1. Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis
- Author
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John M. Ward, Nicholas H. Keep, Helen C. Hailes, and Rebecca Roddan
- Subjects
0301 basic medicine ,Molecular Conformation ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Analytical Chemistry ,03 medical and health sciences ,chemistry.chemical_compound ,Alkaloids ,Biosynthesis ,Tetrahydroisoquinolines ,Drug Discovery ,Ethylamines ,Humans ,chemistry.chemical_classification ,Aldehydes ,Biological Products ,Bacteria ,Tetrahydroisoquinoline ,Drug discovery ,Stereoisomerism ,Ketones ,Plants ,equipment and supplies ,Combinatorial chemistry ,Enzymes ,0104 chemical sciences ,030104 developmental biology ,Enzyme ,chemistry ,Cyclization ,Biocatalysis ,Alkaloid biosynthesis ,Carbolines - Abstract
Pictet-Spenglerases provide a key role in the biosynthesis of many biologically active alkaloids. There is increasing use of these biocatalysts as an alternative to traditional organic synthetic methods as they provide stereoselective and regioselective control under mild conditions. Products from these enzymes also contain privileged drug scaffolds (such as tetrahydroisoquinoline or β-carboline moieties), so there is interest in the characterization and use of these enzymes as versatile biocatalysts to synthesize analogs of the corresponding natural products for drug discovery. This review discusses all known Pictet-Spenglerase enzymes and their applications as biocatalysts.
- Published
- 2020
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