1. Antioxidant activity of quercetin and myricetin in liposomes
- Author
-
Andrea Roedig-Penman and Michael H. Gordon
- Subjects
Antioxidant ,medicine.medical_treatment ,Phospholipid ,In Vitro Techniques ,Biochemistry ,Chloride ,Antioxidants ,chemistry.chemical_compound ,Flavonols ,Drug Stability ,medicine ,Vitamin E ,Organic chemistry ,heterocyclic compounds ,Molecular Biology ,Flavonoids ,chemistry.chemical_classification ,Drug Carriers ,Liposome ,Chemistry ,Organic Chemistry ,Cell Biology ,Hydrogen-Ion Concentration ,Liposomes ,Ferric ,Quercetin ,lipids (amino acids, peptides, and proteins) ,Myricetin ,Oxidation-Reduction ,medicine.drug ,Nuclear chemistry - Abstract
The antioxidant activity during storage at 30 degrees C of quercetin, myricetin and alpha-tocopherol in small unilamellar liposomes has been investigated. Myricetin was more effective than alpha-tocopherol as an antioxidant in liposomes under all conditions studied. At pH 5.4 with a concentration of 10(-2) mol/mol phospholipid, myricetin has been shown to be the strongest antioxidant followed by quercetin and alpha-tocopherol. Cupric chloride and ferric chloride strongly reduced the antioxidant activity of myricetin and quercetin with cupric chloride causing a stronger reduction in activity than ferric chloride. At a pH of 7.4, quercetin was less effective than alpha-tocopherol at a concentration of 10(-2) mol/mol phospholipid, but it's activity increased more strongly with concentration and it was very effective at a concentration of 5 x 10(-2) mol/mol phospholipid.
- Published
- 1998