1. Pregnancy Outcomes in Diabetes Subtypes: How Do They Compare? A Province-based Study of Ontario, 2005–2006
- Author
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Qiuying Yang, Patricia Peticca, Mark Walker, Erin Keely, and Jim Bottomley
- Subjects
Adult ,musculoskeletal diseases ,medicine.medical_specialty ,medicine.medical_treatment ,Population ,Pregnancy in Diabetics ,Preeclampsia ,Cohort Studies ,Shoulder dystocia ,Pregnancy ,Diabetes mellitus ,medicine ,Humans ,Caesarean section ,education ,Pre-Gestational Diabetes ,Retrospective Studies ,Ontario ,Type 1 diabetes ,education.field_of_study ,Obstetrics ,business.industry ,Pregnancy Outcome ,Obstetrics and Gynecology ,medicine.disease ,female genital diseases and pregnancy complications ,Diabetes, Gestational ,Case-Control Studies ,Gestation ,Female ,business - Abstract
Objective To ascertain differences in pregnancy outcomes between women with diabetes subtypes (type 1 [DM1], type 2 [DM2], women with gestational [GDM])] and non-diabetic women within a large Canadian population. Methods We performed a retrospective multi-cohort analysis of all obstetrical deliveries that occurred in the province of Ontario between April 1, 2005, and March 31, 2006. Data were extracted from the Ontario Niday Perinatal Database. Results Increased rates of major negative maternal and perinatal outcomes (i.e. preterm delivery, Caesarean section, pregnancy-induced hypertension/preeclampsia) occurred in women with DM1. Both DM1 and GDM subtypes were associated with the greatest risk of macrosomia, shoulder dystocia, and congenital anomalies. DM2 did not demonstrate an association with an increased risk of congenital malformations and stillbirth. Conclusion Diabetes in pregnancy, irrespective of subtype, predisposes women to poorer outcomes than those of the general obstetric population. However, this large population analysis is consistent with previous studies in showing that the adversity remains greatest for women with type 1 diabetes.
- Published
- 2009
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