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198 results on '"Schrier, Robert W."'

1. Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials

Author

Heerspink, Hiddo J L, primary, Greene, Tom, additional, Tighiouart, Hocine, additional, Gansevoort, Ron T, additional, Coresh, Josef, additional, Simon, Andrew L, additional, Chan, Tak Mao, additional, Hou, Fan Fan, additional, Lewis, Julia B, additional, Locatelli, Francesco, additional, Praga, Manuel, additional, Schena, Francesco Paolo, additional, Levey, Andrew S, additional, Inker, Lesley A, additional, Sevillano, Angel, additional, Kamper, Anne-Lise, additional, van Zuilen, Arjan D., additional, Brenner, Barry M., additional, Maes, Bart, additional, Ihle, Benno U., additional, Barret, Brendan, additional, Leung, CB, additional, Szeto, CC, additional, Fitzner, Christina, additional, Wanner, Christoph, additional, Pozzi, Claudio, additional, Montagnino, Claudio Ponticelli, additional, Xie, Di, additional, de Zeeuw, Dick, additional, Lewis, Edmund, additional, Verde, Eduardo, additional, Gutierrez, Eduardo, additional, Imai, Enyu, additional, Caravaca, Fernando, additional, Fervenza, Fernando C., additional, Kobayashi, Fumiaki, additional, Moroni, Gabriella, additional, Becker, Gavin J., additional, Beck, Gerald J., additional, Appel, Gerald B., additional, Frisch, Gershon, additional, van Essen, GG, additional, Maschio, Giuseppe, additional, Remuzzi, Giuseppe, additional, Montogrino, Giuseppe, additional, Parving, Hans-Henrik, additional, Heerspink, Hiddo J.L., additional, Makino, Hirofumi, additional, Jehan, Imitiaz, additional, Wetzels, Jack F.M., additional, Donadio, James, additional, Dwyer, Jamie, additional, van den Brand, Jan, additional, Kusek, John, additional, Lachin, John M., additional, Luño, Jose, additional, Lewis, Julia B., additional, Floege, Jürgen, additional, Abebe, Kaleab Z., additional, Chow, KM, additional, Hunsicker, Lawrence G., additional, del Vecchio, Lucia, additional, Carlo, Manno, additional, Goicoechea, Marian, additional, von Eynatten, Maximilian, additional, Poulter, Neil, additional, Chaturvedi, Nish, additional, Passerini, Patrizia, additional, de Jong, Paul E., additional, Blankestijn, Peter J., additional, Li, Philip, additional, Ruggenenti, Piero, additional, Zucchelli, Pietro, additional, Kincaid-Smith, Priscilla S., additional, Hilgers, Ralf-Dieter, additional, Estacio, Raymond O., additional, Rohde, Richard D., additional, Katafuchi, Ritsuko, additional, Toto, Robert D., additional, Schrier, Robert W., additional, Rodby, Roger A., additional, Perrone, Ronald D., additional, Ito, Sadayoshi, additional, Klahr, Saulo, additional, Andrulli, Simeone, additional, Strandgaard, Svend, additional, Hannedouche, Thierry P., additional, Rauen, Thomas, additional, Verdalles, Ursula, additional, Perkovic, Vlado, additional, and Keane, William, additional

Published
2019
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2. The Value of Genetic Testing in Polycystic Kidney Diseases Illustrated by a Family With PKD2 and COL4A1 Mutations

Author

Cornec-Le Gall, Emilie, primary, Chebib, Fouad T., additional, Madsen, Charles D., additional, Senum, Sarah R., additional, Heyer, Christina M., additional, Lanpher, Brendan C., additional, Patterson, Marc C., additional, Albright, Robert C., additional, Yu, Alan S., additional, Torres, Vicente E., additional, Harris, Peter C., additional, Abebe, Kaleab Z., additional, Bae, Kyongtae T., additional, Schrier, Robert W., additional, Chapman, Arlene B., additional, Perrone, Ronald D., additional, Braun, William E., additional, and Steinman, Theodore I., additional

Published
2018
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3. Patterns of Kidney Function Decline in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis From the HALT-PKD Trials

Author

Brosnahan, Godela M., primary, Abebe, Kaleab Z., additional, Moore, Charity G., additional, Rahbari-Oskoui, Frederic F., additional, Bae, Kyongtae T., additional, Grantham, Jared J., additional, Schrier, Robert W., additional, Braun, William E., additional, Chapman, Arlene B., additional, Flessner, Michael F., additional, Harris, Peter C., additional, Hogan, Marie C., additional, Perrone, Ronald D., additional, Miskulin, Dana C., additional, Steinman, Theodore I., additional, Torres, Vicente E., additional, Steinman, Theodore, additional, Wei, Jesse, additional, Czarnecki, Peter, additional, Pedrosa, Ivan, additional, Braun, William, additional, Nurko, Saul, additional, Remer, Erick, additional, Chapman, Arlene, additional, Martin, Diego, additional, Rahbari-Oskoui, Frederic, additional, Mittal, Pardeep, additional, Torres, Vicente, additional, El-Zoghby, Ziad, additional, Harris, Peter, additional, Glockner, James, additional, King, Bernard, additional, Perrone, Ronald, additional, Halin, Neil, additional, Miskulin, Dana, additional, Schrier, Robert, additional, Brosnahan, Godela, additional, Gitomer, Berenice, additional, Kelleher, Cass, additional, Masoumi, Amirali, additional, Patel, Nayana, additional, Winklhofer, Franz, additional, Grantham, Jared, additional, Yu, Alan, additional, Wang, Connie, additional, Wetzel, Louis, additional, Bost, James E., additional, Bae, Kyongtae, additional, Miller, J. Philip, additional, Thompson, Paul A., additional, Briggs, Josephine, additional, Flessner, Michael, additional, Meyers, Catherine M., additional, Star, Robert, additional, Shayman, James, additional, Henrich, William, additional, Greene, Tom, additional, Leonard, Mary, additional, McCullough, Peter, additional, Moe, Sharon, additional, Rocco, Michael, additional, and Wendler, David, additional

Published
2018
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4. Longitudinal Assessment of Left Ventricular Mass in Autosomal Dominant Polycystic Kidney Disease

Author

Dad, Taimur, primary, Abebe, Kaleab Z., additional, Bae, K. Ty, additional, Comer, Diane, additional, Torres, Vicente E., additional, Czarnecki, Peter G., additional, Schrier, Robert W., additional, Steinman, Theodore I., additional, Moore, Charity G., additional, Chapman, Arlene B., additional, Kaya, Diana, additional, Tao, Cheng, additional, Braun, William E., additional, Winklhofer, Franz T., additional, Brosnahan, Godela, additional, Hogan, Marie C., additional, Miskulin, Dana C., additional, Rahbari Oskoui, Frederic, additional, Flessner, Michael F., additional, and Perrone, Ronald D., additional

Published
2018
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5. ADPKD Progression in Patients With No Apparent Family History and No Mutation Detected by Sanger Sequencing

Author

Braun, William E., primary, Abebe, Kaleab Z., additional, Brosnahan, Godela, additional, Patterson, Charity G., additional, Chapman, Arlene B., additional, Harris, Peter C., additional, Hogan, Marie C., additional, Perrone, Ronald D., additional, Torres, Vicente E., additional, Miskulin, Dana C., additional, Steinman, Theodore I., additional, Winklhofer, Franz T., additional, Rahbari-Oskoui, Frederic F., additional, Czarnecki, Peter G., additional, Bae, Kyongtae T., additional, Grantham, Jared J., additional, Flessner, Michael F., additional, and Schrier, Robert W., additional

Published
2018
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6. Dietary salt restriction is beneficial to the management of autosomal dominant polycystic kidney disease

Author

Torres, Vicente E., primary, Abebe, Kaleab Z., additional, Schrier, Robert W., additional, Perrone, Ronald D., additional, Chapman, Arlene B., additional, Yu, Alan S., additional, Braun, William E., additional, Steinman, Theodore I., additional, Brosnahan, Godela, additional, Hogan, Marie C., additional, Rahbari, Frederic F., additional, Grantham, Jared J., additional, Bae, Kyongtae T., additional, Moore, Charity G., additional, and Flessner, Michael F., additional

Published
2017
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8. Autosomal-dominant polycystic kidney disease in infancy and childhood: Progression and outcome11See Editorial by Steinman, p. 2398

Author

Shamshirsaz, Abdollah, Bekheirnia, Reza M., Kamgar, Mohammad, Johnson, Ann. M., Mcfann, K., Cadnapaphornchai, Melissa, Haghighi, N.N., and Schrier, Robert W.

Subjects
disease progression, Nephrology, urologic and male genital diseases, ADPKD, childhood
Abstract

Autosomal-dominant polycystic kidney disease in infancy and childhood: Progression and outcome.BackgroundThe natural history of autosomal-dominant polycystic kidney disease (ADPKD) has not been well described in children and infants.MethodsThe present study analyzed the characteristics of 46 ADPKD children diagnosed before 18 months of life (VEO) and 153 children diagnosed between 18 months of age and 18 years of age (non-VEO).ResultsVEO children had more cysts and larger renal volumes than non-VEO children when adjusted for age. In both VEO and non-VEO children, the presence of signs or symptoms at the time of diagnosis as well as the presence of hematuria or proteinuria at the study visit were associated with larger renal volumes. Children diagnosed early (VEO) or diagnosed due to signs or symptoms were also more likely to have high blood pressure. Two VEO children and no non-VEO children reached end-stage renal disease during follow-up.ConclusionIn contrast to many published case reports suggesting the occurrence of early end-stage renal disease in VEO children, the results of the present study were much more optimistic. Over 90% of the VEO children maintained preserved renal function well into childhood.

Published
2005
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9. Modifier genes play a significant role in the phenotypic expression of PKD111See Editorial by Pei, p. 1630

Author

Fain, Pamela R., McFann, Kimberly K., Taylor, Matthew R.G., Tison, Maryellyn, Johnson, Ann M., Reed, Berenice, and Schrier, Robert W.

Subjects
genetic background, polycystic kidney disease, modifier genes, Nephrology, PKD1 mutations, urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract

Modifier genes play a significant role in the phenotypic expression of PKD1.BackgroundPolycystic kidney disease type 1 (PKD1) is characterized by extreme variation in the severity and progression of renal and extrarenal phenotypes. There are significant familial phenotype differences; but it is not clear if this is due to differences in PKD1 mutations, differences in genetic background, or both.MethodsA total of 315 affected relatives (83 PKD1 families) without end-stage renal disease (ESRD) were evaluated for disease markers, including renal volume, creatinine clearance, proteinuria, liver cysts, and hypertension. Of these patients, 19% progressed to ESRD within 1 to 10 years after the initial examination. Nested analysis of variance was used to investigate interfamilial and intrafamilial differences in these phenotypes. Heritability analyses were used to estimate the effect of the genetic background on phenotypic variability. The age of onset of ESRD was also analyzed with an additional 389 family members from the same PKD1 families without clinical evaluation but with data on age of onset of ESRD (or age without ESRD).ResultsThere were significant phenotype differences between patients with the same mutation and different genetic backgrounds. The phenotypic variation between patients with different mutations and different genetic backgrounds was not significantly greater than the variation between patients with the same mutation and different genetic backgrounds. However, when the 389 family members were included, both the mutation and modifier genes had significant effects on the age of onset of ESRD. Inherited differences in genetic background were estimated to account for 18% to 59% of the phenotypic variability in PKD1 disease markers in patients prior to ESRD and in the subsequent progression to ESRD (43% heritability) in the 315 patients who were clinically evaluated.ConclusionModifier loci in the genetic background are important factors in inter- and intrafamilial variability in the phenotypic expression of PKD1. The extreme intrafamilial phenotype differences are consistent with the hypothesis that one or a few modifier genes have a major effect on the progression and severity of PKD1.

Published
2005
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10. Therapeutic Area Data Standards for Autosomal Dominant Polycystic Kidney Disease: A Report From the Polycystic Kidney Disease Outcomes Consortium (PKDOC)

Author

Perrone, Ronald D., primary, Neville, Jon, additional, Chapman, Arlene B., additional, Gitomer, Berenice Y., additional, Miskulin, Dana C., additional, Torres, Vicente E., additional, Czerwiec, Frank S., additional, Dennis, Eslie, additional, Kisler, Bron, additional, Kopko, Steve, additional, Krasa, Holly B., additional, LeRoy, Elizabeth, additional, Castedo, Juliana, additional, Schrier, Robert W., additional, and Broadbent, Steve, additional

Published
2015
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11. Closeout of the HALT-PKD trials

Author

Moore, Charity G., primary, Spillane, Susan, additional, Simon, Gertrude, additional, Maxwell, Barbara, additional, Rahbari-Oskoui, Frederic F., additional, Braun, William E., additional, Chapman, Arlene B., additional, Schrier, Robert W., additional, Torres, Vicente E., additional, Perrone, Ronald D., additional, Steinman, Theodore I., additional, Brosnahan, Godela, additional, Czarnecki, Peter G., additional, Harris, Peter C., additional, Miskulin, Dana C., additional, Flessner, Michael F., additional, Bae, K. Ty, additional, Abebe, Kaleab Z., additional, and Hogan, Marie C., additional

Published
2015
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12. Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Chapman, Arlene B., primary, Devuyst, Olivier, additional, Eckardt, Kai-Uwe, additional, Gansevoort, Ron T., additional, Harris, Tess, additional, Horie, Shigeo, additional, Kasiske, Bertram L., additional, Odland, Dwight, additional, Pei, York, additional, Perrone, Ronald D., additional, Pirson, Yves, additional, Schrier, Robert W., additional, Torra, Roser, additional, Torres, Vicente E., additional, Watnick, Terry, additional, and Wheeler, David C., additional

Published
2015
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13. Liver Involvement in Early Autosomal-Dominant Polycystic Kidney Disease

Author

Hogan, Marie C., primary, Abebe, Kaleab, additional, Torres, Vicente E., additional, Chapman, Arlene B., additional, Bae, Kyongtae T., additional, Tao, Cheng, additional, Sun, Hongliang, additional, Perrone, Ronald D., additional, Steinman, Theodore I., additional, Braun, William, additional, Winklhofer, Franz T., additional, Miskulin, Dana C., additional, Rahbari-Oskoui, Frederic, additional, Brosnahan, Godela, additional, Masoumi, Amirali, additional, Karpov, Irina O., additional, Spillane, Susan, additional, Flessner, Michael, additional, Moore, Charity G., additional, and Schrier, Robert W., additional

Published
2015
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14. The Reply

Author

Verbalis, Joseph G., primary, Goldsmith, Steven R., additional, Greenberg, Arthur, additional, Korzelius, Cynthia, additional, Schrier, Robert W., additional, Sterns, Richard H., additional, and Thompson, Chris J., additional

Published
2014
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15. Bioactive lipid mediators in polycystic kidney disease

Author

Klawitter, Jelena, primary, Klawitter, Jost, additional, McFann, Kim, additional, Pennington, Alexander T., additional, Abebe, Kaleab Z., additional, Brosnahan, Godela, additional, Cadnapaphornchai, Melissa A., additional, Chonchol, Michel, additional, Gitomer, Berenice, additional, Christians, Uwe, additional, and Schrier, Robert W., additional

Published
2014
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16. Health-Related Quality of Life in Patients With Autosomal Dominant Polycystic Kidney Disease and CKD Stages 1-4: A Cross-sectional Study

Author

Miskulin, Dana C., primary, Abebe, Kaleab Z., additional, Chapman, Arlene B., additional, Perrone, Ronald D., additional, Steinman, Theodore I., additional, Torres, Vicente E., additional, Bae, K. Ty, additional, Braun, William, additional, Winklhofer, Franz T., additional, Hogan, Marie C., additional, Rahbari-Oskoui, Fred, additional, Moore, Charity G., additional, Flessner, Michael F., additional, and Schrier, Robert W., additional

Published
2014
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20. Kidney failure: aims for the next 10 years and barriers to success

Author

Remuzzi, Giuseppe, primary, Benigni, Ariela, additional, Finkelstein, Fredric O, additional, Grunfeld, Jean-Pierre, additional, Joly, Dominique, additional, Katz, Ivor, additional, Liu, Zhi-Hong, additional, Miyata, Toshio, additional, Perico, Norberto, additional, Rodriguez-Iturbe, Bernardo, additional, Antiga, Luca, additional, Schaefer, Franz, additional, Schieppati, Arrigo, additional, Schrier, Robert W, additional, and Tonelli, Marcello, additional

Published
2013
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22. Analysis of baseline parameters in the HALT polycystic kidney disease trials

Author

Torres, Vicente E., primary, Chapman, Arlene B., additional, Perrone, Ronald D., additional, Ty Bae, K., additional, Abebe, Kaleab Z., additional, Bost, James E., additional, Miskulin, Dana C., additional, Steinman, Theodore I., additional, Braun, William E., additional, Winklhofer, Franz T., additional, Hogan, Marie C., additional, Oskoui, Frederic R., additional, Kelleher, Cass, additional, Masoumi, Amirali, additional, Glockner, James, additional, Halin, Neil J., additional, Martin, Diego R., additional, Remer, Erick, additional, Patel, Nayana, additional, Pedrosa, Ivan, additional, Wetzel, Louis H., additional, Thompson, Paul A., additional, Miller, J Philip, additional, Meyers, Catherine M., additional, and Schrier, Robert W., additional

Published
2012
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