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Start Over Author "Nwokolo, Chuka" Publisher elsevier bv
34 results on '"Nwokolo, Chuka"'

1. Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study

Author

Chanchlani, Neil, primary, Lin, Simeng, additional, Bewshea, Claire, additional, Hamilton, Benjamin, additional, Thomas, Amanda, additional, Smith, Rebecca, additional, Roberts, Christopher, additional, Bishara, Maria, additional, Nice, Rachel, additional, Lees, Charlie W, additional, Sebastian, Shaji, additional, Irving, Peter M, additional, Russell, Richard K, additional, McDonald, Timothy J, additional, Goodhand, James R, additional, Ahmad, Tariq, additional, Kennedy, Nicholas A, additional, Patel, Vinod, additional, Mazhar, Zia, additional, Saich, Rebecca, additional, Colleypriest, Ben, additional, Tham, Tony C, additional, Iqbal, Tariq, additional, Kaushik, Vishal, additional, Murugesan, Senthil, additional, Singh, Salil, additional, Weaver, Sean, additional, Preston, Cathryn, additional, Butt, Assad, additional, Smith, Melissa, additional, Basude, Dharamveer, additional, Beale, Amanda, additional, Langlands, Sarah, additional, Direkze, Natalie, additional, Parkes, Miles, additional, Torrente, Franco, additional, De La Revella Negro, Juan, additional, MacDonald, Chris Ewen, additional, Evans, Stephen M, additional, Gunasekera, Anton VJ, additional, Thakur, Alka, additional, Elphick, David, additional, Shenoy, Achuth, additional, Nwokolo, Chuka U, additional, Dhar, Anjan, additional, Cole, Andrew T, additional, Agrawal, Anurag, additional, Bridger, Stephen, additional, Doherty, Julie, additional, Cooper, Sheldon C, additional, de Silva, Shanika, additional, Mowat, Craig, additional, Mayhead, Phillip, additional, Lees, Charlie, additional, Jones, Gareth, additional, Hart, James W, additional, Chanchlani, Neil, additional, Al-Nuaimi, Yusur, additional, Richards, Ellen, additional, Haigh, Richard, additional, Greenish, Huw, additional, Heath, Harry, additional, Gaya, Daniel R, additional, Gervais, Lisa, additional, Dunckley, Paul, additional, Mahmood, Tariq, additional, Banim, Paul JR, additional, Sonwalkar, Sunil, additional, Ghosh, Deb, additional, Phillips, Rosemary H, additional, Azaz, Amer, additional, Shenderey, Richard, additional, Armstrong, Lawrence, additional, Bell, Claire, additional, Hariraj, Radhakrishnan, additional, Matthews, Helen, additional, Jafferbhoy, Hasnain, additional, Selinger, Christian P, additional, Zamvar, Veena, additional, De Caestecker, John S, additional, Willmott, Anne, additional, Miller, Richard, additional, Babu, Palani Sathish, additional, Tzivinikos, Christos, additional, Bloom, Stuart L, additional, Chung-Faye, Guy, additional, Croft, Nicholas M, additional, Fell, John ME, additional, Harbord, Marcus, additional, Hart, Ailsa, additional, Hope, Ben, additional, Lindsay, James O, additional, Mawdsley, Joel E, additional, McNair, Alistair, additional, Monahan, Kevin J, additional, Murray, Charles D, additional, Orchard, Timothy, additional, Paul, Thankam, additional, Pollok, Richard, additional, Shah, Neil, additional, Bouri, Sonia, additional, Johnson, Matt W, additional, Modi, Anita, additional, Kabiru, Kasamu Dawa, additional, Baburajan, B K, additional, Bhaduri, Bim, additional, Fagbemi, Andrew Adebayo, additional, Levison, Scott, additional, Limdi, Jimmy K, additional, Watts, Gill, additional, Foley, Stephen, additional, Ramadas, Arvind, additional, MacFaul, George, additional, Mansfield, John, additional, Grellier, Leonie, additional, Morris, Mary-Anne, additional, Tremelling, Mark, additional, Hawkey, Chris, additional, Kirkham, Sian, additional, Charlton, Charles PJ, additional, Rodrigues, Astor, additional, Simmons, Alison, additional, Lewis, Stephen J, additional, Snook, Jonathon, additional, Tighe, Mark, additional, Goggin, Patrick M, additional, De Silva, Aminda N, additional, Lal, Simon, additional, Smith, Mark S, additional, Panter, Simon, additional, Cummings, JR Fraser, additional, Dharmisari, Suranga, additional, Carter, Martyn, additional, Watts, David, additional, Mahmood, Zahid, additional, McLain, Bruce, additional, Sen, Sandip, additional, Pigott, Anna J, additional, Hobday, David, additional, Wesley, Emma, additional, Johnston, Richard, additional, Edwards, Cathryn, additional, Beckly, John, additional, Vani, Deven, additional, Ramakrishnan, Subramaniam, additional, Chaudhary, Rakesh, additional, Trudgill, Nigel J, additional, Cooney, Rachel, additional, Bell, Andy, additional, Prasad, Neeraj, additional, Gordon, John N, additional, Brookes, Matthew J, additional, Li, Andy, additional, and Gore, Stephen, additional

Published
2024
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2. Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC)

Author

Ventham, Nicholas T., primary, Kennedy, Nicholas A., additional, Kalla, Rahul, additional, Adams, Alex T., additional, Noble, Alexandra, additional, Ennis, Holly, additional, Mowat, Craig, additional, Dunlop, Malcolm G., additional, Satsangi, Jack, additional, Arnott, Ian, additional, Cahill, Aiden, additional, Smith, Malcolm, additional, Ahmad, Tariq, additional, Subramanian, Sreedhar, additional, Travis, Simon, additional, Morris, John, additional, Hamlin, John, additional, Dhar, Anjan, additional, Nwokolo, Chuka, additional, Edwards, Cathryn, additional, Creed, Tom, additional, Bloom, Stuart, additional, Yousif, Mohamed, additional, Thomas, Linzi, additional, Campbell, Simon, additional, Lewis, Stephen J., additional, Sebastian, Shaji, additional, Sen, Sandip, additional, Lal, Simon, additional, Hawkey, Chris, additional, Murray, Charles, additional, Cummings, Fraser, additional, Goh, Jason, additional, Lindsay, James O., additional, Arebi, Naila, additional, Potts, Lindsay, additional, McKinley, Aileen J., additional, Thomson, John M., additional, Todd, John A., additional, Collie, Mhairi, additional, Mowat, Ashley, additional, Gaya, Daniel R., additional, Winter, Jack, additional, Naismith, Graham D., additional, Keerie, Catriona, additional, Lewis, Steff, additional, Prescott, Robin J., additional, Lauc, Gordan, additional, Campbell, Harry, additional, McGovern, Dermot P.B., additional, Annese, Vito, additional, Zoldoš, Vlatka, additional, Permberton, Iain K., additional, Wuhrer, Manfred, additional, Kolarich, Daniel, additional, Fernandes, Daryl L., additional, Theorodorou, Evropi, additional, Daniel I. Spencer, Victoria Merrick, additional, Gardner, Richard A., additional, Doran, Ray, additional, Shubhakar, Archana, additional, Boyapati, Ray, additional, Rudan, Igor, additional, Lionetti, Paolo, additional, Akmačić, Irena Trbojević, additional, Krištić, Jasminka, additional, Vuč ković, Frano, additional, Štambuk, Jerko, additional, Novokmet, Mislav, additional, Pučić-Baković, Maja, additional, Gornik, Olga, additional, Andriulli, Angelo, additional, Cantoro, Laura, additional, Sturniolo, Giancarlo, additional, Fiorino, Gionata, additional, Manetti, Natalia, additional, Latiano, Anna, additional, Kohn, Anna, additional, D’Inca`, Renata, additional, Danese, Silvio, additional, Arnott, Ian D., additional, Noble, Colin L., additional, Lees, Charlie W., additional, Shand, Alan G., additional, Ho, Gwo-Tzer, additional, Murphy, Lee, additional, Gibson, Jude, additional, Evenden, Louise, additional, Wrobel, Nicola, additional, Gilchrist, Tamara, additional, Fawkes, Angie, additional, Kammeijer, Guinevere S.M., additional, Clerc, Florent, additional, de Haan, Noortje, additional, Vojta, Aleksandar, additional, Samaržija, Ivana, additional, Markulin, Dora, additional, Klasić, Marija, additional, Dobrinić, Paula, additional, Aulchenko, Yurii, additional, van den Heuve, Tim, additional, Jonkers, Daisy, additional, and Pierik, Marieke, additional

Published
2023
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3. HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn’s Disease

Author

Sazonovs, Aleksejs, primary, Kennedy, Nicholas A., additional, Moutsianas, Loukas, additional, Heap, Graham A., additional, Rice, Daniel L., additional, Reppell, Mark, additional, Bewshea, Claire M., additional, Chanchlani, Neil, additional, Walker, Gareth J., additional, Perry, Mandy H., additional, McDonald, Timothy J., additional, Lees, Charlie W., additional, Cummings, J.R. Fraser, additional, Parkes, Miles, additional, Mansfield, John C., additional, Irving, Peter M., additional, Barrett, Jeffrey C., additional, McGovern, Dermot, additional, Goodhand, James R., additional, Anderson, Carl A., additional, Ahmad, Tariq, additional, Patel, Vinod, additional, Mazhar, Zia, additional, Saich, Rebecca, additional, Colleypriest, Ben, additional, Tham, Tony C, additional, Iqbal, Tariq H, additional, Kaushik, Vishal, additional, Murugesan, Senthil, additional, Singh, Salil, additional, Weaver, Sean, additional, Preston, Cathryn, additional, Butt, Assad, additional, Smith, Melissa, additional, Basude, Dharamveer, additional, Beale, Amanda, additional, Langlands, Sarah, additional, Direkze, Natalie, additional, Torrente, Franco, additional, De La Revella Negro, Juan, additional, Ewen MacDonald, Chris, additional, Evans, Stephen M, additional, Gunasekera, Anton V J, additional, Thakur, Alka, additional, Elphick, David, additional, Shenoy, Achuth, additional, Nwokolo, Chuka U, additional, Dhar, Anjan, additional, Cole, Andrew T, additional, Agrawal, Anurag, additional, Bridger, Stephen, additional, Doherty, Julie, additional, Cooper, Sheldon C, additional, de Silva, Shanika, additional, Mowat, Craig, additional, Mayhead, Phillip, additional, Lees, Charlie, additional, Jones, Gareth, additional, Hart, James W, additional, Gaya, Daniel R, additional, Russell, Richard K, additional, Gervais, Lisa, additional, Dunckley, Paul, additional, Mahmood, Tariq, additional, Banim, Paul J R, additional, Sonwalkar, Sunil, additional, Ghosh, Deb, additional, Phillips, Rosemary H, additional, Azaz, Amer, additional, Sebastian, Shaji, additional, Shenderey, Richard, additional, Armstrong, Lawrence, additional, Bell, Claire, additional, Hariraj, Radhakrishnan, additional, Matthews, Helen, additional, Jafferbhoy, Hasnain, additional, Selinger, Christian P, additional, Zamvar, Veena, additional, De Caestecker, John S, additional, Willmott, Anne, additional, Miller, Richard, additional, Sathish Babu, Palani, additional, Tzivinikos, Christos, additional, Bloom, Stuart L, additional, Chung-Faye, Guy, additional, Croft, Nicholas M, additional, Fell, John ME, additional, Harbord, Marcus, additional, Hart, Ailsa, additional, Hope, Ben, additional, Irving, Peter M, additional, Lindsay, James O, additional, Mawdsley, Joel E, additional, McNair, Alistair, additional, Monahan, Kevin J, additional, Murray, Charles D, additional, Orchard, Timothy, additional, Paul, Thankam, additional, Pollok, Richard, additional, Shah, Neil, additional, Bouri, Sonia, additional, Johnson, Matt W, additional, Modi, Anita, additional, Dawa Kabiru, Kasamu, additional, Baburajan, B K, additional, Bhaduri, Bim, additional, Adebayo Fagbemi, Andrew, additional, Levison, Scott, additional, Limdi, Jimmy K, additional, Watts, Gill, additional, Foley, Stephen, additional, Ramadas, Arvind, additional, MacFaul, George, additional, Mansfield, John, additional, Grellier, Leonie, additional, Morris, Mary-Anne, additional, Tremelling, Mark, additional, Hawkey, Chris, additional, Kirkham, Sian, additional, Charlton, Charles PJ, additional, Rodrigues, Astor, additional, Simmons, Alison, additional, Lewis, Stephen J, additional, Snook, Jonathon, additional, Tighe, Mark, additional, Goggin, Patrick M, additional, De Silva, Aminda N, additional, Lal, Simon, additional, Smith, Mark S, additional, Panter, Simon, additional, Cummings, Fraser, additional, Dharmisari, Suranga, additional, Carter, Martyn, additional, Watts, David, additional, Mahmood, Zahid, additional, McLain, Bruce, additional, Sen, Sandip, additional, Pigott, Anna J, additional, Hobday, David, additional, Wesley, Emma, additional, Johnston, Richard, additional, Edwards, Cathryn, additional, Beckly, John, additional, Vani, Deven, additional, Ramakrishnan, Subramaniam, additional, Chaudhary, Rakesh, additional, Trudgill, Nigel J, additional, Cooney, Rachel, additional, Bell, Andy, additional, Prasad, Neeraj, additional, Gordon, John N, additional, Brookes, Matthew J, additional, Li, Andy, additional, and Gore, Stephen, additional

Published
2020
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4. Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

Author

Kennedy, Nicholas A, primary, Heap, Graham A, additional, Green, Harry D, additional, Hamilton, Benjamin, additional, Bewshea, Claire, additional, Walker, Gareth J, additional, Thomas, Amanda, additional, Nice, Rachel, additional, Perry, Mandy H, additional, Bouri, Sonia, additional, Chanchlani, Neil, additional, Heerasing, Neel M, additional, Hendy, Peter, additional, Lin, Simeng, additional, Gaya, Daniel R, additional, Cummings, J R Fraser, additional, Selinger, Christian P, additional, Lees, Charlie W, additional, Hart, Ailsa L, additional, Parkes, Miles, additional, Sebastian, Shaji, additional, Mansfield, John C, additional, Irving, Peter M, additional, Lindsay, James, additional, Russell, Richard K, additional, McDonald, Timothy J, additional, McGovern, Dermot, additional, Goodhand, James R, additional, Ahmad, Tariq, additional, Patel, Vinod, additional, Mazhar, Zia, additional, Saich, Rebecca, additional, Colleypriest, Ben, additional, Tham, Tony C, additional, Iqbal, Tariq H, additional, Kaushik, Vishal, additional, Murugesan, Senthil, additional, Singh, Salil, additional, Weaver, Sean, additional, Preston, Cathryn, additional, Butt, Assad, additional, Smith, Melissa, additional, Basude, Dharamveer, additional, Beale, Amanda, additional, Langlands, Sarah, additional, Direkze, Natalie, additional, Torrente, Franco, additional, De La Revella Negro, Juan, additional, MacDonald, Chris Ewen, additional, Evans, Stephen M, additional, Gunasekera, Anton V J, additional, Thakur, Alka, additional, Elphick, David, additional, Shenoy, Achuth, additional, Nwokolo, Chuka U, additional, Dhar, Anjan, additional, Cole, Andrew T, additional, Agrawal, Anurag, additional, Bridger, Stephen, additional, Doherty, Julie, additional, Cooper, Sheldon C, additional, de Silva, Shanika, additional, Mowat, Craig, additional, Mayhead, Phillip, additional, Lees, Charlie, additional, Jones, Gareth, additional, Hart, James W, additional, Gervais, Lisa, additional, Dunckley, Paul, additional, Mahmood, Tariq, additional, Banim, Paul J R, additional, Sonwalkar, Sunil, additional, Ghosh, Deb, additional, Phillips, Rosemary H, additional, Azaz, Amer, additional, Shenderey, Richard, additional, Armstrong, Lawrence, additional, Bell, Claire, additional, Hariraj, Radhakrishnan, additional, Matthews, Helen, additional, Jafferbhoy, Hasnain, additional, Zamvar, Veena, additional, De Caestecker, John S, additional, Willmott, Anne, additional, Miller, Richard, additional, Babu, Palani Sathish, additional, Tzivinikos, Christos, additional, Bloom, Stuart L, additional, Chung-Faye, Guy, additional, Croft, Nicholas M, additional, Fell, John ME, additional, Harbord, Marcus, additional, Hart, Ailsa, additional, Hope, Ben, additional, Lindsay, James O, additional, Mawdsley, Joel E, additional, McNair, Alistair, additional, Monahan, Kevin J, additional, Murray, Charles D, additional, Orchard, Timothy, additional, Paul, Thankam, additional, Pollok, Richard, additional, Shah, Neil, additional, Johnson, Matt W, additional, Modi, Anita, additional, Kabiru, Kasamu Dawa, additional, Baburajan, B K, additional, Bhaduri, Bim, additional, Fagbemi, Andrew Adebayo, additional, Levison, Scott, additional, Limdi, Jimmy K, additional, Watts, Gill, additional, Foley, Stephen, additional, Ramadas, Arvind, additional, MacFaul, George, additional, Mansfield, John, additional, Grellier, Leonie, additional, Morris, Mary-Anne, additional, Tremelling, Mark, additional, Hawkey, Chris, additional, Kirkham, Sian, additional, Charlton, Charles PJ, additional, Rodrigues, Astor, additional, Simmons, Alison, additional, Lewis, Stephen J, additional, Snook, Jonathon, additional, Tighe, Mark, additional, Goggin, Patrick M, additional, De Silva, Aminda N, additional, Lal, Simon, additional, Smith, Mark S, additional, Panter, Simon, additional, Dharmisari, Suranga, additional, Carter, Martyn, additional, Watts, David, additional, Mahmood, Zahid, additional, McLain, Bruce, additional, Sen, Sandip, additional, Pigott, Anna J, additional, Hobday, David, additional, Wesley, Emma, additional, Johnston, Richard, additional, Edwards, Cathryn, additional, Beckly, John, additional, Vani, Deven, additional, Ramakrishnan, Subramaniam, additional, Chaudhary, Rakesh, additional, Trudgill, Nigel J, additional, Cooney, Rachel, additional, Bell, Andy, additional, Prasad, Neeraj, additional, Gordon, John N, additional, Brookes, Matthew J, additional, Li, Andy, additional, and Gore, Stephen, additional

Published
2019
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5. Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus

Author

Palles, Claire, Chegwidden, Laura, Li, Xinzhong, Findlay, John M., Farnham, Garry, Castro Giner, Francesc, Peppelenbosch, Maikel P., Kovac, Michal, Adams, Claire L., Prenen, Hans, Briggs, Sarah, Harrison, Rebecca, Sanders, Scott, MacDonald, David, Haigh, Chris, Tucker, Art, Love, Sharon, Nanji, Manoj, deCaestecker, John, Ferry, David, Rathbone, Barrie, Hapeshi, Julie, Barr, Hugh, Moayyedi, Paul, Watson, Peter, Zietek, Barbara, Maroo, Neera, Gay, Laura, Underwood, Tim, Boulter, Lisa, McMurtry, Hugh, Monk, David, Patel, Praful, Ragunath, Krish, Al Dulaimi, David, Murray, Iain, Koss, Konrad, Veitch, Andrew, Trudgill, Nigel, Nwokolo, Chuka, Rembacken, Bjorn, Atherfold, Paul, Green, Elaine, Ang, Yeng, Kuipers, Ernst J., Chow, Wu, Paterson, Stuart, Kadri, Sudarshan, Beales, Ian, Grimley, Charles, Mullins, Paul, Beckett, Conrad, Farrant, Mark, Dixon, Andrew, Kelly, Sean, Johnson, Matthew, Wajed, Shahjehan, Dhar, Anjan, Sawyer, Elinor, Roylance, Rebecca, Onstad, Lynn, Gammon, Marilie D., Corley, Douglas A., Shaheen, Nicholas J., Bird, Nigel C., Hardie, Laura J., Reid, Brian J., Ye, Weimin, Liu, Geoffrey, Romero, Yvonne, Bernstein, Leslie, Wu, Anna H., Casson, Alan G., Fitzgerald, Rebecca, Whiteman, David C., Risch, Harvey A., Levine, David M., Vaughan, Tom L., Verhaar, Auke P., van den Brande, Jan, Toxopeus, Eelke L., Spaander, Manon C., Wijnhoven, Bas P.L., van der Laan, Luc J.W., Krishnadath, Kausilia, Wijmenga, Cisca, Trynka, Gosia, McManus, Ross, Reynolds, John V., O’Sullivan, Jacintha, MacMathuna, Padraic, McGarrigle, Sarah A., Kelleher, Dermot, Vermeire, Severine, Cleynen, Isabelle, Bisschops, Raf, Tomlinson, Ian, and Jankowski, Janusz

Subjects
Risk, Esophageal Neoplasms, LD, linkage disequilibrium, ASE, allele-specific expression, eQTL, expression quantitative trait locus, Polymorphism, Single Nucleotide, Barrett Esophagus, Intestinal Metaplasia, Full Report: Basic and Translational—Alimentary Tract, BE, Barrett’s esophagus, Humans, Genetic Predisposition to Disease, EAC, esophageal adenocarcinoma, EAC, GWAS, genome-wide association study, Original Research, Cancer, BEACON, Barrett's and Esophageal Adenocarcinoma Consortium, Gastroenterology, PC, principal component, SNP, single nucleotide polymorphism, A300, CI, confidence interval, OR, odds ratio, Growth Differentiation Factors, Susceptibility, Bone Morphogenetic Proteins, TCGA, The Cancer Genome Atlas, Human medicine, T-Box Domain Proteins, Genome-Wide Association Study
Abstract

Background & Aims\ud Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subsequently, the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) identified risk loci for BE and esophageal adenocarcinoma near CRTC1 and BARX1, and within 100 kb of FOXP1. We aimed to identify further SNPs that increased BE risk and to validate previously reported associations.\ud \ud Methods\ud We performed a genome-wide association study (GWAS) to identify variants associated with BE and further analyzed promising variants identified by BEACON by genotyping 10,158 patients with BE and 21,062 controls.\ud \ud Results\ud We identified 2 SNPs not previously associated with BE: rs3072 (2p24.1; odds ratio [OR] = 1.14; 95% CI: 1.09–1.18; P = 1.8 × 10−11) and rs2701108 (12q24.21; OR = 0.90; 95% CI: 0.86–0.93; P = 7.5 × 10−9). The closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development. Our data also supported in BE cases 3 risk SNPs identified by BEACON (rs2687201, rs11789015, and rs10423674). Meta-analysis of all data identified another SNP associated with BE and esophageal adenocarcinoma: rs3784262, within ALDH1A2 (OR = 0.90; 95% CI: 0.87–0.93; P = 3.72 × 10−9).\ud \ud Conclusions\ud We identified 2 loci associated with risk of BE and provided data to support a further locus. The genes we found to be associated with risk for BE encode transcription factors involved in thoracic, diaphragmatic, and esophageal development or proteins involved in the inflammatory response.

Published
2015
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6. Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial

Author

Mowat, Craig, primary, Arnott, Ian, additional, Cahill, Aiden, additional, Smith, Malcolm, additional, Ahmad, Tariq, additional, Subramanian, Sreedhar, additional, Travis, Simon, additional, Morris, John, additional, Hamlin, John, additional, Dhar, Anjan, additional, Nwokolo, Chuka, additional, Edwards, Cathryn, additional, Creed, Tom, additional, Bloom, Stuart, additional, Yousif, Mohamed, additional, Thomas, Linzi, additional, Campbell, Simon, additional, Lewis, Stephen J, additional, Sebastian, Shaji, additional, Sen, Sandip, additional, Lal, Simon, additional, Hawkey, Chris, additional, Murray, Charles, additional, Cummings, Fraser, additional, Goh, Jason, additional, Lindsay, James O, additional, Arebi, Naila, additional, Potts, Lindsay, additional, McKinley, Aileen J, additional, Thomson, John M, additional, Todd, John A, additional, Collie, Mhairi, additional, Dunlop, Malcolm G, additional, Mowat, Ashley, additional, Gaya, Daniel R, additional, Winter, Jack, additional, Naismith, Graham D, additional, Ennis, Holly, additional, Keerie, Catriona, additional, Lewis, Steff, additional, Prescott, Robin J, additional, Kennedy, Nicholas A, additional, and Satsangi, Jack, additional

Published
2016
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8. Sa1264 A Randomised, Double-Blind, Placebo-Controlled, Parallel Group, Multi-Centred Pilot Study to Assess the Symptomatic Treatment of Ulcerative Colitis With Cannabidiol

Author

Irving, Peter M., primary, Iqbal, Tariq, additional, Nwokolo, Chuka, additional, Subramanian, Sreedhar, additional, Bloom, Stuart L., additional, Prasad, Neeraj, additional, Hart, Ailsa, additional, Murray, Charles, additional, Lindsay, James O., additional, Taylor, Adam, additional, Barron, Rachel, additional, and Wright, Stephen, additional

Published
2015
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11. Tu1255 Detection of Urinary Volatile Organic Compounds in Patients With Inflammatory Bowel Disease and Controls by an Electronic Nose -A Transatlantic Study

Author

Covington, James, primary, Harbord, Ruth, additional, Westenbrink, Eric W., additional, Bailey, Catherine, additional, O'connell, Nicola, additional, Dhaliwal, Amritpal, additional, Nwokolo, Chuka, additional, Foley, Anne, additional, Marya, Neil B., additional, Baptista, Veronica, additional, Dev Bardhan, Karna, additional, Cave, David R., additional, and Arasaradnam, Ramesh, additional

Published
2014
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12. Su1453 Distinguishing Coeliac Disease (CD) From Irritable Bowel Syndrome (IBS) by Urine Volatile Organic Compound Analysis. A Pilot Study

Author

Covington, James, primary, Harbord, Ruth, additional, Westenbrink, Eric W., additional, Chambers, Samantha, additional, McFarlane, Michael, additional, Dhaliwal, Amritpal, additional, Oconnell, Nicola C., additional, Bailey, Catherine, additional, Nwokolo, Chuka, additional, Bardhan, Karna Dev, additional, and Arasaradnam, Ramesh, additional

Published
2014
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34. Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus

Author

Palles, Claire, Chegwidden, Laura, Li, Xinzhong, Findlay, John M, Farnham, Garry, Castro Giner, Francesc, Peppelenbosch, Maikel P, Kovac, Michal, Adams, Claire L, Prenen, Hans, Briggs, Sarah, Harrison, Rebecca, Sanders, Scott, MacDonald, David, Haigh, Chris, Tucker, Art, Love, Sharon, Nanji, Manoj, DeCaestecker, John, Ferry, David, Rathbone, Barrie, Hapeshi, Julie, Barr, Hugh, Moayyedi, Paul, Watson, Peter, Zietek, Barbara, Maroo, Neera, Gay, Laura, Underwood, Tim, Boulter, Lisa, McMurtry, Hugh, Monk, David, Patel, Praful, Ragunath, Krish, Al Dulaimi, David, Murray, Iain, Koss, Konrad, Veitch, Andrew, Trudgill, Nigel, Nwokolo, Chuka, Rembacken, Bjorn, Atherfold, Paul, Green, Elaine, Ang, Yeng, Kuipers, Ernst J, Chow, Wu, Paterson, Stuart, Kadri, Sudarshan, Beales, Ian, Grimley, Charles, Mullins, Paul, Beckett, Conrad, Farrant, Mark, Dixon, Andrew, Kelly, Sean, Johnson, Matthew, Wajed, Shahjehan, Dhar, Anjan, Sawyer, Elinor, Roylance, Rebecca, Onstad, Lynn, Gammon, Marilie D, Corley, Douglas A, Shaheen, Nicholas J, Bird, Nigel C, Hardie, Laura J, Reid, Brian J, Ye, Weimin, Liu, Geoffrey, Romero, Yvonne, Bernstein, Leslie, Wu, Anna H, Casson, Alan G, Fitzgerald, Rebecca, Whiteman, David C, Risch, Harvey A, Levine, David M, Vaughan, Tom L, Verhaar, Auke P, Van Den Brande, Jan, Toxopeus, Eelke L, Spaander, Manon C, Wijnhoven, Bas PL, Van Der Laan, Luc JW, Krishnadath, Kausilia, Wijmenga, Cisca, Trynka, Gosia, McManus, Ross, Reynolds, John V, O'Sullivan, Jacintha, MacMathuna, Padraic, McGarrigle, Sarah A, Kelleher, Dermot, Vermeire, Severine, Cleynen, Isabelle, Bisschops, Raf, Tomlinson, Ian, and Jankowski, Janusz

Subjects
Risk, Esophageal Neoplasms, Polymorphism, Single Nucleotide, 3. Good health, Growth Differentiation Factors, Intestinal Metaplasia, Barrett Esophagus, Susceptibility, Bone Morphogenetic Proteins, Humans, Genetic Predisposition to Disease, EAC, T-Box Domain Proteins, Cancer, Genome-Wide Association Study
Abstract

BACKGROUND & AIMS: Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subsequently, the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) identified risk loci for BE and esophageal adenocarcinoma near CRTC1 and BARX1, and within 100 kb of FOXP1. We aimed to identify further SNPs that increased BE risk and to validate previously reported associations. METHODS: We performed a genome-wide association study (GWAS) to identify variants associated with BE and further analyzed promising variants identified by BEACON by genotyping 10,158 patients with BE and 21,062 controls. RESULTS: We identified 2 SNPs not previously associated with BE: rs3072 (2p24.1; odds ratio [OR] = 1.14; 95% CI: 1.09-1.18; P = 1.8 × 10(-11)) and rs2701108 (12q24.21; OR = 0.90; 95% CI: 0.86-0.93; P = 7.5 × 10(-9)). The closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development. Our data also supported in BE cases 3 risk SNPs identified by BEACON (rs2687201, rs11789015, and rs10423674). Meta-analysis of all data identified another SNP associated with BE and esophageal adenocarcinoma: rs3784262, within ALDH1A2 (OR = 0.90; 95% CI: 0.87-0.93; P = 3.72 × 10(-9)). CONCLUSIONS: We identified 2 loci associated with risk of BE and provided data to support a further locus. The genes we found to be associated with risk for BE encode transcription factors involved in thoracic, diaphragmatic, and esophageal development or proteins involved in the inflammatory response.

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