1. Arsenic trioxide and thalidomide combination produces multi-lineage hematological responses in myelodysplastic syndromes patients, particularly in those with high pre-therapy EVI1 expression
- Author
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J.Alejandro Gallegos, Hassan Pervaiz, Poluru L. Reddy, Nusrat Ijaz Chaudary, Sefer Gezer, Azra Raza, Silvia Buonamici, Jack W. Singer, Naomi Galili, Giuseppina Nucifora, Donglan Li, Parameswaran Venugopal, Muhammad Mumtaz, M Imran Alvi, Mehnaz Imran, Laurie Lisak, Sarah Tahir, and Anna Candoni
- Subjects
Male ,Oncology ,Cancer Research ,Drug resistance ,Arsenicals ,chemistry.chemical_compound ,Arsenic Trioxide ,Risk Factors ,Talidomide ,Neoplasm ,Agiogenesis ,Aoptosis ,Asenic trioxide ,EVI1 ,Melodysplastic syndromes ,Arsenic trioxide ,Reverse Transcriptase Polymerase Chain Reaction ,Oxides ,Zinc Fingers ,Hematology ,Middle Aged ,Thalidomide ,DNA-Binding Proteins ,medicine.anatomical_structure ,Drug Therapy, Combination ,Female ,Immunosuppressive Agents ,medicine.drug ,medicine.medical_specialty ,Antineoplastic Agents ,Spleen ,Pharmacotherapy ,Internal medicine ,Proto-Oncogenes ,medicine ,Humans ,Cell Lineage ,Aged ,business.industry ,Myelodysplastic syndromes ,medicine.disease ,MDS1 and EVI1 Complex Locus Protein ,In vitro ,chemistry ,Drug Resistance, Neoplasm ,Myelodysplastic Syndromes ,Immunology ,business ,Transcription Factors - Abstract
Twenty-eight myelodysplastic syndromes (MDS) patients were treated with arsenic trioxide (ATO) and thalidomide. Seven patients responded including one complete hematologic and cytogenetic response and one with regression in spleen size. Two trilineage responses were seen in patients with inv(3)(q21q26.2). Three of five patients who had high pre-therapy EVI1 levels showed unexpectedly good responses while two died early in the first cycle. In vitro studies using 32Dcl3 cells forced to express EVI1 confirmed increased sensitivity of these cells to ATO. Both low/high risk MDS may benefit significantly from therapy with ATO/thalidomide, and those with high pre-therapy EVI1 expression may be uniquely sensitive.
- Published
- 2004
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