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Highlights • Frequency following responses can be obtained free from stimulation artifacts in cochlear implant users. • Auditory change complexes can be evoked with pulse rate changes in cochlear implant users. • Electrophysiological responses can potentially be used for the assessment of rate processing in cochlear implant user., The upper limit of rate-based pitch perception and rate discrimination can differ substantially across cochlear implant (CI) users. One potential reason for this difference is the presence of a biological limitation on temporal encoding in the electrically-stimulated auditory pathway, which can be inherent to the electrical stimulation itself and/or to the degenerative processes associated with hearing loss. Electrophysiological measures, like the electrically-evoked frequency following response (eFFR) and auditory change complex (eACC), could potentially provide valuable insights in the temporal processing limitations at the level of the brainstem and cortex in the electrically-stimulated auditory pathway. Obtaining these neural responses, free from stimulation artifacts, is challenging, especially when the neural response is phase-locked to the stimulation rate, as is the case for the eFFR. In this study we investigated the feasibility of measuring eFFRs, free from stimulation artifacts, to stimulation rates ranging from 94 to 196 pulses per second (pps) and eACCs to pulse rate changes ranging from 36 to 108%, when stimulating in a monopolar configuration. A high-sampling rate EEG system was used to measure the electrophysiological responses in five CI users, and linear interpolation was applied to remove the stimulation artifacts from the EEG. With this approach, we were able to measure eFFRs for pulse rates up to 162 pps and eACCs to the different rate changes. Our results show that it is feasible to measure electrophysiological responses, free from stimulation artifacts, that could potentially be used as neural correlates for rate and pitch processing in CI users.

We assessed auditory sensitivity to three classes of temporal-envelope statistics (modulation depth, modulation rate, and comodulation) that are important for the perception of ‘sound textures’. The textures were generated by a probabilistic model that prescribes the temporal statistics of a selected number of modulation envelopes, superimposed onto noise carriers. Discrimination thresholds were measured for normal-hearing (NH) listeners and users of a MED-EL pulsar cochlear implant (CI), for separate manipulations of the average rate and modulation depth of the envelope in each frequency band of the stimulus, and of the co-modulation between bands. Normal-hearing (NH) listeners' discrimination of envelope rate was similar for baseline modulation rates of 5 and 34 Hz, and much poorer than previously reported for sinusoidally amplitude-modulated sounds. In contrast, discrimination of model parameters that controlled modulation depth was poorer at the lower baseline rate, consistent with the idea that, at the lower rate, subjects get fewer ‘looks’ at the relevant information when comparing stimuli differing in modulation depth. NH listeners could discriminate differences in co-modulation across bands; a multidimensional scaling study revealed that this was likely due to genuine across-frequency processing, rather than within-channel cues. CI users' discrimination performance was worse overall than for NH listeners, but showed a similar dependence on stimulus parameters., Highlights • We measure discrimination thresholds for input parameters of a stochastic sound texture generator. • CochIear Implant listeners performed less well than Normal Hearing listeners. • Discrimination of parameters controlling modulation depth in a channel was better at higher overall modulation rates. • Rate discrimination is poorer for our complex stochastic modulation envelopes than ‘deterministic’ stimuli. • Changes in across-modulator interdependence may be derived by summing the outputs across multiple auditory filters.

International audience; Cochlear implants (CIs) stimulate the auditory nerve with trains of symmetric biphasic (BI) pulses. We review studies showing that more efficient stimulation can be achieved by modifying these pulses by (1) increasing the inter-phase gap (IPG) between the two phases of each pulse, thereby delaying the recovery of charge, (2) increasing the duration and decreasing the amplitude of one phase - so-called "pseudomonophasic (PS)" waveforms, and (3) combining the pseudomonophasic stimulus with an IPG in a "delayed pseudomonophasic" waveform (PS_IPG). These efficiency gains, measured using changes in threshold and loudness, occur at a wide range of pulse rates, including those commonly used in current CI systems. In monopolar mode, dynamic ranges are larger for PS and for long-IPG pulse shapes than for BI pulses, but this increase in DR is not accompanied by a higher number of discriminable loudness steps, and hence, in a better coding of loudness. Moreover, waveforms with relatively short and long interphase gaps do not yield different patterns of excitation despite the relatively large differences in threshold. Two important findings are that, contrary to data obtained in animal experiments, anodic currents are more effective than cathodic stimulation for human CI patients and that the thresholds decrease with increases in IPG over a much longer time course (more than 3 ms) than for animals. In this review it is discussed how these alternative pulse shapes may be beneficial in terms of reducing power consumption and channel interactions, which issues remain to be addressed, and how models contribute to guiding our research.

It has been a matter of debate whether the specifically human capacity to process syntactic information draws on attentional resources or is automatic. To address this issue, we recorded neurophysiological indicators of syntactic processing to spoken sentences while subjects were distracted to different degrees from language processing. Subjects were either passively distracted, by watching a silent video film, or their attention was actively streamed away from the language input by performing a demanding acoustic signal detection task. An early index of syntactic violations, the syntactic Mismatch Negativity (sMMN), distinguished between grammatical and ungrammatical speech even under strongest distraction. The magnitude of the early sMMN (at150ms) was unaffected by attention load of the distraction task. The independence of the early syntactic brain response of attentional distraction provides neurophysiological evidence for the automaticity of syntax and for its autonomy from other attention-demanding processes, including acoustic stimulus discrimination. The first attentional modulation of syntactic brain responses became manifest at a later stage, at approximately 200ms, thus demonstrating the narrowness of the early time window of syntactic autonomy. We discuss these results in the light of modular and interactive theories of cognitive processing and draw inferences on the automaticity of both the cognitive MMN response and certain grammar processes in general.

Auditory streaming refers to the perceptual parsing of acoustic sequences into "streams", which makes it possible for a listener to follow the sounds from a given source amidst other sounds. Streaming is currently regarded as an important function of the auditory system in both humans and animals, crucial for survival in environments that typically contain multiple sound sources. This article reviews recent findings concerning the possible neural mechanisms behind this perceptual phenomenon at the level of the auditory cortex. The first part is devoted to intra-cortical recordings, which provide insight into the neural "micromechanisms" of auditory streaming in the primary auditory cortex (A1). In the second part, recent results obtained using functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) in humans, which suggest a contribution from cortical areas other than A1, are presented. Overall, the findings concur to demonstrate that many important features of sequential streaming can be explained relatively simply based on neural responses in the auditory cortex.

Human behavioral thresholds for trains of biphasic pulses applied to a single channel of Nucleus CI24 and LAURA cochlear implants were measured as a function of inter-phase gap (IPG). Experiment 1 used bipolar stimulation, a 100-pps pulse rate, and a 400-ms stimulus duration. In one condition, the two phases of each pulse had opposite polarity. Thresholds continued to drop by 9-10 dB as IPG was increased from near zero to the longest value tested (2900 micros for CI24, 4900 micros for LAURA). This time course is much longer than reported for single-cell recordings from animals. In a second condition, the two phases of each pulse had the same polarity, which alternated from pulse to pulse. Thresholds were independent of IPG, and similar to those in condition 1 at IPG=4900 micros. Experiment 2 used monopolar stimulation. One condition was similar to condition 1 of experiment 1, and thresholds also dropped up to the longest IPG studied (2900 micros). This also happened when the pulse rate was reduced to 20 pps, and when only a single pulse was presented on each trial. Keeping IPG constant at 8 micros and adding an extra biphasic pulse x ms into each period produced thresholds that were roughly independent of x, indicating that the effect of IPG in the other conditions was not due to a release from refractoriness at sites central to the auditory nerve. Experiment 3 measured thresholds at three IPGs, which were less than, equal to, and more than one half of the interval between successive pulses. Thresholds were lowest at the intermediate IPG. The results of all experiments could be fit by a linear model consisting of a lowpass filter based on the function relating threshold to the frequency of sinusoidal electrical stimulation. The data and model have implications for reducing the power consumption of cochlear implants.

Psychophysical measures of the electrically stimulated human auditory system were obtained for different types of symmetric and asymmetric charge-balanced waveforms. Absolute detection thresholds of biphasic, pseudomonophasic, and 'alternating monophasic' current waveforms delivered by a bipolar intra-cochlear electrode pair were determined for four subjects implanted with the LAURA device. Thresholds for alternating monophasic stimuli, in which anodic and cathodic phases alternated every 5 ms, were 5-8 dB lower than for the biphasic waveforms for all four subjects. For two of the four subjects, thresholds for the pseudomonophasic waveforms were also significantly lower than for the biphasic waveforms. These pseudomonophasic thresholds were greatly affected neither by a 500-micros gap inserted between the two phases, nor by whether the shorter phase preceded or followed the longer one. Loudness balancing measures performed at the most comfortable levels also showed that, for equal loudness, alternating monophasic stimuli required a lower level than biphasic and pseudomonophasic waveforms. For three of the four subjects, the dynamic ranges of the pseudomonophasic (but not alternating monophasic) waveforms were greater than those of the biphasic waveforms. The results demonstrate that thresholds and dynamic ranges of human cochlear implant users can be controlled by manipulating the way in which the charge produced by the initial phase of an electrical pulse is recovered.

In everyday life we often listen to one sound, such as someone's voice, in a background of competing sounds. To do this, we must assign simultaneously occurring frequency components to the correct source, and organize sounds appropriately over time. The physical cues that we exploit to do so are well-established; more recent research has focussed on the underlying neural bases, where most progress has been made in the study of a form of sequential organization known as "auditory streaming". Listeners' sensitivity to streaming cues can be captured in the responses of neurons in the primary auditory cortex, and in EEG wave components with a short latency (200ms). However, streaming can be strongly affected by attention, suggesting that this early processing either receives input from non-auditory areas, or feeds into processes that do.

Thresholds were measured for 5-ms 1-kHz tones masked by synchronous bursts of noise containing a spectral notch centered on the signal frequency. Thresholds were reduced by prior exposure to a 200-ms burst of a ‘priming stimulus’ which had the same spectral shape as the masker. The masking release was greatest for notch widths extending between 20–30% above and below the signal frequency. It did not occur when the masker and primer were bandpass noises extending from 200–1800 Hz. A smaller masking release could be obtained with a primer consisting of only the lower band of a notched noise masker. This was also true, but to a lesser extent, for a primer consisting of the higher band alone. A primer that was a narrow band of noise centered on the signal frequency produced an increase in masking, which could not be attributed to forward masking of the tone by the primer. The effects of all primers were independent of primer level over the 30-dB range studied, ruling out explanations in terms of peripheral adaptation or of adaptation of suppression. A significant masking release occurred when the silent interval between primer offset and masker onset was as long as 320 ms, but increasing the duration of the masker and signal beyond 80 ms eliminated the effect in two out of three subjects. The results are consistent with a form of processing which groups together energy in frequency regions containing common amplitude envelopes, and which enhances the internal representation of newly-arriving energy in previously unstimulated frequency regions.