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143 results on '"Pecchioli, A."'

2. Refinement of the diagnostic approach for the identification of children and adolescents affected by familial hypercholesterolemia: Evidence from the LIPIGEN study

Author

Casula, Manuela, primary, Gazzotti, Marta, additional, Capra, Maria Elena, additional, Olmastroni, Elena, additional, Galimberti, Federica, additional, Catapano, Alberico L., additional, Pederiva, Cristina, additional, Anesi, Adriano, additional, Arca, Marcello, additional, Auricchio, Renata, additional, Averna, Maurizio, additional, Baldera, Davide, additional, Banderali, Giuseppe, additional, Beccuti, Guglielmo, additional, Benso, Andrea, additional, Berteotti, Martina, additional, Bertolini, Stefano, additional, Bianconi, Vanessa, additional, Biasucci, Giacomo, additional, Biolo, Gianni, additional, Bonanni, Luca, additional, Borghi, Claudio, additional, Bossi, Antonio Carlo, additional, Branchi, Adriana, additional, Bruzzi, Patrizia, additional, Bucci, Marco, additional, Buonuomo, Paola Sabrina, additional, Calabrò, Paolo, additional, Calandra, Sebastiano, additional, Carubbi, Francesca, additional, Cavallaro, Raimondo, additional, Cefalù, Angelo Baldassarre, additional, Cesaro, Arturo, additional, Cipollone, Francesco, additional, Citroni, Nadia, additional, Colombo, Emanuela, additional, Coppola, Chiara, additional, D'Addato, Sergio, additional, Dal Pino, Beatrice, additional, Dalla Nora, Edoardo, additional, De Corrado, Giuseppe, additional, Del Ben, Maria, additional, Di Molfetta, Sergio, additional, Di Taranto, Maria Donata, additional, Fainelli, Giulia, additional, Federici, Massimo, additional, Ferri, Claudio, additional, Fiorenza, Anna Maria, additional, Formisano, Elena, additional, Fortunato, Giuliana, additional, Giaccari, Andrea, additional, Giorgino, Francesco, additional, Grigore, Liliana, additional, Guardamagna, Ornella, additional, Iannuzzi, Arcangelo, additional, Iannuzzo, Gabriella, additional, Iughetti, Lorenzo, additional, Lia, Salvatore, additional, Longo, Susanna, additional, Lupi, Alessandro, additional, Mandraffino, Giuseppe, additional, Marcucci, Rossella, additional, Maroni, Lorenzo, additional, Massini, Giulia, additional, Mazza, Elisa, additional, Melchioda, Elena, additional, Meregalli, Giancarla, additional, Minicocci, Ilenia, additional, Moffa, Simona, additional, Mombelli, Giuliana, additional, Muntoni, Sandro, additional, Nascimbeni, Fabio, additional, Negri, Emanuele Alberto, additional, Notargiacomo, Serena, additional, Panfili, Filippo Maria, additional, Parati, Gianfranco, additional, Passaro, Angelina, additional, Pavanello, Chiara, additional, Pecchioli, Valerio, additional, Pecchioli, Lorenzo, additional, Pellegatta, Fabio, additional, Perla, Francesco Massimo, additional, Pipolo, Antonio, additional, Piro, Salvatore, additional, Pirro, Matteo, additional, Pisciotta, Livia, additional, Pujia, Roberta, additional, Putotto, Carolina, additional, Repetti, Elena, additional, Rinaldi, Elisabetta, additional, Romandini, Alessandra, additional, Sani, Elena, additional, Sarnari, Silvia, additional, Sarzani, Riccardo, additional, Sbrana, Francesco, additional, Scicali, Roberto, additional, Scuruchi, Michele, additional, Suppressa, Patrizia, additional, Tarugi, Patrizia, additional, Trenti, Chiara, additional, Vinci, Pierandrea, additional, Werba, José Pablo, additional, Zambon, Sabina, additional, Zambon, Alberto, additional, and Zenti, Maria Grazia, additional

Published
2023
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3. Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Author

Dharmayat, Kanika Inamdar, primary, Vallejo-Vaz, Antonio J., additional, Stevens, Christophe A.T., additional, Brandts, Julia M., additional, Lyons, Alexander R.M., additional, Groselj, Urh, additional, Abifadel, Marianne, additional, Aguilar-Salinas, Carlos A., additional, Alhabib, Khalid, additional, Alkhnifsawi, Mutaz, additional, Almahmeed, Wael, additional, Alnouri, Fahad, additional, Alonso, Rodrigo, additional, Al-Rasadi, Khalid, additional, Ashavaid, Tester F., additional, Banach, Maciej, additional, Béliard, Sophie, additional, Binder, Christoph, additional, Bourbon, Mafalda, additional, Chlebus, Krzysztof, additional, Corral, Pablo, additional, Cruz, Diogo, additional, Descamps, Olivier S., additional, Drogari, Euridiki, additional, Durst, Ronen, additional, Ezhov, Marat V., additional, Genest, Jacques, additional, Harada-Shiba, Mariko, additional, Holven, Kirsten B., additional, Humphries, Steve E., additional, Khovidhunkit, Weerapan, additional, Lalic, Katarina, additional, Laufs, Ulrich, additional, Liberopoulos, Evangelos, additional, Roeters van Lennep, Jeanine, additional, Lima-Martinez, Marcos Miguel, additional, Lin, Jie, additional, Maher, Vincent, additional, März, Winfried, additional, Miserez, André R., additional, Mitchenko, Olena, additional, Nawawi, Hapizah, additional, Panayiotou, Andrie G., additional, Paragh, György, additional, Postadzhiyan, Arman, additional, Reda, Ashraf, additional, Reiner, Željko, additional, Reyes, Ximena, additional, Sadiq, Fouzia, additional, Sahebkar, Amirhossein, additional, Schunkert, Heribert, additional, Shek, Aleksandr B., additional, Stroes, Eric, additional, Su, Ta-Chen, additional, Subramaniam, Tavintharan, additional, Susekov, Andrey, additional, Vázquez Cárdenas, Alejandra, additional, Huong Truong, Thanh, additional, Tselepis, Alexandros D., additional, Vohnout, Branislav, additional, Wang, Luya, additional, Yamashita, Shizuya, additional, Al-Sarraf, Ahmad, additional, Al-Sayed, Nasreen, additional, Davletov, Kairat, additional, Dwiputra, Bambang, additional, Gaita, Dan, additional, Kayikcioglu, Meral, additional, Latkovskis, Gustavs, additional, Marais, A. David, additional, Thushara Matthias, Anne, additional, Mirrakhimov, Erkin, additional, Nordestgaard, Børge G., additional, Petrulioniene, Zaneta, additional, Pojskic, Belma, additional, Sadoh, Wilson, additional, Tilney, Myra, additional, Tomlinson, Brian, additional, Tybjærg-Hansen, Anne, additional, Viigimaa, Margus, additional, Catapano, Alberico L., additional, Freiberger, Tomas, additional, Hovingh, G. Kees, additional, Mata, Pedro, additional, Soran, Handrean, additional, Raal, Frederick, additional, Watts, Gerald F., additional, Schreier, Laura, additional, Bañares, Virginia, additional, Greber-Platzer, Susanne, additional, Baumgartner-Kaut, Margot, additional, de Gier, Charlotte, additional, Dieplinger, Hans, additional, Höllerl, Florian, additional, Innerhofer, Reinhold, additional, Karall, Daniela, additional, Lischka, Julia, additional, Ludvik, Bernhard, additional, Mäser, Martin, additional, Scholl-Bürgi, Sabine, additional, Thajer, Alexandra, additional, Toplak, Hermann, additional, Demeure, Fabian, additional, Mertens, Ann, additional, Balligand, Jean-Luc, additional, Stephenne, Xavier, additional, Sokal, Etienne, additional, Petrov, Ivo, additional, Goudev, Assen, additional, Nikolov, Fedya, additional, Tisheva, Snejana, additional, Yotov, Yoto, additional, Tzvetkov, Ivajlo, additional, Hegele, Robert A, additional, Gaudet, Daniel, additional, Brunham, Liam, additional, Ruel, Isabelle, additional, McCrindle, Brian, additional, Cuevas, Ada, additional, Perica, Dražen, additional, Symeonides, Phivos, additional, Trogkanis, Efstratios, additional, Kostis, Andreas, additional, Ioannou, Andreas, additional, Mouzarou, Angeliki, additional, Georgiou, Anthoula, additional, Stylianou, Andreas, additional, Miltiadous, George, additional, Iacovides, Paris, additional, Deltas, Constantinos, additional, Vrablik, Michal, additional, Urbanova, Zuzana, additional, Jesina, Pavel, additional, Tichy, Lukas, additional, Hyanek, Josef, additional, Dvorakova, Jana, additional, Cepova, Jana, additional, Sykora, Josef, additional, Buresova, Kristyna, additional, Pipek, Michal, additional, Pistkova, Eva, additional, Bartkova, Ivana, additional, S|ulakova, Astrid, additional, Toukalkova, Lenka, additional, Spenerova, Michaela, additional, Maly, Jan, additional, Benn, Marianne, additional, Bendary, Ahmed, additional, Elbahry, Atef, additional, Ferrières, Jean, additional, Ferrieres, Dorota, additional, Peretti, Noel, additional, Bruckert, Eric, additional, Gallo, Antonio, additional, Valero, René, additional, Mourre, Florian, additional, Aouchiche, Karine, additional, Reynaud, Rachel, additional, Tounian, Patrick, additional, Lemale, Julie, additional, Boccara, Franck, additional, Moulin, Philippe, additional, Charrières, Sybil, additional, Di Filippo, Mathilde, additional, Cariou, Bertrand, additional, Paillard, François, additional, Dourmap, Caroline, additional, Pradignac, Alain, additional, Verges, Bruno, additional, Simoneau, Isabelle, additional, Farnier, Michel, additional, Cottin, Yves, additional, Yelnik, Cecile, additional, Hankard, Regis, additional, Schiele, François, additional, Durlach, Vincent, additional, Sultan, Ariane, additional, Carrié, Alain, additional, Rabès, Jean-Pierre, additional, Sanin, Veronika, additional, Schmieder, Roland, additional, Ates, Sara, additional, Rizos, Christos V., additional, Skoumas, Ioannis, additional, Tziomalos, Konstantinos, additional, Rallidis, Loukianos, additional, Kotsis, Vasileios, additional, Doumas, Michalis, additional, Skalidis, Emmanouil, additional, Kolovou, Genovefa, additional, Kolovou, Vana, additional, Garoufi, Anastasia, additional, Koutagiar, Iosif, additional, Polychronopoulos, Georgios, additional, Kiouri, Estela, additional, Antza, Christina, additional, Zacharis, Evangelos, additional, Attilakos, Achilleas, additional, Sfikas, George, additional, Koumaras, Charalambos, additional, Anagnostis, Panagiotis, additional, Anastasiou, Georgia, additional, Liamis, George, additional, Adamidis, Petros-Spyridon, additional, Milionis, Haralambos, additional, Lambadiari, Vaia, additional, Stabouli, Stella, additional, Filippatos, Theodosios, additional, Mollaki, Vicky, additional, Tsaroumi, Anastasia, additional, Lamari, Frida, additional, Proyias, Pavlos, additional, Harangi, Mariann, additional, Reddy, Lakshmi Lavanya, additional, Shah, Swarup A. V, additional, Ponde, Chandrashekhar K., additional, Dalal, Jamshed J., additional, Sawhney, Jitendra P.S., additional, Verma, Ishwar C., additional, Hosseini, Susan, additional, Jamialahmadi, Tannaz, additional, Alareedh, Mohammed, additional, Shaghee, Foaad, additional, Rhadi, Sabah Hasan, additional, Abduljalal, Maryam, additional, Alfil, Sarmad, additional, Kareem, Huda, additional, Cohen, Hofit, additional, Leitersdorf, Eran, additional, Schurr, Daniel, additional, Shpitzen, Shoshi, additional, Arca, Marcello, additional, Averna, Maurizio, additional, Bertolini, Stefano, additional, Calandra, Sebastiano, additional, Tarugi, Patrizia, additional, Casula, Manuela, additional, Galimberti, Federica, additional, Gazzotti, Marta, additional, Olmastroni, Elena, additional, Sarzani, Riccardo, additional, Ferri, Claudio, additional, Repetti, Elena, additional, Giorgino, Francesco, additional, Suppressa, Patrizia, additional, Bossi, Antonio Carlo, additional, Borghi, Claudio, additional, Muntoni, Sandro, additional, Cipollone, Francesco, additional, Scicali, Roberto, additional, Pujia, Arturo, additional, Passaro, Angelina, additional, Berteotti, Martina, additional, Pecchioli, Valerio, additional, Pisciotta, Livia, additional, Mandraffino, Giuseppe, additional, Pellegatta, Fabio, additional, Mombelli, Giuliana, additional, Branchi, Adriana, additional, Fiorenza, Anna Maria, additional, Pederiva, Cristina, additional, Werba, José Pablo, additional, Parati, Gianfranco, additional, Nascimbeni, Fabio, additional, Iughetti, Lorenzo, additional, Fortunato, Giuliana, additional, Cavallaro, Raimondo, additional, Iannuzzo, Gabriella, additional, Calabrò, Paolo, additional, Cefalù, Angelo Baldassare, additional, Capra, Maria Elena, additional, Zambon, Alberto, additional, Pirro, Matteo, additional, Sbrana, Francesco, additional, Trenti, Chiara, additional, Minicocci, Ilenia, additional, Federici, Massimo, additional, Del Ben, Maria, additional, Buonuomo, Paola Sabrina, additional, Moffa, Simona, additional, Pipolo, Antonio, additional, Citroni, Nadia, additional, Guardamagna, Ornella, additional, Lia, Salvatore, additional, Benso, Andrea, additional, Biolo, Gianni Biolo, additional, Maroni, Lorenzo, additional, Lupi, Alessandro, additional, Bonanni, Luca, additional, Rinaldi, Elisabetta, additional, Zenti, Maria Grazia, additional, Masuda, Daisaku, additional, Mahfouz, Linda, additional, Jambart, Selim, additional, Ayoub, Carine, additional, Ghaleb, Youmna, additional, Kasim, Noor Alicezah Mohd, additional, Nor, Noor Shafina Mohd, additional, Al-Khateeb, Alyaa, additional, Kadir, Siti Hamimah Sheikh Abdul, additional, Chua, Yung-An, additional, Razman, Aimi Zafira, additional, Nazli, Sukma Azureen, additional, Ranai, Norashikin Mohd, additional, Latif, Ahmad Zubaidi Abd, additional, Torres, María Teresa Magaña, additional, Mehta, Roopa, additional, Martagon, Alexandro J., additional, Ramirez, Gabriela A. Galan, additional, Antonio-Villa, Neftali Eduardo, additional, Vargas-Vazquez, Arsenio, additional, Elias-Lopez, Daniel, additional, Retana, Gustavo Gonzalez, additional, Encinas, Bethsabel Rodriguez, additional, Macias, Jose J. Ceballos, additional, Zazueta, Alejandro Romero, additional, Alvarado, Rocio Martinez, additional, Portano, Julieta D. Morales, additional, Lopez, Humberto Alvares, additional, Sauque-Reyna, Leobardo, additional, Gomez Herrera, Laura G., additional, Simental Mendia, Luis E., additional, Aguilar, Humberto Garcia, additional, Cooremans, Elizabeth Ramirez, additional, Aparicio, Berenice Pe~na, additional, Zubieta, Victoria Mendoza, additional, Gonzalez, Perla A. Carrillo, additional, Ferreira-Hermosillo, Aldo, additional, Portilla, Nacu Caracas, additional, Dominguez, Guadalupe Jimenez, additional, Garcia, Alinna Y. Ruiz, additional, Arriaga Cazares, Hector E., additional, Gonzalez Gonzalez, Jesus R., additional, Mendez Valencia, Carla V., additional, Padilla Padilla, Francisco G., additional, Prado, Ramon Madriz, additional, De los Rios Ibarra, Manuel O., additional, Arjona Villica~na, Ruy D., additional, Acevedo Rivera, Karina J., additional, Carrera, Ricardo Allende, additional, Alvarez, Jose A., additional, Amezcua Martinez, Jose C., additional, Barrera Bustillo, Manuel de los Reyes, additional, Vargas, Gonzalo Carazo, additional, Chacon, Roberto Contreras, additional, Figueroa Andrade, Mario H., additional, Ortega, Ashanty Flores, additional, Alcala, Hector Garcia, additional, Garcia de Leon, Laura E., additional, Guzman, Berenice Garcia, additional, Gardu~no Garcia, Jose J., additional, Garnica Cuellar, Juan C., additional, Gomez Cruz, Jose R., additional, Garcia, Anell Hernandez, additional, Holguin Almada, Jesus R., additional, Herrera, Ursulo Juarez, additional, Sobrevilla, Fabiola Lugo, additional, Rodriguez, Eduardo Marquez, additional, Sibaja, Cristina Martinez, additional, Medrano Rodriguez, Alma B., additional, Morales Oyervides, Jose C., additional, Perez Vazquez, Daniel I., additional, Reyes Rodriguez, Eduardo A., additional, Osorio, Ma. Ludivina Robles, additional, Saucedo, Juan Rosas, additional, Tamayo, Margarita Torres, additional, Valdez Talavera, Luis A., additional, Vera Arroyo, Luis E., additional, Zepeda Carrillo, Eloy A., additional, Galema-Boers, Annette, additional, Weigman, Albert, additional, Bogsrud, Martin P., additional, Malik, Munir, additional, Shah, Saeedullah, additional, Khan, Sabeen Abid, additional, Rana, Muhammad Asim, additional, Batool, Hijab, additional, Starostecka, Ewa, additional, Konopka, Agnieszka, additional, Lewek, Joanna, additional, Bielecka-Dąbrowa, Agata, additional, Gach, Agnieszka, additional, Jóźwiak, Jacek, additional, Pajkowski, Marcin, additional, Romanowska-Kocejko, Marzena, additional, Żarczyńska-Buchowiecka, Marta, additional, Hellman, Marcin, additional, Chmara, Magdalena, additional, Wasąg, Bartosz, additional, Parczewska, Aleksandra, additional, Gilis-Malinowska, Natasza, additional, Borowiec-Wolna, Justyna, additional, Stróżyk, Aneta, additional, Michalska-Grzonkowska, Aleksandra, additional, Chlebus, Izabela, additional, Kleinschmidt, Mariola, additional, Wojtecka, Agnieszka, additional, Zdrojewski, Tomasz, additional, Myśliwiec, Małgorzata, additional, Hennig, Matylda, additional, Medeiros, Ana Margarida, additional, Alves, Ana Catarina, additional, Almeida, Ana Filipa, additional, Lopes, Andreia, additional, Guerra, António, additional, Bilhoto, Carla, additional, Simões, Fernando, additional, Silva, Francisco, additional, Lobarinhas, Goreti, additional, Gama, Guida, additional, Palma, Isabel, additional, Salgado, José Miguel, additional, Matos, Luísa Diogo, additional, Moura, Márcio de, additional, Virtuoso, Maria João, additional, Tavares, Mónica, additional, Ferreira, Patrícia, additional, Pais, Patrícia, additional, Garcia, Paula, additional, Coelho, Raquel, additional, Ribeiro, Raquel, additional, Correia, Susana, additional, Sadykova, Dinara, additional, Slastnikova, Evgenia, additional, Alammari, Dalal, additional, Mawlawi, Horia Ahmed, additional, Alsahari, Atif, additional, Khudary, Alia Abdullah, additional, Alrowaily, Nawal Lafi, additional, Rajkovic, Natasa, additional, Popovic, Ljiljana, additional, Singh, Sandra, additional, Rasulic, Iva, additional, Petakov, Ana, additional, Lalic, Nebojsa M., additional, Peng, Fabian Kok, additional, Vasanwala, Rashida Farhan, additional, Venkatesh, Sreedharan Aravind, additional, Raslova, Katarina, additional, Fabryova, Lubomira, additional, Nociar, Jan, additional, Šaligova, Jana, additional, Potočňáková, Ludmila, additional, Kozárová, Miriam, additional, Varga, Tibor, additional, Kadurova, Michaela, additional, Debreova, Marianna, additional, Novodvorsky, Peter, additional, Gonova, Katarina, additional, Klabnik, Alexander, additional, Buganova, Ingrid, additional, Battelino, Tadej, additional, Bizjan, Barbara Jenko, additional, Debeljak, Marusa, additional, Kovac, Jernej, additional, Mlinaric, Matej, additional, Molk, Neza, additional, Sikonja, Jaka, additional, Sustar, Ursa, additional, Podkrajsek, Katarina Trebusak, additional, Muñiz-Grijalvo, Ovidio, additional, Díaz-Díaz, Jose Luis, additional, de Andrés, Raimundo, additional, Fuentes-Jiménez, Francisco, additional, Blom, Dirk, additional, Miserez, Eleonore B., additional, Shipton, Janine L., additional, Ganokroj, Poranee, additional, Futema, Marta, additional, Ramaswami, Uma, additional, Alieva, Rano B., additional, Fozilov, Khurshid G., additional, Khoshimov, Shavkat U., additional, Nizamov, Ulugbek I., additional, Abdullaeva, Guzal J., additional, Kan, Liliya E., additional, Abdullaev, Alisher A., additional, Zakirova, Daria V., additional, Do, Doan-Loi, additional, Nguyen, Mai-Ngoc-Thi, additional, Kim, Ngoc-Thanh, additional, Le, Thanh-Tung, additional, Le, Hong-An, additional, Santos, Raul, additional, and Ray, Kausik K., additional

Published
2023
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9. On-treatment serum albumin level can guide long-term treatment in patients with cirrhosis and uncomplicated ascites

Author

Caraceni, P, Tufoni, M, Zaccherini, G, Riggio, O, Angeli, P, Alessandria, C, Neri, S, Foschi, F, Levantesi, F, Airoldi, A, Simone, L, Svegliati-Baroni, G, Fagiuoli, S, Laffi, G, Cozzolongo, R, Di Marco, V, Sangiovanni, V, Morisco, F, Toniutto, P, Gasbarrini, A, De Marco, R, Piano, S, Nardelli, S, Elia, C, Roncadori, A, Baldassarre, M, Bernardi, M, Domenicali, M, Giannone, F, Antognoli, A, Merli, M, Pasquale, C, Gioia, S, Fasolato, S, Sticca, A, Campion, D, Risso, A, Saracco, G, Prestianni, L, Fidone, F, Maiorca, D, Rizzotto, A, Cappa, F, Lanzi, A, Neri, E, Visani, A, Mastroianni, A, Perricone, G, Alberti, A, Cesarini, L, Mazzarelli, C, Vangeli, M, Vigano, R, Marzioni, M, Capretti, F, Kostandini, A, Magini, G, Colpani, M, Gabbani, T, Marsico, M, Zappimbulso, M, Petruzzi, J, Calvaruso, V, Parrella, G, Caporaso, N, Auriemma, F, Guarino, M, Pugliese, F, Tortora, A, Leo, P, Angelico, M, De Leonardis, F, Pecchioli, A, Rossi, P, Raimondo, G, Cacciola, I, Elia, G, Negri, E, Dallio, M, Loguercio, C, Federico, A, Conte, D, Massironi, S, Natascia Celli, G, Rendina, M, Bringiotti, R, Castellaneta, N, Salerno, F, Boccia, S, Guarisco, R, Galioto, A, Cavallin, M, Andrealli, A, Caraceni P., Tufoni M., Zaccherini G., Riggio O., Angeli P., Alessandria C., Neri S., Foschi F. G., Levantesi F., Airoldi A., Simone L., Svegliati-Baroni G., Fagiuoli S., Laffi G., Cozzolongo R., Di Marco V., Sangiovanni V., Morisco F., Toniutto P., Gasbarrini A., De Marco R., Piano S., Nardelli S., Elia C., Roncadori A., Baldassarre M., Bernardi M., Domenicali M., Giannone F. A., Antognoli A., Merli M., Pasquale C., Gioia S., Fasolato S., Sticca A., Campion D., Risso A., Saracco G. M., Prestianni L., Fidone F., Maiorca D., Rizzotto A., Cappa F. M., Lanzi A., Neri E., Visani A., Mastroianni A., Perricone G., Alberti A. B., Cesarini L., Mazzarelli C., Vangeli M., Vigano R., Marzioni M., Capretti F., Kostandini A., Magini G., Colpani M., Gabbani T., Marsico M., Zappimbulso M., Petruzzi J., Calvaruso V., Parrella G., Caporaso N., Auriemma F., Guarino M., Pugliese F., Tortora A., Leo P., Angelico M., De Leonardis F., Pecchioli A., Rossi P., Raimondo G., Cacciola I., Elia G., Negri E., Dallio M., Loguercio C., Federico A., Conte D., Massironi S., Natascia Celli G. B., Rendina M., Bringiotti R., Castellaneta N. M., Salerno F., Boccia S., Guarisco R., Galioto A., Cavallin M., Andrealli A., Caraceni, P, Tufoni, M, Zaccherini, G, Riggio, O, Angeli, P, Alessandria, C, Neri, S, Foschi, F, Levantesi, F, Airoldi, A, Simone, L, Svegliati-Baroni, G, Fagiuoli, S, Laffi, G, Cozzolongo, R, Di Marco, V, Sangiovanni, V, Morisco, F, Toniutto, P, Gasbarrini, A, De Marco, R, Piano, S, Nardelli, S, Elia, C, Roncadori, A, Baldassarre, M, Bernardi, M, Domenicali, M, Giannone, F, Antognoli, A, Merli, M, Pasquale, C, Gioia, S, Fasolato, S, Sticca, A, Campion, D, Risso, A, Saracco, G, Prestianni, L, Fidone, F, Maiorca, D, Rizzotto, A, Cappa, F, Lanzi, A, Neri, E, Visani, A, Mastroianni, A, Perricone, G, Alberti, A, Cesarini, L, Mazzarelli, C, Vangeli, M, Vigano, R, Marzioni, M, Capretti, F, Kostandini, A, Magini, G, Colpani, M, Gabbani, T, Marsico, M, Zappimbulso, M, Petruzzi, J, Calvaruso, V, Parrella, G, Caporaso, N, Auriemma, F, Guarino, M, Pugliese, F, Tortora, A, Leo, P, Angelico, M, De Leonardis, F, Pecchioli, A, Rossi, P, Raimondo, G, Cacciola, I, Elia, G, Negri, E, Dallio, M, Loguercio, C, Federico, A, Conte, D, Massironi, S, Natascia Celli, G, Rendina, M, Bringiotti, R, Castellaneta, N, Salerno, F, Boccia, S, Guarisco, R, Galioto, A, Cavallin, M, Andrealli, A, Caraceni P., Tufoni M., Zaccherini G., Riggio O., Angeli P., Alessandria C., Neri S., Foschi F. G., Levantesi F., Airoldi A., Simone L., Svegliati-Baroni G., Fagiuoli S., Laffi G., Cozzolongo R., Di Marco V., Sangiovanni V., Morisco F., Toniutto P., Gasbarrini A., De Marco R., Piano S., Nardelli S., Elia C., Roncadori A., Baldassarre M., Bernardi M., Domenicali M., Giannone F. A., Antognoli A., Merli M., Pasquale C., Gioia S., Fasolato S., Sticca A., Campion D., Risso A., Saracco G. M., Prestianni L., Fidone F., Maiorca D., Rizzotto A., Cappa F. M., Lanzi A., Neri E., Visani A., Mastroianni A., Perricone G., Alberti A. B., Cesarini L., Mazzarelli C., Vangeli M., Vigano R., Marzioni M., Capretti F., Kostandini A., Magini G., Colpani M., Gabbani T., Marsico M., Zappimbulso M., Petruzzi J., Calvaruso V., Parrella G., Caporaso N., Auriemma F., Guarino M., Pugliese F., Tortora A., Leo P., Angelico M., De Leonardis F., Pecchioli A., Rossi P., Raimondo G., Cacciola I., Elia G., Negri E., Dallio M., Loguercio C., Federico A., Conte D., Massironi S., Natascia Celli G. B., Rendina M., Bringiotti R., Castellaneta N. M., Salerno F., Boccia S., Guarisco R., Galioto A., Cavallin M., and Andrealli A.

Abstract

Background & Aims: The ANSWER study reported that long-term albumin administration in patients with cirrhosis and uncomplicated ascites improves survival. During treatment, serum albumin increased within a month and remained stable thereafter. In this post hoc analysis, we aimed to determine whether on-treatment serum albumin levels could guide therapy. Methods: Logistic regression was used to assess the association between baseline serum albumin and mortality, as well as to determine on-treatment factors associated with mortality and to predict the achievement of a given on-treatment serum albumin level. Survival was assessed by Kaplan-Meier estimates and second-order polynomial regression. Patients whose on-treatment serum albumin remained below normal were compared with a subset of patients from the control arm matched by principal score. Results: Baseline serum albumin was closely associated with 18-month mortality in untreated patients; albumin treatment almost effaced this relationship. On-treatment serum albumin and MELD-Na at month 1 were the sole independent variables associated with mortality. Second-order polynomial regression revealed that survival improved in parallel with increased 1-month on-treatment serum albumin. Kaplan-Meier estimations showed that any value of 1-month on-treatment serum albumin (0.1 g/dl intervals) in the range 2.5–4.5 g/dl discriminated patient survival. In the normal range of serum albumin, the best discriminant value was 4.0 g/dl. Compared to untreated patients, survival even improved in patients whose on-treatment serum albumin remained below normal. Conclusion: Baseline serum albumin per se should not guide the decision to start albumin therapy. Conversely, 1-month on-treatment serum albumin levels are strongly associated with outcomes and could guide the use of albumin – 4.0 g/dl being the target threshold. However, even patients whose serum albumin remains below normal benefit from long-term albumin administration. Lay

Published
2021

12. Outcome and prognostic factors for older patients undergoing radiosurgery for brain metastases

Author

Alessandro Della Puppa, Silvia Scoccianti, L. Visani, G. Stocchi, Guido Pecchioli, Lorenzo Livi, Lorenzo Bordi, E. Scoccimarro, Giulio Francolini, Isacco Desideri, Carlotta Becherini, V. Salvestrini, M. Mariotti, Icro Meattini, Daniela Greto, and Pierluigi Bonomo

Subjects
medicine.medical_specialty, Multivariate analysis, medicine.medical_treatment, Radiosurgery, 03 medical and health sciences, 0302 clinical medicine, Older patients, Internal medicine, Humans, Medicine, 030212 general & internal medicine, Survival analysis, Aged, Retrospective Studies, Aged, 80 and over, Univariate analysis, Brain Neoplasms, business.industry, Proportional hazards model, Retrospective cohort study, Prognosis, Survival Analysis, Clinical trial, Oncology, 030220 oncology & carcinogenesis, Geriatrics and Gerontology, business
Abstract

Purpose Older patients with brain metastases (BM) are often excluded from clinical trials. The aim of our study was to investigate the outcomes following Gamma Knife radiosurgery (GKRS) in young old (65–74 years) and very old (≥75 years) patients with BM. Methods Between October 2012 and October 2018, we treated 89 patients aged ≥65 years with GKRS. Patients were divided in two group: young old (YO) and very old (VO) patients. At baseline G8, Graded Prognostic Assessment (DS-GPA) and Basic Score for Brain Metastases (BSBM) were assessed for all patients. Survival analysis was estimated using the Kaplan-Meier (KM) method. Cox regression model was used to investigate the influence of significant factors on KM. Results Median age at the time of GKRS was 72.2 years (range 65–87). A mean of 2.52 lesions were treated per patient (range 1–14). Median overall survival (OS) for YO and VO patients was 14.2 and 15.7 months, respectively. At univariate analysis, there were no significant differences in OS between the two age groups. A high BSBM (p ≤ .0001) and a high DS-GPA score (p = .0069) were associated with longer survival. A low DS-GPA score was the most powerful independent factor for predicting short survival (HR 1.76, 95% CI 1.25–2.46, p = .001) at multivariate analysis. Conclusion GKRS is a safe approach to treat BM in elderly patients. DS-GPA score represents an important prognostic factor for survival in elderly patients undergoing GKRS.

Published
2020

14. Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Author

Vallejo-Vaz, Antonio J., primary, Stevens, Christophe A.T., additional, Lyons, Alexander R.M., additional, Dharmayat, Kanika I., additional, Freiberger, Tomas, additional, Hovingh, G. Kees, additional, Mata, Pedro, additional, Raal, Frederick J., additional, Santos, Raul D., additional, Soran, Handrean, additional, Watts, Gerald F., additional, Abifadel, Marianne, additional, Aguilar-Salinas, Carlos A., additional, Alhabib, Khalid F., additional, Alkhnifsawi, Mutaz, additional, Almahmeed, Wael, additional, Alnouri, Fahad, additional, Alonso, Rodrigo, additional, Al-Rasadi, Khalid, additional, Al-Sarraf, Ahmad, additional, Al-Sayed, Nasreen, additional, Araujo, Francisco, additional, Ashavaid, Tester F., additional, Banach, Maciej, additional, Béliard, Sophie, additional, Benn, Marianne, additional, Binder, Christoph J., additional, Bogsrud, Martin P., additional, Bourbon, Mafalda, additional, Chlebus, Krzysztof, additional, Corral, Pablo, additional, Davletov, Kairat, additional, Descamps, Olivier S., additional, Durst, Ronen, additional, Ezhov, Marat, additional, Gaita, Dan, additional, Genest, Jacques, additional, Groselj, Urh, additional, Harada-Shiba, Mariko, additional, Holven, Kirsten B., additional, Kayikcioglu, Meral, additional, Khovidhunkit, Weerapan, additional, Lalic, Katarina, additional, Latkovskis, Gustavs, additional, Laufs, Ulrich, additional, Liberopoulos, Evangelos, additional, Lima-Martinez, Marcos M., additional, Lin, Jie, additional, Maher, Vincent, additional, Marais, A. David, additional, März, Winfried, additional, Mirrakhimov, Erkin, additional, Miserez, André R., additional, Mitchenko, Olena, additional, Nawawi, Hapizah, additional, Nordestgaard, Børge G., additional, Panayiotou, Andrie G., additional, Paragh, György, additional, Petrulioniene, Zaneta, additional, Pojskic, Belma, additional, Postadzhiyan, Arman, additional, Raslova, Katarina, additional, Reda, Ashraf, additional, Reiner, Željko, additional, Sadiq, Fouzia, additional, Sadoh, Wilson Ehidiamen, additional, Schunkert, Heribert, additional, Shek, Aleksandr B., additional, Stoll, Mario, additional, Stroes, Erik, additional, Su, Ta-Chen, additional, Subramaniam, Tavintharan, additional, Susekov, Andrey V., additional, Tilney, Myra, additional, Tomlinson, Brian, additional, Truong, Thanh Huong, additional, Tselepis, Alexandros D., additional, Tybjærg-Hansen, Anne, additional, Vázquez Cárdenas, Alejandra, additional, Viigimaa, Margus, additional, Wang, Luya, additional, Yamashita, Shizuya, additional, Kastelein, John J.P., additional, Bruckert, Eric, additional, Vohnout, Branislav, additional, Schreier, Laura, additional, Pang, Jing, additional, Ebenbichler, Christoph, additional, Dieplinger, Hans, additional, Innerhofer, Reinhold, additional, Winhofer-Stöckl, Yvonne, additional, Greber-Platzer, Susanne, additional, Krychtiuk, Konstantin, additional, Speidl, Walter, additional, Toplak, Hermann, additional, Widhalm, Kurt, additional, Stulnig, Thomas, additional, Huber, Kurt, additional, Höllerl, Florian, additional, Rega-Kaun, Gersina, additional, Kleemann, Lucas, additional, Mäser, Martin, additional, Scholl-Bürgi, Sabine, additional, Säly, Christoph, additional, Mayer, Florian J., additional, Sablon, Gaelle, additional, Tarantino, Eric, additional, Nzeyimana, Charlotte, additional, Pojskic, Lamija, additional, Sisic, Ibrahim, additional, Nalbantic, Azra D., additional, Jannes, Cinthia E., additional, Pereira, Alexandre C., additional, Krieger, Jose E., additional, Petrov, Ivo, additional, Goudev, Assen, additional, Nikolov, Fedya, additional, Tisheva, Snejana, additional, Yotov, Yoto, additional, Tzvetkov, Ivajlo, additional, Baass, Alexis, additional, Bergeron, Jean, additional, Bernard, Sophie, additional, Brisson, Diane, additional, Brunham, Liam R., additional, Cermakova, Lubomira, additional, Couture, Patrick, additional, Francis, Gordon A., additional, Gaudet, Daniel, additional, Hegele, Robert A., additional, Khoury, Etienne, additional, Mancini, G.B. John, additional, McCrindle, Brian W., additional, Paquette, Martine, additional, Ruel, Isabelle, additional, Cuevas, Ada, additional, Asenjo, Sylvia, additional, Wang, Xumin, additional, Meng, Kang, additional, Song, Xiantao, additional, Yong, Qiang, additional, Jiang, Tao, additional, Liu, Ziyou, additional, Duan, Yanyu, additional, Hong, Jing, additional, Ye, Pucong, additional, Chen, Yan, additional, Qi, Jianguang, additional, Liu, Zesen, additional, Li, Yuntao, additional, Zhang, Chaoyi, additional, Peng, Jie, additional, Yang, Ya, additional, Yu, Wei, additional, Wang, Qian, additional, Yuan, Hui, additional, Cheng, Shitong, additional, Jiang, Long, additional, Chong, Mei, additional, Jiao, Jian, additional, Wu, Yue, additional, Wen, Wenhui, additional, Xu, Liyuan, additional, Zhang, Ruiying, additional, Qu, Yichen, additional, He, Jianxun, additional, Fan, Xuesong, additional, Wang, Zhenjia, additional, Chow, Elaine, additional, Pećin, Ivan, additional, Perica, Dražen, additional, Symeonides, Phivos, additional, Vrablik, Michal, additional, Ceska, Richard, additional, Soska, Vladimir, additional, Tichy, Lukas, additional, Adamkova, Vera, additional, Franekova, Jana, additional, Cifkova, Renata, additional, Kraml, Pavel, additional, Vonaskova, Katerina, additional, Cepova, Jana, additional, Dusejovska, Magdalena, additional, Pavlickova, Lenka, additional, Blaha, Vladimir, additional, Rosolova, Hana, additional, Nussbaumerova, Barbora, additional, Cibulka, Roman, additional, Vaverkova, Helena, additional, Cibickova, Lubica, additional, Krejsova, Zdenka, additional, Rehouskova, Katerina, additional, Malina, Pavel, additional, Budikova, Milena, additional, Palanova, Vaclava, additional, Solcova, Lucie, additional, Lubasova, Alena, additional, Podzimkova, Helena, additional, Bujdak, Juraj, additional, Vesely, Jiri, additional, Jordanova, Marta, additional, Salek, Tomas, additional, Urbanek, Robin, additional, Zemek, Stanislav, additional, Lacko, Jan, additional, Halamkova, Hana, additional, Machacova, Sona, additional, Mala, Sarka, additional, Cubova, Eva, additional, Valoskova, Katerina, additional, Burda, Lukas, additional, Bendary, Ahmed, additional, Daoud, Ihab, additional, Emil, Sameh, additional, Elbahry, Atef, additional, Rafla, Samir, additional, Sanad, Osama, additional, Kazamel, Ghada, additional, Ashraf, Mohamed, additional, Sobhy, Mohamed, additional, El-Hadidy, Amro, additional, Shafy, Mohamed A., additional, Kamal, Saif, additional, Bendary, Mohamed, additional, Talviste, Grete, additional, Angoulvant, Denis, additional, Boccara, Franck, additional, Cariou, Bertrand, additional, Carreau, Valérie, additional, Carrie, Alain, additional, Charrieres, Sybil, additional, Cottin, Yves, additional, Di-Fillipo, Mathilde, additional, Ducluzeau, Pierre H., additional, Dulong, Sonia, additional, Durlach, Vincent, additional, Farnier, Michel, additional, Ferrari, Emile, additional, Ferrieres, Dorota, additional, Ferrieres, Jean, additional, Gallo, Antonio, additional, hankard, Regis, additional, Inamo, Jocelyne, additional, Lemale, Julie, additional, Moulin, Philippe, additional, Paillard, François, additional, Peretti, Noel, additional, Perrin, Agnès, additional, Pradignac, Alain, additional, Rabes, Jean P., additional, Rigalleau, Vincent, additional, Sultan, Ariane, additional, Schiele, François, additional, Tounian, Patrick, additional, Valero, René, additional, Verges, Bruno, additional, Yelnik, Cécile, additional, Ziegler, Olivier, additional, Haack, Ira A., additional, Schmidt, Nina, additional, Dressel, Alexander, additional, Klein, Isabel, additional, Christmann, Jutta, additional, Sonntag, Antonia, additional, Stumpp, Christine, additional, Boger, Diana, additional, Biedermann, Dana, additional, Usme, Monica M.N., additional, Beil, F. Ulrich, additional, Klose, Gerald, additional, König, Christel, additional, Gouni-Berthold, Ioanna, additional, Otte, Britta, additional, Böll, Gereon, additional, Kirschbaum, Anja, additional, Merke, Jürgen, additional, Scholl, Johannes, additional, Segiet, Thomas, additional, Gebauer, Marco, additional, Predica, Florentina, additional, Mayer, Manfred, additional, Leistikow, Frank, additional, Füllgraf-Horst, Sabine, additional, Müller, Cornelius, additional, Schüler, Melanie, additional, Wiener, Judith, additional, Hein, Konrad, additional, Baumgartner, Peter, additional, Kopf, Stefan, additional, Busch, Reinhold, additional, Schömig, Michael, additional, Matthias, Stephan, additional, Allendorf-Ostwald, Nicole, additional, Fink, Bruno, additional, Böhm, Dieter, additional, Jäkel, Alexander, additional, Koschker, Ann-Cathrin, additional, Schweizer, Rüdiger, additional, Vogt, Anja, additional, Parhofer, Klaus, additional, König, Wolfgang, additional, Reinhard, Wibke, additional, Bäßler, Andrea, additional, Stadelmann, Alexander, additional, Schrader, Volker, additional, Katzmann, Julius, additional, Tarr, Adrienne, additional, Steinhagen-Thiessen, Elisabeth, additional, Kassner, Ursula, additional, Paulsen, Gerret, additional, Homberger, Jürgen, additional, Zemmrich, Claudia, additional, Seeger, Wolfgang, additional, Biolik, Kathrin, additional, Deiss, Dorothee, additional, Richter, Corinna, additional, Pantchechnikova, Elina, additional, Dorn, Elena, additional, Schatz, Ulrike, additional, Julius, Ulrich, additional, Spens, Antje, additional, Wiesner, Tobias, additional, Scholl, Michael, additional, Rizos, Christos V., additional, Sakkas, Nikolaos, additional, Elisaf, Moses, additional, Skoumas, Ioannis, additional, Tziomalos, Konstantinos, additional, Rallidis, Loukianos, additional, Kotsis, Vasileios, additional, Doumas, Michalis, additional, Athyros, Vasileios, additional, Skalidis, Emmanouil, additional, Kolovou, Genovefa, additional, Garoufi, Anastasia, additional, Bilianou, Eleni, additional, Koutagiar, Iosif, additional, Agapakis, Dimitrios, additional, Kiouri, Estela, additional, Antza, Christina, additional, Katsiki, Niki, additional, Zacharis, Evangelos, additional, Attilakos, Achilleas, additional, Sfikas, George, additional, Koumaras, Charalambos, additional, Anagnostis, Panagiotis, additional, Anastasiou, Georgia, additional, Liamis, George, additional, Koutsogianni, Amalia-Despoina, additional, Karányi, Zsolt, additional, Harangi, Mariann, additional, Bajnok, László, additional, Audikovszky, Mária, additional, Márk, László, additional, Benczúr, Béla, additional, Reiber, István, additional, Nagy, Gergely, additional, Nagy, András, additional, Reddy, Lakshmi L., additional, Shah, Swarup A.V., additional, Ponde, Chandrashekhar K., additional, Dalal, Jamshed J., additional, Sawhney, Jitendra P.S., additional, Verma, Ishwar C., additional, Altaey, Mays, additional, Al-Jumaily, Khalid, additional, Rasul, Dilshad, additional, Abdalsahib, Ali F., additional, Jabbar, Amer A., additional, Al-ageedi, Mohanad, additional, Agar, Ruth, additional, Cohen, Hofit, additional, Ellis, Avishay, additional, Gavishv, Dov, additional, Harats, Dror, additional, Henkin, Yaacov, additional, Knobler, Hila, additional, Leavit, Leah, additional, Leitersdorf, Eran, additional, Rubinstein, Ardon, additional, Schurr, Daniel, additional, Shpitzen, Shoshi, additional, Szalat, Auryan, additional, Casula, Manuela, additional, Zampoleri, Veronica, additional, Gazzotti, Marta, additional, Olmastroni, Elena, additional, Sarzani, Riccardo, additional, Ferri, Claudio, additional, Repetti, Elena, additional, Sabbà, Carlo, additional, Bossi, Antonio Carlo, additional, Borghi, Claudio, additional, Muntoni, Sandro, additional, Cipollone, Francesco, additional, Purrello, Francesco, additional, Pujia, Arturo, additional, Passaro, Angelina, additional, Marcucci, Rossella, additional, Pecchioli, Valerio, additional, Pisciotta, Livia, additional, Mandraffino, Giuseppe, additional, Pellegatta, Fabio, additional, Mombelli, Giuliana, additional, Branchi, Adriana, additional, Fiorenza, Anna Maria, additional, Pederiva, Cristina, additional, Werba, Josè Pablo, additional, Parati, Gianfranco, additional, Carubbi, Francesca, additional, Iughetti, Lorenzo, additional, Iannuzzi, Arcangelo, additional, Iannuzzo, Gabriella, additional, Calabrò, Paolo, additional, Averna, Maurizio, additional, Biasucci, Giacomo, additional, Zambon, Sabina, additional, Roscini, Anna Rita, additional, Trenti, Chiara, additional, Arca, Marcello, additional, Federici, Massimo, additional, Del Ben, Maria, additional, Bartuli, Andrea, additional, Giaccari, Andrea, additional, Pipolo, Antonio, additional, Citroni, Nadia, additional, Guardamagna, Ornella, additional, Bonomo, Katia, additional, Benso, Andrea, additional, Biolo, Gianni, additional, Maroni, Lorenzo, additional, Lupi, Alessandro, additional, Bonanni, Luca, additional, Zenti, Maria Grazia, additional, Matsuki, Kota, additional, Hori, Mika, additional, Ogura, Masatsune, additional, Masuda, Daisaku, additional, Kobayashi, Takuya, additional, Nagahama, Kumiko, additional, Al-Jarallah, Mohammed, additional, Radovic, Mirjana, additional, Lunegova, Olga, additional, Bektasheva, Erkayim, additional, Khodzhiboboev, Elyor, additional, Erglis, Andrejs, additional, Gilis, Dainus, additional, Nesterovics, Georgijs, additional, Saripo, Vita, additional, Meiere, Ruta, additional, Upena-RozeMicena, Arta, additional, Terauda, Elizabete, additional, Jambart, Selim, additional, Khoury, Petra E., additional, Elbitar, Sandy, additional, Ayoub, Carine, additional, Ghaleb, Youmna, additional, Aliosaitiene, Urte, additional, Kutkiene, Sandra, additional, Kasim, Noor A.M., additional, Nor, Noor S.M., additional, Ramli, Anis S., additional, Razak, Suraya A., additional, Al-Khateeb, Alyaa, additional, Kadir, Siti H.S.A., additional, Muid, Suhaila A., additional, Rahman, Thuhairah A., additional, Kasim, Sazzli S., additional, Radzi, Ahmad B.M., additional, Ibrahim, Khairul S., additional, Razali, Salmi, additional, Ismail, Zaliha, additional, Ghani, Rohana A., additional, Hafidz, Muhammad I.A., additional, Chua, Ang L., additional, Rosli, Marshima M., additional, Annamalai, Muthukkaruppan, additional, Teh, Lay K., additional, Razali, Rafezah, additional, Chua, Yung A., additional, Rosman, Azhari, additional, Sanusi, Abdul R., additional, Murad, Nor A.A., additional, Jamal, A. Rahman A., additional, Nazli, Sukma A., additional, Razman, Aimi Z., additional, Rosman, Norhidayah, additional, Rahmat, Radzi, additional, Hamzan, Nur S., additional, Azzopardi, C., additional, Mehta, Roopa, additional, Martagon, Alexandro J., additional, Ramirez, Gabriela A.G., additional, Villa, Neftali E.A., additional, Vazquez, Arsenio V., additional, Elias-Lopez, Daniel, additional, Retana, Gustavo G., additional, Rodriguez, Betsabel, additional, Macías, Jose J.C., additional, Zazueta, Alejandro R., additional, Alvarado, Rocio M., additional, Portano, Julieta D.M., additional, Lopez, Humberto A., additional, Sauque-Reyna, Leobardo, additional, Herrera, Laura G.G., additional, Mendia, Luis E.S., additional, Aguilar, Humberto Garcia, additional, Cooremans, Elizabeth R., additional, Aparicio, Berenice P., additional, Zubieta, Victoria M., additional, Gonzalez, Perla A.C., additional, Ferreira-Hermosillo, Aldo, additional, Portilla, Nacu C., additional, Dominguez, Guadalupe J., additional, Garcia, Alinna Y.R., additional, Cazares, Hector E.A., additional, Gonzalez, Jesus R., additional, Valencia, Carla V.M., additional, Padilla, Francisco G., additional, Prado, Ramon M., additional, De los Rios Ibarra, Manuel O., additional, Villicaña, Ruy D.A., additional, Rivera, Karina J.A., additional, Carrera, Ricardo A., additional, Alvarez, Jose A., additional, Martinez, Jose C.A., additional, de los Reyes Barrera Bustillo, Manuel, additional, Vargas, Gonzalo C., additional, Chacon, Roberto C., additional, Andrade, Mario H.F., additional, Ortega, Ashanty F., additional, Alcala, Hector G., additional, de Leon, Laura E.G., additional, Guzman, Berenice G., additional, Garcia, Jose J.G., additional, Cuellar, Juan C.G., additional, Cruz, Jose R.G., additional, Garcia, Anell Hernandez, additional, Almada, Jesus R.H., additional, Herrera, Ursulo J., additional, Sobrevilla, Fabiola L., additional, Rodriguez, Eduardo M., additional, Sibaja, Cristina M., additional, Rodriguez, Alma B.M., additional, Oyervides, Jose C.M., additional, Vazquez, Daniel I.P., additional, Rodriguez, Eduardo A.R., additional, Osorio, Ma L.R., additional, Saucedo, Juan R., additional, Tamayo, Margarita T., additional, Talavera, Luis A.V., additional, Arroyo, Luis E.V., additional, Carrillo, Eloy A.Z., additional, Isara, Alphonsus, additional, Obaseki, Darlington E., additional, Al-Waili, Khalid, additional, Al-Zadjali, Fahad, additional, Al-Zakwani, Ibrahim, additional, Al-Kindi, Mohammed, additional, Al-Mukhaini, Suad, additional, Al-Barwani, Hamida, additional, Rana, Asim, additional, Shah, Lahore S.U., additional, Starostecka, Ewa, additional, Konopka, Agnieszka, additional, Lewek, Joanna, additional, Bartłomiejczyk, Marcin, additional, Gąsior, Mariusz, additional, Dyrbuś, Krzysztof, additional, Jóźwiak, Jacek, additional, Gruchała, Marcin, additional, Pajkowski, Marcin, additional, Romanowska-Kocejko, Marzena, additional, Żarczyńska-Buchowiecka, Marta, additional, Chmara, Magdalena, additional, Wasąg, Bartosz, additional, Parczewska, Aleksandra, additional, Gilis-Malinowska, Natasza, additional, Borowiec-Wolna, Justyna, additional, Stróżyk, Aneta, additional, Woś, Marlena, additional, Michalska-Grzonkowska, Aleksandra, additional, Medeiros, Ana M., additional, Alves, Ana C., additional, Silva, Francisco, additional, Lobarinhas, Goreti, additional, Palma, Isabel, additional, de Moura, Jose P., additional, Rico, Miguel T., additional, Rato, Quitéria, additional, Pais, Patrícia, additional, Correia, Susana, additional, Moldovan, Oana, additional, Virtuoso, Maria J., additional, Salgado, Jose M., additional, Colaço, Ines, additional, Dumitrescu, Andreea, additional, Lengher, Calin, additional, Mosteoru, Svetlana, additional, Meshkov, Alexey, additional, Ershova, Alexandra, additional, Rozkova, Tatiana, additional, Korneva, Victoria, additional, Yu, Kuznetsova T., additional, Zafiraki, Vitaliy, additional, Voevoda, Mikhail, additional, Gurevich, Victor, additional, Duplyakov, Dmitry, additional, Ragino, Yulia, additional, Safarova, Maya, additional, Shaposhnik, Igor, additional, Alkaf, Fahmi, additional, Khudari, Alia, additional, Rwaili, Nawal, additional, Al-Allaf, Faisal, additional, Alghamdi, Mohammad, additional, Batais, Mohammed A., additional, Almigbal, Turky H., additional, Kinsara, Abdulhalim, additional, AlQudaimi, Ashraf H.A., additional, Awan, Zuhier, additional, Elamin, Omer A., additional, Altaradi, Hani, additional, Rajkovic, Natasa, additional, Popovic, Ljiljana, additional, Singh, Sandra, additional, Stosic, Ljubica, additional, Rasulic, Iva, additional, Lalic, Nebojsa M., additional, Lam, Carolyn, additional, Le, Tan J., additional, Siang, Eric L.T., additional, Dissanayake, Sanjaya, additional, I-Shing, Justin T., additional, Shyong, Tai E., additional, Jin, Terrance C.S., additional, Balinth, Karin, additional, Buganova, Ingrid, additional, Fabryova, Lubomira, additional, Kadurova, Michaela, additional, Klabnik, Alexander, additional, Kozárová, Miriam, additional, Sirotiakova, Jana, additional, Battelino, Tadej, additional, Kovac, Jernej, additional, Mlinaric, Matej, additional, Sustar, Ursa, additional, Podkrajsek, Katarina T., additional, Fras, Zlatko, additional, Jug, Borut, additional, Cevc, Matija, additional, Pilcher, Gillian J., additional, Blom, D.J., additional, Wolmarans, K.H., additional, Brice, B.C., additional, Muñiz-Grijalvo, Ovidio, additional, Díaz-Díaz, Jose L., additional, de Isla, Leopoldo P., additional, Fuentes, Francisco, additional, Badimon, Lina, additional, Martin, François, additional, Lux, Angela, additional, Chang, Nien-Tzu, additional, Ganokroj, Poranee, additional, Akbulut, Mehmet, additional, Alici, Gökhan, additional, Bayram, Fahri, additional, Can, Levent H., additional, Celik, Ahmet, additional, Ceyhan, Ceyhun, additional, Coskun, Fatma Y., additional, Demir, Mesut, additional, Demircan, Sabri, additional, Dogan, Volkan, additional, Durakoglugil, Emre, additional, Dural, Ibrahim E., additional, Gedikli, Omer, additional, Hacioglu, Aysa, additional, Ildizli, Muge, additional, Kilic, Salih, additional, Kirilmaz, Bahadir, additional, Kutlu, Merih, additional, Oguz, Aytekin, additional, Ozdogan, Oner, additional, Onrat, Ersel, additional, Ozer, Savas, additional, Sabuncu, Tevfik, additional, Sahin, Tayfun, additional, Sivri, Fatih, additional, Sonmez, Alper, additional, Temizhan, Ahmet, additional, Topcu, Selim, additional, Tuncez, Abdullah, additional, Vural, Mirac, additional, Yenercag, Mustafa, additional, Yesilbursa, Dilek, additional, Yigit, Zerrin, additional, Yildirim, Aytul B., additional, Yildirir, Aylin, additional, Yilmaz, Mehmet B., additional, Atallah, Bassam, additional, Traina, Mahmoud, additional, Sabbour, Hani, additional, Hay, Dana A., additional, Luqman, Neama, additional, Elfatih, Abubaker, additional, Abdulrasheed, Arshad, additional, Kwok, See, additional, Oca, Nicolas D., additional, Reyes, Ximena, additional, Alieva, Rano B., additional, Kurbanov, Ravshanbek D., additional, Hoshimov, Shavkat U., additional, Nizamov, Ulugbek I., additional, Ziyaeva, Adolat V., additional, Abdullaeva, Guzal J., additional, Do, Doan L., additional, Nguyen, Mai N.T., additional, Kim, Ngoc T., additional, Le, Thanh T., additional, Le, Hong A., additional, Tokgozoglu, Lale, additional, Catapano, Alberico L., additional, and Ray, Kausik K., additional

Published
2021
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15. Overview on the management of diverticular disease by Italian General Practitioners

Author

Ignazio Grattagliano, Enzo Ubaldi, Claudio Cricelli, Serena Pecchioli, and Francesco Lapi

Subjects
Adult, Male, medicine.medical_specialty, Databases, Factual, Referral, General Practice, Population, Colonoscopy, Comorbidity, Diverticulitis, Colonic, 03 medical and health sciences, chemistry.chemical_compound, Age Distribution, 0302 clinical medicine, Gastrointestinal Agents, Mesalazine, Risk Factors, Internal medicine, Epidemiology, Prevalence, medicine, Humans, education, Aged, education.field_of_study, Hepatology, medicine.diagnostic_test, business.industry, Gastroenterology, Middle Aged, medicine.disease, Anti-Bacterial Agents, Diverticulosis, Rifaximin, Hospitalization, Cross-Sectional Studies, Italy, chemistry, 030220 oncology & carcinogenesis, Diverticular disease, Female, 030211 gastroenterology & hepatology, business
Abstract

Background Although very common in Western countries, poor epidemiological data on diverticular disease (DD) is available from the family practice. Aims To evaluate the behavior of Italian General Practitioners (GPs) on approaching DD. Methods Health Search Database was analyzed retrospectively. Results On a population of 975,523 individuals, 33,597 patients had a registered diagnosis of DD (“lifetime” prevalence = 3.4%, M = 3.2%, F = 3.7%; higher values are found in females over-65 years old; low rates of complications: diverticulitis = 0.3%, bleeding = 0.002%). As risk factors, NSAIDs and ASA were taken by 14.8% and 26.5% respectively, opioids by 7.5%, corticosteroids by 5.2%; as protective factors, 30.4% were under statins and 17.7% under calcium-antagonists. Approximately 13% of patients were referred to specialists. Colonoscopy and abdominal CT were prescribed to 48.5% and to 13% of already diagnosed patients. Among DD sufferers, 27% experienced hospitalization, but only 3.4% of cases were for a DD-linked problem. Treatment included rifaximin (61%), mesalazine (14.7%), probiotics (12.4%), ciprofloxacin (7.6%). Conclusion DD has a large impact in general practice with a higher prevalence in the elderly. GPs are required to pay particular attention to risk factors both for disease development and for its complications in order to reduce the costs deriving from diagnostic procedures, referral and hospitalization.

Published
2019

18. PO-1590 Accuracy of brain radiosurgery: an in phantom study for Gamma Knife treatments

Author

Cinzia Talamonti, Silvia Calusi, Stefania Pallotta, Guido Pecchioli, Daniela Greto, A. Compagnucci, Margherita Zani, C. Arilli, Livia Marrazzo, Marta Casati, and Isacco Desideri

Subjects
Oncology, business.industry, medicine.medical_treatment, Medicine, Radiology, Nuclear Medicine and imaging, Hematology, Gamma knife, business, Nuclear medicine, Radiosurgery, Imaging phantom
Published
2021

19. Evidence of seismic damages on ancient Roman buildings at Ostia: An arch mechanics approach

Author

Laura Pecchioli, Fabrizio Marra, and Giovanni Cangi

Subjects
Archeology, 010504 meteorology & atmospheric sciences, business.industry, Collapse (topology), Mechanics, Masonry, 010502 geochemistry & geophysics, 01 natural sciences, Archaeological evidence, Damages, Seismic damage, Arch, business, Geology, 0105 earth and related environmental sciences
Abstract

In this paper, we present archaeological evidence of seismic damage in the ancient Roman town of Ostia and we perform structural analysis on damaged buildings based on the application of the principles of arch mechanics, in order to provide an objective means to identify the seismogenic origin of the observed ruptures and collapses. We combine a review of literature reports on possible earthquake damages affecting the ancient structures with field investigations, aimed at selecting representative cases in which collapse modalities can be traced back and the seismic origin evidenced. Nine cases of failure affecting masonry structures are analysed, illustrating the collapse dynamics through the virtual arches model. Using this method we also reconstruct tentative collapse vectors for the analysed cases, highlighting iso-oriented, prevalent horizontal components, indicative of earthquake-induced ruptures.

Published
2018

20. Walking variations in healthy women wearing high-heeled shoes: Shoe size and heel height effects

Author

Chiara Simbolotti, Enrica Di Sipio, Luca Padua, Marco Germanotta, Chiara Iacovelli, Giulia Piccinini, Arianna Cruciani, and Cristiano Pecchioli

Subjects
Adult, musculoskeletal diseases, medicine.medical_specialty, Heel, Biophysics, Walking, Kinematics, Shoe size, Barefoot, Young Adult, 03 medical and health sciences, Spatio-Temporal Analysis, 0302 clinical medicine, Physical medicine and rehabilitation, Gait (human), medicine, Humans, Orthopedics and Sports Medicine, Range of Motion, Articular, Gait, High heels, Foot, business.industry, Rehabilitation, 030229 sport sciences, Biomechanical Phenomena, Shoes, body regions, Kinetics, Settore MED/26 - NEUROLOGIA, medicine.anatomical_structure, Gait analysis, Kinematic parameters, Mixed-design analysis of variance, Female, Kinetic parameters, business, Range of motion, human activities, 030217 neurology & neurosurgery, Foot (unit), Settore MED/34 - MEDICINA FISICA E RIABILITATIVA
Abstract

Background The use of high heels is widespread in modern society in professional and social contests. Literature showed that wearing high heels can produce injurious effects on several structures from the toes to the pelvis. No studies considered shoe length as an impacting factor on walking with high heels. Research question The aim of this study is to evaluate walking parameters in young healthy women wearing high heels, considering not only the heel height but also the foot/shoe size. Methods We evaluate spatio-temporal, kinematic and kinetic data, collected using a 8-camera motion capture system, in a sample of 21 healthy women in three different walking conditions: 1) barefoot, 2) wearing 12 cm high heel shoes independently from shoe size, and 3) wearing shoes with heel height based on shoe size, keeping the ankles’ plantar flexion angle constant. The main outcome measures were: spatio-temporal parameters, gait harmony measurement, range of motion, flexion and extension maximal values, power and moment of lower limb joints. Results Comparing the three walking conditions, the Mixed Anova test, showed significant differences between both high heeled conditions (variable and constant height) and barefoot in spatio-temporal, kinematic and kinetic parameters. Significance Regardless of the shoe size, both heeled conditions presented a similar gait pattern and were responsible for negative effects on walking parameters. Considering our results and the relevance of the heel height, further studies are needed to identify a threshold, over which it is possible to observe that wearing high heels could cause harmful effects, independently from the foot/shoe size.

Published
2018

21. On-treatment serum albumin level can guide long-term treatment in patients with cirrhosis and uncomplicated ascites

Author

Caraceni, Paolo, primary, Tufoni, Manuel, additional, Zaccherini, Giacomo, additional, Riggio, Oliviero, additional, Angeli, Paolo, additional, Alessandria, Carlo, additional, Neri, Sergio, additional, Foschi, Francesco G., additional, Levantesi, Fabio, additional, Airoldi, Aldo, additional, Simone, Loredana, additional, Svegliati-Baroni, Gianluca, additional, Fagiuoli, Stefano, additional, Laffi, Giacomo, additional, Cozzolongo, Raffaele, additional, Di Marco, Vito, additional, Sangiovanni, Vincenzo, additional, Morisco, Filomena, additional, Toniutto, Pierluigi, additional, Gasbarrini, Antonio, additional, De Marco, Rosanna, additional, Piano, Salvatore, additional, Nardelli, Silvia, additional, Elia, Chiara, additional, Roncadori, Andrea, additional, Baldassarre, Maurizio, additional, Bernardi, Mauro, additional, Domenicali, Marco, additional, Giannone, Ferdinando A., additional, Antognoli, Agnese, additional, Merli, Manuela, additional, Pasquale, Chiara, additional, Gioia, Stefania, additional, Fasolato, Silvano, additional, Sticca, Antonietta, additional, Campion, Daniela, additional, Risso, Alessandro, additional, Saracco, Giorgio M., additional, Prestianni, Loredana, additional, Fidone, Federica, additional, Maiorca, Daniela, additional, Rizzotto, Agostino, additional, Cappa, Federica Mirici, additional, Lanzi, Arianna, additional, Neri, Elga, additional, Visani, Anna, additional, Mastroianni, Antonio, additional, Perricone, Giovanni, additional, Alberti, Alberto B., additional, Cesarini, Lucia, additional, Mazzarelli, Chiara, additional, Vangeli, Marcello, additional, Viganò, Raffaella, additional, Marzioni, Marco, additional, Capretti, Francesca, additional, Kostandini, Alba, additional, Magini, Giulia, additional, Colpani, Maria, additional, Gabbani, Tommaso, additional, Marsico, Maria, additional, Zappimbulso, Marianna, additional, Petruzzi, Josè, additional, Calvaruso, Vincenza, additional, Parrella, Giovanni, additional, Caporaso, Nicola, additional, Auriemma, Francesco, additional, Guarino, Maria, additional, Pugliese, Fabio, additional, Tortora, Annalisa, additional, Leo, Pietro, additional, Angelico, Mario, additional, De Leonardis, Francesco, additional, Pecchioli, Alessandra, additional, Rossi, Piera, additional, Raimondo, Giovanni, additional, Cacciola, Irene, additional, Elia, Gianfranco, additional, Negri, Elisa, additional, Dallio, Marcello, additional, Loguercio, Carmelina, additional, Federico, Alessandro, additional, Conte, Dario, additional, Massironi, Sara, additional, Natascia Celli, Giorgio Ballardini, additional, Rendina, Maria, additional, Bringiotti, Roberto, additional, Castellaneta, Nicola Maurizio, additional, Salerno, Francesco, additional, Boccia, Sergio, additional, Guarisco, Riccardo, additional, Galioto, Alessandra, additional, Cavallin, Marta, additional, and Andrealli, Alida, additional

Published
2021
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22. Outcome and prognostic factors for older patients undergoing radiosurgery for brain metastases

Author

Desideri, Isacco, primary, Becherini, Carlotta, additional, Visani, Luca, additional, Stocchi, Giulia, additional, Scoccimarro, Erika, additional, Mariotti, Matteo, additional, Salvestrini, Viola, additional, Scoccianti, Silvia, additional, Greto, Daniela, additional, Bonomo, Pierluigi, additional, Pecchioli, Guido, additional, Bordi, Lorenzo, additional, Della Puppa, Alessandro, additional, Francolini, Giulio, additional, Meattini, Icro, additional, and Livi, Lorenzo, additional

Published
2020
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23. Use of a remediated dredged marine sediment as a substrate for food crop cultivation: Sediment characterization and assessment of fruit safety and quality using strawberry (Fragaria x ananassa Duch.) as model species of contamination transfer

Author

Tozzi, Francesca, primary, Del Bubba, Massimo, additional, Petrucci, William Antonio, additional, Pecchioli, Simona, additional, Macci, Cristina, additional, Hernández García, Francisca, additional, Martínez Nicolás, Juan José, additional, and Giordani, Edgardo, additional

Published
2020
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24. Effectiveness of adherence to lipid lowering therapy on LDL-cholesterol in patients with very high cardiovascular risk: A real-world evidence study in primary care

Author

Francesco Lapi, Davide Lauro, Iacopo Cricelli, Valeria Guglielmi, Serena Pecchioli, Paolo Sbraccia, Damiano Parretti, David Della-Morte, Gerardo Medea, Alfonso Bellia, and Claudio Cricelli

Subjects
Male, Settore MED/09 - Medicina Interna, Atorvastatin, 030204 cardiovascular system & hematology, Settore MED/13 - Endocrinologia, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Longitudinal Studies, 030212 general & internal medicine, education.field_of_study, Middle Aged, Primary care, Treatment Outcome, Cholesterol, Italy, Cardiovascular Diseases, Adherence to statins, Female, High cardiovascular risk, Lipid lowering drugs, Low density lipoproteins, lipids (amino acids, peptides, and proteins), Cardiology and Cardiovascular Medicine, medicine.drug, medicine.medical_specialty, Statin, medicine.drug_class, Population, Drug Administration Schedule, Medication Adherence, 03 medical and health sciences, Ezetimibe, Internal medicine, medicine, Humans, Rosuvastatin, education, Aged, Probability, Retrospective Studies, Primary Health Care, business.industry, Cholesterol, LDL, chemistry, Simvastatin, Physical therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, Follow-Up Studies
Abstract

Background and aims Despite management guidelines advocating statin/ezetimibe use in very high cardiovascular risk (CV) conditions, adherence to this therapy is still suboptimal and LDL-C target attainment unsatisfactory. We aimed to investigate the level of adherence to statin/ezetimibe and LDL-C target achievement rates in an unselected very high CV risk population in primary care setting in Italy. Methods We performed a retrospective population-based study using the Health Search IMS Health Longitudinal Patient Database (HSD), including adult patients at very high CV risk, newly treated with statin, ezetimibe or their combination, with 3 and 6 months of follow-up. Results Although the large majority of patients had previous major CV events (99.9%), only 61% and 55.14% resulted adherent (Proportion of Days Covered, PDC≥80%) after 3 and 6 months, respectively. High adherence entailed almost a three times higher probability to reach the therapeutic LDL-C target (3 months: OR = 2.26 [95% [CI]: 1.88 to 2.72]; 6-months: OR = 2.74 [95% CI: 2.27 to 3.31]). The odds to treat to LDL-C target was greater for simvastatin-ezetimibe fixed combination, simvastatin, atorvastatin and rosuvastatin, in decreasing order. Finally, poor adherence was slightly more prevalent among patients treated with less effective statins, and at both low and maximal dosage regimens. Conclusions This population-based study showed that adherence to statin therapy is poor even among patients who have already experienced a CV event. Failure to achieve recommended LDL-C levels appears imputable to the use of moderate doses and low to standard efficacy statins.

Published
2017

25. What is the actual epidemiology of familial hypercholesterolemia in Italy? Evidence from a National Primary Care Database

Author

Francesco Lapi, Paolo Sbraccia, Damiano Parretti, Valeria Guglielmi, Davide Lauro, Claudio Cricelli, Alfonso Bellia, Gerardo Medea, Massimo Federici, Serena Pecchioli, and Iacopo Cricelli

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, Settore MED/09 - Medicina Interna, Adolescent, Databases, Factual, Familial hypercholesterolemia, Population, Settore MED/09, Primary care, 030204 cardiovascular system & hematology, Dutch Lipid Clinical Network, Settore MED/13 - Endocrinologia, Hyperlipoproteinemia Type II, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, Prevalence, Diabetes Mellitus, medicine, Humans, 030212 general & internal medicine, education, Caucasian population, Primary care database, Reimbursement, Aged, Retrospective Studies, Aged, 80 and over, education.field_of_study, Primary Health Care, business.industry, Gold standard (test), Middle Aged, medicine.disease, Lipids, Italy, Dyslipidemia, Population Surveillance, Female, Cardiology and Cardiovascular Medicine, business, Algorithms, Primary care, Dyslipidemia, Diabetes Mellitus
Abstract

Background There are some inconsistencies on prevalence estimates of familial hypercholesterolemia (FH) in general population across Europe due to variable application of its diagnostic criteria. We aimed to investigate the FH epidemiology in Italy applying the Dutch Lipid Clinical Network (DLCN) score, and two alternative diagnostic algorithms to a primary care database. Methods We performed a retrospective population-based study using the Health Search IMS Health Longitudinal Patient Database (HSD) and including active (alive and currently registered with their general practitioners (GPs)) patients on December 31, 2014. Cases of FH were identified by applying DLCN score. Two further algorithms, based on either ICD9CM coding for FH or some clinical items adopted by the DLCN, were tested towards DLCN itself as gold standard. Results We estimated a prevalence of 0.01% for "definite" and 0.18% for "definite" plus "probable" cases as per the DLCN. Algorithms 1 and 2 reported a FH prevalence of 0.9 and 0.13%, respectively. Both algorithms resulted in consistent specificity (1: 99.10%; 2: 99.9%) towards DLCN, but Algorithm 2 considerably better identified true positive (sensitivity=85.90%) than Algorithm 1 (sensitivity=10.10%). Conclusion The application of DLCN or valid diagnostic alternatives in the Italian primary care setting provides estimates of FH prevalence consistent with those reported in other screening studies in Caucasian population. These diagnostic criteria should be therefore fostered among GPs. In the perspective of FH new therapeutic options, the epidemiological picture of FH is even more relevant to foresee the costs and to plan affordable reimbursement programs in Italy.

Published
2016

26. Use of a remediated dredged marine sediment as a substrate for food crop cultivation: Sediment characterization and assessment of fruit safety and quality using strawberry (Fragaria x ananassa Duch.) as model species of contamination transfer

Author

Francesca Tozzi, Cristina Macci, Massimo Del Bubba, Francisca Hernández García, Simona Pecchioli, William Antonio Petrucci, Juan José Martínez Nicolás, and Edgardo Giordani

Subjects
Crops, Agricultural, Geologic Sediments, Environmental Engineering, Peat, Environmental remediation, Health, Toxicology and Mutagenesis, 0208 environmental biotechnology, 02 engineering and technology, Sustainable sediment management, 010501 environmental sciences, Dioxins, Fragaria, 01 natural sciences, Aliphatic hydrocarbons, Polychlorinated biphenyls, Metals, Heavy, Soil Pollutants, Environmental Chemistry, media_common.cataloged_instance, Cultivar, European union, Sugar, 0105 earth and related environmental sciences, media_common, Minerals, Chemistry, Public Health, Environmental and Occupational Health, Sediment, General Medicine, General Chemistry, Contamination, Ascorbic acid, Pollution, Polycyclic aromatic hydrocarbons, 020801 environmental engineering, Italy, Heavy metals, Fruit, Environmental chemistry, Environmental Monitoring
Abstract

A harbour sediment, previously remediated, was tested for soilless strawberry cultivation (Camarosa and Monterey cultivars), as an innovative, cost-effective and environment-friendly approach of sediment management. Sediments were tested as such (TS100) and mixed 1/1 (v/v) with a peat-based commercial substrate (TS50), using the peat-based medium as control (TS0). Substrates were characterized for some physicochemical properties (e.g. density, porosity and water capacity). Minerals (P, Ca, K, Na and Fe), heavy metals (Cu, Zn, Mn, Ni, Cr, Pb and Cd), aliphatic hydrocarbons (C> 12), polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), dibenzodioxins and dibenzofurans were analysed in substrates and fruits. Sugars and organic acids, including the ascorbic, were also determined in fruits, as quality indicators. Notwithstanding remediation, sediments showed concentrations of Zn (206 mg kg(-1)), C> 12 (86 mg kg(-1)) and PAHs (47 mg kg(-1)) exceeding the limits established by the Italian L.D. 152/2006, regulating the contamination of soil in green areas, thus making its relocation in the environment not permitted as such. No evidence of fruit contamination by Cr, Pb and Cd was highlighted. Moreover, Cu, Zn and Ni fruit concentrations were comparable among treatments. Conversely, Mn showed statistically higher concentrations in TS0 fruits (56-57 mg kg(-1)) compared to those grown in sediment-based substrates (8-20 mg kg(-1)). Among organic contaminants, only dioxin-like PCBs were determined in fruits, at toxic equivalent concentrations fourfold lower than the limit established by the European Union. TS100 fruits showed a yield reduction from 40 to 70% for Camarosa and Monterey, but higher sugar and ascorbic acid contents. (C) 2019 Elsevier Ltd. All rights reserved.

Published
2020

29. Efficacy of end-effector robot-assisted gait training combined with robotic balance training in sub-acute stroke patients: preliminary results

Author

Chiara Iacovelli, Cristiano Pecchioli, L. Castelli, and Irene Aprile

Subjects
medicine.medical_specialty, Stroke patient, business.industry, Rehabilitation, Biophysics, Balance training, Sub acute, Robot end effector, law.invention, Physical medicine and rehabilitation, Gait training, law, Medicine, Robot, Orthopedics and Sports Medicine, business
Published
2019

30. SAT-433-Portal venous velocity and platelet count as a simple non-invasive tool to rule out the presence of varices needing treatment in patients with compensated cirrhosis

Author

Angelico Mario, Simona Francioso, C. Masetti, Martina Milana, A. Bosa, Francesco Santopaolo, A. Pecchioli, Piera Rossi, Ilaria Lenci, A. Brega, Leonardo Baiocchi, Francesca Antenucci, and B. Neri

Subjects
medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Non invasive, medicine.disease, Venous velocity, Internal medicine, medicine, Cardiology, Platelet, In patient, business, Varices
Published
2019

31. OC-0276 Stereotactic radiosurgery plus immunotherapy or targeted therapy for brain metastases from NSCLC

Author

Emanuela Olmetto, A. Compagnucci, Silvia Scoccianti, Livia Marrazzo, Marta Casati, S. Erika, Isacco Desideri, Gabriele Simontacchi, C. Delli Paoli, Roberta Grassi, Daniela Greto, Guido Pecchioli, Stefania Pallotta, L.P. Ciccone, M. Perna, C. Arilli, and Lorenzo Livi

Subjects
Oncology, medicine.medical_specialty, business.industry, Internal medicine, medicine.medical_treatment, medicine, Radiology, Nuclear Medicine and imaging, Hematology, Immunotherapy, business, Radiosurgery, Targeted therapy
Published
2019

32. Reply to the comment of Misirlioglu et al. 'Periscapular muscle ultrasound as a diagnostic aid in scapular winging secondary to long thoracic nerve lesion'

Author

Marcello Romano, Daniele Coraci, Silvia Giovannini, Luca Padua, and Cristiano Pecchioli

Subjects
Muscle ultrasound, medicine.medical_specialty, Thoracic Nerves, Rehabilitation, business.industry, medicine.medical_treatment, Scapular winging, Ultrasound, Peripheral Nervous System Diseases, Magnetic Resonance Imaging, Diagnostic aid, Scapula, Long thoracic nerve lesion, Rheumatology, Humans, Medicine, Radiology, business, Ultrasonography
Published
2019

39. SAT-433-Portal venous velocity and platelet count as a simple non-invasive tool to rule out the presence of varices needing treatment in patients with compensated cirrhosis

Author

Santopaolo, Francesco, primary, baiocchi, leonardo, additional, Rossi, Piera, additional, Pecchioli, Alessandra, additional, Bosa, Alessandra, additional, Francioso, Simona, additional, Brega, Arianna, additional, Lenci, Ilaria, additional, Masetti, Chiara, additional, Milana, Martina, additional, Antenucci, Francesca, additional, Neri, Benedetto, additional, and Mario, Angelico, additional

Published
2019
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40. OC-0276 Stereotactic radiosurgery plus immunotherapy or targeted therapy for brain metastases from NSCLC

Author

Olmetto, E., primary, Paoli, C. Delli, additional, Ciccone, L.P., additional, Perna, M., additional, Grassi, R., additional, Erika, S., additional, Scoccianti, S., additional, Greto, D., additional, Desideri, I., additional, Simontacchi, G., additional, Marrazzo, L., additional, Arilli, C., additional, Casati, M., additional, Compagnucci, A., additional, Pecchioli, G., additional, Pallotta, S., additional, and Livi, L., additional

Published
2019
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43. The past encounters the future: “old” diagnostic methods to check innovative treatments for carpal tunnel syndrome. Comment on: “Treatment of carpal tunnel syndrome: from ultrasonography to ultrasound surgery” by Petrover and Richette. Joint Bone Spine 2017 https://doi.org/10.1016/j.jbspin.2017.11.003

Author

Coraci, Daniele, primary, Giovannini, Silvia, additional, Loreti, Claudia, additional, Pecchioli, Cristiano, additional, Piccinini, Giulia, additional, and Padua, Luca, additional

Published
2018
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44. The past encounters the future: 'old' diagnostic methods to check innovative treatments for carpal tunnel syndrome. Comment on: 'Treatment of carpal tunnel syndrome: from ultrasonography to ultrasound surgery' by Petrover and Richette. Joint Bone Spine 2017 https://doi.org/10.1016/j.jbspin.2017.11.003

Author

Daniele Coraci, Silvia Giovannini, Claudia Loreti, Cristiano Pecchioli, Giulia Piccinini, and Luca Padua

Subjects
03 medical and health sciences, 0302 clinical medicine, Rheumatology, Humans, Carpal Tunnel Syndrome, 030217 neurology & neurosurgery, Ultrasonography, 030218 nuclear medicine & medical imaging
Published
2018

45. A score including ADAM17 substrates correlates to recurring cardiovascular event in subjects with atherosclerosis

Author

Massimiliano Copetti, Arnaldo Ippoliti, Stefano Rizza, Chiara Pecchioli, F Romeo, Marina Cardellini, Ottavia Porzio, Alessio Luzi, Fabio Pellegrini, Rossella Menghini, Massimo Federici, and Giovanni Di Cola

Subjects
Male, Time Factors, Rome, Myocardial Infarction, Endothelium-derived factors, Settore MED/09, Kaplan-Meier Estimate, Disease, Substrate Specificity, Recurrence, Risk Factors, Medicine, Myocardial infarction, Settore MED/49 - Scienze Tecniche Dietetiche Applicate, Cardiovascular disease outcomes, Stroke, Settore BIO/12, Middle Aged, Intercellular Adhesion Molecule-1, Prognosis, Receptors, Tumor Necrosis Factor, Type I, Cardiology, Female, Follow up study, Cardiology and Cardiovascular Medicine, Adult, Cardiovascular event, medicine.medical_specialty, Vascular Cell Adhesion Molecule-1, Enzyme-Linked Immunosorbent Assay, ADAM17 Protein, Risk Assessment, Decision Support Techniques, Cardiovascular death, Predictive Value of Tests, Diabetes mellitus, Internal medicine, Humans, Atherosclerosis, Inflammation, Aged, Proportional Hazards Models, business.industry, medicine.disease, Receptors, Interleukin-6, Clinical method, Surgery, ADAM Proteins, Increased risk, Multivariate Analysis, business, Biomarkers
Abstract

Atherosclerosis disease is a leading cause for mortality and morbidity. The narrowing/rupture of a vulnerable atherosclerotic plaque is accountable for acute cardiovascular events. However, despite of an intensive research, a reliable clinical method which may disclose a vulnerable patient is still unavailable.We tested the association of ADAM17 (A Disintegrin and Metallo Protease Domain 17) circulating substrates (sICAM-1, sVCAM-1, sIL6R and sTNFR1) with a second major cardiovascular events [MACEs] (cardiovascular death, peripheral artery surgeries, non-fatal myocardial infarction and non-fatal stroke) in 298 patients belonging to the Vascular Diabetes (AVD) study. To evaluate ADAM17 activity we create ADAM17 score through a RECPAM model. Finally we tested the discrimination ability and the reclassification of clinical models. At follow-up (mean 47 months, range 1-118 months), 55 MACEs occurred (14 nonfatal MI, 14 nonfatal strokes, 17 peripheral artery procedures and 10 cardiovascular deaths) (incidence = 7.8% person-years). An increased risk for incident events was observed among the high ADAM17 score individuals both in univariable (HR 19.20, 95% CI 15.82-63.36, p0.001) and multivariable analysis (HR 3.42, 95% CI 1.55-7.54, p0.001). Finally we found that ADAM17 score significantly increases the prediction accuracy of the Framingham Recurring-Coronary-Heart-Disease-Score, with a significant improvement in discrimination (integrated discrimination improvement = 9%, p = 0.012) and correctly reclassifying 10% of events and 41% of non-events resulting in a cNRI = 0.51 (p = 0.005).We demonstrated a positive role of ADAM17 activity to predicting CV events. We think that an approach that targets strategies beyond classic cardiovascular risk factors control is necessary in individuals with an established vascular atherosclerosis.

Published
2015

46. Venous thromboembolism in medical patients treated in the setting of primary care: A nationwide case-control study in Italy

Author

Claudio Cricelli, Giampiero Mazzaglia, Alessandro Filippi, Serena Pecchioli, Claudio Cimminiello, G. Arpaia, Cimminiello, C, Filippi, A, Mazzaglia, G, Pecchioli, S, Arpaia, G, and Cricelli, C

Subjects
Medical disease, Adult, Male, medicine.medical_specialty, Population, Disease, Deep vein thrombosi, Risk Factors, Internal medicine, medicine, Humans, Intensive care medicine, education, Stroke, Aged, Retrospective Studies, Univariate analysis, education.field_of_study, COPD, Primary Health Care, business.industry, Pulmonary embolism, Case-control study, Venous Thromboembolism, Hematology, Case-control, Middle Aged, Primary care, medicine.disease, Venous thrombosis, Italy, Case-Control Studies, Female, business
Abstract

Objectives: The risk of venous thrombotic events (VTE) among medical outpatients is still not clear and it remains to be clarified whether medical diseases involve the same risk if managed at home or in hospital. The aim of this study was to evaluate in the setting of outpatient family medicine the relationship between VTE and medical conditions known to be at risk during a hospital stay. Design and setting: The study involved a nationwide retrospective observation according to a nested case-control method; 400 general practitioners throughout Italy constituted the network for data collection. Between 2001 and 2004, all cases recorded as having VTE were entered; ten control patients without VTE, matched by sex, physician, and age, were selected from the database for each case. Results: The eligible population comprised 372,000 patients and 1,624 incident VTE were recorded. Univariate analysis indicated hospitalization (OR 5.02; 95% CI 4.01-6.29), cancer (OR 3.06; 95% CI 2.47-3.79), acute infectious disease (OR 2.93; 95% CI 1.94-4.43), neurological disease (OR 2.60; 95% CI 1.56-4.33), congestive heart failure (CHF) (OR 2.48; 95% CI 1.68-3.69), paralysis (OR 1.87; 95% CI 1.51-2.32), COPD (OR 1.58; 95% CI 1.29-1.95), stroke (OR 1.62; 95% CI 1.24-2.12), superficial venous thrombosis (OR 1.51; 95% CI 1.11-2.04, and rheumatic diseases (OR 1.49; 95% CI 1.28-1.74) as significantly associated with an increased risk for VTE. After adjustment, only transient or definitive paralysis, cancer, acute infectious disease, congestive heart failure, neurological diseases, and previous hospitalization remained associated. Conclusions: This large study indicates that VTE outpatients seen by general practitioners in Italy have a high prevalence of the same medical diseases associated with VTE among patients treated in hospital. (C) 2010 Elsevier Ltd. All rights reserved.

Published
2010

47. In vivo definition of parieto-motor connections involved in planning of grasping movements

Author

Carlo Caltagirone, Giacomo Koch, Viviana Versace, Marco Bozzali, John C. Rothwell, Cristiano Pecchioli, Mara Cercignani, Massimiliano Oliveri, KOCH, G, CERCIGNANI, M, PECCHIOLI, C, VERSACE, V, OLIVERI, M, CALTAGIRONE, C, ROTHWELL, JC, and BOZZALI, M

Subjects
Male, genetic structures, Cognitive Neuroscience, medicine.medical_treatment, Intraparietal sulcus, Motor Activity, behavioral disciplines and activities, Functional Laterality, Lateralization of brain function, NO, Superior longitudinal fasciculus, Angular gyrus, Young Adult, Supramarginal gyrus, Parietal Lobe, Neural Pathways, medicine, Humans, Diffusion Tensor Imaging, Hand, Motor Skills, Frontal Lobe, Motor Cortex, Evoked Potentials, Motor, Psychomotor Performance, Transcranial Magnetic Stimulation, Female, Evoked Potentials, Connectivity, Settore M-PSI/02 - Psicobiologia E Psicologia Fisiologica, musculoskeletal, neural, and ocular physiology, Transcranial magnetic stimulation, TMS, Connectivity, Movement planning, Superior longitudinal fasciculus,Tractography, Transcranial magnetic stimulation, medicine.anatomical_structure, Movement planning, TMS, Tractography, Motor, nervous system, Neurology, Settore MED/26 - Neurologia, Primary motor cortex, Psychology, Neuroscience, psychological phenomena and processes
Abstract

We combined bifocal transcranial magnetic stimulation (TMS) and diffusion tensor imaging (DTI) tractography to investigate in humans the contribution of connections originating from different parietal areas in planning of different reaching to grasp movements. TMS experiments revealed that in the left hemisphere functional connectivity between the primary motor cortex (M1) and a portion of the angular gyrus (AG) close to the caudal intraparietal sulcus was activated during early preparation of reaching and grasping movements only when the movement was made with a whole hand grasp (WHG) towards objects in contralateral space. In contrast, a different pathway, linking M1 with a part of the supramarginal gyrus (SMG) close to the anterior intraparietal sulcus, was sensitive only to the type of grasp required (precision grasping) but not to the position of the object in space. A triple coil experiment revealed that inactivation of the ventral premotor area (PMv) by continuous theta burst stimulation interfered with some of these interactions. Anatomical DTI tractography revealed that AG and SMG are strongly connected with PMv and with M1 by different bundles of the superior longitudinal fasciculus (SLF). These results demonstrate the existence of segregated parieto-premotor-motor pathways crucial for preparation of different grasping actions and indicate that these may process information relevant to both the position of the object and the hand shape required to use it.

Published
2010

48. Characterization of the rabbit agouti signaling protein (ASIP) gene: Transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colour

Author

Lionel Forestier, Vincenzo Russo, Ahmad Oulmouden, Séverine Deretz-Picoulet, Daniel Allain, Terence J. Robinson, Luca Fontanesi, Elena Pecchioli, Cristiano Vernesi, Francesca Beretti, Emilio Scotti, Jason L. Malaney, Sezione di Allevamenti Zootecnici, Alma Mater Studiorum University of Bologna (UNIBO), Unité de Génétique Moléculaire Animale (UGMA), Université de Limoges (UNILIM)-Institut National de la Recherche Agronomique (INRA), Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Génétique Expérimentale en Productions Animales (GEPA), Research and Innovation Centre, Edmund Mach Foundation (FEM), Department of Botany and Zoology, Evolutionary Genomics Group, Stellenbosch University, Museum of Southwestern Biology and Department of Biology, The University of New Mexico [Albuquerque], Unité de Génétique Moléculaire Animale (UMR GMA), Institut National de la Recherche Agronomique (INRA)-Université de Limoges (UNILIM), Fontanesi L., Forestier L., Allain D., Scotti E., Beretti F., Deretz-Picoulet S., Pecchioli E., Vernesi C., Robinson T.J., Malaney J.L., Russo V., and Oulmouden A.

Subjects
Coat, GENE EXPRESSION, Genotype, [SDV]Life Sciences [q-bio], DNA Mutational Analysis, Molecular Sequence Data, rabbit, Locus (genetics), transcription analysis, Biology, oryctolagus cuniculus, 03 medical and health sciences, Exon, Signaling proteins, Genetics, Animals, Allele, lagomorpha, Gene, Alleles, Phylogeny, 030304 developmental biology, Melanins, 0303 health sciences, Phylogenetic tree, integumentary system, Pigmentation, 0402 animal and dairy science, Wild type, 04 agricultural and veterinary sciences, Sequence Analysis, DNA, 040201 dairy & animal science, Molecular biology, Mutation, agouti, Agouti Signaling Protein, Rabbits, Hair, coat colour
Abstract

The agouti locus encodes the agouti signalling protein (ASIP) which is involved in determining the switch from eumelanin to pheomelanin synthesis in melanocytes. In the domestic rabbit (Oryctolagus cuniculus) early studies indicated three alleles at this locus: A, light-bellied agouti (wild type); at, black and tan; a, black nonagouti. We characterized the rabbit ASIP gene and identified the causative mutation (an insertion in exon 2) of the black nonagouti allele whose frequency was evaluated in 31 breeds. Phylogenetic analysis of ASIP sequences from Oryctolagus and 9 other species of the family Leporidae placed Oryctolagus as sister species to Pentalagus and Bunolagus. Transcription analysis in wild type agouti rabbits revealed the presence of two major transcripts with different 5′-untranslated regions having ventral or dorsal skin specific expression. ASIP gene transcripts were also detected in all examined rabbit tissues distinguishing the rabbit expression pattern from what was observed in wild type mice.

Published
2010
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49. Efficacy of Robotic-Assisted Gait Training in sub-acute stroke patients: An Italian bi-centre study

Author

Chiara Iacovelli, Michela Goffredo, Luca Padua, Chiara Simbolotti, Arianna Cruciani, Marco Franceschini, Daniele Galafate, Sanaz Pournajaf, Cristiano Pecchioli, and Irene Aprile

Subjects
medicine.medical_specialty, Physical medicine and rehabilitation, Gait training, Stroke patient, Robotic assisted, business.industry, Rehabilitation, Biophysics, medicine, Orthopedics and Sports Medicine, Sub acute, business
Published
2018

50. Effects of a robotic rehabilitation treatment in a patient with traumatic lesion of the right brachial plexus measured by means of motion analysis: A case stud

Author

Marco Germanotta, Luca Padua, Irene Aprile, E. Di Sipio, Cristiano Pecchioli, and Arianna Cruciani

Subjects
Motion analysis, medicine.medical_specialty, business.industry, 0206 medical engineering, Rehabilitation, Biophysics, 02 engineering and technology, Robotic rehabilitation, 020601 biomedical engineering, Traumatic lesion, 030218 nuclear medicine & medical imaging, Surgery, 03 medical and health sciences, 0302 clinical medicine, medicine, Orthopedics and Sports Medicine, business, Brachial plexus
Published
2018

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