Search

Your search keyword '"Pu, Rong"' showing total 21 results
Start Over Author "Pu, Rong" Publisher elsevier bv
21 results on '"Pu, Rong"'

10. Osteoblasts activate the Nrf2 signalling pathway in response to arsenic trioxide treatment

Author

Li-Wen Huang, Tzu-Ching Huang, Hsiao-Ling Cheng, Yu-Chen Hu, Kee-Lung Chang, Pu-Rong Chiu, and Bau-Shan Hsieh

Subjects
0301 basic medicine, Programmed cell death, NF-E2-Related Factor 2, chemistry.chemical_element, Antineoplastic Agents, Apoptosis, medicine.disease_cause, Biochemistry, Arsenicals, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, Arsenic Trioxide, Cell Line, Tumor, Heat shock protein, medicine, Humans, Arsenic trioxide, Heat-Shock Proteins, Arsenic, Cell Proliferation, Osteoblasts, Arsenic toxicity, biology, Chemistry, Oxides, Osteoblast, Cell Biology, Cell biology, Gene Expression Regulation, Neoplastic, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, biology.protein, Oxidative stress, DNA Damage, Signal Transduction
Abstract

Arsenic trioxide is used to treat a variety of leukaemia types and causes tumour cell death. However, it is not well known whether arsenic trioxide is toxic to bone osteoblast cells, the precursor cells from which leukaemia cells originate. The aim of this study was to examine the response of osteosarcoma cell line MG63 and primary cultured osteoblasts to arsenic trioxide treatment. After 24h of treatment, arsenic trioxide was more effective at inhibiting cell growth and increasing oxidative stress and DNA damage in MG63 cells than in osteoblasts. In addition, arsenic trioxide arrested cell cycle progression in the G2/M phase, and induced apoptosis in MG63 cells, but not in primary cultured osteoblasts. The results further showed that the expression of transcription factor Nrf2 and its downstream antioxidant effectors, including hemeoxygenase-1, glutathione, and superoxide dismutase, was increased in primary cultured osteoblasts. Additionally, expression of heat shock proteins was also increased. Experiments using inhibitors of antioxidant enzymes in the presence of arsenic trioxide-treated osteoblasts demonstrated that glutathione and superoxide dismutase were responsible for reducing oxidative stress, caspase-3 activity, and apoptosis and that heat shock proteins helped reduce caspase-3 activity. Unexpectedly, there was no apparent effect of the markedly increased hemeoxygenase-1, suggesting that other functions might exist for hemeoxygenase-1. These findings demonstrate that osteosarcoma cells are more sensitive to arsenic trioxide treatment than primary cultured osteoblasts and that primary cultured osteoblasts activate the Nrf2 signalling pathway in response to arsenic trioxide exposure to escape from oxidative damage and apoptosis.

Published
2016
Full Text
View/download PDF

12. Erratum to “A novel ultra-high-temperature oxidation protective MoSi2-TaSi2 ceramic coating for tantalum substrate” [J. Eur. Ceram. Soc. 39 (July 7) (2019) 2277–2286]

Author

Cai, Zhenyang, primary, Zhang, Daxu, additional, Chen, Xinxiang, additional, Huang, Yuntong, additional, Peng, Yuqing, additional, Xu, Canhui, additional, Huang, Siyu, additional, Pu, Rong, additional, Liu, Sainan, additional, Zhao, Xiaojun, additional, and Xiao, Lairong, additional

Published
2019
Full Text
View/download PDF

15. The use of herbal preparations as complementary and alternative medicine in advanced lung cancer

Author

Zhang Lingyan, Luo Xiaolu, Duan Xiaopeng, Liu Hong, Pu Rong, Yin Weihua, and Li Xianyong

Subjects
medicine.medical_specialty, Chemotherapy, Hematology, biology, business.industry, medicine.medical_treatment, biology.organism_classification, medicine.disease, Chemotherapy regimen, Astragalus, Ginseng, Oncology, Quality of life, Internal medicine, medicine, Adverse effect, business, Lung cancer
Abstract

Background Advanced lung cancer presents an upward trend mortality rates that need maintains treatment concurrent with chemotherapy or target therapy. Recently, complementary and alternative medicine (CAM) is considered and used as maintains treatment, special herbal medicines. In this paper, we reported the improvement of quality of life (QOL) in advanced lung cancer by herbal medicines. Methods: 83 advanced non-small cell lung cancer patients, who were failure with first-line treatment or refused receiving chemotherapy, reported using herbal extractive medicines based complementary and alternative medicine. Senghuang capsule (SH) and Xianhe Baijiang capsule (XB), which consist of ginseng, astragalus, herba agrimoniae and herba patriniae etc, have been approved by the China Food and Drug Administration (CFDA). Meanwhile, hyperthermia and arginine were also initiated. NRS pain, NRS2002 nutrition and ECOG score, which associated with QOL, were used to evaluate the effectiveness of CAM treatment. The results were analyzed by SPSS16.0 in t-test. RESULTS: After fifteen days treatment, 67.86%, 47.44% and 54.22% of patients’ pain, nutrition status and QOL were improved, respectively. In detail, NRS pain, NRS2002 nutrition and ECOG score dropped to 2.4 ± 1.8, 2.0 ± 1.5 and 2.4 ± 1.0 compared to 4.0 ± 1.5, 2.8 ± 1.6 and 2.8 ± 0.7 (P value

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results