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509 results on '"Orazi, A"'

5. Acute and post-acute multidisciplinary outcomes of newborns born from mothers with SARS-CoV-2 infection during pregnancy or the perinatal period

Author

Buonsenso, Danilo, primary, Poretti, Giulia, additional, Mariani, Francesco, additional, Colonna, Arianna Turriziani, additional, Costa, Simonetta, additional, Giordano, Lucia, additional, Priolo, Francesca, additional, Conti, Guido, additional, Tizio, Angelo, additional, Rodolico, Daniela, additional, Amorelli, Giulia Maria, additional, Orazi, Lorenzo, additional, Petrianni, Maria, additional, Ricci, Daniela, additional, Lanzone, Antonio, additional, Sanguinetti, Maurizio, additional, Cattani, Paola, additional, Raffaelli, Francesca, additional, Sali, Michela, additional, Zampino, Giuseppe, additional, Vento, Giovanni, additional, and Valentini, Piero, additional

Published
2023
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6. Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study

Author

Medas, Fabio, primary, Dobrinja, Chiara, additional, Al-Suhaimi, Ebtesam Abdullah, additional, Altmeier, Julia, additional, Anajar, Said, additional, Arikan, Akif Enes, additional, Azaryan, Irina, additional, Bains, Lovenish, additional, Basili, Giancarlo, additional, Bolukbasi, Hakan, additional, Bononi, Marco, additional, Borumandi, Farzad, additional, Bozan, Mehmet Buğra, additional, Brenta, Gabriela, additional, Brunaud, Laurent, additional, Brunner, Maximilian, additional, Buemi, Antoine, additional, Canu, Gian Luigi, additional, Cappellacci, Federico, additional, Cartwright, Sara Burchfield, additional, Castells Fusté, Ignasi, additional, Cavalheiro, Beatriz, additional, Cavallaro, Giuseppe, additional, Chala, Andres, additional, Chan, Shun Yan Bryant, additional, Chaplin, John, additional, Cheema, Mustafa Sajjad, additional, Chiapponi, Costanza, additional, Chiofalo, Maria Grazia, additional, Chrysos, Emmanuel, additional, D'Amore, Annamaria, additional, de Cillia, Michael, additional, De Crea, Carmela, additional, de Manzini, Nicolò, additional, de Matos, Leandro Luongo, additional, De Pasquale, Loredana, additional, Del Rio, Paolo, additional, Demarchi, Marco Stefano, additional, Dhiwakar, Muthuswamy, additional, Donatini, Gianluca, additional, Dora, Jose Miguel, additional, D'Orazi, Valerio, additional, Doulatram Gamgaram, Viyey Kishore, additional, Eismontas, Vitalijus, additional, Kabiri, El Hassane, additional, El Malki, Hadj Omar, additional, Elzahaby, Islam, additional, Enciu, Octavian, additional, Eskander, Antoine, additional, Feroci, Francesco, additional, Figueroa-Bohorquez, David, additional, Filis, Dimitrios, additional, Gorostidi, François, additional, Frías-Fernández, Pedro, additional, Gamboa-Dominguez, Armando, additional, Genc, Volkan, additional, Giordano, Davide, additional, Gómez-Pedraza, Antonio, additional, Graceffa, Giuseppa, additional, Griffin, James, additional, Guerreiro, Sofia Cuco, additional, Gupta, Karan, additional, Gupta, Keshav Kumar, additional, Gurrado, Angela, additional, Hajiioannou, Jiannis, additional, Hakala, Tommi, additional, Harahap, Wirsma Arif, additional, Hargitai, Lindsay, additional, Hartl, Dana, additional, Hellmann, Andrzej, additional, Hlozek, Jiri, additional, Hoang, Van Trung, additional, Iacobone, Maurizio, additional, Innaro, Nadia, additional, Ioannidis, Orestis, additional, Jang, J H Isabelle, additional, Xavier-Junior, Jose Candido, additional, Jovanovic, Milan, additional, Kaderli, Reto Martin, additional, Kakamad, Fahmi, additional, Kaliszewski, Krzysztof, additional, Karamanliev, Martin, additional, Katoh, Hiroshi, additional, Košec, Andro, additional, Kovacevic, Bozidar, additional, Kowalski, Luiz Paulo, additional, Králik, Robert, additional, Yadav, Sanjay Kumar, additional, Kumorová, Adriána, additional, Lampridis, Savvas, additional, Lasithiotakis, Konstantinos, additional, Leclere, Jean-Christophe, additional, Leong, Eugene Kwong Fei, additional, Leow, Melvin Khee-Shing, additional, Lim, James Y, additional, Lino-Silva, Leonardo S, additional, Liu, Shirley Yuk Wah, additional, Llorach, Núria Perucho, additional, Lombardi, Celestino Pio, additional, López-Gómez, Javier, additional, Lori, Eleonora, additional, Quintanilla-Dieck, Lourdes, additional, Lucchini, Roberta, additional, Madani, Amin, additional, Manatakis, Dimitrios, additional, Markovic, Ivan, additional, Materazzi, Gabriele, additional, Mazeh, Haggi, additional, Mercante, Giuseppe, additional, Meyer-Rochow, Goswin Yason, additional, Mihaljevic, Olgica, additional, Miller, Julie A, additional, Minuto, Michele, additional, Monacelli, Massimo, additional, Mulita, Francesk, additional, Mullineris, Barbara, additional, Muñoz-de-Nova, José Luis, additional, Muradás Girardi, Fábio, additional, Nader, Saki, additional, Napadon, Tangjaturonrasme, additional, Nastos, Constantinos, additional, Offi, Chiara, additional, Ronen, Ohad, additional, Oragano, Luigi, additional, Orois, Aida, additional, Pan, Yongqin, additional, Panagiotidis, Emmanouil, additional, Panchangam, Ramakanth Bhargav, additional, Papavramidis, Theodosios, additional, Parida, Pradipta Kumar, additional, Paspala, Anna, additional, Pérez, Òscar Vidal, additional, Petrovic, Sabrina, additional, Raffaelli, Marco, additional, Ramacciotti, Constanza Fernanda, additional, Ratia Gimenez, Tomas, additional, Rivo Vázquez, Ángel, additional, Roh, Jong-Lyel, additional, Rossi, Leonardo, additional, Sanabria, Alvaro, additional, Santeerapharp, Alena, additional, Semenov, Arseny, additional, Seneviratne, Sanjeewa, additional, Serdar, Altinay, additional, Sheahan, Patrick, additional, Sheppard, Sean C, additional, Slotcavage, Rachel L, additional, Smaxwil, Constantin, additional, Kim, Soo Young, additional, Sorrenti, Salvatore, additional, Spartalis, Eleftherios, additional, Sriphrapradang, Chutintorn, additional, Testini, Mario, additional, Turk, Yigit, additional, Tzikos, George, additional, Vabalayte, Kristina, additional, Vargas-Osorio, Kelly, additional, Vázquez Rentería, Rafael Sebastián, additional, Velázquez-Fernández, David, additional, Vithana, Sanura Malinda Pallegoda, additional, Yücel, Levent, additional, Yulian, Erwin Danil, additional, Zahradnikova, Petra, additional, Zarogoulidis, Paul, additional, Ziablitskaia, Evgeniia, additional, Zolotoukho, Anna, additional, Calò, Pietro Giorgio, additional, Abdallah, A, additional, Abentroth, AL, additional, Acheimastos, V, additional, Agunaoun, M, additional, Al Bisher, HM, additional, Al Ghuzlan, A, additional, Alakus, H, additional, Alkan, M, additional, Almaraz Almaraz, MC, additional, Amram, K, additional, Anesidis, S, additional, Anestiadou, E, additional, Angelucci, D, additional, Ansaldo, GL, additional, Antonopoulou, MI, additional, Arciniegas, M, additional, Armellin, C, additional, Arredondo Saldaña, G, additional, Astl, J, additional, Athanasakis, E, additional, Avenia, S, additional, Aydın, H, additional, Baba, B, additional, Babala, J, additional, Banús, MV, additional, Barba-Valadez, LA, additional, Barcons, SV, additional, Battafarano, F, additional, Bayat, A, additional, Bella, RMC, additional, Benariba, F, additional, Bernardi, S, additional, Bignami, EG, additional, Bitenc, M, additional, Bitsianis, S, additional, Bolaños de la Torre, JDD, additional, Bonati, E, additional, Bonetti, T, additional, Borges, FA, additional, Bouchagier, K, additional, Boudina, M, additional, Bourial, A, additional, Breuskin, I, additional, Brock, P, additional, Bruns, C, additional, Burlacu, MC, additional, Burton, T, additional, Buta, M, additional, Buzanakov, D, additional, Caliseo, C, additional, Callanan, D, additional, Calu, V, additional, Cameselle-Teijeiro, JM, additional, Camilo-Junior, DJ, additional, Canberk, S, additional, Candalise, V, additional, Candanedo-Gonzalez, F, additional, Carrillo Lizarazo, LJ, additional, Carvalho, GB, additional, Casallas, D, additional, Casolino, C, additional, Castellani, L, additional, Castillo Morales, C, additional, Chambon, G, additional, Chatzipavlidou, V, additional, Chernikov, R, additional, Chorti, A, additional, Chow, TCM, additional, Chrisoulidou, A, additional, Chrysos, E, additional, Conrado-Neto, S, additional, Cordova García, D, additional, Corigliano, A, additional, Crocco, A, additional, Cuesta, A, additional, Čukman, M, additional, Curto, LS, additional, Damilano, RA, additional, D'Anna, R, additional, De, M, additional, De Virgilio, A, additional, Dellaportas, D, additional, Demarquet, L, additional, Devresse, A, additional, Di Meo, G, additional, Diaz Pedrero, R, additional, Dimitrov, D, additional, Dmitry, Z, additional, Domínguez Garijo, P, additional, Dulgeroglu, O, additional, Dural, AC, additional, Eksi, A, additional, El Hammoumi, M, additional, El Kaoui, H, additional, Eleni, G, additional, Elliyanti, A, additional, Ersöz, Ş, additional, Escobar-Jiménez, M, additional, Fedorova, L, additional, Feeley, L, additional, Fernández Rodríguez, E, additional, Ferreli, F, additional, Filoia, A, additional, Fingeret, A, additional, Francescato, A, additional, Gaino, F, additional, Galiandro, F, additional, Gallegos-Hernández, JF, additional, Garas, G, additional, García Lorenzo, F, additional, García-Chávez, JP, additional, Gaudiello, M, additional, Gay, S, additional, Gerasimos, S, additional, Gerek, M, additional, Gervasi, R, additional, Giordano, A, additional, Gjeloshi, B, additional, Gocký, L, additional, Golubinskaya, E, additional, González Romero, S, additional, González-Mínguez, C, additional, Goran, M, additional, Gosman, A, additional, Granados Garcia, M, additional, Greco, E, additional, Grünbart, M, additional, Grützmann, R, additional, Guerlain, J, additional, Guirao, XG, additional, Guzey, D, additional, Hajjij, A, additional, Hamdy, O, additional, Hameed, MS, additional, Hauth, LA, additional, Hernández-Acevedo, JD, additional, Hernandez-Carrillo, JF, additional, Hevilla Sánchez, F, additional, Hoi, H, additional, Hongkwon, K, additional, Hu Zhu, R, additional, Huang, E, additional, Hyeung Kyoo, K, additional, Ignjatovic, V, additional, Ioannidis, A, additional, Iossa, A, additional, Işık, A, additional, James, D, additional, Jung Hoon, L, additional, Kara, H, additional, Karajovic, J, additional, Kartini, D, additional, Khambri, D, additional, Kholová, I, additional, Kisiel, M, additional, Knežević, M, additional, Koh, YQ, additional, Konca, C, additional, Kosmidis, C, additional, Kotsovolis, G, additional, Kowalski, LP, additional, Kralik, R, additional, Kuczma, P, additional, Kuravi, BG, additional, Kurnia, A, additional, Kyriaki, V, additional, Lai, CM, additional, Lallemant, B, additional, Lardhi, AA, additional, Leboulleux, S, additional, Lee, JW, additional, Lelli, G, additional, Leutner, M, additional, Lim, MY, additional, Lim, CM, additional, Llanos, A, additional, Lo, X, additional, Loderer, T, additional, López-Corrales, MA, additional, Ludwig, M, additional, Magnabosco, FF, additional, Maheo, C, additional, Maia, AL, additional, Makay, O, additional, Maksimova, P, additional, Mallick, S, additional, Mallouk, C, additional, Mamani, Z, additional, Mandal, S, additional, Manyalich Blasi, M, additional, Marincola, G, additional, Marulanda, M, additional, Mavromati, M, additional, Mayilvaganan, S, additional, Metso, S, additional, Micalizzi, A, additional, Michalopoulos, A, additional, Min-Su, K, additional, Miron, A, additional, Mishra, AK, additional, Misso, C, additional, Mittermair, C, additional, Morosán Allo, Y, additional, Mourad, M, additional, Moysidis, M, additional, Nabhan, F, additional, Nasiri, R, additional, Nastos, C, additional, Ngiam, KY, additional, Nomine-Criqui, C, additional, Ntziovara, AM, additional, Nuño Vázquez-Garza, JM, additional, Nutautiene, V, additional, Obtulovičová, K, additional, O'Keeffe, L, additional, Okudur, NO, additional, Ossola, P, additional, Ovejero Merino, E, additional, Ozdemir, M, additional, Pangonis, A, additional, Panigoro, SS, additional, Panuzi, A, additional, Papaconstantinou, D, additional, Pardo Matamoros, N, additional, Paschou, S, additional, Pasculli, A, additional, Paterakis, K, additional, Peiris, K, additional, Pennestrì, F, additional, Peppa, M, additional, Perdikaris, P, additional, Perdikaris, I, additional, Pérez-Soto, RH, additional, Piana, S, additional, Piccoli, M, additional, Pietrasanta, D, additional, Placentino, G, additional, Pliakos, I, additional, Polistena, A, additional, Pongtippan, A, additional, Potard, G, additional, Quinn, V, additional, Rahul, P, additional, Ramos, T, additional, Rankin, A, additional, Ratnayake, P, additional, Reuto-Castillo, J, additional, Ridolfo, A, additional, Rios-Valencia, J, additional, Riss, P, additional, Rival, E, additional, Rivillas, J, additional, Roi, D, additional, Rollo, EM, additional, Romanchishen, A, additional, Romito, M, additional, Rotnagl, J, additional, Rovcanin, B, additional, Russo, G, additional, Sabol, M, additional, Saki, S, additional, Saleh, S, additional, Salih, A, additional, Saltiki, A, additional, Salvador-Camarmo, G, additional, Samal, DK, additional, Sánchez-Flores, S, additional, Sapalidis, K, additional, Sarin, D, additional, Sarin, H, additional, Savkovic, N, additional, Scheffel, RS, additional, Scheinpflug, AL, additional, Scheuba, C, additional, Scheyer, N, additional, Schmidt, M, additional, Senashova, O, additional, Serafini, E, additional, Serrano Arévalo, ML, additional, Shank, J, additional, Shindo, ML, additional, Shoshkova, M, additional, Shvan, M, additional, Sičák, M, additional, Silva, TG, additional, Simó Guerrero, O, additional, Skuletic, V, additional, Slijepcevic, N, additional, Slovic, Z, additional, Soares, P, additional, Somova, A, additional, Soto, S, additional, Spiezia, S, additional, Stankovic, V, additional, Stephenson, KJ, additional, Straub, E, additional, Summa, M, additional, Surani, S, additional, Syed, AA, additional, Symeonidis, S, additional, Taciak, A, additional, Tarallo, M, additional, Tarle, A, additional, Tasis, N, additional, Tausanovic, K, additional, Tchabashvili, L, additional, Thierry, M, additional, Tokarczyk, U, additional, Toma, EA, additional, Topuz, S, additional, Torresan, F, additional, Uras, C, additional, Vaccaro, C, additional, Valdés de Anca, Á, additional, Valentini, M, additional, Varaldo, E, additional, Vartanian, JG, additional, Verras, GI, additional, Vithanage, A, additional, Wijayalathge, H, additional, Wiriyaamornchai, P, additional, Wong, YLC, additional, Wongwattana, P, additional, Xenaki, S, additional, Xie, S, additional, Xu, M, additional, Yang, W, additional, Yilmaz, S, additional, Yılmaz, YF, additional, Yotsov, T, additional, Zahid, MT, additional, and Zielke, A, additional

Published
2023
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9. Acute leukemias with complex karyotype show a similarly poor outcome independent of mixed, myeloid or lymphoblastic immunophenotype: A study from the Bone Marrow Pathology Group

Author

Kirtek, Timothy, primary, Chen, Weina, additional, Laczko, Dorottya, additional, Bagg, Adam, additional, Koduru, Prasad, additional, Foucar, Kathryn, additional, Venable, Elisa, additional, Nichols, Meredith, additional, Rogers, Heesun J., additional, Tam, Wayne, additional, Orazi, Attilio, additional, Hsi, Eric D., additional, Hasserjian, Robert P., additional, Wang, Sa A., additional, Arber, Daniel A., additional, and Weinberg, Olga K., additional

Published
2023
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12. Clinicopathologic characteristics of myeloproliferative neoplasms with JAK2 exon 12 mutation

Author

Suknuntha, Kran, primary, Geyer, Julia T., additional, Patel, Keyur Pravinchandra, additional, Weinberg, Olga K., additional, Rogers, Heesun J., additional, Lake, Jonathan I., additional, Lauridsen, Luke, additional, Patel, Jay L., additional, Kluk, Michael J., additional, Arber, Daniel A., additional, Hsi, Eric D., additional, Bagg, Adam, additional, Bueso-Ramos, Carlos, additional, and Orazi, Attilio, additional

Published
2023
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13. Triple-Negative Primary Myelofibrosis: A Bone Marrow Pathology Group Study

Author

Al-Ghamdi, Yahya A., primary, Lake, Jonathan, additional, Bagg, Adam, additional, Thakral, Beenu, additional, Wang, Sa A., additional, Bueso-Ramos, Carlos, additional, Masarova, Lucia, additional, Verstovsek, Srdan, additional, Rogers, Heesun J., additional, Hsi, Eric D., additional, Gralewski, Jonathon H., additional, Chabot-Richards, Devon, additional, George, Tracy I., additional, Rets, Anton, additional, Hasserjian, Robert P., additional, Weinberg, Olga K., additional, Parilla, Megan, additional, Arber, Daniel A., additional, Padilla, Osvaldo, additional, Orazi, Attilio, additional, and Tam, Wayne, additional

Published
2023
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15. A novel algorithm for a continuous and fast 3D projection of points on triangulated surfaces for CAM/CAD/CAE applications

Author

Leonardo Orazi and Barbara Reggiani

Subjects
Surface (mathematics), General Computer Science, Computer science, 3D projection, Continuous projection, Parameterization, 020206 networking & telecommunications, CAD, 02 engineering and technology, Bilinear projection, Projection method, Triangle mesh, Vertex normals, 0202 electrical engineering, electronic engineering, information engineering, A priori and a posteriori, 020201 artificial intelligence & image processing, Point (geometry), Projection (set theory), Algorithm, ComputingMethodologies_COMPUTERGRAPHICS
Abstract

In the present work, a novel algorithm for the continuous projection of point triangles belonging to a triangle mesh is presented. The algorithm uses the normals defined at the vertices of the triangle to perform the projection. The direction of projection is not chosen a priori but depends on the point to be projected: the proposed algorithm, named Fast Continuous Projection method (FCP) lets the projection direction vary continuously on the mesh. Moreover, the direction is coherent with the original surface that is approximated with the triangle mesh. An optimized version of the algorithm is also presented: this uses pre-evaluated matrices to reduce the calculation time. This algorithm can be effectively used when a large set of points has to be projected on a coarse mesh as, for example, to generate the scanning vectors for laser engraving/milling.

Published
2022

16. Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Author

Mark J. Routbort, Guillermo Garcia-Manero, Kyle Devins, Paola Dal Cin, Kim Anh Do, Rashmi Kanagal-Shamanna, Olga Pozdnyakova, Sa A. Wang, Patricia T. Greipp, Robert P. Hasserjian, Tracy I. George, Kaaren K. Reichard, Keyur P. Patel, Eric D. Hsi, Adam Bagg, Attilio Orazi, L. Jeffrey Medeiros, Srdan Verstovsek, Heesun J. Rogers, Daniel A. Arber, Carlos E. Bueso-Ramos, Faezeh Darbaniyan, and Julia T. Geyer

Subjects
Adult, Pathology, medicine.medical_specialty, Myeloid, Isochromosome, Chronic myelomonocytic leukemia, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Pathology and Forensic Medicine, Bone Marrow, hemic and lymphatic diseases, medicine, Humans, Myeloproliferative neoplasm, Retrospective Studies, Biological Products, Thrombocytosis, business.industry, food and beverages, Myeloid leukemia, medicine.disease, Isochromosomes, medicine.anatomical_structure, Mutation, Atypical chronic myeloid leukemia, Bone marrow, business
Abstract

Classification of myeloid neoplasms with isolated isochromosome i(17q) [17p deletion with inherent monoallelic TP53 loss plus 17q duplication] is controversial. Most cases fall within the WHO unclassifiable myelodysplastic/myeloproliferative neoplasms (MDS/MPN-U) category. The uniformly dismal outcomes warrant better understanding of this entity. We undertook a multi-institutional retrospective study of 92 adult MDS/MPN-U cases from eight institutions. Twenty-nine (32%) patients had isolated i(17q) [MDS/MPN-i(17q)]. Compared to MDS/MPN without i(17q), MDS/MPN-i(17q) patients were significantly younger, had lower platelet and absolute neutrophil counts, and higher frequency of splenomegaly and circulating blasts. MDS/MPN-i(17q) cases showed frequent bilobed neutrophils (75% vs. 23%; P = 0.03), hypolobated megakaryocytes (62% vs. 20%; P = 0.06), and a higher frequency of SETBP1 (69% vs. 5%; P = 0.002) and SRSF2 (63% vs. 5%; P = 0.006) mutations that were frequently co-existent (44% vs. 0%; P = 0.01). TP53 mutations were rare. The mutation profile of MDS/MPN-U-i(17q) was similar to other myeloid neoplasms with i(17q) including atypical chronic myeloid leukemia, chronic myelomonocytic leukemia, myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis, myelodysplastic syndrome and acute myeloid leukemia, with frequent concomitant SETBP1/SRSF2 mutations observed across all the diagnostic entities. Over a median follow-up of 52 months, patients with MDS/MPN-i(17q) showed a shorter median overall survival (11 vs. 28 months; P < 0.001). The presence of i(17q) retained independent poor prognostic value in multivariable Cox-regression analysis [HR 3.686 (1.17-11.6); P = 0.026] along with splenomegaly. We suggest that MDS/MPN-i(17q) warrants recognition as a distinct subtype within the MDS/MPN-U category based on its unique clinico-biologic features and uniformly poor prognosis.

Published
2022

17. NGF and BDNF in pediatrics syndromes

Author

Ferraguti, Giampiero, primary, Terracina, Sergio, additional, Micangeli, Ginevra, additional, Lucarelli, Marco, additional, Tarani, Luigi, additional, Ceccanti, Mauro, additional, Spaziani, Matteo, additional, D’Orazi, Valerio, additional, Petrella, Carla, additional, and Fiore, Marco, additional

Published
2023
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24. Safety and efficacy of once-daily risdiplam in type 2 and non-ambulant type 3 spinal muscular atrophy (SUNFISH part 2): a phase 3, double-blind, randomised, placebo-controlled trial

Author

Eugenio Mercuri, Nicolas Deconinck, Elena S Mazzone, Andres Nascimento, Maryam Oskoui, Kayoko Saito, Carole Vuillerot, Giovanni Baranello, Odile Boespflug-Tanguy, Nathalie Goemans, Janbernd Kirschner, Anna Kostera-Pruszczyk, Laurent Servais, Marianne Gerber, Ksenija Gorni, Omar Khwaja, Heidemarie Kletzl, Renata S Scalco, Hannah Staunton, Wai Yin Yeung, Carmen Martin, Paulo Fontoura, John W Day, Joseph J. Volpe, John Posner, Ulrich Kellner, Rosaline Quinlivan, Aurore Daron, Stéphanie Delstanche, Romain Bruninx, Fabian Dal Farra, Olivier Schneider, Irina Balikova, Patricia Delbeke, Inge Joniau, Valentine Tahon, Sylvia Wittevrongel, Elke De Vos, Ingele Casteels, Liesbeth De Waele, Catherine Cassiman, Lies Prové, David Kinoo, Lisa Vancampenhout, Marleen Van Den Hauwe, Annelies Van Impe, Alexandra Prufer de Queiroz Campos Araujo, Aline Chacon Pereira, Flávia Nardes, Lorena Haefeli, Julia Rossetto, Marcos Ferreira Rebel, Jaqueline Almeida Pereira, Craig Campbell, Sapna Sharan, Wendy McDonald, Cheryl Scholtes, Jean Mah, Maria Sframeli, Angela Chiu, Jane Hagel, Raquel Beneish, Gaela Cariou-Palmer, Connie Pham, Daniela Toffoli, Stephanie Arpin, Sarah Turgeon Desilets, Yi Wang, Chaoping Hu, Jianfeng Huan, Chen Qian, Li Shen, Ying Xiao, Zhenxuan Zhou, Hui Li, Sujuan Wang, Hui Xiong, Xingzhi Chang, Hui Dong, Ying Liu, Tian Sang, Cuijie Wei, Jing Wen, Yiwen Cao, Xingyao Ly, Jingjing Zhao, Wenzhu Li, Lun Qin, Nina Barisic, Martina Galiot Delic, Petra Kristina Ivkic, Nenad Vukojevic, Ivana Kern, Boris Najdanovic, Marin Skugor, Teresa Gidaro, Andreea Seferian, Silvana De Lucia, Emmanuel Barreau, Nabila Mnafek, Marta Milkova Momtchilova, Helene Peche, Carole Valherie, Allison Grange, Charlotte Lilien, Darko Milascevic, Shotaro Tachibana, Claudia Ravelli, Ruxandra Cardas, Jessica Taytard, Guillaume Aubertin, Laure Vanden Brande, Jean-Baptiste Davion, Stephanie Coopman, Ikram Bouacha, Philippe Debruyne, Sabine Defoort, Gilles Derlyn, Florian Leroy, Loïc Danjoux, Julie Guilbaud, Isabelle Desguerre, Christine Barnérias, Michaela Semeraro, Dominique Bremond-Gignac, Lenaic Bruere, Maxence Rateaux, Élodie Deladrière, Virginie Germa, Yann Pereon, Sandra Mercie, Fanny Billaud, Lucie Le Goff, Guy Letellier, Aurélie Portefaix, Camille De-Montferrand, Laure Le-Goff, Stephanie Fontaine, Manel Saidi, Nabil Bouzid, Aurélie Barriere, Marie Tinat, Michelle Dreesbach, Wolf Lagréze, Bettina Michaelis, Fanni Molnar, Dorina Seger, Sibylle Vogt, Enrico Bertini, Adele D'Amico, Sergio Petroni, Anna Maria Bonetti, Adelina Carlesi, Irene Mizzoni, Claudio Bruno, Enrico Priolo, Giuseppe Rao, Simone Morando, Paola Tacchetti, Ambra Zuffi, Giacomo Pietro Comi, Roberta Brusa, Stefania Corti, Velardo Daniele, Alessandra Govoni, Francesca Magri, Valeria Minorini, Silvia Gabriella Osnaghi, Francesca Abbati, Federica Fassini, Michaela Foa, Amaqlia Lopopolo, Megi Meneri, Francesca Zoppas, Valeria Parente, Riccardo Masson, Stefania Bianchi Marzoli, Diletta Santarsiero, Myriam Garcia Sierra, Gemma Tremolada, Maria Teresa Arnoldi, Marta Vigano, Riccardo Zanin, Laura Antonaci, Roberto de Sanctis, Marika Pane, Maria Carmela Pera, Giulia Maria Amorelli, Costanza Barresi, Gugliemo D'Amico, Lorenzo Orazi, Giorgia Coratti, Kazuhiro Haginoya, Atsuko Kato, Yuko Morishita, Ryutaro Kira, Kiyomu Akiyama, Miwako Goto, Yujiro Mori, Misato Okamoto, Saki Tsutsui, Yuta Takatsuji, Aya Tanaka, Hirofumi Komaki, Miina Omori, Ippei Suzuki, Mizuki Takeuchi, Daisuke Todoroki, Seji Watanabe, Tomoko Matsubayashi, Emi Inakazu, Hiroe Nagura, Akira Suzuki, Manami Usui, Nobutsune Ishikawa, Yousuke Harada, Kenishi Fudeyasu, Kazuhiko Hirata, Kana Michiue, Kazuyuki Ueda, Junko Fujitani, Reiko Arakawa, Kozue Takano, Shigeko Yashiro, Maiko Seki, Nozomi Sano, Koji Fukuyama, Yuki Matsumoto, Hirofumi Miyazaki, Minoru Shibata, Kyoko Kobayashi, Yukie Nakamura, Yasuhiro Takeshima, Moe Kuma, Anna Fraczek, Maria Jedrzejowska, Anna Lusakowska, Agnieszka Czeszyk-Piotrowicz, Wojciech Hautz, Klaudia Rakusiewicz, Malgorzata Burlewicz, Zuzanna Gierlak-Wojcicka, Malwina Kepa, Adam Sikorski, Marcin Sobieraj, Maria Mazurkiewicz-Beldzinska, Anna Lemska, Sandra Modrzejewska, Mateusz Koberda, Urszula Stodolska-Koberda, Agnieszka Waskowska, Jagoda Kolendo, Agnieszka Sobierajska-Rek, Barbara Steinborn, Magdalena Dalz, Julia Grabowska, Wojciech Hajduk, Justyna Janasiewicz-Karachitos, Monika Klimas, Marcin Stopa, Ewa Gajewska, Beata Pusz, Dmitry Vlodavets, Evgenia Melnik, Natalya Leppenen, Nataliya Yupatova, Anastasya Monakhova, Yulia Papina, Olga Shidlovsckaia, Vedrana Milic Rasic, Vesna Brankovic, Ana Kosac, Olivera Djokic, Vesna Jakšic, Ana Pepic, Jelena Martinovic, Francina Munell Casadesus, Eduardo Tizzano, Nieves Martín Begué, Charlotte Wolley Dod, Olaia Subira, Bernat Planas Pascual, Esther Toro Tamargo, Marcos Madruga Garrido, José David Medina Romero, Marta Peña Salinas, Andrés Nascimento Osorio, Ana Díaz Cortés, Enrique Jiménez Gañan, Simone Dowon Suh, Julita Medina Cantillo, Obdulia Moya, Nuria Padros, Sandra Roca Urraca, Hugo Gonzalez Valdivia, Samuel Pascual Pascual, Sofía de Manuel, Susana Noval Martin, Paul Burnham, Sandra Espinosa, Mercedes Martinez Moreno, Haluk Topaloglu, Ibrahim Oncel, Nesibe Eroglu Ertugru, Bahadir Konuskan, Bora Eldem, Sibel Kadayifçilar, Ipek Alemdaroglu, Aynur Ayse Karaduman, Oznur Tunca Yilmaz, Neslihan Bilgin, Seher Sari, Claudia Chiriboga, John J. Lee, Donnielle Rome-Martin, John W. Day, Shannon Beres, Tina Duong, Richard Gee, Sally Dunaway Young, Sabine Fuerst-Recktenwald, Anne Marquet, Nicoletta Muelhardt, and Dylan Trundell

Subjects
Adult, Risdiplam, spinal muscular atrophy, Adolescent, Spinal Muscular Atrophies of Childhood, Settore MED/26 - NEUROLOGIA, Young Adult, Pyrimidines, Settore MED/39 - NEUROPSICHIATRIA INFANTILE, Double-Blind Method, Child, Preschool, Humans, Neurology (clinical), Child, Preschool, Azo Compounds, Aged
Abstract

BACKGROUND: Risdiplam is an oral small molecule approved for the treatment of patients with spinal muscular atrophy, with approval for use in patients with type 2 and type 3 spinal muscular atrophy granted on the basis of unpublished data. The drug modifies pre-mRNA splicing of the SMN2 gene to increase production of functional SMN. We aimed to investigate the safety and efficacy of risdiplam in patients with type 2 or non-ambulant type 3 spinal muscular atrophy. METHODS: In this phase 3, randomised, double-blind, placebo-controlled study, patients aged 2-25 years with confirmed 5q autosomal recessive type 2 or type 3 spinal muscular atrophy were recruited from 42 hospitals in 14 countries across Europe, North America, South America, and Asia. Participants were eligible if they were non-ambulant, could sit independently, and had a score of at least 2 in entry item A of the Revised Upper Limb Module. Patients were stratified by age and randomly assigned (2:1) to receive either daily oral risdiplam, at a dose of 5·00 mg (for individuals weighing =20 kg) or 0·25 mg/kg (for individuals weighing

Published
2022

25. Safety and efficacy of risdiplam in patients with type 1 spinal muscular atrophy (FIREFISH part 2): secondary analyses from an open-label trial

Author

Masson, Riccardo, primary, Mazurkiewicz-Bełdzińska, Maria, additional, Rose, Kristy, additional, Servais, Laurent, additional, Xiong, Hui, additional, Zanoteli, Edmar, additional, Baranello, Giovanni, additional, Bruno, Claudio, additional, Day, John W, additional, Deconinck, Nicolas, additional, Klein, Andrea, additional, Mercuri, Eugenio, additional, Vlodavets, Dmitry, additional, Wang, Yi, additional, Dodman, Angela, additional, El-Khairi, Muna, additional, Gorni, Ksenija, additional, Jaber, Birgit, additional, Kletzl, Heidemarie, additional, Gaki, Eleni, additional, Fontoura, Paulo, additional, Darras, Basil T, additional, Volpe, Joseph J, additional, Posner, John, additional, Kellner, Ulrich, additional, Quinlivan, Rosaline, additional, Gerber, Marianne, additional, Khwaja, Omar, additional, Scalco, Renata S, additional, Seabrook, Timothy, additional, Koch, Armin, additional, Balikova, Irina, additional, Joniau, Inge, additional, Accou, Geraldine, additional, Tahon, Valentine, additional, Wittevrongel, Sylvia, additional, De Vos, Elke, additional, de Holanda Mendonça, Rodrigo, additional, Matsui Jr, Ciro, additional, Fornazieri Darcie, Ana Letícia, additional, Machado, Cleide, additional, Kiyoko Oyamada, Maria, additional, Martini, Joyce, additional, Polido, Graziela, additional, Rodrigues Iannicelli, Juliana, additional, Caires de Oliveira Achili Ferreira, Juliana, additional, Hu, Chaoping, additional, Zhu, Xiaomei, additional, Qian, Chen, additional, Shen, Li, additional, Li, Hui, additional, Shi, Yiyun, additional, Zhou, Shuizhen, additional, Xiao, Ying, additional, Zhou, Zhenxuan, additional, Wang, Sujuan, additional, Sang, Tian, additional, Wei, Cuijie, additional, Dong, Hui, additional, Cao, Yiwen, additional, Wen, Jing, additional, Li, Wenzhu, additional, Qin, Lun, additional, Barisic, Nina, additional, Celovec, Ivan, additional, Galiot Delic, Martina, additional, Ivkic, Petra Kristina, additional, Vukojevic, Nenad, additional, Kern, Ivana, additional, Najdanovic, Boris, additional, Skugor, Marin, additional, Tomas, Josipa, additional, Boespflug-Tanguy, Odile, additional, De Lucia, Silvana, additional, Seferian, Andrea, additional, Barreau, Emmanuel, additional, Mnafek, Nabila, additional, Peche, Helene, additional, Grange, Allison, additional, Trang Nguyen, Diem, additional, Milascevic, Darko, additional, Tachibana, Shotaro, additional, Pagliano, Emanuela, additional, Bianchi Marzoli, Stefania, additional, Santarsiero, Diletta, additional, Garcia Sierra, Myriam, additional, Tremolada, Gemma, additional, Arnoldi, Maria Teresa, additional, Vigano, Marta, additional, Dosi, Claudia, additional, Zanin, Riccardo, additional, Schembri, Veronica, additional, Brolatti, Noemi, additional, Rao, Giuseppe, additional, Tassara, Elisa, additional, Morando, Simone, additional, Tacchetti, Paola, additional, Pedemonte, Marina, additional, Priolo, Enrico, additional, Sposetti, Lorenza, additional, Comi, Giacomo Pietro, additional, Govoni, Alessandra, additional, Osnaghi, Silvia Gabriella, additional, Minorini, Valeria, additional, Abbati, Francesca, additional, Fassini, Federica, additional, Foa, Michaela, additional, Lopopolo, Amalia, additional, Pane, Marika, additional, Palermo, Concetta, additional, Pera, Maria Carmela, additional, Amorelli, Giulia Maria, additional, Barresi, Costanza, additional, D'Amico, Guglielmo, additional, Orazi, Lorenzo, additional, Coratti, Giorgia, additional, Leone, Daniela, additional, Laura, Antonaci, additional, De Sanctis, Roberto, additional, Berti, Beatrice, additional, Kimura, Naoki, additional, Takeshima, Yasuhiro, additional, Shimomura, Hideki, additional, Lee, Tomoko, additional, Gomi, Fumi, additional, Morimatsu, Takanobu, additional, Furukawa, Toru, additional, Stodolska-Koberda, Urszula, additional, Waskowska, Agnieszka, additional, Kolendo, Jagoda, additional, Sobierajska-Rek, Agnieszka, additional, Modrzejewska, Sandra, additional, Lemska, Anna, additional, Melnik, Evgenia, additional, Artemyeva, Svetlana, additional, Leppenen, Natalya, additional, Yupatova, Nataliya, additional, Monakhova, Anastasya, additional, Papina, Yulia, additional, Shidlovsckaia, Olga, additional, Litvinova, Elena, additional, Enzmann, Cornelia, additional, Galiart, Elea, additional, Gugleta, Konstantin, additional, Wondrusch Haschke, Christine, additional, Topaloglu, Haluk, additional, Oncel, Ibrahim, additional, Ertugrul, Nesibe Eroglu, additional, Konuskan, Bahadir, additional, Eldem, Bora, additional, Kadayifçilar, Sibel, additional, Alemdaroglu, Ipek, additional, Sari, Seher, additional, Bilgin, Neslihan, additional, Karaduman, Aynur Ayse, additional, Sarikaya, Fatma Gokcem Yildiz, additional, Graham, Robert J, additional, Ghosh, Partha, additional, Casavant, David, additional, Levine, Alexis, additional, Titus, Rachael, additional, Engelbrekt, Amanda, additional, Ambrosio, Lucia, additional, Fulton, Anne, additional, Baglieri, Anna Maria, additional, Dias, Courtney, additional, Maczek, Elizabeth, additional, Pasternak, Amy, additional, Beres, Shannon, additional, Duong, Tina, additional, Gee, Richard, additional, and Young, Sally, additional

Published
2022
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27. Myeloid/lymphoid neoplasms with FLT3 rearrangement

Author

Stephanie N. Hurwitz, Robert P. Hasserjian, Adam Bagg, Eric D. Hsi, L. Jeffrey Medeiros, Valentina Nardi, Prithviraj Bose, Attilio Orazi, Roberto N. Miranda, Daniel A. Arber, Kathryn Foucar, Guilin Tang, David Wu, Wei Wang, Heesun J. Rogers, Carlos E. Bueso-Ramos, Nicholas J. Short, Wayne Tam, Sa A. Wang, and Andrés E. Quesada

Subjects
0301 basic medicine, Chronic eosinophilic leukemia, Pathology, medicine.medical_specialty, Myeloid, business.industry, Chronic myelomonocytic leukemia, PDGFRB, Gene rearrangement, medicine.disease, Pathology and Forensic Medicine, Lymphoma, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, medicine, Myeloid sarcoma, Eosinophilia, medicine.symptom, business
Abstract

Myeloid/lymphoid neoplasms (M/LN) with 13q12/FLT3 rearrangement have been suggested as candidates for possible inclusion in the World Health Organization classification group of M/LN with eosinophilia (M/LN-eo). We report 12 patients with confirmed FLT3 rearrangement, six with t(12;13)/ETV6-FLT3; one with ins(13;22)/BCR-FLT3; and five with an unconfirmed partner gene located on chromosome bands 2p16, 3q27, 5q15, 5q35, and 7q36. Disease presentations were heterogeneous, including lymphoblastic leukemia/lymphoma, myeloid sarcoma, chronic eosinophilic leukemia, chronic myelomonocytic leukemia, and myelodysplastic syndrome. However, some common features were observed, such as extramedullary involvement (n = 7, 58%), associated eosinophilia in blood, bone marrow, or tissue (n = 8, 67%), multilineage involvement, either as biphasic myeloid/lymphoid neoplasms (n = 2) or mixed phenotype acute leukemia (n = 2). Mutations were detected in 4/8 (50%) patients by next-generation sequencing. None (0/10) had FLT3 or KIT mutations. Eleven patients received disease-based chemotherapy or hypomethylating agents, three received FLT3 inhibitors, and five patients proceeded to hematopoietic stem cell transplant. Together with a review of 16 cases published in the literature, it is apparent that M/LNs with FLT3 rearrangement show disease features reminiscent of members in the category of M/LN-eo with PDGFRA, PDGFRB, FGFR1, and PCM1/JAK2 rearrangement, characterized by a specific gene rearrangement, frequent eosinophilia, multi-lineage involvement and therapeutic benefit from kinase inhibitors.

Published
2021

28. Tailoring surface properties, biocompatibility and corrosion behavior of stainless steel by laser induced periodic surface treatment towards developing biomimetic stents

Author

Saqib, Muhammad, primary, Beshchasna, Natalia, additional, Pelaccia, Riccardo, additional, Roshchupkin, Anton, additional, Yanko, Ilya, additional, Husak, Yevheniia, additional, Kyrylenko, Sergiy, additional, Reggiani, Barbara, additional, Cuniberti, Gianaurelio, additional, Pogorielov, Maksym, additional, Opitz, Joerg, additional, and Orazi, Leonardo, additional

Published
2022
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30. Clinical, immunophenotypic and genomic findings of NK lymphoblastic leukemia: a study from the Bone Marrow Pathology Group

Author

Robert P. Hasserjian, Karen M. Chisholm, Mina L. Xu, Olga K. Weinberg, Daniel Babu, Wayne Tam, Tracy I. George, Bartosz Grzywacz, Adam Bagg, Daniel A. Arber, Jason H. Kurzer, Sa A. Wang, Siddharth Bhattacharya, Wei Wang, Yuri Fedoriw, Kathryn Foucar, Attilio Orazi, Emily F. Mason, Chi Young Ok, and Karen A. Moser

Subjects
0301 basic medicine, Acute leukemia, Pathology, medicine.medical_specialty, business.industry, CD33, Myeloid leukemia, medicine.disease, Pathology and Forensic Medicine, 03 medical and health sciences, ETV6, Leukemia, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, White blood cell, medicine, Acute Undifferentiated Leukemia, Bone marrow, business
Abstract

Natural killer (NK) cells are lymphocytes of the native immune system that play a pivotal role in host defense and immune surveillance. While the conceptual view of NK-neoplasms is evolving, little is known about the rare NK lymphoblastic leukemia (NK-LL), which remains as a provisional entity in the 2016 WHO Classification. The goal of this study is to characterize NK-LL cases and compare with other CD56 co-expressing acute leukemias. We identified 105 cases, diagnosed as NK-LL (6), CD56+ acute undifferentiated leukemia (AUL) (6), CD56+ T-lymphoblastic leukemia (T-LL) (51), and CD56+ acute myeloid leukemia (AML) (42). Compared to AUL patients, NK-LL patients were significantly younger (p = 0.021) and presented with higher white blood cell (WBC) (p = 0.037) and platelet counts (p = 0.041). Flow cytometry showed more frequent expression of cytoplasmic CD3 (cCD3, p = 0.064) and CD33, (p = 0.065), while HLA-DR was significantly absent from NK-LL (p = 0.035) compared to AUL. Compared to T-ALL, NK-LL cases showed less frequent cCD3 (p = 0.002), CD4 (p = 0.051), and CD10 expression (p = 0.06). The frequency of abnormal karyotypes was similar between NK-LL, AUL, and T-ALL. The mutational profile differed in four leukemia groups, with a significance enrichment of NOTCH1 (p = 0.002), ETV6 (p = 0.002) and JAK3 (p = 0.02) mutations in NK-LL as compared to AML. As compared to T-ALL, NK-LL cases showed a higher number of total mutations (p = 0.04) and significantly more frequent ETV6 mutations (p = 0.004). Clinical outcome data showed differences in overall survival between all four groups (p = 0.0175), but no difference in event free survival (p = 0.246). In this largest study to date, we find that that NK-LL shows clinical presentation, immunophenotypic and molecular characteristics distinct from AUL, T-ALL, and AML. Our findings suggest NK-LL is a distinct acute leukemia entity and should be considered in the clinical diagnosis of acute leukemias of ambiguous lineage.

Published
2021

31. The effect of ending disclosure on the persuasiveness of narrative PSAs

Author

Davide C. Orazi, Liliana L. Bove, and Jing Lei

Subjects
Marketing, Counterfactual thinking, Persuasion, media_common.quotation_subject, 05 social sciences, Marketing communication, Business economics, 0502 economics and business, 050211 marketing, Narrative, Public service, Psychology, Social psychology, 050203 business & management, media_common
Abstract

Cautionary stories in which misbehavior results in negative outcomes are often used in public service announcements (PSAs) to promote behavioral change. These cautionary stories can either disclose or withhold their endings and the associated negative outcomes for the characters involved. In four experiments, we show that disclosing (vs. withholding) a story’s ending increases persuasion due to greater counterfactual thinking about alternative actions that could have prevented the negative outcomes. Integrating these findings within the Transportation-Imagery Model of narrative persuasion, we also show how dispositional levels of need for cognitive closure can amplify the effect of ending disclosure in a PSA. Our findings have important implications for both marketing communicators and policy makers who seek to improve the effectiveness of PSAs.

Published
2021

38. Chronic myeloid neoplasms harboring concomitant mutations in myeloproliferative neoplasm driver genes (JAK2/MPL/CALR) and SF3B1

Author

Olga K. Weinberg, Chi Young Ok, Tracy I. George, Sa A. Wang, Adam Bagg, Daniel A. Arber, Heesun J. Rogers, Kevin T. Trowell, Wayne Tam, Kaaren K. Reichard, Kyle Parker, Robert P. Hasserjian, Attilio Orazi, Eric D. Hsi, Carlos E. Bueso-Ramos, and Karen A. Moser

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, Myeloid, Thrombocytosis, food and beverages, Biology, Neutropenia, medicine.disease, Pathology and Forensic Medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, Concomitant, medicine, Cancer research, Myelofibrosis, Gene, Myeloproliferative neoplasm, Dominance (genetics)
Abstract

JAK2, CALR, and MPL are myeloproliferative neoplasm (MPN)-driver mutations, whereas SF3B1 is strongly associated with ring sideroblasts (RS) in myelodysplastic syndrome (MDS). Concomitant mutations of SF3B1 and MPN-driver mutations out of the context of MDS/MPN with RS and thrombocytosis (MDS/MPN-RS-T) are not well-studied. From the cases (

Published
2021

39. Parchment processing and analysis: Ionizing radiation treatment by the REX source and multidisciplinary approach characterization

Author

N. Perini, Fabio Borgognoni, Monia Vadrucci, F. Mercuri, N. Orazi, C. Cicero, A Rubechini, Luciana Migliore, Vadrucci, M., Borgognoni, F., Cicero, C., Perini, N., Migliore, L., Mercuri, F., Orazi, N., and Rubechini, A.

Subjects
Paper, Light transmission, Radiation, Materials science, Bacteria, Parchment, X-Rays, Fungi, Bacterial Physiological Phenomena, 010403 inorganic & nuclear chemistry, Pulp and paper industry, 01 natural sciences, Environmental, 030218 nuclear medicine & medical imaging, 0104 chemical sciences, Characterization (materials science), Ionizing radiation, 03 medical and health sciences, Biodegradation, Environmental, 0302 clinical medicine, Biodegradation, Irradiation
Abstract

Library material, and thus parchment, is frequently subjected to bio-deterioration processes caused by microorganisms. Fungi and bacteria cause alterations in the parchment inducing, in some cases, even the partial detachments of the surface layer and the loss of any text present on it. An important contribution to disinfection of the cultural heritage artefacts is given by the use of ionizing radiation. In this work, a preliminary study on the applicability of X-ray radiation as treatment for bio-deterioration removal is proposed. The results on the microbial growth after different irradiation treatments are shown in order to detect the dose protocol for the bio-degradation removal. Furthermore, the evaluation of the irradiation effects on the parchment microstructure is presented in order to define the applicability of the method on parchment artefacts.

Published
2019

40. Evaluation of 'long-term behaviour under traffic' of cement treated mixture with RAP

Author

Corrado Accardo, Elena Romeo, Stefano Noto, Gabriele Tebaldi, Ugo Sergio Orazi, and Michele Orazi

Subjects
Cement, animal structures, Materials science, 0211 other engineering and technologies, Stiffness, 020101 civil engineering, 02 engineering and technology, Building and Construction, 0201 civil engineering, Asphalt pavement, 021105 building & construction, medicine, General Materials Science, medicine.symptom, Composite material, Civil and Structural Engineering
Abstract

A laboratory investigation was performed to better understand the performance of Cement-Treated Base (CTB) mixtures containing Recycled Asphalt Pavement (RAP) during a long-lasting service period. Two CTB mixtures, one containing only virgin aggregates and the other containing RAP and virgin aggregates, were tested by triaxial tests (static and cyclic) and resonant column tests to evaluate stiffness and dampening at very small deformations. Similar mechanical properties and response to cyclic loadings were obtained for the two mixtures. The results led to the conclusion that the use of RAP as a replacement for virgin aggregates for a CTB mixture does not cause any significant alteration in terms of mechanical performance.

Published
2019

42. Correction to: Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Author

Kanagal-Shamanna, Rashmi, primary, Orazi, Attilio, additional, Hasserjian, Robert P., additional, Arber, Daniel A., additional, Reichard, Kaaren, additional, Hsi, Eric D., additional, Bagg, Adam, additional, Rogers, Heesun Joyce, additional, Geyer, Julia, additional, Darbaniyan, Faezeh, additional, Do, Kim-Anh, additional, Devins, Kyle M., additional, Pozdnyakova, Olga, additional, George, Tracy I., additional, Cin, Paola Dal, additional, Greipp, Patricia T., additional, Routbort, Mark J., additional, Patel, Keyur, additional, Garcia-Manero, Guillermo, additional, Verstovsek, Srdan, additional, Medeiros, L. Jeffrey, additional, Wang, Sa A., additional, and Bueso-Ramos, Carlos, additional

Published
2022
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43. Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Author

Kanagal-Shamanna, Rashmi, primary, Orazi, Attilio, additional, Hasserjian, Robert P., additional, Arber, Daniel A., additional, Reichard, Kaaren, additional, Hsi, Eric D., additional, Bagg, Adam, additional, Rogers, Heesun Joyce, additional, Geyer, Julia, additional, Darbaniyan, Faezeh, additional, Do, Kim-Anh, additional, Devins, Kyle M., additional, Pozdnyakova, Olga, additional, George, Tracy I., additional, Cin, Paola Dal, additional, Greipp, Patricia T., additional, Routbort, Mark J., additional, Patel, Keyur, additional, Garcia-Manero, Guillermo, additional, Verstovsek, Srdan, additional, Medeiros, L. Jeffrey, additional, Wang, Sa A., additional, and Bueso-Ramos, Carlos, additional

Published
2022
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45. DFT study of the hydrogen adsorption and storage on Ni4 cluster embedded in multivacancy graphene

Author

M.E. Pronsato, Jorge Mario Marchetti, V. Orazi, and R.E. Ambrusi

Subjects
Materials science, Renewable Energy, Sustainability and the Environment, Graphene, Energy Engineering and Power Technology, 02 engineering and technology, Electronic structure, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, London dispersion force, 0104 chemical sciences, law.invention, Hydrogen storage, symbols.namesake, Fuel Technology, Adsorption, Chemical physics, law, symbols, Molecule, Density functional theory, van der Waals force, 0210 nano-technology
Abstract

Hydrogen adsorption stability, geometry, electronic structure and mechanism has been investigated on Ni4 cluster embedded in graphene with three, four and six vacancies by density functional theory (DFT) calculations. An energetic analysis of hydrogen adsorption by addition of one to four H2 molecules was performed for each system in order to determine their hydrogen storage capacity. Dispersion force contribution to the adsorption energy is quantitative evaluated to know whether H2 molecules adsorption behavior is dominated by chemical or van der Waals interactions. A further analysis of this type of interactions is also addressed by total and partial density of states. Bonding and charge transfer characteristics for the different steps involved in the adsorption mechanism are also included. Special attention is given to the effects caused by this new Ni/graphene interface to the hydrogen adsorption behavior.

Published
2020

46. The study of artistic bronzes by infrared thermography: A review

Author

N. Orazi

Subjects
Archeology, Engineering drawing, Infrared, Computer science, Manufacturing process, Materials Science (miscellaneous), 010401 analytical chemistry, 02 engineering and technology, Conservation, engineering.material, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Characterization (materials science), Thermal transport, Chemistry (miscellaneous), Thermography, engineering, Bronze, 0210 nano-technology, General Economics, Econometrics and Finance, Spectroscopy
Abstract

The study of bronze statues obtained by the lost-wax casting method results of particular relevance from the artistic and historical points of view. In particular, the characterization of structural and subsurface elements of bronzes is very useful to gather insight concerning their preservation state and manufacturing process. For these purposes, infrared thermography has been successfully employed to investigate different kind of items of artistic bronzes, such as repairs, defects and inserts, providing also the possibility to perform the depth-resolved study of the observed subsurface features thanks to the possibility it also provides to evaluate the thermal transport properties of the investigated materials. In this work, the experimental configurations and the capabilities of such a technique have been reviewed. The state of the art of the results obtained by infrared thermography for the analysis of artistic bronzes is presented. It is thus shown that infrared thermography can be nowadays considered as a reliable and consolidated technique to map in a non-destructive way a wide spectrum of features of bronzes.

Published
2020

47. Chronic lymphocytic leukemia with TP53 gene alterations: a detailed clinicopathologic analysis

Author

John N. Allan, Joseph Casano, Richard R. Furman, Erica B. Bhavsar, Susan Mathew, Julia T. Geyer, Attilio Orazi, Yen-Chun Liu, and Elizabeth Margolskee

Subjects
0301 basic medicine, Chemotherapy, Pathology, medicine.medical_specialty, Atypical Lymphocyte, business.industry, medicine.medical_treatment, Chronic lymphocytic leukemia, Disease, medicine.disease, Pathology and Forensic Medicine, 03 medical and health sciences, Leukemia, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Medicine, Immunohistochemistry, Bone marrow, business, Lymph node
Abstract

TP53 alteration in chronic lymphocytic leukemia indicates a high-risk disease that is usually refractory to chemotherapy. It may be caused by deletion of 17p involving the loss of TP53 gene, which occurs in low percentage of patients at diagnosis but can be acquired as the disease progresses. Since patients may harbor TP53 mutation without chromosome 17p deletion, consensus recommendations call for both cytogenetic and PCR mutation analysis of TP53 in chronic lymphocytic leukemia. We conducted a single-institution retrospective study to investigate the clinicopathologic features of chronic lymphocytic leukemia with TP53 alterations as well as the utility of different diagnostic modalities to identify p53 alterations. Forty percent of chronic lymphocytic leukemia patients with TP53 alterations demonstrated atypical lymphocytes with cleaved/irregularly shaped nuclei and/or large atypical lymphoid cells with abundant cytoplasm in the peripheral blood. Progression was also observed in lymph node and bone marrow samples (21% with Richter transformation; 33% with findings suggestive of “accelerated phase” of chronic lymphocytic leukemia including prominent proliferation centers and/or increased numbers of prolymphocytes). However, the presence of the morphologic features suggestive of “accelerated phase” had no effect on overall survival within the chronic lymphocytic leukemia group with TP53 abnormalities (p > 0.05). As previously reported by others, a subset of patients with TP53 alterations were only identified by either PCR mutation analysis (12%) or cytogenetic studies (14%). p53 immunostain positivity was only identified in approximately half of the patients with TP53 alterations identified by either method, and it failed to identify any additional patients with p53 abnormalities. In summary, chronic lymphocytic leukemia patients with TP53 alterations frequently show atypical morphologic features. Use of multiple modalities to identify p53 abnormalities is recommended to ensure optimal sensitivity and specificity.

Published
2020

48. Surface micro and nanostructuring of three-dimensional components of micro medical devices

Author

Giuliano Bissacco, Francesco Giuseppe Biondani, Lorenzo Benassi, Peter Torben Tang, and Leonardo Orazi

Subjects
Surface (mathematics), 0209 industrial biotechnology, Materials science, Free form surfaces, Nanotechnology, 02 engineering and technology, Molding (process), 010501 environmental sciences, Curvature, 01 natural sciences, Structuring, 020901 industrial engineering & automation, Complex geometry, Nano, Medical devices, General Earth and Planetary Sciences, Deposition (phase transition), Nanostructuring, Nanoscopic scale, 0105 earth and related environmental sciences, General Environmental Science
Abstract

Surface structuring of medical implants has been shown to reduce the rejection rate of medical devices inserted inside living tissue. Several studies have shown that by texturing the surface of medical implants at micro/nanoscale it is possible to foster cell adhesion. The surface texturing of medical devices poses many challenges in terms of cost and time when the nano texturing process is performed directly on the part surface. A viable solution for mass production of polymer based surface enhanced medical devices is achieved via injection molding. However, nano structuring of micro injection molding molds, requires techniques enabling processing of complex surfaces, small curvature radii and with high aspect ratios. Furthermore the accessibility of all surfaces to be structured and the processing time are the main concerns and limiting factors on the selection of the structures dimensions and geometries. In this work, two different process chains are analyzed for the nano structuring of a bone micro plug. The first method relies on a chemical deposition process in order to produce a semi random structure on the entire mold surface of the medical component. The characteristic size of the structures is controlled by acting on the deposition parameters. The second process, relies on laser structuring of the mold components by producing Laser-Induced Periodic Surface Structures (LIPSS).The two process chains are compared and an evaluation of the applicability in different production scenarios presented, with specific focus on surface accessibility, nano structures uniformity and applicability to surfaces with complex geometry

Published
2020

49. Fast LIPSS based texturing process of dental implants with complex geometries

Author

Oleg Mishchenko, Riccardo Pelaccia, Leonardo Orazi, Barbara Reggiani, and Maksym Pogorielov

Subjects
Laser micro machining, Surface modification, Texture, 0209 industrial biotechnology, Scanner, Nanostructure, Materials science, Mechanical Engineering, Laser source, Process (computing), 02 engineering and technology, Laser, Industrial and Manufacturing Engineering, law.invention, 020303 mechanical engineering & transports, 020901 industrial engineering & automation, 0203 mechanical engineering, law, Femtosecond, Biomedical engineering
Abstract

In the present work, the generation of Laser Induced Periodic Surface Structures (LIPSS) by using femtosecond laser source is investigated in the surface texturing of Ti grade 5 dental implants. The proposed procedure permits a fast treatment of dental implants characterized by complex shape through the combined and synchronous use of a galvo scanner and of workpiece movements. The obtained surface micro- and nanostructures are characterized from a morphological point of view while in-vitro essays are performed to evaluate cellular proliferation. The results indicate the effectiveness of the LIPSS as method to increase cell viability and the efficiency of the proposed procedure to treat complex geometries as dental implants.

Published
2020

50. The Utility of Narrative Agency

Author

Tom van Laer and Davide Orazi

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022

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