11 results on '"Qiangqiang Jia"'
Search Results
2. Juvenile hormone membrane signaling phosphorylates USP and thus potentiates 20-hydroxyecdysone action in Drosophila
- Author
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Subba Reddy Palli, Suning Liu, Qiangqiang Jia, Dong‐Wei Yuan, Guirong Wang, Emma Yiyang Li, Sheng Li, Jian Wang, Qili Feng, Lixian Wu, and Yue Gao
- Subjects
Multidisciplinary ,biology ,PKC Phosphorylation Site ,20-Hydroxyecdysone ,Methoprene ,Halloween genes ,Receptor tyrosine kinase ,Cell biology ,Juvenile Hormones ,chemistry.chemical_compound ,Ecdysterone ,Drosophila melanogaster ,chemistry ,Juvenile hormone ,biology.protein ,Animals ,Phosphorylation ,Drosophila ,Signal transduction ,Protein Kinase C ,Protein kinase C ,Signal Transduction - Abstract
Juvenile hormone (JH) and 20-hydroxyecdysone (20E) coordinately regulate development and metamorphosis in insects. Two JH intracellular receptors, methoprene-tolerant (Met) and germ-cell expressed (Gce), have been identified in the fruit fly Drosophila melanogaster. To investigate JH membrane signaling pathway without the interference from JH intracellular signaling, we characterized phosphoproteome profiles of the Met gce double mutant in the absence or presence of JH in both chronic and acute phases. Functioning through a potential receptor tyrosine kinase and phospholipase C pathway, JH membrane signaling activated protein kinase C (PKC) which phosphorylated ultraspiracle (USP) at Ser35, the PKC phosphorylation site required for the maximal action of 20E through its nuclear receptor complex EcR-USP. The uspS35A mutant, in which Ser was replaced with Ala at position 35 by genome editing, showed decreased expression of Halloween genes that are responsible for ecdysone biosynthesis and thus attenuated 20E signaling that delayed developmental timing. The uspS35A mutant also showed lower Yorkie activity that reduced body size. Altogether, JH membrane signaling phosphorylates USP at Ser35 and thus potentiates 20E action that regulates the normal fly development. This study helps better understand the complex JH signaling network.
- Published
- 2022
3. Lead-free bilayer heterometallic halide perovskite with reversible phase transition and photoluminescence properties
- Author
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Qiangqiang Jia, Ting Shao, Liang Tong, Changyuan Su, Dawei Fu, and Haifeng Lu
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General Chemistry - Published
- 2023
4. Integrating Metabolomics and Transcriptomics Reveals the Molecular Mechanism of Global Metabolic Differences in Three Species of Nitraria Berries
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qiangqiang jia, Zufan Yang, qian wang, ping hu, and chengzhou zhao
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2021
5. An aqueous fluorescent sensor for Pb2+ based on phenothiazine-polyamide
- Author
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Zhaoqian Wang, Xingliang Liu, Chao Zhang, Qiangqiang Jia, Jianfang Cao, Yadian Xie, Aixia Han, Han Li, and Haitang Lv
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Diethanolamine ,Aqueous solution ,010405 organic chemistry ,Chemistry ,Metal ions in aqueous solution ,Inorganic chemistry ,010402 general chemistry ,01 natural sciences ,Fluorescence ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Analytical Chemistry ,Ion ,chemistry.chemical_compound ,Water soluble ,Phenothiazine ,Polyamide ,Instrumentation ,Spectroscopy - Abstract
A sensitive and selective fluorescent sensor for Pb2+ ion based on phenothiazine-polyamide was built (named sensor PP). Due to introducing of four diethanolamine groups to polyamide, this sensor was totally water soluble. PP could detect Pb2+ ion within 1 min in the presence of other metal ions in aqueous solution, the detect limit was 9.11 × 10−8 M.
- Published
- 2018
6. Yorkie overexpression in the posterior silk gland improves silk yield in Bombyx mori
- Author
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Panli Zhang, Shumin Liu, Qiangqiang Jia, Guozheng Zhang, Sheng Li, and Hong-Sheng Song
- Subjects
0301 basic medicine ,030102 biochemistry & molecular biology ,biology ,Physiology ,Transgene ,fungi ,Fibroin ,biology.organism_classification ,Cell biology ,03 medical and health sciences ,030104 developmental biology ,SILK ,Bombyx mori ,Insect Science ,Complementary DNA ,Botany ,Protein biosynthesis ,Enhancer ,Gene - Abstract
The traditional hybrid breeding techniques can no longer meet the increasing demands for silk production by the silkworm, Bombyx mori, and further improvement of the silk yield will depend on modern molecular breeding techniques. Here, we report improved silk yield in transgenic silkworms overexpressing the oncogene YorkieCA specifically in the posterior silk gland (PSG). The YorkieCA cDNA was ligated downstream of the hr3 enhancer and the fibroin L-chain (Fil) promoter, then inserted into a piggyBac vector for transgene. Overexpression of YorkieCA in the PSG significantly increased the weight of the PSG, and also increased the weight of the cocoon, larval body, and pupal body to decreasing degrees. Overexpression of YorkieCA up-regulated the Yorkie target genes resulting in increased cell size, endomitosis, the number of protein synthesis organelles, the expression of fibroin genes in the PSG, and eventually silk yield. Additionally, as we reported previously using the binary GAL4/UAS system, transgenic silkworms overexpressing Ras1CA with the hr3 enhancer and the Fil promoter also showed improved silk yield. Unfortunately, the hybrid progeny of YorkieCA-overexpressing silkworms and Ras1CA-overexpressing silkworms did not show overlapping improved silk yield due to the failure to increase expression of both Yorkie and Ras1.
- Published
- 2017
7. Knockdown of LmCYP303A1 alters cuticular hydrocarbon profiles and increases the susceptibility to desiccation and insecticides in Locusta migratoria
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Kun Yan Zhu, René Feyereisen, Sheng Li, Jianzhen Zhang, Qiangqiang Jia, Xueyao Zhang, Enbo Ma, Zhitao Yu, and Lixian Wu
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0106 biological sciences ,0301 basic medicine ,Insecticides ,animal structures ,Health, Toxicology and Mutagenesis ,media_common.quotation_subject ,Locusta migratoria ,Insect ,01 natural sciences ,03 medical and health sciences ,RNA interference ,Animals ,Desiccation ,Nymph ,media_common ,Gene knockdown ,biology ,fungi ,General Medicine ,biology.organism_classification ,Hydrocarbons ,Cell biology ,010602 entomology ,Drosophila melanogaster ,030104 developmental biology ,Ecdysis ,Insect Proteins ,Agronomy and Crop Science ,Moulting ,Locust - Abstract
Cytochrome P450 monooxygenases (CYPs) serve many functions in insects, from the regulation of development to xenobiotic detoxification. Several conserved CYPs have been shown to play a role in insect growth and development. CYP303A1 is a highly conserved CYP with a single ortholog in most insects, but its underlying molecular characteristics and specific physiological functions remain poorly understood. In Drosophila melanogaster and Locusta migratoria, CYP303A1 is indispensable for eclosion to adult. Here, we report additional functions of the locust gene LmCYP303A1 in nymphal molts, cuticular lipid deposition and insecticide penetration. RT-qPCR revealed that LmCYP303A1 had a high expression level before ecdysis and was highly expressed in integument, wing pads, foregut and hindgut. Suppression of LmCYP303A1 expression by RNA interference (RNAi) caused a lethal phenotype with molting defect from nymph to nymph. In addition, LmCYP303A1 RNAi resulted in locusts being more susceptible to desiccation and to insecticide toxicity. Furthermore, knockdown of LmCYP303A1 efficiently suppressed the transcript level of key genes (ELO7, FAR15 and CYP4G102) responsible for cuticular hydrocarbon (CHC) synthesis, which led to a decrease in some CHC levels. Taken together, our results suggest that one of the functions of LmCYP303A1 is to regulate the biosynthesis of CHC, which plays critical roles in protecting locusts from water loss and insecticide penetration.
- Published
- 2020
8. Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice
- Author
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Yu Li, Dandan Zhao, Sihua Gao, Qiangqiang Jia, Lili Wang, Beibei Chen, Ruyuan Zhu, Chenyue Liu, Lin Li, Yimiao Tian, Fangfang Mo, Rui Li, Haixia Liu, Xiang-Dong Wang, Junping Wei, and Dongwei Zhang
- Subjects
Male ,0301 basic medicine ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Mice, Obese ,Adipose tissue ,Peroxisome proliferator-activated receptor ,Type 2 diabetes ,Biochemistry ,Mice ,chemistry.chemical_compound ,Lycopene ,0302 clinical medicine ,Adipose Tissue, Brown ,Adipocyte ,Brown adipose tissue ,Adipocytes ,Insulin ,Receptor ,chemistry.chemical_classification ,Mice, Inbred ICR ,Nutrition and Dietetics ,Cell Differentiation ,Thermogenin ,Phenotype ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine.medical_specialty ,Cell Survival ,Adipose Tissue, White ,Lipolysis ,Diet, High-Fat ,03 medical and health sciences ,Oxygen Consumption ,3T3-L1 Cells ,Internal medicine ,medicine ,Animals ,Obesity ,Molecular Biology ,Cell Proliferation ,Body Weight ,Lipid metabolism ,Glucose Tolerance Test ,Lipid Metabolism ,medicine.disease ,PPAR gamma ,Glucose ,030104 developmental biology ,Endocrinology ,chemistry - Abstract
Lycopene (LYC), one of the major carotenoids in tomatoes, has been preclinically and clinically used to obesity and type 2 diabetes management. However, whether its ability of countering body weight gain is related to induction of brown-like adipocyte phenotype in white adipose tissues (WAT) remains largely unknown. Activation of peroxisome proliferator-activated receptor γ (PPARγ) serves the brown-like phenotype conversion and energy expenditure. Here, we show that LYC treatment promotes glucose consumption and improves insulin sensitivity, as well as fosters white adipocytes browning through up-regulating mRNA and protein expression levels of PPARγ, uncoupling protein 1, PPARγ coactivator-1α and PR domain-containing 16 in the differentiated 3T3-L1 adipocytes and primary adipocytes, as well as in the WAT of HFD-exposed obese mice. In addition, LYC treatment attenuates body weight gain and improves serum lipid profiles as well as promotes brown adipose tissue activation in obese mice. Moreover, PPARγ is induced with LYC intervention in mitochondria respiration and browning in white adipocytes and tissues. Taken together, these results suggest that LYC counteracts obesity and improves glucose and lipid metabolism through induction of the browning via up-regulation of PPARγ, which offers a new perspective of this compound to combat obesity and obesity-related disorders.
- Published
- 2020
9. CYP303A1 has a conserved function in adult eclosion in Locusta migratoria and Drosophila melanogaster
- Author
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Suning Liu, Jianzhen Zhang, René Feyereisen, Xubo Zhang, Sheng Li, Enbo Ma, Yoonseong Park, Lixian Wu, Qiangqiang Jia, Kun Yan Zhu, and Xueyao Zhang
- Subjects
Nymph ,0106 biological sciences ,Embryo, Nonmammalian ,animal structures ,Mutant ,Embryonic Development ,Locusta migratoria ,Molting ,01 natural sciences ,Biochemistry ,03 medical and health sciences ,Cytochrome P-450 Enzyme System ,RNA interference ,Melanogaster ,Animals ,Drosophila Proteins ,Molecular Biology ,Gene ,Ovum ,030304 developmental biology ,0303 health sciences ,Gene knockdown ,biology ,fungi ,Pupa ,Gene Expression Regulation, Developmental ,Cytochrome P450 ,biology.organism_classification ,Cell biology ,010602 entomology ,RNA silencing ,Drosophila melanogaster ,Larva ,Insect Science ,biology.protein ,Insect Proteins - Abstract
Insect cytochrome P450 monooxygenases (CYPs) play essential roles in both xenobiotic metabolism and developmental processes. However, the exact physiological function of many CYP genes remains largely unknown. Screening the expression of the CYP genes from the CYP2 and mitochondrial CYP clans of Drosophila melanogaster revealed that Cyp303a1 is highly expressed in the pupal stage. Knockdown of CYP303A1 transcripts by RNAi using the Gal4/UAS system with a ubiquitous driver (tubulin-Gal4) in Drosophila or by dsRNA injection in the last nymph stage of Locusta migratoria resulted in severe defects in eclosion and lethality during and after adult emergence. In Drosophila, tissue-specific RNAi of Cyp303a1 with a wing-specific driver (MS1096-Gal4) revealed that Cyp303a1 was essential for wing extension. Stage-specific RNAi of Cyp303a1 using Gal80ts for thermal-dependent-suppression found that the expression of Cyp303a1 at the middle pupal stage was absolutely required. Meanwhile, Cyp303a1 mutants exhibited more than 80% lethality at the late embryonic development stages. Embryonic lethality of the Cyp303a1 mutants was fully rescued by the ubiquitous overexpression of exogenous Cyp303a1. Taken together, we conclude that Cyp303a1 is indispensable for embryonic development and adult eclosion in D. melanogaster, the latter role being conserved over 400 million years of insect evolution.
- Published
- 2019
10. Heat Shock Protein 83 (Hsp83) Facilitates Methoprene-tolerant (Met) Nuclear Import to Modulate Juvenile Hormone Signaling
- Author
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Di Wen, Chunlai Cui, Qianyu He, Subba Reddy Palli, Qiangqiang Jia, Sheng Li, and Jian Wang
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endocrine system ,Active Transport, Cell Nucleus ,Kruppel-Like Transcription Factors ,Biology ,Biochemistry ,Heat shock protein ,medicine ,Animals ,Drosophila Proteins ,Promoter Regions, Genetic ,Receptor ,Molecular Biology ,Heat-Shock Proteins ,Cell Nucleus ,Cell Biology ,Methoprene ,Molecular biology ,Juvenile Hormones ,Cell nucleus ,medicine.anatomical_structure ,Hormone receptor ,Cytoplasm ,Larva ,Juvenile hormone ,Drosophila ,Nuclear transport ,Signal transduction ,Signal Transduction ,Protein Binding - Abstract
Juvenile hormone (JH) receptors, methoprene-tolerant (Met) and Germ-cell expressed (Gce), transduce JH signals to induce Kr-h1 expression in Drosophila. Dual luciferase assay identified a 120-bp JH response region (JHRR) in the Kr-h1α promoter. Both in vitro and in vivo experiments revealed that Met and Gce transduce JH signals to induce Kr-h1 expression through the JHRR. DNA affinity purification identified chaperone protein Hsp83 as one of the proteins bound to the JHRR in the presence of JH. Interestingly, Hsp83 physically interacts with PAS-B and basic helix-loop-helix domains of Met, and JH induces Met-Hsp83 interaction. As determined by immunohistochemistry, Met is mainly distributed in the cytoplasm of fat body cells of the larval when the JH titer is low and JH induces Met nuclear import. Hsp83 was accumulated in the cytoplasm area adjunct to the nucleus in the presence of JH and Met/Gce. Loss-of-function of Hsp83 attenuated JH binding and JH-induced nuclear import of Met, resulting in a decrease in the JHRR-driven reporter activity leading to reduction of Kr-h1 expression. These data show that Hsp83 facilitates the JH-induced nuclear import of Met that induces Kr-h1 expression through the JHRR.
- Published
- 2014
11. Salvia miltiorrhiza in diabetes: A review of its pharmacology, phytochemistry, and safety
- Author
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Rui Li, Ruyuan Zhu, Sihua Gao, Qiangqiang Jia, Lin Li, Lili Wang, Dongwei Zhang, Beibei Chen, Yimiao Tian, Dandan Zhao, Yiwen Che, and Fangfang Mo
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Phytochemicals ,Pharmaceutical Science ,Salvia miltiorrhiza ,Blood stasis ,Traditional Chinese medicine ,Pharmacology ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Drug Discovery ,Diabetes Mellitus ,medicine ,Humans ,Hypoglycemic Agents ,Medicine, Chinese Traditional ,Protein kinase B ,PI3K/AKT/mTOR pathway ,030304 developmental biology ,0303 health sciences ,Plants, Medicinal ,business.industry ,AMPK ,medicine.disease ,Clinical trial ,Complementary and alternative medicine ,030220 oncology & carcinogenesis ,Molecular Medicine ,business - Abstract
Background Salvia miltiorrhiza (SM), one of the frequently used herbs in traditional Chinese medicine (TCM), has now attracted rising interests for a possible alternative in the management of diabetes. This review is aimed to providing a comprehensive perspective of SM in phytochemical constituents, pharmacological activities against diabetes and its complications, and safety. Methods A comprehensive search of published literatures was conducted to locate original publications pertaining to SM and diabetes till the end of 2017 using PubMed, China National Knowledge Infrastructure, National Science and Technology Library, China Science and Technology Journal Database, and Web of Science database. The main inquiry was used for the presence of the following keywords in various combinations in the titles and abstracts: Salvia miltiorrhiza, diabetes, obesity, phytochemistry, pharmacology, and safety. About 200 research papers and reviews were consulted. Results SM exhibited anti-diabetic activities by treating macro- and micro-vascular diseases in preclinical experiments and clinical trials through an improvement of redox homeostasis and inhibition of apoptosis and inflammation via the regulation of Wnt/β-catenin, TSP-1/TGF-β1/STAT3, JNK/PI3K/Akt, kinin B2 receptor-Akt-GSK-3β, AMPKβ/PGC-1α/Sirt3, Akt/AMPK, TXNIP/NLRP3, TGF-β1/NF-κB, mineralocorticoid receptor/Na+/K+-ATPase, AGEs/RAGE, Nrf2/Keap1, CaMKKβ/AMPK, AMPK/ACC, IRS-1/PI3K signaling pathways, and modulation of K+-Ca2+ channels, as well as influence of VEGF, NOS, AGEs, PPAR expression and hIAPP aggregation. The antidiabetic effects of this herb may be related to its TCM characters of improving blood circulation and reliving blood stasis. The main ingredients of SM included salvianolic acids and diterpenoid tanshinones, which have been well studied in the diabetic animals. Acute and subacute toxicity studies supported the notion that SM is well tolerated. Conclusion SM may offer a new strategy for prevention and treatment of diabetes and its complications that stimulates extensive research into identifying potential anti-diabetic compounds and fractions as well as exploring the underlying mechanisms of this herb. Further scientific evidences are still required from well-designed preclinical experiments and clinical trials on its anti-diabetic effects and safety.
- Published
- 2019
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