1. Ischemia and apoptosis in an animal model of permanent infarct-related artery occlusion
- Author
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Antonio, Abbate, Celina, Morales, Maria De Falco, Valentina, Fedele, BIONDI ZOCCAI, Giuseppe, Daniele, Santini, Jimena, Palleiro, Scarpa, Susanna, Fortunata, Vasaturo, Giovanna, Liuzzo, Anna, Severino, Feliciano, Baldi, Filippo, Crea, Biasucci, Luigi M., Vetrovec, George W., Gelpi, Ricardo J., Alfonso, Baldi, Santini, Daniele, Abbate, A, Morales, C, DE FALCO, Maria, Fedele, V, BIONDI ZOCCAI, G. G., Santini, D, Palleiro, J, Vasaturo, F, Scarpa, S, Liuzzo, G, Severino, A, Baldi, F, Crea, F, Biasucci, L. M., Vetrovec, G. W., Gelpi, R. J., Baldi, A., DE FALCO, M, BIONDI ZOCCAI, Gl, Biasucci, Lm, Vetrovec, Gw, Gelpi, Rj, and Baldi, Alfonso
- Subjects
medicine.medical_specialty ,Time Factors ,Myocardial Ischemia ,Ischemia ,Apoptosis ,Coronary Disease ,ischemia ,Left coronary artery ,medicine.artery ,Internal medicine ,Occlusion ,medicine ,Animals ,remodelling ,Myocytes, Cardiac ,cardiovascular diseases ,Myocardial infarction ,Artery occlusion ,electron microscopy ,business.industry ,animal model ,Myocardium ,Apoptosi ,medicine.disease ,Disease Models, Animal ,Cyclooxygenase 2 ,Heart failure ,apoptosis ,Circulatory system ,Cardiology ,Female ,Rabbits ,Cardiology and Cardiovascular Medicine ,business ,Ligation - Abstract
Apoptosis is a pathologic feature of cardiomyocytes in acute myocardial infarction (AMI) and heart failure. The temporal course of apoptosis in the peri-infarct area in the weeks following an AMI is still uncompletely defined. In order to study the time course of apoptosis after AMI, 16 rabbits underwent left coronary artery ligation and were sacrificed at 16, 26, 35, and 56 days after surgery. Increased apoptotic rate (AR) was observed at in the peri-infarct region than in remote myocardium (5.4% [2.5-9.6] vs 0.4% [0.1-0.9], respectively, P < 0.001) and than in sham-operated cases (0.01% [0-0.02], P < 0.001). A gradual decrease of AR in the peri-infarct region was observed over time with a 90% reduction at 8 weeks after coronary ligation. © 2006 Elsevier Ireland Ltd. All rights reserved.
- Published
- 2007
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