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55 results on '"SHU, J."'

2. P004 Pyrotinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer : a multicenter, open-label, phase 2 trial

Author

Cao, F., primary, Ma, Z., additional, Hu, G., additional, Zhu, X., additional, Li, S., additional, Chen, S., additional, Chen, B., additional, Li, Z., additional, Wu, W., additional, Ji, X., additional, Shu, J., additional, Tao, D., additional, Hu, X., additional, Zheng, M., additional, Wang, O., additional, Feng, Q., additional, Hao, J., additional, and Li, X., additional

Published
2023
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7. Mucosal vaccines: Strategies and challenges

Author

Hua-Ji Qiu, Yuan Sun, Hongyu Cui, Miao Li, Shu J. Zhu, and Yi Wang

Subjects
Immune defense, B-Lymphocytes, Vaccines, Mucous Membrane, Mucosal Immune Responses, business.industry, T-Lymphocytes, First line, Vaccination, Immunology, Dendritic Cells, Mucosal vaccine, Immune system, Adjuvants, Immunologic, Immunization, Humans, Immunology and Allergy, Medicine, business, Immunity, Mucosal, Mucosal immunity
Abstract

Mucosal immunization has potential benefits over conventional parenteral immunization, eliciting immune defense in both mucosal and systemic tissue for protecting from pathogen invasion at mucosal surfaces. To provide a first line of protection at these entry ports, mucosal vaccines have been developed and hold a significant promise for reducing the burden of infectious diseases. However, until very recently, only limited mucosal vaccines are available. This review summarizes recent advances in selected aspects regarding mucosal vaccination, including appropriate administration routes, reasonable formulations, antigen-sampling and immune responses of mucosal immunity, and the strategies used to improve mucosal vaccine efficacy. Finally, the challenges of developing successful mucosal vaccines and the potential solutions are discussed.

Published
2020
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8. Multiscale similarity ensemble framework for remaining useful life prediction

Author

Xia, T., Shu, J., Xu, Y., Zheng, Y., Wang, D., and Publica

Subjects
Applied Mathematics, Electrical and Electronic Engineering, Condensed Matter Physics, Instrumentation
Abstract

Accurate prediction of remaining useful life (RUL) is crucially important to perform prognostics and health management. A new similarity-based autoencoder multiscale ensemble (Similarity-based AE MSEN) methodology is proposed in this paper to improve RUL prediction accuracy and characterize RUL prediction uncertainty by considering the differences in equipment degradation rates, monitoring data lengths and fault modes. Firstly, multiscale sliding window sets are designed to divide health index (HI) curves generated by autoencoder into multiscale HI segments, which are used to measure the similarities between training and testing units. Then, multiscale prediction results obtained from similar training units are fused by kernel density estimation to fit a RUL distribution and then provide uncertainty for RUL prediction. The proposed multiscale ensemble strategy can overcome accuracy limitation caused by a fixed time scale and enhance generalization ability. Analysis of e xperimental datasets shows that the proposed multiscale method achieves state-of -the-art prediction performance.

Published
2022
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9. Antimicrobial polymeric nanoparticles

Author

Cyrille Boyer, Greg G. Qiao, Shu J. Lam, and Edgar H. H. Wong

Subjects
Materials science, Polymers and Plastics, Organic Chemistry, Biofilm, Nanotechnology, 02 engineering and technology, Surfaces and Interfaces, Superparamagnetic nanoparticles, 010402 general chemistry, 021001 nanoscience & nanotechnology, Antimicrobial, Polymeric nanoparticles, 01 natural sciences, 0104 chemical sciences, 3. Good health, Materials Chemistry, Ceramics and Composites, 0210 nano-technology
Abstract

Currently, infections caused by multidrug-resistant bacteria have reached critical levels. Thus, various approaches are being explored for the development of new and effective antimicrobial agents, one of which lies in the form of polymeric nanoparticles. Driven by the significant advancements in controlled polymerization techniques over the last few decades, antimicrobial polymeric nanoparticles have recently been investigated as potential new antibiotics to combat the rise of infectious diseases. This review aims at presenting an overview of the history and state-of-the-art of antimicrobial polymeric nanoparticles including their available structure-activity relationship, and highlights the impact of controlled polymerization has on the antimicrobial field as well as some of the key challenges that still need to be overcome for potential clinical applications. Herein, potential new developments are suggested as well.

Published
2018
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15. Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis

Author

Wei, Q., primary, Ye, Z., additional, Zhong, X., additional, Li, L., additional, Wang, C., additional, Myers, R.E., additional, Palazzo, J.P., additional, Fortuna, D., additional, Yan, A., additional, Waldman, S.A., additional, Chen, X., additional, Posey, J.A., additional, Basu-Mallick, A., additional, Jiang, B.H., additional, Hou, L., additional, Shu, J., additional, Sun, Y., additional, Xing, J., additional, Li, B., additional, and Yang, H., additional

Published
2017
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16. Evolution of the prohormone convertases: identification of a homologue of PC6 in the protochordate amphioxus

Author

Anthony A. Oliva, Shu J. Chan, and Donald F. Steiner

Subjects
Gene isoform, DNA, Complementary, animal structures, Molecular Sequence Data, Biophysics, Proprotein convertase 2, Biology, Biochemistry, Evolution, Molecular, Chordata, Nonvertebrate, Structural Biology, Animals, Aspartic Acid Endopeptidases, Protein Isoforms, Amino Acid Sequence, Subtilisins, Cloning, Molecular, Molecular Biology, Furin, Gene, Caenorhabditis elegans, Genetics, Base Sequence, Reverse Transcriptase Polymerase Chain Reaction, Alternative splicing, biology.organism_classification, Alternative Splicing, Proprotein Convertase 2, Proprotein Convertase 5, biology.protein, Proprotein Convertases, Drosophila melanogaster
Abstract

Many of the protein precursors traversing the secretory pathway undergo cleavage at multibasic sites to generate their bioactive forms. The proprotein convertases (PCs), a family of subtilisin-like proteases, are the major endoproteases that serve this function. Genes encoding seven distinct members of this family have so far been characterized in vertebrates: furin, PC2, PC1/PC3, PC4, PACE4, PC5/PC6 and PC7/PC8/LPC. Multiple PC genes have also been cloned from a number of invertebrates, including Drosophila melanogaster and Caenorhabditis elegans. These findings suggest that gene duplication and diversification of the PCs have occurred throughout metazoan evolution. To investigate the structural and functional changes which have occurred during vertebrate development, we have analyzed the expression of PC genes in the protochordate amphioxus. We have previously shown that amphioxus express homologous PC2 and PC1/PC3 genes [Proc. Natl. Acad. Sci. USA 92 (1995) 3591]. Here we report the characterization of amphioxus cDNAs encoding proteases with a high degree of similarity to mammalian PC6. Three cDNAs encoding three PC6 isoforms differing only in their carboxy-terminal sequences were found, derived by alternative splicing. Two isoforms appear to be soluble enzymes, whereas the third contains a transmembrane hydrophobic segment and thus is likely to be membrane-bound. All three variants contain many repeats of a cysteine-rich motif that is found in several other PC family members. Thus, amphioxus, like the vertebrates, expresses two types of PCs, e.g., PC2 and PC1/PC3 which function in the regulated secretory pathway in neuroendocrine cells, and the more widely expressed PC6 which functions mainly in the constitutive pathway.

Published
2000
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17. Evolution of insulin-like growth factor-I (IGF-I) action: in vitro characterization of vertebrate IGF-I proteins

Author

Catherine A. Yandell, Brian G Degger, Shu J Chan, G L Francis, Shunsuke Moriyama, Zee Upton, and F. John Ballard

Subjects
Physiology, medicine.medical_treatment, Molecular Sequence Data, Chick Embryo, In Vitro Techniques, Biology, Fish Proteins, Biochemistry, law.invention, Evolution, Molecular, Insulin-like growth factor, Species Specificity, law, biology.animal, medicine, Animals, Humans, Amino Acid Sequence, Insulin-Like Growth Factor I, Receptor, Molecular Biology, chemistry.chemical_classification, Sequence Homology, Amino Acid, Fishes, Molecular biology, In vitro, Rats, Amino acid, Cell biology, chemistry, Cell culture, Recombinant DNA, Hagfish
Abstract

While there is considerable structural evidence that IGFs share a long evolutionary history, less is known about the conservation of IGF action. These studies have primarily been hampered by the small amounts of purified IGFs that have been available for testing. More recently, however, we have adopted recombinant strategies to produce milligram quantities of IGFs for biological studies. Thus we have been able to compare the properties of rat, kangaroo, chicken, salmon and barramundi IGF-I, proteins that differ from human IGF-I by 3, 6, 8, 14 and 16 amino acids respectively. While we have found that the IGF-I proteins exhibit similar biological activities and type-1 IGF receptor binding affinities, regardless of whether mammalian, avian or piscine cell lines are used, there was a trend suggesting that the fish proteins at least, were most effective in studies using homologous systems. Thus, salmon IGF-I was not as potent as human IGF-I in bioassays in mammalian cells, but was as effective as human IGF-I in piscine cells. As expected, the IGF-I proteins competed poorly for binding to type-2 receptors present on ovine placental membranes. Interestingly however, the two fish IGF-I proteins exhibited greater affinity for this receptor than the other IGF-I proteins, hence reminiscent of the results previously found with recombinant hagfish IGF. Despite these small differences, these results taken together indicate that the IGF-I proteins appear to have been remarkably conserved in both structure and in vitro action during vertebrate radiation.

Published
1998
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36. Elasticity of iron-rich silicate in Earth’s D″ layer

Author

Mao, W.L., primary, Mao, H.K., additional, Shu, J., additional, Fei, Y., additional, Hemley, R.J., additional, Meng, Y., additional, Shen, G., additional, Prakapenka, V.B., additional, Campbell, A.J., additional, Heinz, D.L., additional, Sturhahn, W., additional, and Zhao, J., additional

Published
2006
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