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Your search keyword '"Roxanis, Ioannis"' showing total 12 results
Start Over Author "Roxanis, Ioannis" Publisher elsevier bv
12 results on '"Roxanis, Ioannis"'

1. A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

Author

Mannion, Jonathan, primary, Gifford, Valentina, additional, Bellenie, Benjamin, additional, Fernando, Winnie, additional, Ramos Garcia, Laura, additional, Wilson, Rebecca, additional, John, Sidonie Wicky, additional, Udainiya, Savita, additional, Patin, Emmanuel C., additional, Tiu, Crescens, additional, Smith, Angel, additional, Goicoechea, Maria, additional, Craxton, Andrew, additional, Moraes de Vasconcelos, Nathalia, additional, Guppy, Naomi, additional, Cheung, Kwai-Ming J., additional, Cundy, Nicholas J., additional, Pierrat, Olivier, additional, Brennan, Alfie, additional, Roumeliotis, Theodoros I., additional, Benstead-Hume, Graeme, additional, Alexander, John, additional, Muirhead, Gareth, additional, Layzell, Scott, additional, Lyu, Wenxin, additional, Roulstone, Victoria, additional, Allen, Mark, additional, Baldock, Holly, additional, Legrand, Arnaud, additional, Gabel, Florian, additional, Serrano-Aparicio, Natalia, additional, Starling, Chris, additional, Guo, Hongyan, additional, Upton, Jason, additional, Gyrd-Hansen, Mads, additional, MacFarlane, Marion, additional, Seddon, Benedict, additional, Raynaud, Florence, additional, Roxanis, Ioannis, additional, Harrington, Kevin, additional, Haider, Syed, additional, Choudhary, Jyoti S., additional, Hoelder, Swen, additional, Tenev, Tencho, additional, and Meier, Pascal, additional

Published
2024
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2. Longitudinal assessment of tumor-infiltrating lymphocytes in primary breast cancer following neoadjuvant radiotherapy

Author

Yoneyama, Miki, primary, Zormpas-Petridis, Konstantinos, additional, Robinson, Ruth, additional, Sobhani, Faranak, additional, Provenzano, Elena, additional, Steel, Harriet, additional, Lightowlers, Sara, additional, Towns, Catherine, additional, Castillo, Simon P., additional, Anbalagan, Selvakumar, additional, Lund, Tom, additional, Wennerberg, Erik, additional, Melcher, Alan, additional, Coles, Charlotte E., additional, Roxanis, Ioannis, additional, Yuan, Yinyin, additional, and Somaiah, Navita, additional

Published
2024
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3. Rates and Outcomes of Breast Lesions of Uncertain Malignant Potential (B3) benchmarked against the National Breast Screening Pathology Audit; Improving Performance in a High Volume Screening Unit

Author

Sheikh, Soha El, primary, Rathbone, Michael, additional, Chaudhary, Khurram, additional, Joshi, Anupam, additional, Lee, Jasmin, additional, Muthukumar, Sonali, additional, Mylona, Evangelia, additional, Roxanis, Ioannis, additional, and Rees, Julia, additional

Published
2022
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6. Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer

Author

Lord, Simon R., primary, Cheng, Wei-Chen, additional, Liu, Dan, additional, Gaude, Edoardo, additional, Haider, Syed, additional, Metcalf, Tom, additional, Patel, Neel, additional, Teoh, Eugene J., additional, Gleeson, Fergus, additional, Bradley, Kevin, additional, Wigfield, Simon, additional, Zois, Christos, additional, McGowan, Daniel R., additional, Ah-See, Mei-Lin, additional, Thompson, Alastair M., additional, Sharma, Anand, additional, Bidaut, Luc, additional, Pollak, Michael, additional, Roy, Pankaj G., additional, Karpe, Fredrik, additional, James, Tim, additional, English, Ruth, additional, Adams, Rosie F., additional, Campo, Leticia, additional, Ayers, Lisa, additional, Snell, Cameron, additional, Roxanis, Ioannis, additional, Frezza, Christian, additional, Fenwick, John D., additional, Buffa, Francesca M., additional, and Harris, Adrian L., additional

Published
2018
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7. Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project

Author

Robbe, Pauline, primary, Popitsch, Niko, additional, Knight, Samantha J.L., additional, Antoniou, Pavlos, additional, Becq, Jennifer, additional, He, Miao, additional, Kanapin, Alexander, additional, Samsonova, Anastasia, additional, Vavoulis, Dimitrios V., additional, Ross, Mark T., additional, Kingsbury, Zoya, additional, Cabes, Maite, additional, Ramos, Sara D.C., additional, Page, Suzanne, additional, Dreau, Helene, additional, Ridout, Kate, additional, Jones, Louise J., additional, Tuff-Lacey, Alice, additional, Henderson, Shirley, additional, Mason, Joanne, additional, Buffa, Francesca M., additional, Verrill, Clare, additional, Maldonado-Perez, David, additional, Roxanis, Ioannis, additional, Collantes, Elena, additional, Browning, Lisa, additional, Dhar, Sunanda, additional, Damato, Stephen, additional, Davies, Susan, additional, Caulfield, Mark, additional, Bentley, David R., additional, Taylor, Jenny C., additional, Turnbull, Clare, additional, and Schuh, Anna, additional

Published
2018
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8. Metformin increases 18F-FDG flux and inhibits fatty acid oxidation at clinical doses in breast cancer: Results of a phase 0 clinical trial

Author

Lord, Simon, primary, Liu, Dan, additional, Cheng, Wei-Chen, additional, Haider, Syed, additional, Gaude, Edoardo, additional, Teoh, Eugene, additional, Patel, Neel, additional, Metcalf, Tom, additional, McGowan, Daniel, additional, Roxanis, Ioannis, additional, Qifeng, Zhang, additional, Roy, Pankaj, additional, Gleeson, Fergus, additional, Thompson, Alastair, additional, Pollak, Michael, additional, Wakelam, Michael, additional, Buffa, Francesca, additional, Frezza, Christian, additional, Fenwick, John, additional, and Harris, Adrian, additional

Published
2016
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12. Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer

Author

Lord, Simon R, Cheng, Wei-Chen, Liu, Dan, Gaude, Edoardo, Haider, Syed, Metcalf, Tom, Patel, Neel, Teoh, Eugene J, Gleeson, Fergus, Bradley, Kevin, Wigfield, Simon, Zois, Christos, McGowan, Daniel R, Ah-See, Mei-Lin, Thompson, Alastair M, Sharma, Anand, Bidaut, Luc, Pollak, Michael, Roy, Pankaj G, Karpe, Fredrik, James, Tim, English, Ruth, Adams, Rosie F, Campo, Leticia, Ayers, Lisa, Snell, Cameron, Roxanis, Ioannis, Frezza, Christian, Fenwick, John D, Buffa, Francesca M, and Harris, Adrian L

Subjects
Adult, positron emission tomography, endocrine system diseases, cancer metabolism, Antineoplastic Agents, Breast Neoplasms, clinical study, Middle Aged, metabolomics, Metformin, 3. Good health, Mitochondria, Gene Expression Regulation, Neoplastic, Glucose, Positron Emission Tomography Computed Tomography, gene expression profiling, Humans, Hypoglycemic Agents, Female, Transcriptome, Metabolic Networks and Pathways, Aged
Abstract

Late-phase clinical trials investigating metformin as a cancer therapy are underway. However, there remains controversy as to the mode of action of metformin in tumors at clinical doses. We conducted a clinical study integrating measurement of markers of systemic metabolism, dynamic FDG-PET-CT, transcriptomics, and metabolomics at paired time points to profile the bioactivity of metformin in primary breast cancer. We show metformin reduces the levels of mitochondrial metabolites, activates multiple mitochondrial metabolic pathways, and increases 18-FDG flux in tumors. Two tumor groups are identified with distinct metabolic responses, an OXPHOS transcriptional response (OTR) group for which there is an increase in OXPHOS gene transcription and an FDG response group with increased 18-FDG uptake. Increase in proliferation, as measured by a validated proliferation signature, suggested that patients in the OTR group were resistant to metformin treatment. We conclude that mitochondrial response to metformin in primary breast cancer may define anti-tumor effect.

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