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Your search keyword '"O'Sullivan, Jacintha"' showing total 28 results
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28 results on '"O'Sullivan, Jacintha"'

1. Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial

Author

Reynolds, John V, primary, Preston, Shaun R, additional, O'Neill, Brian, additional, Lowery, Maeve A, additional, Baeksgaard, Lene, additional, Crosby, Thomas, additional, Cunningham, Moya, additional, Cuffe, Sinead, additional, Griffiths, Gareth O, additional, Parker, Imelda, additional, Risumlund, Signe Lenora, additional, Roy, Rajarshi, additional, Falk, Stephen, additional, Hanna, George B, additional, Bartlett, Frederick R, additional, Alvarez-Iglesias, Alberto, additional, Achiam, Michael P, additional, Nilsson, Magnus, additional, Piessen, Guillaume, additional, Ravi, Narayanasamy, additional, O'Toole, Dermot, additional, Johnston, Ciaran, additional, McDermott, Raymond S, additional, Turkington, Richard C, additional, Wahed, Shajahan, additional, Sothi, Sharmila, additional, Ford, Hugo, additional, Wadley, Martin S, additional, Power, Derek, additional, Mukherjee, Somnath, additional, Morgan, Carys, additional, Parsons, Simon L, additional, Bhuva, Neel, additional, Campbell, Sorcha, additional, Grogan, Liam, additional, Leonard, Greg, additional, Bateman, Andrew R, additional, Mitchell, Catherine, additional, O'Reilly, Seamus, additional, Mulroe, Eibhlin, additional, McLoughlin, Olivia, additional, Shevlin, Anna, additional, Shannon, Aoife M, additional, Marron, Jacinta, additional, Nolan, Marc, additional, Burch, Grace, additional, Costello, Michelle, additional, Griffiths, Daniel, additional, Cozens, Kelly, additional, Foley, Emma, additional, Donohoe, Claire L, additional, O'Farrell, Catherine, additional, Moore, Jennifer, additional, and O'Sullivan, Jacintha, additional

Published
2023
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2. Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS

Author

Guo, Naici, primary, Minas, Giorgos, additional, Synowsky, Silvia A., additional, Dunne, Margaret R., additional, Ahmed, Hasnain, additional, McShane, Rhiannon, additional, Bhardwaj, Anshul, additional, Donlon, Noel E., additional, Lorton, Cliona, additional, O'Sullivan, Jacintha, additional, Reynolds, John V., additional, Caie, Peter D., additional, Shirran, Sally L., additional, Lynch, Andy G., additional, Stewart, Alan J., additional, and Arya, Swati, additional

Published
2022
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6. Radiation-induced Bystander Effect (RIBE) alters mitochondrial metabolism using a human rectal cancer ex vivo explant model

Author

Heeran, Aisling B., primary, Berrigan, Helen P., additional, Buckley, Croí E., additional, Bottu, Heleena Moni, additional, Prendiville, Orla, additional, Buckley, Amy M., additional, Clarke, Niamh, additional, Donlon, Noel E., additional, Nugent, Timothy S., additional, Durand, Michael, additional, Dunne, Cara, additional, Larkin, John O., additional, Mehigan, Brian, additional, McCormick, Paul, additional, Brennan, Lorraine, additional, Lynam-Lennon, Niamh, additional, and O'Sullivan, Jacintha, additional

Published
2021
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8. KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment

Author

Caiazza, Francesco, primary, Oficjalska, Katarzyna, additional, Tosetto, Miriam, additional, Phelan, James J., additional, Noonan, Sinéad, additional, Martin, Petra, additional, Killick, Kate, additional, Breen, Laura, additional, O'Neill, Fiona, additional, Nolan, Blathnaid, additional, Furney, Simon, additional, Power, Robert, additional, Fennelly, David, additional, Craik, Charles S., additional, O'Sullivan, Jacintha, additional, Sheahan, Kieran, additional, Doherty, Glen A., additional, and Ryan, Elizabeth J., additional

Published
2019
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9. Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma

Author

Buckley, Amy M., primary, Dunne, Margaret R., additional, Lynam-Lennon, Niamh, additional, Kennedy, Susan A., additional, Cannon, Aoife, additional, Reynolds, Alison L., additional, Maher, Stephen G., additional, Reynolds, John V., additional, Kennedy, Breandán N., additional, and O'Sullivan, Jacintha, additional

Published
2019
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10. SAT-377-Significant reductions in intrahepatic Mucosal Associated Invariant T cells with increased terminal activation marker expression amongst NAFLD patients following a 12 week aerobic exercise program: a paired liver biopsy study

Author

Naimimohasses, Sara, primary, O’Gorman, Philip, additional, Monaghan, Ann, additional, Kennedy, Megan, additional, Holden, Dean, additional, Beddy, Peter, additional, Conlon, Niall, additional, Finn, Stephen, additional, Dunne, Margaret, additional, Gormley, John, additional, O’Sullivan, Jacintha, additional, and Norris, Suzanne, additional

Published
2019
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11. Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus

Author

Palles, Claire, Chegwidden, Laura, Li, Xinzhong, Findlay, John M., Farnham, Garry, Castro Giner, Francesc, Peppelenbosch, Maikel P., Kovac, Michal, Adams, Claire L., Prenen, Hans, Briggs, Sarah, Harrison, Rebecca, Sanders, Scott, MacDonald, David, Haigh, Chris, Tucker, Art, Love, Sharon, Nanji, Manoj, deCaestecker, John, Ferry, David, Rathbone, Barrie, Hapeshi, Julie, Barr, Hugh, Moayyedi, Paul, Watson, Peter, Zietek, Barbara, Maroo, Neera, Gay, Laura, Underwood, Tim, Boulter, Lisa, McMurtry, Hugh, Monk, David, Patel, Praful, Ragunath, Krish, Al Dulaimi, David, Murray, Iain, Koss, Konrad, Veitch, Andrew, Trudgill, Nigel, Nwokolo, Chuka, Rembacken, Bjorn, Atherfold, Paul, Green, Elaine, Ang, Yeng, Kuipers, Ernst J., Chow, Wu, Paterson, Stuart, Kadri, Sudarshan, Beales, Ian, Grimley, Charles, Mullins, Paul, Beckett, Conrad, Farrant, Mark, Dixon, Andrew, Kelly, Sean, Johnson, Matthew, Wajed, Shahjehan, Dhar, Anjan, Sawyer, Elinor, Roylance, Rebecca, Onstad, Lynn, Gammon, Marilie D., Corley, Douglas A., Shaheen, Nicholas J., Bird, Nigel C., Hardie, Laura J., Reid, Brian J., Ye, Weimin, Liu, Geoffrey, Romero, Yvonne, Bernstein, Leslie, Wu, Anna H., Casson, Alan G., Fitzgerald, Rebecca, Whiteman, David C., Risch, Harvey A., Levine, David M., Vaughan, Tom L., Verhaar, Auke P., van den Brande, Jan, Toxopeus, Eelke L., Spaander, Manon C., Wijnhoven, Bas P.L., van der Laan, Luc J.W., Krishnadath, Kausilia, Wijmenga, Cisca, Trynka, Gosia, McManus, Ross, Reynolds, John V., O’Sullivan, Jacintha, MacMathuna, Padraic, McGarrigle, Sarah A., Kelleher, Dermot, Vermeire, Severine, Cleynen, Isabelle, Bisschops, Raf, Tomlinson, Ian, and Jankowski, Janusz

Subjects
Risk, Esophageal Neoplasms, LD, linkage disequilibrium, ASE, allele-specific expression, eQTL, expression quantitative trait locus, Polymorphism, Single Nucleotide, Barrett Esophagus, Intestinal Metaplasia, Full Report: Basic and Translational—Alimentary Tract, BE, Barrett’s esophagus, Humans, Genetic Predisposition to Disease, EAC, esophageal adenocarcinoma, EAC, GWAS, genome-wide association study, Original Research, Cancer, BEACON, Barrett's and Esophageal Adenocarcinoma Consortium, Gastroenterology, PC, principal component, SNP, single nucleotide polymorphism, A300, CI, confidence interval, OR, odds ratio, Growth Differentiation Factors, Susceptibility, Bone Morphogenetic Proteins, TCGA, The Cancer Genome Atlas, Human medicine, T-Box Domain Proteins, Genome-Wide Association Study
Abstract

Background & Aims\ud Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subsequently, the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) identified risk loci for BE and esophageal adenocarcinoma near CRTC1 and BARX1, and within 100 kb of FOXP1. We aimed to identify further SNPs that increased BE risk and to validate previously reported associations.\ud \ud Methods\ud We performed a genome-wide association study (GWAS) to identify variants associated with BE and further analyzed promising variants identified by BEACON by genotyping 10,158 patients with BE and 21,062 controls.\ud \ud Results\ud We identified 2 SNPs not previously associated with BE: rs3072 (2p24.1; odds ratio [OR] = 1.14; 95% CI: 1.09–1.18; P = 1.8 × 10−11) and rs2701108 (12q24.21; OR = 0.90; 95% CI: 0.86–0.93; P = 7.5 × 10−9). The closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development. Our data also supported in BE cases 3 risk SNPs identified by BEACON (rs2687201, rs11789015, and rs10423674). Meta-analysis of all data identified another SNP associated with BE and esophageal adenocarcinoma: rs3784262, within ALDH1A2 (OR = 0.90; 95% CI: 0.87–0.93; P = 3.72 × 10−9).\ud \ud Conclusions\ud We identified 2 loci associated with risk of BE and provided data to support a further locus. The genes we found to be associated with risk for BE encode transcription factors involved in thoracic, diaphragmatic, and esophageal development or proteins involved in the inflammatory response.

Published
2015
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13. A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF)-independent Angiogenesis and Exerts an Additive Antiangiogenic Response with Bevacizumab

Author

Butler, Clare T., primary, Reynolds, Alison L., additional, Tosetto, Miriam, additional, Dillon, Eugene T., additional, Guiry, Patrick J., additional, Cagney, Gerard, additional, O'Sullivan, Jacintha, additional, and Kennedy, Breandán N., additional

Published
2017
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15. Impact of the inflammatory microenvironment on T-cell phenotype in the progression from reflux oesophagitis to Barrett oesophagus and oesophageal adenocarcinoma

Author

Kavanagh, Maria E., primary, Conroy, Melissa J., additional, Clarke, Niamh E., additional, Gilmartin, Niamh T., additional, O'Sullivan, Katie E., additional, Feighery, Ronan, additional, MacCarthy, Finbar, additional, O'Toole, Dermot, additional, Ravi, Narayanasamy, additional, Reynolds, John V., additional, O'Sullivan, Jacintha, additional, and Lysaght, Joanne, additional

Published
2016
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16. Determinants of short- and long-term survival from colorectal cancer in very elderly patients

Author

Sheridan, Juliette, primary, Walsh, Paul, additional, Kevans, David, additional, Cooney, Therese, additional, O'Hanlon, Shane, additional, Nolan, Blathnaid, additional, White, Anne, additional, McDermott, Edel, additional, Sheahan, Kieran, additional, O'Shea, Diarmuid, additional, Hyland, John, additional, O'Donoghue, Diarmuid, additional, O'Sullivan, Jacintha, additional, Mulcahy, Hugh, additional, and Doherty, Glen, additional

Published
2014
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20. Array-based comparative genomic hybridization in ulcerative colitis neoplasia: single non-dysplastic biopsies distinguish progressors from non-progressors

Author

Bronner, Mary P, primary, Skacel, Marek, additional, Crispin, David A, additional, Hoff, Peter D, additional, Emond, Mary J, additional, Lai, Lisa A, additional, Tubbs, Raymond R, additional, O'Sullivan, Jacintha N, additional, Rabinovitch, Peter S, additional, and Brentnall, Teresa A, additional

Published
2010
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22. W1766 Novel Migrastatin and Dorrigocin Analogues Affect Angiogenic and Pro-Inflammatory Cytokine Production in Colorectal Cancer Tumour Explants and Circulating Monocytes

Author

Cheriyan, Danny, primary, Murray, David W., additional, Tosetto, Miriam, additional, Anquetin, Guillaume, additional, Zhou, Ying, additional, Zhao, Yunxue, additional, Doran, Peter, additional, O'Donoghue, Diarmuid P., additional, Mulcahy, Hugh, additional, Murphy, Paul V., additional, and O'Sullivan, Jacintha, additional

Published
2010
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24. Increased topoisomerase IIα expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis

Author

Coss, Alan, primary, Tosetto, Miriam, additional, Fox, Edward J., additional, Sapetto-Rebow, Beata, additional, Gorman, Sheeona, additional, Kennedy, Breandán N., additional, Lloyd, Andrew T., additional, Hyland, John M., additional, O’Donoghue, Diarmuid P., additional, Sheahan, Kieran, additional, Leahy, Dermot T., additional, Mulcahy, Hugh E., additional, and O’Sullivan, Jacintha N., additional

Published
2009
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28. Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus

Author

Palles, Claire, Chegwidden, Laura, Li, Xinzhong, Findlay, John M, Farnham, Garry, Castro Giner, Francesc, Peppelenbosch, Maikel P, Kovac, Michal, Adams, Claire L, Prenen, Hans, Briggs, Sarah, Harrison, Rebecca, Sanders, Scott, MacDonald, David, Haigh, Chris, Tucker, Art, Love, Sharon, Nanji, Manoj, DeCaestecker, John, Ferry, David, Rathbone, Barrie, Hapeshi, Julie, Barr, Hugh, Moayyedi, Paul, Watson, Peter, Zietek, Barbara, Maroo, Neera, Gay, Laura, Underwood, Tim, Boulter, Lisa, McMurtry, Hugh, Monk, David, Patel, Praful, Ragunath, Krish, Al Dulaimi, David, Murray, Iain, Koss, Konrad, Veitch, Andrew, Trudgill, Nigel, Nwokolo, Chuka, Rembacken, Bjorn, Atherfold, Paul, Green, Elaine, Ang, Yeng, Kuipers, Ernst J, Chow, Wu, Paterson, Stuart, Kadri, Sudarshan, Beales, Ian, Grimley, Charles, Mullins, Paul, Beckett, Conrad, Farrant, Mark, Dixon, Andrew, Kelly, Sean, Johnson, Matthew, Wajed, Shahjehan, Dhar, Anjan, Sawyer, Elinor, Roylance, Rebecca, Onstad, Lynn, Gammon, Marilie D, Corley, Douglas A, Shaheen, Nicholas J, Bird, Nigel C, Hardie, Laura J, Reid, Brian J, Ye, Weimin, Liu, Geoffrey, Romero, Yvonne, Bernstein, Leslie, Wu, Anna H, Casson, Alan G, Fitzgerald, Rebecca, Whiteman, David C, Risch, Harvey A, Levine, David M, Vaughan, Tom L, Verhaar, Auke P, Van Den Brande, Jan, Toxopeus, Eelke L, Spaander, Manon C, Wijnhoven, Bas PL, Van Der Laan, Luc JW, Krishnadath, Kausilia, Wijmenga, Cisca, Trynka, Gosia, McManus, Ross, Reynolds, John V, O'Sullivan, Jacintha, MacMathuna, Padraic, McGarrigle, Sarah A, Kelleher, Dermot, Vermeire, Severine, Cleynen, Isabelle, Bisschops, Raf, Tomlinson, Ian, and Jankowski, Janusz

Subjects
Risk, Esophageal Neoplasms, Polymorphism, Single Nucleotide, 3. Good health, Growth Differentiation Factors, Intestinal Metaplasia, Barrett Esophagus, Susceptibility, Bone Morphogenetic Proteins, Humans, Genetic Predisposition to Disease, EAC, T-Box Domain Proteins, Cancer, Genome-Wide Association Study
Abstract

BACKGROUND & AIMS: Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subsequently, the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) identified risk loci for BE and esophageal adenocarcinoma near CRTC1 and BARX1, and within 100 kb of FOXP1. We aimed to identify further SNPs that increased BE risk and to validate previously reported associations. METHODS: We performed a genome-wide association study (GWAS) to identify variants associated with BE and further analyzed promising variants identified by BEACON by genotyping 10,158 patients with BE and 21,062 controls. RESULTS: We identified 2 SNPs not previously associated with BE: rs3072 (2p24.1; odds ratio [OR] = 1.14; 95% CI: 1.09-1.18; P = 1.8 × 10(-11)) and rs2701108 (12q24.21; OR = 0.90; 95% CI: 0.86-0.93; P = 7.5 × 10(-9)). The closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development. Our data also supported in BE cases 3 risk SNPs identified by BEACON (rs2687201, rs11789015, and rs10423674). Meta-analysis of all data identified another SNP associated with BE and esophageal adenocarcinoma: rs3784262, within ALDH1A2 (OR = 0.90; 95% CI: 0.87-0.93; P = 3.72 × 10(-9)). CONCLUSIONS: We identified 2 loci associated with risk of BE and provided data to support a further locus. The genes we found to be associated with risk for BE encode transcription factors involved in thoracic, diaphragmatic, and esophageal development or proteins involved in the inflammatory response.

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