30 results on '"Rautio, Jarkko"'
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2. A technological comparison of freeze-dried poly-ɛ-caprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with clozapine for nose-to-brain delivery
3. Altering distribution profile of palbociclib by its prodrugs
4. In-vitro dynamic dissolution/bioconversion/permeation of fosamprenavir using a novel tool with an artificial biomimetic permeation barrier and microdialysis-sampling
5. Impact of a Novel Anti-Inflammatory Ketoprofen-Lysine Prodrug on Cerebral Pathology and Cognition in a Comorbid APP21 Transgenic Rat with Diet-Induced Metabolic Syndrome
6. Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation
7. Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats
8. Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens
9. Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase
10. Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug
11. Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake
12. Prodrugs – Recent approvals and a glimpse of the pipeline
13. Prodrugs in medicinal chemistry and enzyme prodrug therapies
14. High-accuracy mass spectrometry for identification of sulphur-containing bioactive constituents and flavonoids in extracts of Raphanus sativus var. caudatus Alef (Thai rat-tailed radish)
15. Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835
16. Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1)
17. Glutathione-S-transferase selective release of metformin from its sulfonamide prodrug
18. Amino acids as promoieties in prodrug design and development
19. Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin
20. Structure–activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion
21. In Vitro and In Vivo Evaluation of a Sulfenamide Prodrug of Basic Metformin
22. Brain uptake of ketoprofen–lysine prodrug in rats
23. Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor
24. Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography
25. Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol
26. Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases
27. Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone
28. Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives
29. Synthesis, Stability and In Vitro Dermal Evaluation of Aminocarbonyloxymethyl Esters as Prodrugs of Carboxylic Acid Agents
30. Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation
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