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14 results on '"Omerovic E"'

4. 17-year trends in incidence and prognosis of cardiogenic shock in patients with acute myocardial infarction in western Sweden

Author

Redfors, B., primary, Angerås, O., additional, Råmunddal, T., additional, Dworeck, C., additional, Haraldsson, I., additional, Ioanes, D., additional, Petursson, P., additional, Libungan, B., additional, Odenstedt, J., additional, Stewart, J., additional, Lodin, E., additional, Wahlin, M., additional, Albertsson, P., additional, Matejka, G., additional, and Omerovic, E., additional

Published
2015
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14. McConnell's sign — An insight into the pathogenesis of Takotsubo syndrome?

Author

Björn Redfors, Anwar Ali, Eduardo Bossone, Elmir Omerovic, Alexander R. Lyon, Yangzhen Shao, Shao, Yz, Redfors, B, Ali, A, Bossone, E, Lyon, A, and Omerovic, E

Subjects
medicine.medical_specialty, Contraction (grammar), business.industry, Heart Ventricles, Cardiomyopathy, Ventricular outflow tract obstruction, medicine.disease, Radiography, Pathogenesis, Lesion, Lipotoxicity, Takotsubo Cardiomyopathy, Internal medicine, medicine, Cardiology, Humans, Myocardial infarction, Endothelial dysfunction, medicine.symptom, Pulmonary Embolism, Cardiology and Cardiovascular Medicine, business, Ultrasonography
Abstract

Takotsubo syndrome (TTS), also known as stress-induced cardiomyopathy, is an acute cardiac syndrome. The unique characteristics of TTS are that one or more circumferential cardiac segments are stunned out of contraction in the absence of an explanatory coronary lesion [1]. Although the peculiar myocardial akinesia can affect any part of the ventricular wall, two common patterns of TTS are apical akinesis (the typical TTS) and basal akinesis (the inverted pattern) [2]. The pathogenesis underlying Takotsubo syndrome is incompletely understood. Several mechanisms have been proposed for the development of TTS, including overstimulation of the β2-adrenoceptor-Gi pathway [3], acute coronary microvascular and endothelial dysfunction [4], aborted myocardial infarction with spontaneous recanalisation [5], acute metabolic stunning [6], lipotoxicity [1,7], acute left ventricular outflow tract obstruction (LVOTO) and abnormal ventriculo-arterial coupling [8]. One critical shortcoming of some of these proposed mechanisms is that they are not able to elucidate why myocardial akinesia in TTS is usually segmental and circumferential. Although the gradient distribution of β-adrenoceptors or sympathetic nerves in the heart may explain why catecholamine-induced myocardial akinesia can be apical or basal, such physiological properties, including genetic profiles, currently fail to

Published
2015

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