1. Cytotoxic alkaloids from the fruits and seeds of Alangium salviifolium (L.f.) Wangerin
- Author
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Ling Chen, Ji-Zheng Sun, Fengkai Fan, Qing-Qing Tang, Jianqing Yu, Si-Yuan Zhou, Sheng-Ping Yang, Ziyan Guo, You-Sheng Cai, Guofu Qiu, and Wen-Ting Sun
- Subjects
Cisplatin ,Natural product ,Traditional medicine ,biology ,010405 organic chemistry ,Alkaloid ,Plant Science ,010402 general chemistry ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,HeLa ,chemistry.chemical_compound ,chemistry ,Cell culture ,Alangium salviifolium ,medicine ,Cytotoxic T cell ,heterocyclic compounds ,Agronomy and Crop Science ,Two-dimensional nuclear magnetic resonance spectroscopy ,Biotechnology ,medicine.drug - Abstract
One new cepheline-type alkaloid 8-hydroxyl-cepheline (1) and one new natural product Δ1′,2′-deoxytubulosine (2), together with 9 known alkaloids have been isolated from the fruits and seeds of Alangium salviifolium (L.f.) Wangerin. The structures of the new alkaloids were elucidated by means of extensive spectroscopic analysis (2D NMR, HRESIMS). All alkaloids were evaluated for their cytotoxic activity against three human cancer cell lines, A-549, Hela and SKOV-3. Compounds 1-4, 6, 8 and 9 exhibited significant inhibitory effects against three human cancer cells with IC50 values (0.1–14 μM) comparable to those of cisplatin.
- Published
- 2018