1. Interplay between autophagy and apoptosis in selenium deficient cardiomyocytes in chicken
- Author
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Sattar Hamid, Shiwen Xu, Rihong Zhao, Hao Li, Qi Liu, Jingzeng Cai, Hong Wang, Yuan Zhang, Jie Yang, and Ziwei Zhang
- Subjects
0301 basic medicine ,Muscle Proteins ,Apoptosis ,Creatine ,Biochemistry ,Avian Proteins ,Inorganic Chemistry ,Selenium ,03 medical and health sciences ,chemistry.chemical_compound ,Western blot ,Selenium deficiency ,Proteinase 3 ,Autophagy ,medicine ,Animals ,Myocytes, Cardiac ,PI3K/AKT/mTOR pathway ,030102 biochemistry & molecular biology ,medicine.diagnostic_test ,medicine.disease ,Molecular biology ,Leukemia ,030104 developmental biology ,chemistry ,Apoptosis Regulatory Proteins ,Chickens - Abstract
Dietary selenium (Se) deficiency can cause heart dysfunction, however the exact mechanism remains unclear. To understand this mechanism, 180day-old chicks, divided into two groups, C (control group) and L (low Se group), were fed with either a Se-sufficient (0.23mg/kg) or Se-deficient (0.033mg/kg) diets for 25days, respectively. Heart tissues and blood samples were collected. In L group, the activities of serum creatine kinase (CK) and creatine kinase-myoglobin (CK-MB) increased and typical ultrastructural apoptotic features were observed. Se deficiency up-regulated the mRNA levels of Cysteinyl aspartate specific proteinase 3 (Caspase-3), Cysteinyl aspartate specific proteinase 8 (Caspase-8), Cysteinyl aspartate specific proteinase 9 (Caspase-9), B cell lymphoma/leukemia 2 (Bcl-2), Bcl-2 Associated X Protein (Bax), (P
- Published
- 2017
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