1. ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores
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Mariana Frizzo de Godoy, Luana Martins Oliveira, Christiane Correa Rodrigues cimini, Fernando Antônio Botoni, Raquel Lutkmeier, Neimy Ramos de Oliveira, Andre Pinheiro Weber, Roberta Xavier Campos, Andressa Barreto Glaeser, Cintia Alcantara de Carvalho, Renan Goulart Finger, Israel Júnior Borges do Nascimento, Yuri Carlotto Ramires, Carolina Marques Ramos, Angelinda Rezende Bhering, Karina Paula Medeiros Prado Martins, Julia Drumond Parreiras de Morais, Rufino de Freitas Silva, Heloisa Reniers Vianna, Amanda de Oliveira Maurilio, Luis Cesar Souto de Moura, Giovanna Grunewald Vietta, Alexandre Vargas Schwarzbold, Daniel Taiar Marinho Oliveira Ferrara, Maíra Viana Rego Souza-Silva, Milton Henriques Guimarães-Júnior, Luís César de Castro, Thaiza Simonia Marinho Albino de Araujo, Silvia Ferreira Araujo, Caroline Danubia Gomes, Marilia Mastrocolla de Almeida Cardoso, Berta Raventós, Milena Soriano Marcolino, Saionara Cristina Francisco, Rafael Guimarães Tavares da Silva, José Miguel Chatkin, Carisi Anne Polanczyk, Raphael Castro Martins, Lucas de Deus Sousa, Susany Anastacia Pereira, Eric Boersma, Pedro Ledic Assaf, Patricia Klarmann Ziegelmann, Karen Cristina Jung Rech Pontes, Tatiana Kurtz, Roger Mendes de Abreu, Petrônio José de Lima Martelli, Angelica Aparecida Coelho Madureira, Carla Thais Candida Alves da Silva, Lilian Santos Pinheiro, Luanna da Silva Monteiro, Frederico Bartolazzi, Kauane Aline Maciel dos Santos, Natalia Lima Rangel, Marcela Goncalves Trindade Tofani, Maria Aparecida Camargos Bicalho, Natalia da Cunha Severino Sampaio, Virginia Mara Reis Gomes, Maria Angelica Pires Ferreira, Luisa Elem Almeida Santos, Bruno Mateus de Castro, Thaís Lorenna Souza Sales, Ana Luiza Bahia Alves Scotton, Joanna d'Arc L. Batista, Fernando Graca Aranha, Thainara Conceicao de Oliveira, Fernando Anschau, Felipe Barbosa Vallt, Thulio Henrique Oliveira Diniz, Rafael Lima Rodrigues de Carvalho, Guilherme Fagundes Nascimento, Roberta Pozza, Elayne Crestani Pereira, Máderson Alvares de Souza Cabral, Rodolfo Lucas Silva Mourato, Isabela Moraes Gomes, Julia Di Sabatino Santos Guimaraes, Ana Paula Beck da Silva Etges, Luciana Siuves Ferreira Couto, Gisele Alsina Nader Bastos, Juliana Machado Rugolo, Rochele Mosmann Menezes, L. E. F. Ramos, Liliane Souto Pacheco, Helena Carolina Noal, Veridiana Baldon dos Santos Santos, Henrique Cerqueira Guimaraes, Matheus Carvalho Alves Nogueira, Ricardo Bertoglio Cardoso, Glicia Cristina de Castro Madeira, Daniela Ponce, Helena Duani, Vitor Augusto Lima do Vale, Marcelo Carneiro, Leonardo Seixas de Oliveira, Talita Fischer Oliveira, Emanuele Marianne Souza Kroger, Israel Molina, Natalia Trifiletti Crespo, Edilson Cezar, Karen Brasil Ruschel, Tatiani Oliveira Fereguetti, Rafaela dos Santos Charao de Almeida, Joice Coutinho de Alvarenga, Maiara Anschau Floriani, Maira Dias Souza, Adrián Sánchez-Montalvá, Barbara Lopes Farace, Maria Clara Pontello Barbosa Lima, Meire Pereira de Figueiredo, Luciane Kopittke, Gabriela Petry Crestani, Andre Soares de Moura Costa, Silvana Mangeon Meirelles Guimarães, Fernanda Barbosa Lucas, Reginaldo Aparecido Valacio, Daniel Vitorio Silveira, Magda Carvalho Pires, Cardiology, Universidade Federal de Minas Gerais (UFMG), Institute for Health Technology Assessment IATS/ CNPq)., Universidade Federal de São João del-Rei, Universitat Autònoma de Barcelona, Grupo Hospitalar Conceição, Pontifícia Universidade Católica do Rio Grande do Sul RGS), Hospital São Lucas PUCRS, Rede Mater Dei de Saúde, Hospital Márcio Cunha, Universidade do Sul de Santa Catarina UNISUL, Dissertare Scientific Advice, SOS Cardio Hospital, Universidade Estadual Paulista (UNESP), Universidade Federal do Rio Grande do Sul, Hospital Bruno Born, Research Center of Vale do Taquari., Hospital Mãe de Deus, Hospital Universitário de Canoas, Universidade Federal de Viçosa (UFV), Hospital Santa Rosalia, Hospital Metropolitano Doutor Célio de Castro, Hospital Moinhos de Vento, Hospital Unimed BH, Hospital Risoleta Tolentino Neves, Hospital Metropolitano Odilon Behrens, Hospital Eduardo de Menezes, Universidade FUMEC, Hospital Julia Kubitschek, Hospital Universitário de Santa Maria, Universidade Federal de Santa Maria, Hospital São João de Deus, Hospital Regional Antônio Dias, Faculdade Ciências Médicas de Minas Gerais, Faculdade de Ciências Humanas de Curvelo, Av. Professor Alfredo Balena, Hospital Santo Antônio, Hospital Universitário Ciências Médicas, PROSICS Barcelona, Instituto René Rachou-FIOCRUZ Minas., Universidade Federal da Fronteira Sul, Hospital Regional do Oeste, Pontifícia Universidade Católica de Minas Gerais, Hospital Tacchini, Centro Universitário de Patos de Minas. RPatos de Minas, Hospital Semper, Hospital Santa Cruz, Universidade de Santa Cruz, Fundação Hospitalar do Estado de Minas Gerais – FHEMIG., Universidade Federal de Ouro Preto, Universidade Federal de Pernambuco (UFPE), Centro Universitário de Belo Horizonte UniBH), University Medical Center Rotterdam, Institut Català de la Salut, [Marcolino MS] Department of Internal Medicine, Medical School, Universidade Federal de Minas Gerais. Belo Horizonte, Brazil. Telehealth Center, University Hospital, Universidade Federal de Minas Gerais. Belo Horizonte, Brazil. Institute for Health Technology Assessment (IATS/ CNPq). Rua Ramiro Barcelos, 2359. Prédio 21 | Sala 507, Porto Alegre, Brazil. [Pires MC] Institute for Health Technology Assessment (IATS/ CNPq). Rua Ramiro Barcelos, 2359. Prédio 21 | Sala 507, Porto Alegre, Brazil. Department of Statistics, Universidade Federal de Minas Gerais. Belo Horizonte, Brazil. [Ramos LEF, Silva RT] Department of Statistics, Universidade Federal de Minas Gerais. Belo Horizonte, Brazil. [Oliveira LM] Institute for Health Technology Assessment (IATS/ CNPq). Rua Ramiro Barcelos, 2359. Prédio 21 | Sala 507, Porto Alegre, Brazil. Center for Research and Graduate Studies in Business Administration, Universidade Federal de Minas Gerais. Belo Horizonte, Brazil. [Carvalho RLR] Institute for Health Technology Assessment (IATS/ CNPq). Rua Ramiro Barcelos, 2359. Prédio 21 | Sala 507, Porto Alegre, Brazil. [Sánchez-Montalvá A, Raventós B] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. PROSICS, Barcelona, Spain. [Molina I] Vall d’Hebron Hospital Universitari, Barcelona, Spain. PROSICS Barcelona. Barcelona, Spain. Instituto René Rachou-FIOCRUZ Minas. Belo Horizonte, Brazil, and Vall d'Hebron Barcelona Hospital Campus
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Microbiology (medical) ,Percentile ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,COVID-19 (Malaltia) - Mortalitat ,Infectious and parasitic diseases ,RC109-216 ,Logistic regression ,Article ,SDG 3 - Good Health and Well-being ,Mortalitat - Estadístiques ,Other subheadings::Other subheadings::Other subheadings::/mortality [Other subheadings] ,Internal medicine ,Heart rate ,virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES] ,técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::mortalidad::mortalidad hospitalaria [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,medicine ,score ,Humans ,Hospital Mortality ,Mortality ,Diagnosis::Prognosis [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Hospital Mortality [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,diagnóstico::pronóstico [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Blood urea nitrogen ,Aged ,Retrospective Studies ,Hospitalizations ,COVID-19 (Malaltia) - Prognosi ,Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad [Otros calificadores] ,Framingham Risk Score ,SARS-CoV-2 ,business.industry ,Score ,COVID-19 ,Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES] ,General Medicine ,Emergency department ,Middle Aged ,Prognosis ,Hospitalization ,Infectious Diseases ,Risk factors ,Cohort ,business - Abstract
Made available in DSpace on 2022-04-29T08:31:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Objectives: The majority of available scores to assess mortality risk of coronavirus disease 2019 (COVID-19) patients in the emergency department have high risk of bias. Therefore, this cohort aimed to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients and to compare this score with other existing ones. Methods: Consecutive patients (≥ 18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Logistic regression analysis was performed to develop a prediction model for in-hospital mortality, based on the 3978 patients admitted between March–July, 2020. The model was validated in the 1054 patients admitted during August–September, as well as in an external cohort of 474 Spanish patients. Results: Median (25–75th percentile) age of the model-derivation cohort was 60 (48–72) years, and in-hospital mortality was 20.3%. The validation cohorts had similar age distribution and in-hospital mortality. Seven significant variables were included in the risk score: age, blood urea nitrogen, number of comorbidities, C-reactive protein, SpO2/FiO2 ratio, platelet count, and heart rate. The model had high discriminatory value (AUROC 0.844, 95% CI 0.829–0.859), which was confirmed in the Brazilian (0.859 [95% CI 0.833–0.885]) and Spanish (0.894 [95% CI 0.870–0.919]) validation cohorts, and displayed better discrimination ability than other existing scores. It is implemented in a freely available online risk calculator (https://abc2sph.com/). Conclusions: An easy-to-use rapid scoring system based on characteristics of COVID-19 patients commonly available at hospital presentation was designed and validated for early stratification of in-hospital mortality risk of patients with COVID-19. Department of Internal Medicine Medical School Universidade Federal de Minas Gerais Telehealth Center University Hospital Universidade Federal de Minas Gerais Institute for Health Technology Assessment IATS/ CNPq)., Rua Ramiro Barcelos, 2359. Prédio 21 | Sala 507 Department of Statistics Universidade Federal de Minas Gerais Center for Research and Graduate Studies in Business Administration Universidade Federal de Minas Gerais Universidade Federal de São João del-Rei Infectious Diseases Department Vall d'Hebron University Hospita Universitat Autònoma de Barcelona Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor Grupo Hospitalar Conceição Pontifícia Universidade Católica do Rio Grande do Sul RGS) Hospital São Lucas PUCRS Rede Mater Dei de Saúde Hospital Márcio Cunha Universidade do Sul de Santa Catarina UNISUL Dissertare Scientific Advice SOS Cardio Hospital Internal Medicine Department University Hospital Universidade Federal de Minas Gerais Faculdade de Medicina de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho Hospital das Clínicas da Faculdade de Medicina de Botucatu Universidade Federal do Rio Grande do Sul Hospital Bruno Born Research Center of Vale do Taquari. Hospital Mãe de Deus Hospital Universitário de Canoas Mucuri Medical School FAMMUC Universidade Federal dos Vales do Jequitinhonha e Mucuri – UFVJM Hospital Santa Rosalia Hospital Metropolitano Doutor Célio de Castro Hospital Moinhos de Vento Hospital Unimed BH Hospital Risoleta Tolentino Neves Post-graduation Center Medical School Universidade Federal de Minas Gerais Hospital Metropolitano Odilon Behrens Hospital Eduardo de Menezes Universidade FUMEC Hospital Julia Kubitschek Hospital Universitário de Santa Maria Departamento de Medicina Interna Universidade Federal de Santa Maria Hospital São João de Deus Hospital Regional Antônio Dias Faculdade Ciências Médicas de Minas Gerais Hospital de Clínicas de Porto Alegre Universidade Federal do Rio Grande do Sul Faculdade de Ciências Humanas de Curvelo Hospital João XXIII Av. Professor Alfredo Balena Hospital Santo Antônio Hospital Universitário Ciências Médicas Vall d'Hebron University Hospital PROSICS Barcelona Instituto René Rachou-FIOCRUZ Minas. Universidade Federal da Fronteira Sul Hospital Regional do Oeste Pontifícia Universidade Católica de Minas Gerais Hospital Tacchini Centro Universitário de Patos de Minas. RPatos de Minas Hospital Semper Hospital Santa Cruz Universidade de Santa Cruz Fundação Hospitalar do Estado de Minas Gerais – FHEMIG. Universidade Federal de Ouro Preto Hospital das Clínicas da Universidade Federal de Pernambuco Universidade Federal de Pernambuco Centro de Ciências Médicas Centro Universitário de Belo Horizonte UniBH) Erasmus MC University Medical Center Rotterdam Department of Cardiology Faculdade de Medicina de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho Hospital das Clínicas da Faculdade de Medicina de Botucatu
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- 2021
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