1. Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation
- Author
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Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Brubaker, Douglas, Paulo, Joao A., Sheth, Shikha, Poulin, Emily J., Popow, Olesja, Joughin, Brian Alan, Strasser, Samantha Dale, Starchenko, Alina, Gygi, Steven P., Lauffenburger, Douglas A, Haigis, Kevin M., Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Brubaker, Douglas, Paulo, Joao A., Sheth, Shikha, Poulin, Emily J., Popow, Olesja, Joughin, Brian Alan, Strasser, Samantha Dale, Starchenko, Alina, Gygi, Steven P., Lauffenburger, Douglas A, and Haigis, Kevin M.
- Abstract
To better understand how tissue context contributes to cancer-specific signaling by the same protein, Brubaker and Paulo et al. performed mass-spectrometry-based analysis of total and phosphoproteomic datasets from four murine tissues with mutationally activated K-RAS and developed computational techniques to translate mouse signaling insights to patient tumors.
- Published
- 2020