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Your search keyword '"Piel, M"' showing total 12 results
Start Over Author "Piel, M" Publisher elsevier bv
12 results on '"Piel, M"'

7. Synthesis and evaluation of (S)-2-(2-[18F]fluoroethoxy)-4-([3-methyl-1-(2-piperidin-1-yl-phenyl)-butyl-carbamoyl]-methyl)-benzoic acid ([18F]repaglinide): a promising radioligand for quantification of pancreatic β-cell mass with positron emission tomography (PET)

Author

Wängler, B, primary, Schneider, S, additional, Thews, O, additional, Schirrmacher, E, additional, Comagic, S, additional, Feilen, P, additional, Schwanstecher, C, additional, Schwanstecher, M, additional, Shiue, C.-Y, additional, Alavi, A, additional, Höhnemann, S, additional, Piel, M, additional, Rösch, F, additional, and Schirrmacher, R, additional

Published
2004
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12. Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells

Author

Raphaël Voituriez, Maël Le Berre, Franziska Lautenschlaeger, Mélina L. Heuzé, Yan-Jun Liu, Tohru Takaki, Paolo Maiuri, Andrew Callan-Jones, Matthieu Piel, Liu, Yj, Le Berre, M, Lautenschlaeger, F, Maiuri, P, Callan-Jones, A, Heuze, M, Takaki, T, Voituriez, R, and Piel, M

Subjects
Focal Adhesions, Biochemistry, Genetics and Molecular Biology(all), Mesenchymal stem cell, Epithelial Cells, Adhesion, Anatomy, Fibroblasts, Biology, Phenotype, General Biochemistry, Genetics and Molecular Biology, Mesoderm, Focal adhesion, Cell Movement, Cell culture, Cell Line, Tumor, Cancer cell, Cell cortex, Cell Adhesion, Biophysics, Animals, Humans, Cell adhesion, HeLa Cells, Skin
Abstract

SummaryThe mesenchymal-amoeboid transition (MAT) was proposed as a mechanism for cancer cells to adapt their migration mode to their environment. While the molecular pathways involved in this transition are well documented, the role of the microenvironment in the MAT is still poorly understood. Here, we investigated how confinement and adhesion affect this transition. We report that, in the absence of focal adhesions and under conditions of confinement, mesenchymal cells can spontaneously switch to a fast amoeboid migration phenotype. We identified two main types of fast migration—one involving a local protrusion and a second involving a myosin-II-dependent mechanical instability of the cell cortex that leads to a global cortical flow. Interestingly, transformed cells are more prone to adopt this fast migration mode. Finally, we propose a generic model that explains migration transitions and predicts a phase diagram of migration phenotypes based on three main control parameters: confinement, adhesion, and contractility.

Published
2015
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