1. Coenzyme A fuels T cell anti-tumor immunity
- Author
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Michael St. Paul, Samuel D. Saibil, SeongJun Han, Kavita Israni-Winger, Scott C. Lien, Rob C. Laister, Azin Sayad, Susanne Penny, Rodabe N. Amaria, Lauren E. Haydu, Carlos R. Garcia-Batres, Meghan Kates, David T. Mulder, Céline Robert-Tissot, Matthew J. Gold, Charles W. Tran, Alisha R. Elford, Linh T. Nguyen, Trevor J. Pugh, Devanand M. Pinto, Jennifer A. Wargo, and Pamela S. Ohashi
- Subjects
Mice ,T-Lymphocyte Subsets ,Physiology ,Animals ,Humans ,Cell Differentiation ,Coenzyme A ,Cell Biology ,CD8-Positive T-Lymphocytes ,Lymphocyte Activation ,Molecular Biology - Abstract
Metabolic programming is intricately linked to the anti-tumor properties of T cells. To study the metabolic pathways associated with increased anti-tumor T cell function, we utilized a metabolomics approach to characterize three different CD8
- Published
- 2021