Search

Your search keyword '"Saeideh Nozohouri"' showing total 3 results
Start Over Author "Saeideh Nozohouri" Publisher elsevier bv
3 results on '"Saeideh Nozohouri"'

1. Studies on diketopiperazine and dipeptide analogs as opioid receptor ligands

Author

Siavash Shahbazi Nia, Mohammad Anwar Hossain, Guangchen Ji, Sravan K. Jonnalagadda, Samuel Obeng, Md Ashrafur Rahman, Ali Ehsan Sifat, Saeideh Nozohouri, Collin Blackwell, Dhavalkumar Patel, Jon Thompson, Scott Runyon, Takato Hiranita, Christopher R. McCurdy, Lance McMahon, Thomas J. Abbruscato, Paul C. Trippier, Volker Neugebauer, and Nadezhda A. German

Subjects
Pharmacology, Organic Chemistry, Drug Discovery, General Medicine
Published
2023

2. Novel approaches for the delivery of therapeutics in ischemic stroke

Author

Thomas J. Abbruscato, Ali Ehsan Sifat, Bhuvaneshwar Vaidya, and Saeideh Nozohouri

Subjects
0301 basic medicine, medicine.medical_specialty, Ischemic brain injury, Article, Brain Ischemia, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, Neuroprotective Drugs, Internal medicine, Drug Discovery, medicine, Animals, Humans, Tissue Distribution, Drug Approval, Stroke, Ischemic Stroke, Thrombectomy, Pharmacology, business.industry, Extramural, medicine.disease, Neuroprotective Agents, 030104 developmental biology, Blood-Brain Barrier, 030220 oncology & carcinogenesis, Ischemic stroke, Cardiology, business
Abstract

Here, we review novel approaches to deliver neuroprotective drugs to salvageable penumbral brain areas of stroke injury with the goals of offsetting ischemic brain injury and enhancing recovery.

Published
2020

3. Repurposing metformin to treat age-related neurodegenerative disorders and ischemic stroke

Author

Thomas J. Abbruscato, Sejal Sharma, Bhuvaneshwar Vaidya, and Saeideh Nozohouri

Subjects
0301 basic medicine, Drug, Aging, media_common.quotation_subject, Central nervous system, Bioinformatics, 030226 pharmacology & pharmacy, Article, General Biochemistry, Genetics and Molecular Biology, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, medicine, Animals, Humans, Hypoglycemic Agents, General Pharmacology, Toxicology and Pharmaceutics, Risk factor, Repurposing, media_common, business.industry, Drug Repositioning, Cerebrovascular disorder, Neurodegenerative Diseases, General Medicine, medicine.disease, Metformin, Stroke, 030104 developmental biology, medicine.anatomical_structure, Ischemic stroke, business, medicine.drug
Abstract

Aging is a risk factor for major central nervous system (CNS) disorders. More specifically, aging can be inked to neurodegenerative diseases (NDs) because of its deteriorating impact on neurovascular unit (NVU). Metformin, a first line FDA-approved anti-diabetic drug, has gained increasing interest among researchers for its role in improving aging-related neurodegenerative disorders. Additionally, numerous studies have illustrated metformin’s role in ischemic stroke, a cerebrovascular disorder in which the NVU becomes dysfunctional which can lead to permanent life-threatening disabilities. Considering metformin’s beneficial preclinical actions on various disorders, and the drug’s role in alleviating severity of these conditions through involvement in commonly characterized cellular pathways, we discuss the potential of metformin as a suitable drug candidate for repurposing in CNS disorders.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results