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Background and Aim Accumulating evidence indicates a plausible association between inflammatory bowel diseases and the risk of adverse health outcomes. However, the conclusions are inconsistent. We aimed to perform an umbrella review of meta-analyses to appraise and grade the evidence of the association between inflammatory bowel diseases and the risk of adverse health outcomes. Methods Meta-analyses of observational studies that examined the associations between inflammatory bowel disease and the risk of adverse health outcomes in PubMed, EMBASE, and Web of Science were screened. Results This umbrella review identified 25 meta-analyses, which yielded 123 effect estimates for 60 unique putative health outcomes. Patients with inflammatory bowel diseases had a higher risk of adverse health outcomes, including multiple cancers, cardiovascular disease, adverse pregnancy outcomes, adverse oral outcomes, and other adverse events. Moreover, inflammatory bowel diseases caused greater harm to health based on the presented evidence. However, none of the evidence was classified as “high” quality, only 15% was classified as “moderate,” and 65% of outcomes were rated as “very low.” Conclusion Patients with inflammatory bowel diseases had a higher risk of adverse health outcomes and further studies should be conducted to draw firmer conclusions.

Background Fish contains a variety of essential nutrients, which may contribute to multiple health benefits in humans. Conversely, it also may contain contaminants, resulting in confusion over the health impact of fish consumption. Scope and approach To assess the strength and validity of associations between fish intake and multiple health outcomes. We performed an umbrella review of systematic reviews and meta-analyses in humans. Key findings and conclusions: Of the 55 unique outcomes in the identified 89 systematic reviews and meta-analyses, fish consumption did more benefit than harm for a variety of health outcomes with largest risk reduction at 2 to 4 servings per week. Dose-response analyses revealed that every 20 g/d (approximately one serving/week) increment could decrease 2%–7% risk of coronary heart disease mortality, cardiovascular disease mortality, all-cause mortality, stroke, myocardial infarction, acute coronary syndrome, heart failure, gastrointestinal cancer, metabolic syndrome, dementia and Alzheimer's disease. Beneficial associations were also found for cancers, atopic, musculoskeletal, gastrointestinal and ophthalmologic outcomes. Caution is warranted for potential allergy or contamination when advising during pregnancy and young children. Fish intake appears generally safe in this umbrella review with largest risk reduction for a range of health outcomes at two to four servings per week, and seems more beneficial than harmful. High-quality prospective studies are needed.

The development of rapid nucleic acid detection methods, which are promising the diagnostic standard of the infectious disease, could expand more options for disease traceability and controllability. Nucleic acid hybridization-based biosensing techniques still encounter limitations in meeting the requirements for rapid detection. Therefore, we proposed a potential-assisted ratiometric electrochemical biosensor for rapid and accurate target DNA detection. This dual-signal analysis system actuated an enzyme-free detection process. The application of an external electric field accelerated molecular dynamics, resulting in highly efficient collision chances. This hybridization process was thus improved from hours to minutes compared with passive hybridization approach. The biosensor not only had a high sensitivity with the detection limit of 12 fM, but also features a robust capability in identifying single-base mismatch. Moreover, the biosensor realized sensitive detection of target DNA in complex biological environments. Overall, this sensing strategy exhibits a promising potential for application in point-of-care testing.

Background: A growing body of evidence has pointed to the prognostic value of immune infiltration in gastrointestinal stromal tumors (GISTs). Thus, we aimed to develop a novel immune-based prognostic (IP) nomogram for better prognosis prediction of GISTs. Methods: Gene expression profiles of 22 immune features of GISTs were extracted from the GEO dataset. The immunoscore (IS) was constructed using the LASSO Cox regression model and validated in 54 GISTs via immunohistochemistry. The IP nomogram integrating IS and clinicopathological factors was constructed. The performance of the IP nomogram was evaluated and compared with conventional risk prognostic criteria. Results: The IS was established based on 4 features: CD8, CD8/CD3, CD68, CD163/CD68. Significant differences were observed between the low- and high-IS groups in the 5-year RFS (93.9% vs. 33.3%, p

Lycopene is a potent lipophilic antioxidant in tomato. We aim to clarify the evidence for associations between tomato and lycopene and multiple health outcomes. Umbrella review of meta-analyses and systematic reviews was performed in humans. A total of 174 articles were searched, 17 articles with 20 health outcomes were identified by eligibility criteria. Tomato intake was inversely associated with all-cause mortality, coronary heart disease mortality, cerebrovascular disease mortality, prostate cancer, and gastric cancer. Dietary lycopene intake or serum lycopene was inversely associated with all-cause mortality, prostate cancer, stroke, cardiovascular disease, metabolic syndrome, and male infertility. Caution was warranted for potential allergy and pollution. The quality of the vast majority of evidence by GRADE was low or very low with the remaining six as moderate. The intake of tomato or lycopene was generally safe and beneficial for multiple health outcomes in humans. But the quality of the evidence was not high.

Background: Aspirin has been widely used as treatment for inflammation, pain and cardiovascular events, and recently some studies found that patients of cancer with aspirin use seemed to have longer survival. However, the supporting data varied, and the arguments existed among studies. To better understand this issue, we conducted this systematic review and meta-analysis to investigate whether patients of cancer with aspirin use had longer survival. Methods: This study has been registered in PROSPERO (No· CRD42018102280). We searched the PubMed, Web of Science and Embase for studies about aspirin use and survival of cancer published before May 2018, and the references of related studies were also reviewed. The primary outcomes were cancer-specific survival and overall survival for patients of cancer. In meta-analysis, pooled odds ratios (OR) and 95% confidence intervals (CI) were estimated with random-effects or fixed-effects model according to the heterogeneity which was estimated by Q statistic. Subgroup analysis was performed to identify the associations between aspirin use and survival of different kinds of cancers, and the influences of prediagnosis or postdiagnosis aspirin use and duration of aspirin use were also assessed. For colorectal cancer, we specially assessed the influence of PIK3CA mutation status and prostaglandin-endoperoxide synthase 2 (PTGS2) expression in this study. Findings: Totally 57 observational studies with 17 kinds of cancers and 1274 933 participants were included. Compared with aspirin nonusers, patients of cancer with postdiagnosis aspirin use had both prolonged cancer-specific survival (OR 0·86; 95% CI 0·72-0·99; P heterogeneity