1. Thermal Ablation, Embolization, and Selective Internal Radiation Therapy Combined with Checkpoint Inhibitor Cancer Immunotherapy: Safety Analysis
- Author
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Konstantin S Leppelmann, Eric Wehrenberg-Klee, Florian J. Fintelmann, Kerry L. Reynolds, Zubin Irani, Joshua A Hirsch, Ronald S. Arellano, Meghan J. Mooradian, Kei Yamada, Leyre Zubiri, Suvranu Ganguli, Raul N. Uppot, and Ryan J. Sullivan
- Subjects
Ablation Techniques ,Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Brachytherapy ,Programmed Cell Death 1 Receptor ,Ipilimumab ,Pembrolizumab ,Risk Assessment ,Gastroenterology ,B7-H1 Antigen ,Article ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Atezolizumab ,Interquartile range ,Neoplasms ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Immune Checkpoint Inhibitors ,Aged ,Retrospective Studies ,business.industry ,Selective internal radiation therapy ,Common Terminology Criteria for Adverse Events ,Cryoablation ,Middle Aged ,Combined Modality Therapy ,Embolization, Therapeutic ,Treatment Outcome ,030220 oncology & carcinogenesis ,Female ,Patient Safety ,Nivolumab ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Purpose To describe interventional oncology therapies combined with immune checkpoint inhibitor (ICI) therapy targeting the programmed death 1 pathway in patients with different neoplasms. Materials and Methods This was a retrospective cohort study of patients who underwent tumor-directed thermal ablation, embolization, or selective internal radiation therapy (SIRT) between January 1, 2011, and May 1, 2019, and received anti–programmed death 1/PD-L1 agents ≤ 90 days before or ≤ 30 days after the interventional procedure. Immune-related adverse events (irAEs) and procedural complications ≤ 90 days after the procedure were graded according to the Common Terminology Criteria for Adverse Events version 5.0. The study included 65 eligible patients (49% female; age 63 years ± 11.1). The most common tumors were metastatic melanoma (n = 28) and non–small cell lung cancer (NSCLC) (n = 12). Patients underwent 78 procedures (12 patients underwent > 1 procedure), most frequently SIRT (35.9%) and cryoablation (28.2%). The most common target organs were liver (46.2%), bone (24.4%), and lung (9.0%). Most patients received ICI monotherapy with pembrolizumab (n = 30), nivolumab (n = 22), and atezolizumab (n = 6); 7 patients received ipilimumab and nivolumab. Results Seven (10.8%) patients experienced an irAE (71.4% grade 1–2), mostly affecting the skin. Median time to irAE was 33 days (interquartile range, 19–38 days). Five irAEs occurred in patients with melanoma, and no irAEs occurred in patients with NSCLC. Management required corticosteroids (n = 3) and immunotherapy discontinuation (n = 1); all irAEs resolved to grade ≤ 1. There were 4 intraprocedural and 32 postprocedural complications (77.8% grade Conclusions No unmanageable or unanticipated toxicities occurred within 90 days after interventional oncology therapies combined with ICIs.
- Published
- 2021