Search

Your search keyword '"Radhakrishnan, Arun"' showing total 39 results
Start Over Author "Radhakrishnan, Arun" Publisher elsevier bv
39 results on '"Radhakrishnan, Arun"'

12. Experimental study of condensation heat transfer on hydrophobic vertical tube

Author

Lazarus Godson Asirvatham, Somchai Wongwises, Arjunan Praveen, Radhakrishnan Arun Krishnan, and Mattacaud Ramachandralal Rajkumar

Subjects
Fluid Flow and Transfer Processes, Materials science, 020209 energy, Mechanical Engineering, Condensation, chemistry.chemical_element, 02 engineering and technology, engineering.material, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Copper, Contact angle, Coating, chemistry, Heat transfer, 0202 electrical engineering, electronic engineering, information engineering, engineering, Surface modification, Tube (fluid conveyance), Texture (crystalline), Composite material, 0210 nano-technology
Abstract

Condensation heat transfer on surfaces can be enhanced by altering the surface topography. Surface modification technology can promote dropwise condensation which can exhibit higher heat transfer rate than filmwise condensation. This paper presents experimental data on the condensation of steam on vertical bare copper tubes and lead coated copper tubes for degree of sub-cooling in the range 0.5 °C ≤ ΔT ≤ 20 °C. The chemical texture of the tube surface was altered by coating with lead of thickness 10 µm and the physical texture of the surface was transformed by providing four grooves each having equal depths 0.10 mm, 0.15 mm and 0.30 mm. The condensation heat transfer characteristics of the tube surface is explained based on contact angle hysteresis and sliding velocity of the droplet. The results of the study reveal that for the tubes tested the average condensation heat transfer coefficient decreases with increase in degree of sub-cooling. It is also found that for copper tubes, providing grooves aids condensation heat transfer for the range of sub-cooling. However, for lead coated copper tube with/without grooves the heat transfer performance at ΔT 2 °C.

Published
2018

13. Enhanced oral bioavailability of an antipsychotic drug through nanostructured lipid carriers

Author

Jubie Selvaraj, Nagaraju G, Radhakrishnan Arun, Arigo Anbarasan, N Jawahar, Prashant Kumar Hingarh, and S. Sathianarayanan

Subjects
Male, Drug, Castor Oil, media_common.quotation_subject, Administration, Oral, Biological Availability, Poloxamer, 02 engineering and technology, 030226 pharmacology & pharmacy, Biochemistry, Benzodiazepines, 03 medical and health sciences, First pass effect, 0302 clinical medicine, Structural Biology, Lecithins, Zeta potential, Animals, Distribution (pharmacology), Rats, Wistar, Molecular Biology, Triglycerides, media_common, Drug Carriers, Chromatography, Chemistry, General Medicine, 021001 nanoscience & nanotechnology, Rats, Bioavailability, Olanzapine, Nanoparticles, 0210 nano-technology, Drug carrier, Drug metabolism, Antipsychotic Agents
Abstract

Olanzapine is an atypical antipsychotic, undergoes extensive first pass metabolism, also has poor aqueous solubility and belongs to BCS (Biopharmaceutical Classification System) Class II drug) exhibit low oral bioavailability. To overcome this and to enhance the bioavailability, intestinal lymphatic transport of drugs can be exploited through Nano structured lipid carriers (NLCs). The NLCs were formulated by solvent diffusion method using solid lipid (glyceryl tripalmitate), liquid lipid (castor oil) and surfactants (Pluronic F-68, Soylecithin). The formulated NLCs were characterized for physico-chemical properties, in-vitro release studies and in-vivo oral bioavailability. F6 has shown average particle size of 158.5 nm with PI of 0.115 indicating narrow particle size distribution and follows uni modal distribution. It was found that the batch with stearyl amine has a zeta potential of 28.39 mV which confers stability to the dispersion. Bioavailability studies indicate that there was more than 5½-fold increase in oral bioavailability in case of NLCs (F6) compared to olanzapine suspension which indicates that NLCs provided sustained release of the drugs, and these systems can be the preferred as drug carriers for lipophilic drugs in long term disease conditions such as schizophrenia for enhanced bioavailability.

Published
2018

16. Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Author

Wang, Xiaobo, primary, Cai, Bishuang, additional, Yang, Xiaoming, additional, Sonubi, Oluwatoni O., additional, Zheng, Ze, additional, Ramakrishnan, Rajasekhar, additional, Shi, Hongxue, additional, Valenti, Luca, additional, Pajvani, Utpal B., additional, Sandhu, Jaspreet, additional, Infante, Rodney E., additional, Radhakrishnan, Arun, additional, Covey, Douglas F., additional, Guan, Kun-Liang, additional, Buck, Jochen, additional, Levin, Lonny R., additional, Tontonoz, Peter, additional, Schwabe, Robert F., additional, and Tabas, Ira, additional

Published
2020
Full Text
View/download PDF

26. Direct Demonstration That Loop1 of Scap Binds to Loop7

Author

Zhang, Yinxin, primary, Lee, Kwang Min, additional, Kinch, Lisa N., additional, Clark, Lindsay, additional, Grishin, Nick V., additional, Rosenbaum, Daniel M., additional, Brown, Michael S., additional, Goldstein, Joseph L., additional, and Radhakrishnan, Arun, additional

Published
2016
Full Text
View/download PDF

34. Purified NPC1 Protein

Author

Infante, Rodney E., primary, Radhakrishnan, Arun, additional, Abi-Mosleh, Lina, additional, Kinch, Lisa N., additional, Wang, Michael L., additional, Grishin, Nick V., additional, Goldstein, Joseph L., additional, and Brown, Michael S., additional

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results