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An efficient, one-pot and multi-component synthesis of trans -perfluoroalkylated [1,3]oxazino[2,3- a ]isoquinoline derivatives is described. Moderate to excellent yields have been achieved under mild conditions. A plausible mechanism for this type of cyclization is proposed. In addition, isoquinolines as the nucleophilic reagent have been examined. Furthermore, excellent regioselectivity and diastereoselectivity can be observed in this reaction.

A multicomponent reaction involving quinolines, methyl perfluoroalk-2-ynoates and aromatic aldehydes for the synthesis of perfluoroalkylated fused [1,3]oxazine derivatives has been described. The whole process is carried out under mild conditions and furnishes the desired products in good yields. Furthermore, excellent regioselectivity and diastereoselectivity can be observed in this reaction.