46 results on '"Rosen, Neal"'
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2. Phase 1 Clinical Trial of Trametinib and Ponatinib in Patients With NSCLC Harboring KRAS Mutations
3. Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis
4. The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression
5. Acquired BRAF Rearrangements Induce Secondary Resistance to EGFR therapy in EGFR-Mutated Lung Cancers
6. Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway
7. Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer
8. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study
9. Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma
10. Biomarkers That Predict Sensitivity to Heat Shock Protein 90 Inhibitors
11. BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition
12. AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas
13. Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ
14. Combination of RAF and MEK Inhibition for the Treatment of BRAF-Mutated Melanoma: Feedback Is Not Encouraged
15. Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors
16. Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas
17. Inhibition of Mycobacterial Infection by the Tumor Suppressor PTEN
18. Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer
19. Mutant BRAF Melanomas—Dependence and Resistance
20. AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
21. 4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors
22. Uncoupling of hormone-dependence from chaperone-dependence in the L701H mutation of the androgen receptor
23. An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function
24. AKT and cancer—Is it all mTOR?
25. The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells
26. Development of a Fluorescence Polarization Assay for the Molecular Chaperone Hsp90
27. Targeting Wide-Range Oncogenic Transformation via PU24FCl, a Specific Inhibitor of Tumor Hsp90
28. Synthesis of novel fluorescent probes for the molecular chaperone Hsp90
29. Microtiter Cell-Based Assay for Detection of Agents that Alter Cellular Levels of Her2 and EGFR
30. Development of a Purine-Scaffold Novel Class of Hsp90 Binders that Inhibit the Proliferation of Cancer Cells and Induce the Degradation of Her2 Tyrosine Kinase
31. Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function
32. LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family
33. A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells
34. Synthesis and evaluation of geldanamycin–testosterone hybrids
35. Synthesis and evaluation of geldanamycin-estradiol hybrids
36. Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway
37. A Farnesyl-Protein Transferase Inhibitor Induces p21 Expression and G1 Block in p53 Wild Type Tumor Cells
38. Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent
39. Identification of a Novel Repressive Element in the Proximal lck Promoter
40. Herbimycin A Induces the 20 S Proteasome- and Ubiquitin-dependent Degradation of Receptor Tyrosine Kinases
41. DARPP-32 development in the caudate nucleus is independent of afferent input from the substantia nigra
42. Trypanosoma congolense: Isolation and purification
43. Trypanosoma congolense: Surface glycoproteins of two early bloodstream variants
44. Trypanosoma congolense: Surface glycoproteins of two early bloodstream variants
45. Growth regulatory peptide production by human breast carcinoma cells
46. Methionyl Residue Critical for Activity and Regulation of Bovine Liver Glutamate Dehydrogenase
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