angiopathy
49. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid β-protein metabolism in mouse models of Alzheimer disease
50. Decreased Catalytic Activity of the Insulin-degrading Enzyme in Chromosome 10-Linked Alzheimer Disease Families
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