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4. B-PO03-143 LOCALIZED PULMONARY VEIN STRESS INDUCED BY POSTURAL CHANGE IN HEALTHY HUMANS

Author

Ruben Coronel, Dounia El-Hamrani, Jérôme Naulin, Lisa A. Gottlieb, Jerome Lamy, Bruno Quesson, Lorena Sanchez Y Blanco, Hubert Cochet, Lukas R.C. Dekker, and Nadjia Kachenoura

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), Internal medicine, Stress induced, Cardiology, medicine, Cardiology and Cardiovascular Medicine, business, Pulmonary vein
Published
2021

20. 0240: Percutaneous left atrial appendage closure for stroke patients with nonvalvular atrial fibrillation and contraindication for oral anticoagulation

Author

Nadir Tafer, François Rouanet, Xavier Iriart, Matilde Poli, Pauline Renou, Stephanie Nicot, Igor Sibon, Sabrina Debruxelle, Jean-Bernard Selly, Corinne Delfanne, Jean-Benoit Thambo, Zakaria Jalal, and Lorena Sanchez Y Blanco

Subjects
Intracerebral hemorrhage, medicine.medical_specialty, Percutaneous, business.industry, Warfarin, Atrial fibrillation, medicine.disease, Pericardial effusion, Surgery, Internal medicine, medicine, Cardiology, cardiovascular diseases, Cerebral amyloid angiopathy, Cardiology and Cardiovascular Medicine, business, Contraindication, Stroke, medicine.drug
Abstract

Background The PROTECT AF trial previously demonstrated that left atrial appendage closure (LAAC) was non inferior to warfarin in patients with nonvalvular atrial fibrillation (NVAF). However, this trial included patients eligible for anticoagulation therapy who received warfarin for 6 weeks after device implantation. The purpose of the present study was to assess the safety and efficacy of LAAC for stroke patients with NVAF and contraindication for anticoagulation. Methods Consecutive patients with a previous ischemic or hemorrhagic stroke, NVAF and contraindication for anticoagulation underwent LAAC with the Amplatzer Cardiac Plug device between July 2010 and July 2013 in a French university hospital. Follow-up included clinical evaluation at 3 and 12 months, and a cardiac computed tomography (CT) at 3 months. Single-antiplatelet therapy was prescribed after the procedure for a minimum of 3 months and stopped if the control cardiac CT demonstrated complete LAA exclusion. RESULTS: 26 patients (age 73±8 years) were included. The mean CHA2DS2-VASc and HAS-BLED scores were 4±1.5 and 4±0.8, respectively. The main contraindications for anticoagulation were: intracerebral hemorrhage while receiving anticoagulation (62%), ischemic stroke with large hemorrhagic transformation (15%) and probable cerebral amyloid angiopathy (8%). The procedure was successful in 100%. Procedure-related complications were serious pericardial effusion (3.8%) and femoral bleeding (7.7%). During a mean follow-up of 8.6 (3-16) months, ischemic stroke occurred in 2 patients (7.7%), after antiplatelet therapy was stopped for one of them. One patient died of an intracranial hemorrhage. Conclusion LAAC followed by a single antiplatelet therapy could be a reasonable alternative for stroke patients with NVAF and contraindication for anticoagulation. Lifelong rather than short-term single antiplatelet therapy should be prescribed after the procedure for patients at high cardio-vascular risk.

Published
2015

21. Multicenter study for the detection of antibodies against influenza A virus

Author

Manjarrez, M.E., primary, Castañeda, I., additional, Herrera, N., additional, Sanchez, Y., additional, Romero, M., additional, Maravilla, P., additional, Fernez, A.M., additional, Tirado, R., additional, Contreras, C., additional, Sarmiento, R.E., additional, Morales, C., additional, Reyes, S., additional, Villaba, J., additional, Valle, L., additional, Valencia, E., additional, Cabello, C., additional, Palma-Cortes, G., additional, Romo, J., additional, Higuera, A., additional, Rosete, D., additional, Mejia, F., additional, Paramo, I., additional, and Sanchez, S., additional

Published
2012
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