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160 results on '"Oluyomi A"'

1. Mitophagy and spermatogenesis: Role and mechanisms

Author

Rotimi, Damilare Emmanuel, primary, Iyobhebhe, Matthew, additional, Oluwayemi, Elizabeth Temidayo, additional, Evbuomwan, Ikponmwosa Owen, additional, Asaleye, Rotdelmwa Maimako, additional, Ojo, Oluwafemi Adeleke, additional, and Adeyemi, Oluyomi Stephen, additional

Published
2024
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5. Case-controlled field study of the ICD-11 clinical descriptions and diagnostic requirements for Bodily Distress Disorders

Author

Jared Keeley, Geoffrey M. Reed, Tahilia Rebello, Julia Brechbiel, Jose Angel Garcia-Pacheco, Kazeem Adebayo, Oluyomi Esan, Oluyinka Majekodunmi, Akin Ojagbemi, Lucky Onofa, Rebeca Robles, Chihiro Matsumoto, Maria Elena Medina-Mora, Cary S. Kogan, Maya Kulygina, Wolfgang Gaebel, Min Zhao, Michael C. Roberts, Pratap Sharan, Jose Luis Ayuso-Mateos, Brigitte Khoury, Dan J. Stein, Anne M. Lovell, Kathleen Pike, Francis Creed, and Oye Gureje

Subjects
Psychiatry and Mental health, Clinical Psychology
Published
2023

6. Mycoplasma genitalium

Author

Obafemi, Oluyomi A., primary, Rowan, Sarah E., additional, Nishiyama, Masayo, additional, and Wendel, Karen A., additional

Published
2023
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8. Case-controlled field study of the ICD-11 clinical descriptions and diagnostic requirements for Bodily Distress Disorders

Author

Keeley, Jared, primary, Reed, Geoffrey M., additional, Rebello, Tahilia, additional, Brechbiel, Julia, additional, Garcia-Pacheco, Jose Angel, additional, Adebayo, Kazeem, additional, Esan, Oluyomi, additional, Majekodunmi, Oluyinka, additional, Ojagbemi, Akin, additional, Onofa, Lucky, additional, Robles, Rebeca, additional, Matsumoto, Chihiro, additional, Medina-Mora, Maria Elena, additional, Kogan, Cary S., additional, Kulygina, Maya, additional, Gaebel, Wolfgang, additional, Zhao, Min, additional, Roberts, Michael C., additional, Sharan, Pratap, additional, Ayuso-Mateos, Jose Luis, additional, Khoury, Brigitte, additional, Stein, Dan J., additional, Lovell, Anne M., additional, Pike, Kathleen, additional, Creed, Francis, additional, and Gureje, Oye, additional

Published
2023
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21. Chemical fingerprinting, comparative in vitro antioxidant properties, and biochemical effects of ginger and bitterleaf infusion

Author

Elebiyo, Tobiloba Christiana, primary, Olori, Oghenemaero Oghale, additional, Rotimi, Damilare Emmanuel, additional, Al-Megrin, Wafa Abdullah I., additional, De Waard, Michel, additional, Alkhuriji, Afrah Fahd, additional, Batiha, Gaber El-Saber, additional, Adeyanju, Adebukola Anne, additional, and Adeyemi, Oluyomi Stephen, additional

Published
2022
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32. Increasing sexually transmitted infections among adolescents in the USA

Author

Jami S. Leichliter, Laura T. Haderxhanaj, and Oluyomi A Obafemi

Subjects
Sexual behavior, business.industry, Environmental health, Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology, MEDLINE, Medicine, Social determinants of health, business
Published
2021

35. New imidazoles cause cellular toxicity by impairing redox balance, mitochondrial membrane potential, and modulation of HIF-1α expression

Author

Oluyomi Stephen Adeyemi, Tobiloba Christiana Elebiyo, Chiagoziem A. Otuechere, Abiodun Omokehinde Eseola, and Winfried Plass

Subjects
0301 basic medicine, Antioxidant, Cell Survival, medicine.medical_treatment, Drug Evaluation, Preclinical, Biophysics, Pharmacology, medicine.disease_cause, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Cytotoxicity, Molecular Biology, Cells, Cultured, Membrane Potential, Mitochondrial, chemistry.chemical_classification, Membrane potential, Reactive oxygen species, Antiparasitic Agents, Imidazoles, Cell Biology, Fibroblasts, Hypoxia-Inducible Factor 1, alpha Subunit, 030104 developmental biology, Mechanism of action, chemistry, 030220 oncology & carcinogenesis, Toxicity, Trolox, medicine.symptom, Reactive Oxygen Species, Oxidation-Reduction, Oxidative stress
Abstract

Background Our previous reports demonstrated the prospects of a new series of imidazoles as a source of alternative anti-parasite treatments, thus warranting further studies that include toxicity profiling. Objective In this study, we evaluated three imidazoles: bis-imidazole (compound 1), phenyl-substituted 1H-imidazole (compound 2), and thiopene-imidazole (compound 3) for cellular toxicity and possible mechanisms. Methods The three (3) compounds were assessed for in vitro cytotoxic action. Additionally, we probed likely mechanistic actions of these imidazoles. Findings showed dose-dependent cellular toxicity by these imidazoles. Results In the presence of antioxidant (Trolox), cytotoxicity was improved for compounds 2 and 3 but not for compound 1. Meantime, compound 7 promoted reactive oxygen species (ROS) production, which was abated in the presence of a standard antioxidant (Trolox). Additionally, the three (3) imidazoles impaired mitochondrial membrane potential (MMP). While MMP was not restored after treatment removal, the addition of antioxidant (Trolox) improved MMP for compounds 2 and 3 treatment. Additionally, compound 1 elevated expression of hypoxia-inducing factor 1-alpha (HIF-1α). This may not be unconnected with the capacity of compound 1 to cause oxidative stress. Conclusion We show evidence that supports the cytotoxic action of imidazoles involves likely impairment to redox balance and mitochondrial membrane potential. The findings help our understanding of the mechanistic action of these imidazoles in living cells, and altogether may boost their prospects as new and alternative anti-protozoans.

Published
2020

43. Common NLRP3 inflammasome inhibitors and Covid-19: Divide and conquer

Author

Gaber El-Saber Batiha, Ali I. Al-Gareeb, Damilare Rotimi, Oluyomi Stephen Adeyemi, and Hayder M. Al-kuraishy

Subjects
Multidisciplinary
Abstract

Severe SARS-CoV-2 infection causes systemic inflammation, cytokine storm, and hypercytokinemia due to activation of the release of pro-inflammatory cytokines that have been associated with case-fatality rate. The immune overreaction and cytokine storm in the infection caused by SARS-CoV-2 may be linked to NLRP3 inflammasome activation which has supreme importance in human innate immune response mainly against viral infections. In SARS-CoV-2 infection, NLRP3 inflammasome activation results in the stimulation and synthesis of natural killer cells (NKs), NFκB, and interferon-gamma (INF-γ), while inhibiting IL-33 expression. Various efforts have identified selective inhibitors of NLRP3 inflammasome. To achieve this, studies are exploring the screening of natural compounds and/or repurposing of clinical drugs to identify potential NLRP3 inhibitors. NLRP3 inflammasome inhibitors are expected to suppress exaggerated immune reaction and cytokine storm-induced-organ damage in SARS-CoV-2 infection. Therefore, NLRP3 inflammasome inhibitors could mitigate the immune-overreaction and hypercytokinemia in Covid-19 infection.

Published
2022

44. Chemical fingerprinting, comparative in vitro antioxidant properties, and biochemical effects of ginger and bitterleaf infusion

Author

Tobiloba Christiana, Elebiyo, Oghenemaero Oghale, Olori, Damilare Emmanuel, Rotimi, Wafa Abdullah I, Al-Megrin, Michel, De Waard, Afrah Fahd, Alkhuriji, Gaber El-Saber, Batiha, Adebukola Anne, Adeyanju, and Oluyomi Stephen, Adeyemi

Subjects
Flavonoids, Pharmacology, Tea, Plant Extracts, Palmitic Acid, General Medicine, Ginger, Antioxidants, Rats, Creatinine, Gallic Acid, Ergosterol, Animals, Urea, Quercetin, Oleic Acid
Abstract

Botanicals with remarkable pharmacological properties include Zingiber officinale Roscoe [Zingiberaceae] (ginger) and Gymnanthemum amygdalinum (Delie) Sch. Bip [Asteraceae] (bitterleaf). The plants are frequently used as teas and decoctions, and have been studied in the treatment of various illnesses. Thus, this study investigated the in vitro antioxidant activities and chemical fingerprints of ginger and bitter leaf infusions separately and as a combination. In addition, we assessed the effects of the tea infusions on rat liver and kidney indices. The findings from this study showed that the bitterleaf infusion had the highest phenolic content (21.77 ± 3.140 µg gallic acid equivalent/mg) in comparison with that of ginger (15.17 ± 1.50 µg gallic acid equivalent/mg) and their combination (8.81 ± 0.48 µg gallic acid equivalent/mg). The ginger infusion had the highest flavonoid content (547.15 ± 1.17 µg quercetin equivalent/mg), which was preceded by bitterleaf (473.02 ± 10.48 µg quercetin equivalent/mg) and the ginger and bitterleaf infusion (415.08 ± 4.15 µg quercetin equivalent/mg). Furthermore, our results showed that the tea infusions had no significant effect on the liver function indices (ALT and AST) compared to the control. In contrast, the rat plasma urea significantly increased in the groups given bitterleaf and a combination of ginger and bitterleaf infusions, while creatinine significantly decreased in the group that received the combined form of the infusion. The GC-MS analysis of ginger and bitterleaf infusions revealed that n-hexadecanoic acid, oleic acid, and ergosterol were most abundant in the bitterleaf infusion. At the same time, gingerol, 2-butanone, and 4-(4-hydroxy-3-methoxyphenyl) were the most abundant in the ginger infusion. Together, the findings are not only evidence in support of the medicinal value of these plants but also reinforce their prospects as nutriceuticals.

Published
2022

47. The anti-parasite action of imidazole derivatives likely involves oxidative stress but not HIF-1α signaling

Author

Adeyemi, Oluyomi Stephen, primary, Eseola, Abiodun Omokehinde, additional, Plass, Winfried, additional, Kato, Kentaro, additional, Otuechere, Chiagoziem A., additional, Awakan, Oluwakemi Josephine, additional, Atolani, Olubunmi, additional, Otohinoyi, David Adeiza, additional, Elebiyo, Tobiloba Christiana, additional, and Evbuomwan, Ikponmwosa Owen, additional

Published
2021
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