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3. COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure

Author

Pironi, L, Jezerski, D, Sobocki, J, Lal, S, Vanuytsel, T, Theilla, M, Sasdelli, A, Chambrier, C, Matysiak, K, Aimasso, U, Rasmussen, H, Jukes, A, Kunecki, M, Seguy, D, Schneider, S, Daniels, J, Poullenot, F, Mundi, M, Matras, P, Folwarski, M, Crivelli, A, Wyer, N, Ellegard, L, Santarpia, L, Arvanitakis, M, Spaggiari, C, Lamprecht, G, Guglielmi, F, Lezo, A, Layec, S, Boluda, E, Guz-Mark, A, Gandullia, P, Cuerda, C, Osland, E, Spagnuolo, M, Krznaric, Z, Masconale, L, Chapman, B, Maiz-Jimenez, M, Orlandoni, P, Martins da Rocha, M, Virgili-Casas, M, Doitchinova-Simeonova, M, Czako, L, Van Gossum, A, D'Antiga, L, Ee, L, Warodomwichit, D, Taus, M, Kolacek, S, Thibault, R, Verlato, G, Serralde-Zuniga, A, Botella-Carretero, J, Aguayo, P, Olveira, G, Chomtho, S, Pisprasert, V, Moisejevs, G, Murillo, A, Jauregui, M, Diez, M, Jahit, M, Densupsoontorn, N, Tamer, A, Brillanti, G, Joly, F, Pironi L., Jezerski D., Sobocki J., Lal S., Vanuytsel T., Theilla M., Sasdelli A. S., Chambrier C., Matysiak K., Aimasso U., Rasmussen H. H., Jukes A., Kunecki M., Seguy D., Schneider S. M., Daniels J., Poullenot F., Mundi M. S., Matras P., Folwarski M., Crivelli A., Wyer N., Ellegard L., Santarpia L., Arvanitakis M., Spaggiari C., Lamprecht G., Guglielmi F. W., Lezo A., Layec S., Boluda E. R., Guz-Mark A., Gandullia P., Cuerda C., Osland E., Spagnuolo M. I., Krznaric Z., Masconale L., Chapman B., Maiz-Jimenez M., Orlandoni P., Martins da Rocha M. H., Virgili-Casas M. N., Doitchinova-Simeonova M., Czako L., Van Gossum A., D'Antiga L., Ee L. C., Warodomwichit D., Taus M., Kolacek S., Thibault R., Verlato G., Serralde-Zuniga A. E., Botella-Carretero J. I., Aguayo P. S., Olveira G., Chomtho S., Pisprasert V., Moisejevs G., Murillo A. Z., Jauregui M. E. P., Diez M. B., Jahit M. S., Densupsoontorn N., Tamer A., Brillanti G., Joly F., Pironi, L, Jezerski, D, Sobocki, J, Lal, S, Vanuytsel, T, Theilla, M, Sasdelli, A, Chambrier, C, Matysiak, K, Aimasso, U, Rasmussen, H, Jukes, A, Kunecki, M, Seguy, D, Schneider, S, Daniels, J, Poullenot, F, Mundi, M, Matras, P, Folwarski, M, Crivelli, A, Wyer, N, Ellegard, L, Santarpia, L, Arvanitakis, M, Spaggiari, C, Lamprecht, G, Guglielmi, F, Lezo, A, Layec, S, Boluda, E, Guz-Mark, A, Gandullia, P, Cuerda, C, Osland, E, Spagnuolo, M, Krznaric, Z, Masconale, L, Chapman, B, Maiz-Jimenez, M, Orlandoni, P, Martins da Rocha, M, Virgili-Casas, M, Doitchinova-Simeonova, M, Czako, L, Van Gossum, A, D'Antiga, L, Ee, L, Warodomwichit, D, Taus, M, Kolacek, S, Thibault, R, Verlato, G, Serralde-Zuniga, A, Botella-Carretero, J, Aguayo, P, Olveira, G, Chomtho, S, Pisprasert, V, Moisejevs, G, Murillo, A, Jauregui, M, Diez, M, Jahit, M, Densupsoontorn, N, Tamer, A, Brillanti, G, Joly, F, Pironi L., Jezerski D., Sobocki J., Lal S., Vanuytsel T., Theilla M., Sasdelli A. S., Chambrier C., Matysiak K., Aimasso U., Rasmussen H. H., Jukes A., Kunecki M., Seguy D., Schneider S. M., Daniels J., Poullenot F., Mundi M. S., Matras P., Folwarski M., Crivelli A., Wyer N., Ellegard L., Santarpia L., Arvanitakis M., Spaggiari C., Lamprecht G., Guglielmi F. W., Lezo A., Layec S., Boluda E. R., Guz-Mark A., Gandullia P., Cuerda C., Osland E., Spagnuolo M. I., Krznaric Z., Masconale L., Chapman B., Maiz-Jimenez M., Orlandoni P., Martins da Rocha M. H., Virgili-Casas M. N., Doitchinova-Simeonova M., Czako L., Van Gossum A., D'Antiga L., Ee L. C., Warodomwichit D., Taus M., Kolacek S., Thibault R., Verlato G., Serralde-Zuniga A. E., Botella-Carretero J. I., Aguayo P. S., Olveira G., Chomtho S., Pisprasert V., Moisejevs G., Murillo A. Z., Jauregui M. E. P., Diez M. B., Jahit M. S., Densupsoontorn N., Tamer A., Brillanti G., and Joly F.

Abstract

Background and aims: To investigate the incidence and the severity of COVID-19 infection in patients enrolled in the database for home parenteral nutrition (HPN) for chronic intestinal failure (CIF) of the European Society for Clinical Nutrition and Metabolism (ESPEN). Methods: Period of observation: March 1st, 2020 March 1st, 2021. Inclusion criteria: patients included in the database since 2015 and still receiving HPN on March 1st, 2020 as well as new patients included in the database during the period of observation. Data related to the previous 12 months and recorded on March 1st 2021: 1) occurrence of COVID-19 infection since the beginning of the pandemic (yes, no, unknown); 2) infection severity (asymptomatic; mild, no-hospitalization; moderate, hospitalization no-ICU; severe, hospitalization in ICU); 3) vaccinated against COVID-19 (yes, no, unknown); 4) patient outcome on March 1st 2021: still on HPN, weaned off HPN, deceased, lost to follow up. Results: Sixty-eight centres from 23 countries included 4680 patients. Data on COVID-19 were available for 55.1% of patients. The cumulative incidence of infection was 9.6% in the total group and ranged from 0% to 21.9% in the cohorts of individual countries. Infection severity was reported as: asymptomatic 26.7%, mild 32.0%, moderate 36.0%, severe 5.3%. Vaccination status was unknown in 62.0% of patients, non-vaccinated 25.2%, vaccinated 12.8%. Patient outcome was reported as: still on HPN 78.6%, weaned off HPN 10.6%, deceased 9.7%, lost to follow up 1.1%. A higher incidence of infection (p = 0.04), greater severity of infection (p < 0.001) and a lower vaccination percentage (p = 0.01) were observed in deceased patients. In COVID-19 infected patients, deaths due to infection accounted for 42.8% of total deaths. Conclusions: In patients on HPN for CIF, the incidence of COVID-19 infection differed greatly among countries. Although the majority of cases were reported to be asymptomatic or have mild symptoms only, COV

Published
2023

5. The Top Ten Research Priorities For Home Parenteral Support

Author

Sowerbutts, A.M., primary, Lal, S., additional, Pironi, L., additional, Jones, D., additional, French, C., additional, Riis, M., additional, Clamp, A., additional, McCracken, J., additional, Williamson, L., additional, Wheatley, C., additional, Johnson, B., additional, and Burden, S., additional

Published
2023
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8. Intestinal Microbiome In Chronic Intestinal Failure

Author

Pironi, L., primary, D’Amico, F., additional, Guidetti, M., additional, Musio, A., additional, Sasdelli, A.S., additional, Turroni, S., additional, Rossetti, C., additional, Albanese, M.G., additional, Agnelli, G., additional, and Brigidi, P., additional

Published
2023
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15. OC.14.6 ATTITUDES TOWARDS VACCINATIONS IN AN ITALIAN COHORT OF IBD PATIENTS

Author

Costantino, A., primary, Michelon, M., additional, Noviello, D., additional, Leone, S., additional, Aloi, M., additional, Armuzzi, A., additional, Bossa, F., additional, Ficari, F., additional, Manguso, F., additional, Mocci, G., additional, Orlando, A., additional, Pironi, L., additional, Radice, S., additional, Rizzello, F., additional, Tongiorgi, A., additional, Costantino, C., additional, Vecchi, M., additional, and Caprioli, F.A., additional

Published
2023
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16. Real-life prevalence of Metabolic Associated Fatty Liver Disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in a tertiary obesity clinic in Italy

Author

Ravaioli, F., primary, Petroni, M.L., additional, Brodosi, L., additional, Leoni, L., additional, Marchignoli, F., additional, Osti, V., additional, Mita, D., additional, Bocedi, G., additional, Sacilotto, F., additional, Barbanti, F.A., additional, Marchesini, G.R., additional, and Pironi, L., additional

Published
2022
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17. A multi-national survey of experience and attitudes towards commencing home parenteral nutrition for patients with advanced cancer

Author

Naghibi, M., primary, Skinner, C., additional, Burden, S.T., additional, Bozzetti, F., additional, Cuerda, C., additional, Joly, F., additional, Jeppesen, P., additional, Lamprecht, G., additional, Mundi, M., additional, Szczepanek, K., additional, Van Gossum, A., additional, Wanten, G., additional, Pironi, L., additional, and Lal, S., additional

Published
2022
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20. Intestinal failure associated liver disease after weaning off home parenteral nutrition: a 12-month follow up

Author

Sasdelli, A.S., primary, Guidetti, M., additional, Musio, A., additional, Mari, G.A., additional, Battaiola, C., additional, Baracco, B., additional, Bocedi, G., additional, Leoni, L., additional, Ravaioli, F., additional, Agnelli, G., additional, Rossetti, C., additional, Sacillotto, F., additional, Albanese, M.G., additional, Venerito, F.M., additional, Serra, C., additional, and Pironi, L., additional

Published
2021
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22. AF.49 DETERMINANTS OF COVID-19 VACCINE HESITANCY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE (IBD): RESULTS OF A NATIONAL SURVEY OF THE ITALIAN IBD PATIENTS’ ASSOCIATION (AMICI ONLUS)

Author

Costantino, A., primary, Noviello, D., additional, Conforti, F.S., additional, Aloi, M., additional, Armuzzi, A., additional, Bossa, F., additional, Ficari, F., additional, Leone, S., additional, Manguso, F., additional, Mocci, G., additional, Orlando, A., additional, Pironi, L., additional, Radice, S., additional, Rizzello, F., additional, Tongiorgi, A., additional, Costantino, C., additional, Vecchi, M., additional, and Caprioli, F., additional

Published
2021
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23. Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey.

Author

Pironi, L, Steiger, E, Joly, F, Jeppesen, PB, Wanten, G, Sasdelli, AS, Chambrier, C, Aimasso, U, Mundi, MS, Szczepanek, K, Jukes, A, Theilla, M, Kunecki, M, Daniels, J, Serlie, M, Poullenot, F, Cooper, SC, Rasmussen, HH, Compher, C, Seguy, D, Crivelli, A, Santarpia, L, Guglielmi, FW, Kozjek, NR, Schneider, SM, Ellegard, L, Thibault, R, Matras, P, Matysiak, K, Van Gossum, A, Forbes, A, Wyer, N, Taus, M, Virgili, NM, O'Callaghan, M, Chapman, B, Osland, E, Cuerda, C, Udvarhelyi, G, Jones, L, Won Lee, AD, Masconale, L, Orlandoni, P, Spaggiari, C, Díez, MB, Doitchinova-Simeonova, M, Serralde-Zúñiga, AE, Olveira, G, Krznaric, Z, Czako, L, Kekstas, G, Sanz-Paris, A, Jáuregui, MEP, Murillo, AZ, Schafer, E, Arends, J, Suárez-Llanos, JP, Youssef, NN, Brillanti, G, Nardi, E, Lal, S, Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN, European Society for Clinical Nutrition and Metabolism, Pironi, L, Steiger, E, Joly, F, Jeppesen, PB, Wanten, G, Sasdelli, AS, Chambrier, C, Aimasso, U, Mundi, MS, Szczepanek, K, Jukes, A, Theilla, M, Kunecki, M, Daniels, J, Serlie, M, Poullenot, F, Cooper, SC, Rasmussen, HH, Compher, C, Seguy, D, Crivelli, A, Santarpia, L, Guglielmi, FW, Kozjek, NR, Schneider, SM, Ellegard, L, Thibault, R, Matras, P, Matysiak, K, Van Gossum, A, Forbes, A, Wyer, N, Taus, M, Virgili, NM, O'Callaghan, M, Chapman, B, Osland, E, Cuerda, C, Udvarhelyi, G, Jones, L, Won Lee, AD, Masconale, L, Orlandoni, P, Spaggiari, C, Díez, MB, Doitchinova-Simeonova, M, Serralde-Zúñiga, AE, Olveira, G, Krznaric, Z, Czako, L, Kekstas, G, Sanz-Paris, A, Jáuregui, MEP, Murillo, AZ, Schafer, E, Arends, J, Suárez-Llanos, JP, Youssef, NN, Brillanti, G, Nardi, E, Lal, S, Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN, and European Society for Clinical Nutrition and Metabolism

Abstract

BACKGROUND AND AIMS: The case-mix of patients with intestinal failure due to short bowel syndrome (SBS-IF) can differ among centres and may also be affected by the timeframe of data collection. Therefore, the ESPEN international multicenter cross-sectional survey was analyzed to compare the characteristics of SBS-IF cohorts collected within the same timeframe in different countries. METHODS: The study included 1880 adult SBS-IF patients collected in 2015 by 65 centres from 22 countries. The demographic, nutritional, SBS type (end jejunostomy, SBS-J; jejuno-colic anastomosis, SBS-JC; jejunoileal anastomosis with an intact colon and ileocecal valve, SBS-JIC), underlying disease and intravenous supplementation (IVS) characteristics were analyzed. IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorized as <1, 1-2, 2-3 and >3 L/day. RESULTS: In the entire group: 60.7% were females and SBS-J comprised 60% of cases, while mesenteric ischaemia (MI) and Crohn' disease (CD) were the main underlying diseases. IVS dependency was longer than 3 years in around 50% of cases; IVS was infused ≥5 days/week in 75% and FE in 10% of cases. Within the SBS-IF cohort: CD was twice and thrice more frequent in SBS-J than SBS-JC and SBS-JIC, respectively, while MI was more frequent in SBS-JC and SBS-JIC. Within countries: SBS-J represented 75% or more of patients in UK and Denmark and 50-60% in the other countries, except Poland where SBS-JC prevailed. CD was the main underlying disease in UK, USA, Denmark and The Netherlands, while MI prevailed in France, Italy and Poland. CONCLUSIONS: SBS-IF type is primarily determined by the underlying disease, with significant variation between countries. These novel data will be useful for planning and managing both clinical activity and research studies on SBS.

Published
2021

32. Multimodal Surgical Approach for Adult Patients With Chronic Intestinal Pseudo-Obstruction: Clinical and Psychosocial Long-term Outcomes

Author

Lauro, A., primary, Pinna, A.D., additional, Tossani, E., additional, Stanghellini, V., additional, Manno, M., additional, Caio, G., additional, Golfieri, L., additional, Zanfi, C., additional, Cautero, N., additional, Bagni, A., additional, Volta, U., additional, Di Simone, M., additional, Pironi, L., additional, Cogliandro, R.F., additional, Serra, M., additional, Venturoli, A., additional, Grandi, S., additional, and De Giorgio, R., additional

Published
2018
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