1. Maternal coffee and alcohol consumption during pregnancy, parental smoking and risk of childhood acute leukaemia
- Author
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Christoph Steffen, André Baruchel, Brigitte Lescoeur, Denis Hémon, Stéphanie Bellec, Brigitte Nelken, Jacqueline Clavel, N Philippe, Guy Leverger, Florence Menegaux, Danièle Sommelet, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hématologie pédiatrique, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service d'hématologie et immunologie pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service pédiatrique d'hématologie-oncologie, Hôpital Jeanne de Flandre [Lille], Service d'Hématologie Pédiatrique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Kaniewski, Nadine, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Subjects
Male ,Cancer Research ,Pediatrics ,Maternal smoking ,Ethnic origin ,Coffee ,MESH: Pregnancy ,0302 clinical medicine ,Pregnancy ,Risk Factors ,MESH: Risk Factors ,MESH: Child ,030212 general & internal medicine ,MESH: Maternal Exposure ,Child ,Acute leukemia ,Leukemia ,MESH: Case-Control Studies ,MESH: Infant ,MESH: Mothers ,Alcohol consumption during pregnancy ,3. Good health ,Oncology ,Maternal Exposure ,Child, Preschool ,030220 oncology & carcinogenesis ,MESH: Tobacco Smoke Pollution ,Female ,MESH: Socioeconomic Factors ,medicine.medical_specialty ,Adolescent ,Alcohol Drinking ,Childhood leukemia ,Mothers ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,03 medical and health sciences ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,MESH: Leukemia ,medicine ,Humans ,MESH: Adolescent ,MESH: Humans ,business.industry ,MESH: Child, Preschool ,Case-control study ,Infant ,MESH: Coffee ,medicine.disease ,MESH: Male ,[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,Socioeconomic Factors ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Case-Control Studies ,Tobacco Smoke Pollution ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,MESH: Female ,MESH: Alcohol Drinking - Abstract
International audience; INTRODUCTION: We investigated the role of maternal alcohol and coffee drinking and parental smoking on the risk of childhood acute leukemia in a multicenter case-control study. METHODS: The study included 280 incident cases and 288 hospitalized controls, frequency matched with the cases by age, gender and center. Data collection was completed by face-to-face standardized interviews of the case and control mothers. RESULTS: An association with maternal alcohol consumption during pregnancy was observed with acute lymphoid leukemia (ALL) (OR=2.0 [1.4-3.0]) and acute non-lymphoid leukemia (ANLL) (OR=2.6 [1.2-5.8]). Maternal coffee consumption during pregnancy was associated with childhood acute leukemia, ORs increasing in ALL with coffee consumption (OR=1.1 [0.7-1.8], OR=2.4 [1.3-4.7] and OR=3.1 [1.0-9.5], respectively, for < or =3, 4-8 and >8 cups/day). No association with maternal smoking during pregnancy or parental smoking before or after the index child's birth was observed. DISCUSSION: Our results suggest an association with maternal alcohol and coffee drinking during pregnancy and call for further investigations. Besides, the present study does not support the hypothesis of an increase in the risk of childhood leukemia related to parental smoking.
- Published
- 2005
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