Search

Your search keyword '"Porcel, M. A."' showing total 11 results
Start Over Author "Porcel, M. A." Publisher elsevier bv
11 results on '"Porcel, M. A."'

1. Farmers’ management of functional biodiversity goes beyond pest management in organic European apple orchards

Author

Penvern, S., primary, Fernique, S., additional, Cardona, A., additional, Herz, A., additional, Ahrenfeldt, E., additional, Dufils, A., additional, Jamar, L., additional, Korsgaard, M., additional, Kruczyńska, D., additional, Matray, S., additional, Ozolina-Pole, L., additional, Porcel, M., additional, Ralle, B., additional, Steinemann, B., additional, Świergiel, W., additional, Tasin, M., additional, Telfser, J., additional, Warlop, F., additional, and Sigsgaard, L., additional

Published
2019
Full Text
View/download PDF

7. Medicinal plants in the Mediterranean area: Synthesis of the results of the project Rubia

Author

González-Tejero, M.R., primary, Casares-Porcel, M., additional, Sánchez-Rojas, C.P., additional, Ramiro-Gutiérrez, J.M., additional, Molero-Mesa, J., additional, Pieroni, A., additional, Giusti, M.E., additional, Censorii, E., additional, de Pasquale, C., additional, Della, A., additional, Paraskeva-Hadijchambi, D., additional, Hadjichambis, A., additional, Houmani, Z., additional, El-Demerdash, M., additional, El-Zayat, M., additional, Hmamouchi, M., additional, and ElJohrig, S., additional

Published
2008
Full Text
View/download PDF

11. Endothelin-1 receptor blockade prevents renal injury in experimental hypercholesterolemia

Author

C. Napoli, Joerg Herrmann, Tatsuya Sawamura, Lilach O. Lerman, Martin Rodriguez-Porcel, Patricia J.M. Best, Alejandro R. Chade, Xiang Yang Zhu, Amir Lerman, Chade, Ar, Best, Pj, RODRIGUEZ PORCEL, M, Herrmann, J, Zhu, X, Sawamura, T, Napoli, Claudio, Lerman, A, and Lerman, Lo

Subjects
medicine.medical_specialty, Pyrrolidines, Normal diet, Endothelin A Receptor Antagonists, Swine, Hypercholesterolemia, Renal function, medicine.disease_cause, Kidney, Renal Circulation, chemistry.chemical_compound, Fibrosis, Internal medicine, medicine, Animals, biology, business.industry, Nitrotyrosine, Hemodynamics, medicine.disease, regional blood flow, Body Fluids, Nitric oxide synthase, Oxidative Stress, Endocrinology, medicine.anatomical_structure, chemistry, Nephrology, Atrasentan, biology.protein, Kidney Diseases, Endothelin receptor, business, endothelin, Oxidative stress
Abstract

Endothelin-1 receptor blockade prevents renal injury in experimental hypercholesterolemia. Background The potent vasoconstrictor endothelin-1 is involved in regulation of renal function, and is up-regulated in hypercholesterolemia (HC), a risk factor for renal disease that increases oxidative stress and impairs renal hemodynamic responses. However, the involvement of endothelin (ET) in this disease process is yet unknown. Methods Regional renal hemodynamics and function in vivo were quantified in pigs at baseline and during infusion of acetylcholine using electron beam computed tomography after a 12-week normal diet ( N = 6), HC diet ( N = 6), and HC diet orally supplemented (4mg/kg/day) with the selective ET receptor-A (ET-A) blocker ABT-627 (HC+ET-A, N = 6). Plasma levels of 8-epi-PGF2-α-isoprostanes, markers of oxidative stress, were measured using enzyme immunoassay, and renal tissue was studied ex vivo using Western blotting, electrophoretic mobility shift assay, and immunohistochemistry. Results Total and low-density lipoprotein (LDL) cholesterol were similarly increased, but isoprostanes were decreased in HC+ET-A compared to HC alone. Basal renal perfusion was similar among the groups, while glomerular filtration rate (GFR) increased in HC+ET-A compared to HC. Stimulated perfusion and GFR were blunted in HC, but normalized in HC+ET-A. Moreover, ET blockade increased expression of endothelial nitric oxide synthase, and decreased endothelial expression of the oxidized-LDL receptor LOX-1, as well as tubular immunoreactivity of inducible nitric oxide synthase, nitrotyrosine, nuclear factor-κB, transforming growth factor-β, and tubulointerstitial and perivascular trichrome staining. Conclusion ET-A blockade improves renal hemodynamic and function in HC, and decreases oxidative stress, and renal vascular and tubulointerstitial inflammation and fibrosis. These findings support a role for the endogenous ET system in renal injury in HC and atherosclerosis.

Published
2003
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results