1. Monodeoxy-1,4:3,6-dianhydrohexitol nitrates
- Author
-
Peter Stoss and Siegfried Erhardt
- Subjects
chemistry.chemical_compound ,chemistry ,Organic Chemistry ,Clinical Biochemistry ,Drug Discovery ,Substituent ,Pharmaceutical Science ,Molecular Medicine ,Organic chemistry ,Alkylation ,Nitrate ester ,Molecular Biology ,Biochemistry - Abstract
Monodeoxy-1,4:3,6-dianhydrohexitol nitrates with (5) or without (6) an additional chloro substituent were synthesized, starting from 1,4:3,6-dianhydrohexitol-monoacetates, via 3 as key intermediates. Attempts to generate an unsaturated nitrate ester resulted in a DBN alkylation product (9). Both the endo- and exo-configurated monodeoxy-1,4:3,6-dianhydrohexitol nitrates have been prepared. Attempts to generate an unsaturated nitrate ester resulted in a DBN alkylation produkt.
- Published
- 1991
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