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Your search keyword '"Riesenfeld, Samantha"' showing total 12 results
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12 results on '"Riesenfeld, Samantha"'

1. A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

Author

Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Howard Hughes Medical Institute, Boroughs, Angela C, Larson, Rebecca C, Marjanovic, Nemanja D, Gosik, Kirk, Castano, Ana P, Porter, Caroline BM, Lorrey, Selena J, Ashenberg, Orr, Jerby, Livnat, Hofree, Matan, Smith-Rosario, Gabriela, Morris, Robert, Gould, Joshua, Riley, Lauren S, Berger, Trisha R, Riesenfeld, Samantha J, Rozenblatt-Rosen, Orit, Choi, Bryan D, Regev, Aviv, Maus, Marcela V, Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Howard Hughes Medical Institute, Boroughs, Angela C, Larson, Rebecca C, Marjanovic, Nemanja D, Gosik, Kirk, Castano, Ana P, Porter, Caroline BM, Lorrey, Selena J, Ashenberg, Orr, Jerby, Livnat, Hofree, Matan, Smith-Rosario, Gabriela, Morris, Robert, Gould, Joshua, Riley, Lauren S, Berger, Trisha R, Riesenfeld, Samantha J, Rozenblatt-Rosen, Orit, Choi, Bryan D, Regev, Aviv, and Maus, Marcela V

Published
2023

2. GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology

Author

Earley, Zachary M., primary, Lisicka, Wioletta, additional, Sifakis, Joseph J., additional, Aguirre-Gamboa, Raúl, additional, Kowalczyk, Anita, additional, Barlow, Jacob T., additional, Shaw, Dustin G., additional, Discepolo, Valentina, additional, Tan, Ineke L., additional, Gona, Saideep, additional, Ernest, Jordan D., additional, Matzinger, Polly, additional, Barreiro, Luis B., additional, Morgun, Andrey, additional, Bendelac, Albert, additional, Ismagilov, Rustem F., additional, Shulzhenko, Natalia, additional, Riesenfeld, Samantha J., additional, and Jabri, Bana, additional

Published
2023
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3. Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection

Author

Yang, Daping, primary, Jacobson, Amanda, additional, Meerschaert, Kimberly A., additional, Sifakis, Joseph Joy, additional, Wu, Meng, additional, Chen, Xi, additional, Yang, Tiandi, additional, Zhou, Youlian, additional, Anekal, Praju Vikas, additional, Rucker, Rachel A., additional, Sharma, Deepika, additional, Sontheimer-Phelps, Alexandra, additional, Wu, Glendon S., additional, Deng, Liwen, additional, Anderson, Michael D., additional, Choi, Samantha, additional, Neel, Dylan, additional, Lee, Nicole, additional, Kasper, Dennis L., additional, Jabri, Bana, additional, Huh, Jun R., additional, Johansson, Malin, additional, Thiagarajah, Jay R., additional, Riesenfeld, Samantha J., additional, and Chiu, Isaac M., additional

Published
2022
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4. Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling

Author

Pawlak, Mathias, primary, DeTomaso, David, additional, Schnell, Alexandra, additional, Meyer zu Horste, Gerd, additional, Lee, Youjin, additional, Nyman, Jackson, additional, Dionne, Danielle, additional, Regan, Brianna M.L., additional, Singh, Vasundhara, additional, Delorey, Toni, additional, Schramm, Markus A., additional, Wang, Chao, additional, Wallrapp, Antonia, additional, Burkett, Patrick R., additional, Riesenfeld, Samantha J., additional, Anderson, Ana C., additional, Regev, Aviv, additional, Xavier, Ramnik J., additional, Yosef, Nir, additional, and Kuchroo, Vijay K., additional

Published
2022
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5. A cellular and spatial map of the choroid plexus across brain ventricles and ages

Author

McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology. Department of Biological Engineering, Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology. Department of Biology, Dani, Neil, Herbst, Rebecca H, McCabe, Cristin, Green, Gilad S, Kaiser, Karol, Head, Joshua P, Cui, Jin, Shipley, Frederick B, Jang, Ahram, Dionne, Danielle, Nguyen, Lan, Rodman, Christopher, Riesenfeld, Samantha J, Prochazka, Jan, Prochazkova, Michaela, Sedlacek, Radislav, Zhang, Feng, Bryja, Vitezslav, Rozenblatt-Rosen, Orit, Habib, Naomi, Regev, Aviv, Lehtinen, Maria K, McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology. Department of Biological Engineering, Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology. Department of Biology, Dani, Neil, Herbst, Rebecca H, McCabe, Cristin, Green, Gilad S, Kaiser, Karol, Head, Joshua P, Cui, Jin, Shipley, Frederick B, Jang, Ahram, Dionne, Danielle, Nguyen, Lan, Rodman, Christopher, Riesenfeld, Samantha J, Prochazka, Jan, Prochazkova, Michaela, Sedlacek, Radislav, Zhang, Feng, Bryja, Vitezslav, Rozenblatt-Rosen, Orit, Habib, Naomi, Regev, Aviv, and Lehtinen, Maria K

Published
2022

6. A cellular and spatial map of the choroid plexus across brain ventricles and ages

Author

Dani, Neil, primary, Herbst, Rebecca H., additional, McCabe, Cristin, additional, Green, Gilad S., additional, Kaiser, Karol, additional, Head, Joshua P., additional, Cui, Jin, additional, Shipley, Frederick B., additional, Jang, Ahram, additional, Dionne, Danielle, additional, Nguyen, Lan, additional, Rodman, Christopher, additional, Riesenfeld, Samantha J., additional, Prochazka, Jan, additional, Prochazkova, Michaela, additional, Sedlacek, Radislav, additional, Zhang, Feng, additional, Bryja, Vitezslav, additional, Rozenblatt-Rosen, Orit, additional, Habib, Naomi, additional, Regev, Aviv, additional, and Lehtinen, Maria K., additional

Published
2021
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7. A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

Author

Boroughs, Angela C., primary, Larson, Rebecca C., additional, Marjanovic, Nemanja D., additional, Gosik, Kirk, additional, Castano, Ana P., additional, Porter, Caroline B.M., additional, Lorrey, Selena J., additional, Ashenberg, Orr, additional, Jerby, Livnat, additional, Hofree, Matan, additional, Smith-Rosario, Gabriela, additional, Morris, Robert, additional, Gould, Joshua, additional, Riley, Lauren S., additional, Berger, Trisha R., additional, Riesenfeld, Samantha J., additional, Rozenblatt-Rosen, Orit, additional, Choi, Bryan D., additional, Regev, Aviv, additional, and Maus, Marcela V., additional

Published
2020
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Author

Broad Institute of MIT and Harvard, Massachusetts Institute of Technology. Department of Biology, Xu, Heping, Ding, Jiarui, Porter, Caroline, Wallrapp, Antonia, Tabaka, Marcin, Ma, Sai, Fu, Shujie, Guo, Xuanxuan, Riesenfeld, Samantha J., Su, Chienwen, Dionne, Danielle, Nguyen, Lan T., Lefkovith, Ariel, Ashenberg, Orr, Burkett, Patrick R., Shi, Hai Ning, Rozenblatt-Rosen, Orit, Graham, Daniel B., Kuchroo, Vijay K., Regev, Aviv, Xavier, Ramnik J., Broad Institute of MIT and Harvard, Massachusetts Institute of Technology. Department of Biology, Xu, Heping, Ding, Jiarui, Porter, Caroline, Wallrapp, Antonia, Tabaka, Marcin, Ma, Sai, Fu, Shujie, Guo, Xuanxuan, Riesenfeld, Samantha J., Su, Chienwen, Dionne, Danielle, Nguyen, Lan T., Lefkovith, Ariel, Ashenberg, Orr, Burkett, Patrick R., Shi, Hai Ning, Rozenblatt-Rosen, Orit, Graham, Daniel B., Kuchroo, Vijay K., Regev, Aviv, and Xavier, Ramnik J.

Published
2020

9. Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses

Author

Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Wallrapp, Antonia, Burkett, Patrick R., Riesenfeld, Samantha J., Kim, Se-Jin, Christian, Elena, Abdulnour, Raja-Elie E., Thakore, Pratiksha I., Schnell, Alexandra, Lambden, Conner, Herbst, Rebecca H., Khan, Pavana, Tsujikawa, Kazutake, Xavier, Ramnik J., Chiu, Isaac M., Levy, Bruce D., Regev, Aviv, Kuchroo, Vijay K., Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Wallrapp, Antonia, Burkett, Patrick R., Riesenfeld, Samantha J., Kim, Se-Jin, Christian, Elena, Abdulnour, Raja-Elie E., Thakore, Pratiksha I., Schnell, Alexandra, Lambden, Conner, Herbst, Rebecca H., Khan, Pavana, Tsujikawa, Kazutake, Xavier, Ramnik J., Chiu, Isaac M., Levy, Bruce D., Regev, Aviv, and Kuchroo, Vijay K.

Abstract

Neuroimmune interactions have emerged as critical modulators of allergic inflammation, and type 2 innate lymphoid cells (ILC2s) are an important cell type for mediating these interactions. Here, we show that ILC2s expressed both the neuropeptide calcitonin gene-related peptide (CGRP) and its receptor. CGRP potently inhibited alarmin-driven type 2 cytokine production and proliferation by lung ILC2s both in vitro and in vivo. CGRP induced marked changes in ILC2 expression programs in vivo and in vitro, attenuating alarmin-driven proliferative and effector responses. A distinct subset of ILCs scored highly for a CGRP-specific gene signature after in vivo alarmin stimulation, suggesting CGRP regulated this response. Finally, we observed increased ILC2 proliferation and type 2 cytokine production as well as exaggerated responses to alarmins in mice lacking the CGRP receptor. Together, these data indicate that endogenous CGRP is a critical negative regulator of ILC2 responses in vivo.

Published
2020

10. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses

Author

Xu, Heping, primary, Ding, Jiarui, additional, Porter, Caroline B.M., additional, Wallrapp, Antonia, additional, Tabaka, Marcin, additional, Ma, Sai, additional, Fu, Shujie, additional, Guo, Xuanxuan, additional, Riesenfeld, Samantha J., additional, Su, Chienwen, additional, Dionne, Danielle, additional, Nguyen, Lan T., additional, Lefkovith, Ariel, additional, Ashenberg, Orr, additional, Burkett, Patrick R., additional, Shi, Hai Ning, additional, Rozenblatt-Rosen, Orit, additional, Graham, Daniel B., additional, Kuchroo, Vijay K., additional, Regev, Aviv, additional, and Xavier, Ramnik J., additional

Published
2019
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11. Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses

Author

Wallrapp, Antonia, primary, Burkett, Patrick R., additional, Riesenfeld, Samantha J., additional, Kim, Se-Jin, additional, Christian, Elena, additional, Abdulnour, Raja-Elie E., additional, Thakore, Pratiksha I., additional, Schnell, Alexandra, additional, Lambden, Conner, additional, Herbst, Rebecca H., additional, Khan, Pavana, additional, Tsujikawa, Kazutake, additional, Xavier, Ramnik J., additional, Chiu, Isaac M., additional, Levy, Bruce D., additional, Regev, Aviv, additional, and Kuchroo, Vijay K., additional

Published
2019
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