1. Zinc(II) and copper(II) complexes of β-substituted hydroxylporphyrins as tumor photosensitizers
- Author
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Qimao Huang, Zhangping Chen, Ping Wang, Xiao-Lian Zhang, Zhiquan Pan, and Hansheng Xu
- Subjects
Porphyrins ,Stereochemistry ,medicine.medical_treatment ,Clinical Biochemistry ,Pharmaceutical Science ,chemistry.chemical_element ,Antineoplastic Agents ,Photodynamic therapy ,Zinc ,Hydroxylation ,Biochemistry ,Chemical synthesis ,chemistry.chemical_compound ,Drug Discovery ,medicine ,Humans ,Photosensitizer ,Molecular Biology ,Cell Proliferation ,Photosensitizing Agents ,Molecular Structure ,Singlet oxygen ,Organic Chemistry ,Biological activity ,Copper ,chemistry ,Zinc Compounds ,Molecular Medicine ,DNA ,Plasmids ,Nuclear chemistry - Abstract
Novel photosensitizers beta-(hydroquinon-2-yl)-5,10,15,20-tetra(4-hydroxylphenyl)porphyrinato zinc(II) (Zn(II)P) and beta-(hydroquinon-2-yl)-5,10,15,20-tetra(4-hydroxylphenyl)porphyrinato copper(II) (Cu(II)P) were synthesized and characterized. Their ability of producing singlet oxygen under irradiation was detected by the measurement of decomposition of 1,3-diphenylisobenzofuran (DPBF). The preliminary biological activity studies show that the Zn(II)P has photo-toxicity on human chronic myelogenous leukemia cell (K562) and could cleave supercoiled DNA (pBR 322 DNA), while the Cu(II)P has inferior biological activity. Results showed Zn(II)P having high anti-tumor activity, which presents a promising photosensitizer for photodynamic therapy.
- Published
- 2006
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